ATE456379T1 - Verbindung aus hydrophilem polymer und polycarboxyloligopeptid und arzneimittel, die obige verbindung enthaltender medizinischer verbund und verwendung der obigen verbindung in arzneimitteln - Google Patents
Verbindung aus hydrophilem polymer und polycarboxyloligopeptid und arzneimittel, die obige verbindung enthaltender medizinischer verbund und verwendung der obigen verbindung in arzneimittelnInfo
- Publication number
- ATE456379T1 ATE456379T1 AT03711787T AT03711787T ATE456379T1 AT E456379 T1 ATE456379 T1 AT E456379T1 AT 03711787 T AT03711787 T AT 03711787T AT 03711787 T AT03711787 T AT 03711787T AT E456379 T1 ATE456379 T1 AT E456379T1
- Authority
- AT
- Austria
- Prior art keywords
- compound
- medicinal
- above compound
- polycarboxylo
- ligopeptide
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 4
- 229940126601 medicinal product Drugs 0.000 title 1
- 229920000642 polymer Polymers 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 abstract 1
- KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 abstract 1
- 102000015636 Oligopeptides Human genes 0.000 abstract 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 1
- 229930012538 Paclitaxel Natural products 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 229940041181 antineoplastic drug Drugs 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 abstract 1
- 229940127093 camptothecin Drugs 0.000 abstract 1
- VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 125000004404 heteroalkyl group Chemical group 0.000 abstract 1
- 125000005647 linker group Chemical group 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 229960001592 paclitaxel Drugs 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 abstract 1
- 229920003169 water-soluble polymer Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
- Polyamides (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polyesters Or Polycarbonates (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021066914A CN100475269C (zh) | 2002-03-05 | 2002-03-05 | 亲水性聚合物-谷氨酸寡肽与药物分子的结合物、包含该结合物的组合物及用途 |
| PCT/CN2003/000164 WO2003074586A1 (en) | 2002-03-05 | 2003-03-05 | Compound of hydrophilic polymer-polycarboxyl oligopeptide and medicines, medical composite comprising above compound and use of above compound in medicimes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE456379T1 true ATE456379T1 (de) | 2010-02-15 |
Family
ID=27768504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03711787T ATE456379T1 (de) | 2002-03-05 | 2003-03-05 | Verbindung aus hydrophilem polymer und polycarboxyloligopeptid und arzneimittel, die obige verbindung enthaltender medizinischer verbund und verwendung der obigen verbindung in arzneimitteln |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7498035B2 (https=) |
| EP (1) | EP1489125B1 (https=) |
| JP (1) | JP4365221B2 (https=) |
| CN (2) | CN100475269C (https=) |
| AT (1) | ATE456379T1 (https=) |
| AU (1) | AU2003221208A1 (https=) |
| DE (1) | DE60331135D1 (https=) |
| ES (1) | ES2340374T3 (https=) |
| WO (1) | WO2003074586A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2291620T3 (es) * | 2002-03-13 | 2008-03-01 | Beijing Jiankai Technology Co., Ltd. | Derivado de polimeros hidrfilicos con rama tipo y y metodo de preparacion de compuesto metodo que comprende el compuesto anterior. |
| CN1613868A (zh) * | 2003-11-07 | 2005-05-11 | 北京键凯科技有限公司 | 亲水性聚合物－黄杨木提取物的结合物及其药物组合物 |
| CN100374443C (zh) * | 2004-03-29 | 2008-03-12 | 北京键凯科技有限公司 | 亲水性聚合物-雷公藤提取物的结合物及其药物组合物 |
| CN100475837C (zh) * | 2004-06-11 | 2009-04-08 | 北京键凯科技有限公司 | 多叉分支的聚乙二醇-氨基酸寡肽及其活性衍生物和药物结合物 |
| JP4820758B2 (ja) * | 2004-09-22 | 2011-11-24 | 日本化薬株式会社 | 新規ブロック共重合体、ミセル調製物及びそれを有効成分とする抗癌剤 |
| JP5249016B2 (ja) | 2006-03-28 | 2013-07-31 | 日本化薬株式会社 | タキサン類の高分子結合体 |
| KR20090009241A (ko) | 2006-05-18 | 2009-01-22 | 니폰 가야꾸 가부시끼가이샤 | 포도필로톡신류의 고분자 결합체 |
| MX2009002855A (es) * | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Profarmacos polimericos dirigidos que contienen enlazadores multifuncionales. |
| ES2584840T3 (es) * | 2006-10-03 | 2016-09-29 | Nippon Kayaku Kabushiki Kaisha | Compuesto de un derivado de resorcinol con un polímero |
| CN101168594B (zh) * | 2006-10-24 | 2011-07-27 | 北京键凯科技有限公司 | 寡肽为骨架的聚乙二醇活性衍生物、其制备方法及与药物分子的结合物 |
| WO2008056596A1 (fr) * | 2006-11-06 | 2008-05-15 | Nippon Kayaku Kabushiki Kaisha | Dérivé polymère d'un antagoniste métabolique d'acide nucléique |
| JP5548365B2 (ja) * | 2006-11-08 | 2014-07-16 | 日本化薬株式会社 | 核酸系代謝拮抗剤の高分子誘導体 |
| US8703878B2 (en) * | 2007-09-28 | 2014-04-22 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight conjugate of steroids |
| WO2009116509A1 (ja) | 2008-03-18 | 2009-09-24 | 日本化薬株式会社 | 生理活性物質の高分子結合体 |
| WO2009136572A1 (ja) | 2008-05-08 | 2009-11-12 | 日本化薬株式会社 | 葉酸若しくは葉酸誘導体の高分子結合体 |
| JP2011162569A (ja) * | 2008-05-23 | 2011-08-25 | Nano Career Kk | カンプトテシン高分子誘導体及びその用途 |
| ITRM20080551A1 (it) * | 2008-10-15 | 2010-04-16 | Univ Catania | Derivati anfifilici del poliossietilenglicole (peg), procedimento di preparazione e loro usi nella preparazione di sistemi farmaceutici. |
| EP2431403B1 (en) * | 2009-05-15 | 2016-09-28 | Nipponkayaku Kabushikikaisha | Polymer conjugate of bioactive substance having hydroxy group |
| JP2013234207A (ja) * | 2010-08-31 | 2013-11-21 | Jsr Corp | 新規重合体及び新規ｎ−カルボキシアミノ酸無水物、ならびにそれらの製造方法 |
| EP2641605B1 (en) | 2010-11-17 | 2018-03-07 | Nippon Kayaku Kabushiki Kaisha | Polymer derivative of cytidine metabolism antagonist |
| KR101849142B1 (ko) | 2011-09-11 | 2018-04-16 | 니폰 가야꾸 가부시끼가이샤 | 블록 공중합체의 제조방법 |
| CN103083680B (zh) * | 2011-11-07 | 2014-12-24 | 北京键凯科技有限公司 | 聚乙二醇-氨基酸寡肽-依诺替康药物结合物及其药物组合物 |
| WO2014093343A2 (en) * | 2012-12-10 | 2014-06-19 | Massachusetts Institute Of Technology | Multistage nanoparticle drug delivery system for the treatment of solid tumors |
| US9700633B2 (en) | 2013-01-28 | 2017-07-11 | Jenkem Technology Co., Ltd., Tianjin Branch | Conjugates of water soluble polymer-amino acid oligopeptide-drug, preparation method and use thereof |
| WO2014114262A1 (zh) * | 2013-01-28 | 2014-07-31 | 天津键凯科技有限公司 | 水溶性聚合物-氨基酸寡肽-药物结合物及其制备方法和用途 |
| WO2015081821A1 (zh) * | 2013-12-02 | 2015-06-11 | 北京键凯科技有限公司 | 聚乙二醇-多爪寡肽键合的雷帕霉素衍生物 |
| CN107033305B (zh) * | 2017-05-20 | 2019-03-01 | 西南大学 | 一种还原性响应的两亲性蠕虫状单分子前药的制备方法 |
| CN114948850B (zh) * | 2022-05-26 | 2024-02-27 | 中国药科大学 | 可载药寡肽及其可溶性分层微针的制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6096605A (ja) * | 1983-10-31 | 1985-05-30 | Mitsubishi Chem Ind Ltd | 低分子量の水溶性物質の分離方法 |
| DE3730797A1 (de) * | 1987-09-14 | 1989-03-23 | Siegel Rolf | Materialien mit nicht-thrombogener oberflaeche |
| EP0835931A4 (en) * | 1995-06-26 | 2000-11-15 | Daiichi Pure Chemicals Co Ltd | STABLE PLASMINE SOLUTION |
| US5672662A (en) * | 1995-07-07 | 1997-09-30 | Shearwater Polymers, Inc. | Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications |
| DE69735057T2 (de) * | 1996-03-12 | 2006-08-31 | PG-TXL Co., L.P., Houston | Wasserlösliche paclitaxel-prodrogen |
| CN1110681C (zh) * | 1996-04-10 | 2003-06-04 | 丰田自动车株式会社 | 有色金属熔化保持炉与有色金属熔液保持炉 |
| US6824766B2 (en) * | 1998-04-17 | 2004-11-30 | Enzon, Inc. | Biodegradable high molecular weight polymeric linkers and their conjugates |
| US7060708B2 (en) * | 1999-03-10 | 2006-06-13 | New River Pharmaceuticals Inc. | Active agent delivery systems and methods for protecting and administering active agents |
| US6733755B2 (en) * | 2000-02-04 | 2004-05-11 | Supratek Pharma, Inc. | Ligand for vascular endothelial growth factor receptor |
| CN1376785A (zh) * | 2001-03-22 | 2002-10-30 | 上海博德基因开发有限公司 | 一种多肽——硫氨焦磷酸激酶－26.73和编码这种多肽的多核苷酸 |
| US6489153B1 (en) * | 2001-10-31 | 2002-12-03 | Pe Corporation (Ny) | Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof |
| EP1580216B1 (en) * | 2002-10-31 | 2014-05-14 | Nippon Kayaku Kabushiki Kaisha | High-molecular weight derivatives of camptothecins |
-
2002
- 2002-03-05 CN CNB021066914A patent/CN100475269C/zh not_active Expired - Lifetime
-
2003
- 2003-03-05 JP JP2003573050A patent/JP4365221B2/ja not_active Expired - Lifetime
- 2003-03-05 WO PCT/CN2003/000164 patent/WO2003074586A1/zh not_active Ceased
- 2003-03-05 AT AT03711787T patent/ATE456379T1/de not_active IP Right Cessation
- 2003-03-05 DE DE60331135T patent/DE60331135D1/de not_active Expired - Lifetime
- 2003-03-05 EP EP03711787A patent/EP1489125B1/en not_active Expired - Lifetime
- 2003-03-05 AU AU2003221208A patent/AU2003221208A1/en not_active Abandoned
- 2003-03-05 ES ES03711787T patent/ES2340374T3/es not_active Expired - Lifetime
- 2003-03-05 US US10/506,524 patent/US7498035B2/en not_active Expired - Lifetime
- 2003-12-31 CN CNB2003801109158A patent/CN100400657C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP4365221B2 (ja) | 2009-11-18 |
| CN100400657C (zh) | 2008-07-09 |
| EP1489125A4 (en) | 2006-09-13 |
| JP2005519122A (ja) | 2005-06-30 |
| US20050147617A1 (en) | 2005-07-07 |
| CN1886500A (zh) | 2006-12-27 |
| EP1489125A1 (en) | 2004-12-22 |
| EP1489125B1 (en) | 2010-01-27 |
| US7498035B2 (en) | 2009-03-03 |
| ES2340374T3 (es) | 2010-06-02 |
| DE60331135D1 (de) | 2010-03-18 |
| CN100475269C (zh) | 2009-04-08 |
| AU2003221208A1 (en) | 2003-09-16 |
| WO2003074586A1 (en) | 2003-09-12 |
| CN1442440A (zh) | 2003-09-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |