JP4365221B2 - 親水性ポリマー−マルチカルボキシルオリゴペプチドと薬剤分子との結合生成物、医薬組成物およびその薬学上の使用 - Google Patents

親水性ポリマー−マルチカルボキシルオリゴペプチドと薬剤分子との結合生成物、医薬組成物およびその薬学上の使用 Download PDF

Info

Publication number
JP4365221B2
JP4365221B2 JP2003573050A JP2003573050A JP4365221B2 JP 4365221 B2 JP4365221 B2 JP 4365221B2 JP 2003573050 A JP2003573050 A JP 2003573050A JP 2003573050 A JP2003573050 A JP 2003573050A JP 4365221 B2 JP4365221 B2 JP 4365221B2
Authority
JP
Japan
Prior art keywords
group
binding product
product according
hydrophilic polymer
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2003573050A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005519122A (ja
JP2005519122A5 (https=
Inventor
世山 ▲稽▼
▲徳▼▲權▼ 朱
Original Assignee
北京鍵▲凱▼科技有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 北京鍵▲凱▼科技有限公司 filed Critical 北京鍵▲凱▼科技有限公司
Publication of JP2005519122A publication Critical patent/JP2005519122A/ja
Publication of JP2005519122A5 publication Critical patent/JP2005519122A5/ja
Application granted granted Critical
Publication of JP4365221B2 publication Critical patent/JP4365221B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Polyamides (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polyesters Or Polycarbonates (AREA)
JP2003573050A 2002-03-05 2003-03-05 親水性ポリマー−マルチカルボキシルオリゴペプチドと薬剤分子との結合生成物、医薬組成物およびその薬学上の使用 Expired - Lifetime JP4365221B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CNB021066914A CN100475269C (zh) 2002-03-05 2002-03-05 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途
PCT/CN2003/000164 WO2003074586A1 (en) 2002-03-05 2003-03-05 Compound of hydrophilic polymer-polycarboxyl oligopeptide and medicines, medical composite comprising above compound and use of above compound in medicimes

Publications (3)

Publication Number Publication Date
JP2005519122A JP2005519122A (ja) 2005-06-30
JP2005519122A5 JP2005519122A5 (https=) 2005-12-22
JP4365221B2 true JP4365221B2 (ja) 2009-11-18

Family

ID=27768504

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003573050A Expired - Lifetime JP4365221B2 (ja) 2002-03-05 2003-03-05 親水性ポリマー−マルチカルボキシルオリゴペプチドと薬剤分子との結合生成物、医薬組成物およびその薬学上の使用

Country Status (9)

Country Link
US (1) US7498035B2 (https=)
EP (1) EP1489125B1 (https=)
JP (1) JP4365221B2 (https=)
CN (2) CN100475269C (https=)
AT (1) ATE456379T1 (https=)
AU (1) AU2003221208A1 (https=)
DE (1) DE60331135D1 (https=)
ES (1) ES2340374T3 (https=)
WO (1) WO2003074586A1 (https=)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2291620T3 (es) * 2002-03-13 2008-03-01 Beijing Jiankai Technology Co., Ltd. Derivado de polimeros hidrfilicos con rama tipo y y metodo de preparacion de compuesto metodo que comprende el compuesto anterior.
CN1613868A (zh) * 2003-11-07 2005-05-11 北京键凯科技有限公司 亲水性聚合物－黄杨木提取物的结合物及其药物组合物
CN100374443C (zh) * 2004-03-29 2008-03-12 北京键凯科技有限公司 亲水性聚合物-雷公藤提取物的结合物及其药物组合物
CN100475837C (zh) * 2004-06-11 2009-04-08 北京键凯科技有限公司 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物
JP4820758B2 (ja) * 2004-09-22 2011-11-24 日本化薬株式会社 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤
JP5249016B2 (ja) 2006-03-28 2013-07-31 日本化薬株式会社 タキサン類の高分子結合体
KR20090009241A (ko) 2006-05-18 2009-01-22 니폰 가야꾸 가부시끼가이샤 포도필로톡신류의 고분자 결합체
MX2009002855A (es) * 2006-09-15 2009-03-30 Enzon Pharmaceuticals Inc Profarmacos polimericos dirigidos que contienen enlazadores multifuncionales.
ES2584840T3 (es) * 2006-10-03 2016-09-29 Nippon Kayaku Kabushiki Kaisha Compuesto de un derivado de resorcinol con un polímero
CN101168594B (zh) * 2006-10-24 2011-07-27 北京键凯科技有限公司 寡肽为骨架的聚乙二醇活性衍生物、其制备方法及与药物分子的结合物
WO2008056596A1 (fr) * 2006-11-06 2008-05-15 Nippon Kayaku Kabushiki Kaisha Dérivé polymère d'un antagoniste métabolique d'acide nucléique
JP5548365B2 (ja) * 2006-11-08 2014-07-16 日本化薬株式会社 核酸系代謝拮抗剤の高分子誘導体
US8703878B2 (en) * 2007-09-28 2014-04-22 Nippon Kayaku Kabushiki Kaisha High-molecular weight conjugate of steroids
WO2009116509A1 (ja) 2008-03-18 2009-09-24 日本化薬株式会社 生理活性物質の高分子結合体
WO2009136572A1 (ja) 2008-05-08 2009-11-12 日本化薬株式会社 葉酸若しくは葉酸誘導体の高分子結合体
JP2011162569A (ja) * 2008-05-23 2011-08-25 Nano Career Kk カンプトテシン高分子誘導体及びその用途
ITRM20080551A1 (it) * 2008-10-15 2010-04-16 Univ Catania Derivati anfifilici del poliossietilenglicole (peg), procedimento di preparazione e loro usi nella preparazione di sistemi farmaceutici.
EP2431403B1 (en) * 2009-05-15 2016-09-28 Nipponkayaku Kabushikikaisha Polymer conjugate of bioactive substance having hydroxy group
JP2013234207A (ja) * 2010-08-31 2013-11-21 Jsr Corp 新規重合体及び新規ｎ−カルボキシアミノ酸無水物、ならびにそれらの製造方法
EP2641605B1 (en) 2010-11-17 2018-03-07 Nippon Kayaku Kabushiki Kaisha Polymer derivative of cytidine metabolism antagonist
KR101849142B1 (ko) 2011-09-11 2018-04-16 니폰 가야꾸 가부시끼가이샤 블록 공중합체의 제조방법
CN103083680B (zh) * 2011-11-07 2014-12-24 北京键凯科技有限公司 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物
WO2014093343A2 (en) * 2012-12-10 2014-06-19 Massachusetts Institute Of Technology Multistage nanoparticle drug delivery system for the treatment of solid tumors
US9700633B2 (en) 2013-01-28 2017-07-11 Jenkem Technology Co., Ltd., Tianjin Branch Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof
WO2014114262A1 (zh) * 2013-01-28 2014-07-31 天津键凯科技有限公司 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途
WO2015081821A1 (zh) * 2013-12-02 2015-06-11 北京键凯科技有限公司 聚乙二醇-多爪寡肽键合的雷帕霉素衍生物
CN107033305B (zh) * 2017-05-20 2019-03-01 西南大学 一种还原性响应的两亲性蠕虫状单分子前药的制备方法
CN114948850B (zh) * 2022-05-26 2024-02-27 中国药科大学 可载药寡肽及其可溶性分层微针的制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6096605A (ja) * 1983-10-31 1985-05-30 Mitsubishi Chem Ind Ltd 低分子量の水溶性物質の分離方法
DE3730797A1 (de) * 1987-09-14 1989-03-23 Siegel Rolf Materialien mit nicht-thrombogener oberflaeche
EP0835931A4 (en) * 1995-06-26 2000-11-15 Daiichi Pure Chemicals Co Ltd STABLE PLASMINE SOLUTION
US5672662A (en) * 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
DE69735057T2 (de) * 1996-03-12 2006-08-31 PG-TXL Co., L.P., Houston Wasserlösliche paclitaxel-prodrogen
CN1110681C (zh) * 1996-04-10 2003-06-04 丰田自动车株式会社 有色金属熔化保持炉与有色金属熔液保持炉
US6824766B2 (en) * 1998-04-17 2004-11-30 Enzon, Inc. Biodegradable high molecular weight polymeric linkers and their conjugates
US7060708B2 (en) * 1999-03-10 2006-06-13 New River Pharmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
US6733755B2 (en) * 2000-02-04 2004-05-11 Supratek Pharma, Inc. Ligand for vascular endothelial growth factor receptor
CN1376785A (zh) * 2001-03-22 2002-10-30 上海博德基因开发有限公司 一种多肽——硫氨焦磷酸激酶－26.73和编码这种多肽的多核苷酸
US6489153B1 (en) * 2001-10-31 2002-12-03 Pe Corporation (Ny) Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
EP1580216B1 (en) * 2002-10-31 2014-05-14 Nippon Kayaku Kabushiki Kaisha High-molecular weight derivatives of camptothecins

Also Published As

Publication number Publication date
CN100400657C (zh) 2008-07-09
EP1489125A4 (en) 2006-09-13
JP2005519122A (ja) 2005-06-30
ATE456379T1 (de) 2010-02-15
US20050147617A1 (en) 2005-07-07
CN1886500A (zh) 2006-12-27
EP1489125A1 (en) 2004-12-22
EP1489125B1 (en) 2010-01-27
US7498035B2 (en) 2009-03-03
ES2340374T3 (es) 2010-06-02
DE60331135D1 (de) 2010-03-18
CN100475269C (zh) 2009-04-08
AU2003221208A1 (en) 2003-09-16
WO2003074586A1 (en) 2003-09-12
CN1442440A (zh) 2003-09-17

Similar Documents

Publication Publication Date Title
JP4365221B2 (ja) 親水性ポリマー−マルチカルボキシルオリゴペプチドと薬剤分子との結合生成物、医薬組成物およびその薬学上の使用
JP4272537B2 (ja) Ｙ型分鎖親水性ポリマー誘導体、それらの調製方法、前記誘導体および薬剤分子の結合生成物、ならびに前記結合生成物を含む医薬組成物
WO2005121181A1 (en) Multi-drop tree branching polyethylene glycol-oligopeptides and active derivates and pharmaceutical compounds there of
CN103755949B (zh) 多臂聚乙二醇衍生物及其与药物的结合物和凝胶
CA2208841C (en) High molecular weight polymer-based prodrugs
WO2010060260A1 (zh) 新型的多臂聚乙二醇及其制备方法和应用
JP6790133B2 (ja) マルチアームポリエチレングリコール及びその活性誘導体
US11180615B2 (en) Cationic polyphosphazene compound, polyphosphazenes-drug conjugate compound and method for preparing same
WO2013067767A1 (zh) 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物
CN100374443C (zh) 亲水性聚合物-雷公藤提取物的结合物及其药物组合物
US20050220753A1 (en) Hydrophilic polymers-flavoids conjugates and pharmaceutical compositions comprising them
CN101306203B (zh) 亲水性聚合物-黄杨木提取物的结合物及其药物组合物
US7708978B2 (en) Targeted hydrophilic polymer, binders with interferon and medical composite comprising above binders
CN1259314C (zh) 亲水性聚合物－黄酮结合物以及包含该结合物的药物组合物
CN110772643B (zh) α-生育酚聚乙二醇琥珀酸酯修饰的强心苷类化合物前药

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050401

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050401

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20081127

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090227

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090409

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090703

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20090728

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090820

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120828

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 4365221

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130828

Year of fee payment: 4

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term