JP4258575B2 - 新規ａ８３５４３化合物及びそれらの製造法 - Google Patents

新規ａ８３５４３化合物及びそれらの製造法 Download PDF

Info

Publication number
JP4258575B2
JP4258575B2 JP52034194A JP52034194A JP4258575B2 JP 4258575 B2 JP4258575 B2 JP 4258575B2 JP 52034194 A JP52034194 A JP 52034194A JP 52034194 A JP52034194 A JP 52034194A JP 4258575 B2 JP4258575 B2 JP 4258575B2
Authority
JP
Japan
Prior art keywords
formula
compound
compounds
nrrl
insect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP52034194A
Other languages
English (en)
Japanese (ja)
Other versions
JPH08507533A (ja
Inventor
ジヨン・エス ミンダース，
パトリク・ジエイ ベイカー，
ジエイムズ・エイ メイブ，
ジヤン・アール ターナー，
メアリー・エル・ビー フバー，
メアリー・シー ブロートン，
ウオルター・エム ナカツカサ，
ローレンス クリーマー，
ハーバート・エイ カースト，
ジエイムズ・ダブリユー マーテイン，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Corteva Agriscience LLC
Original Assignee
Dow AgroSciences LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow AgroSciences LLC filed Critical Dow AgroSciences LLC
Publication of JPH08507533A publication Critical patent/JPH08507533A/ja
Application granted granted Critical
Publication of JP4258575B2 publication Critical patent/JP4258575B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/08—Systemic pesticides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/10—Insect repellent
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Environmental Sciences (AREA)
  • Dentistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Devices That Are Associated With Refrigeration Equipment (AREA)
  • Manufacturing Of Printed Wiring (AREA)
  • Medicines Containing Plant Substances (AREA)
JP52034194A 1993-03-12 1994-03-11 新規ａ８３５４３化合物及びそれらの製造法 Expired - Lifetime JP4258575B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US3052293A 1993-03-12 1993-03-12
US08/030,522 1993-03-12
PCT/US1994/002674 WO1994020518A1 (en) 1993-03-12 1994-03-11 New a83543 compounds and process for production thereof

Publications (2)

Publication Number Publication Date
JPH08507533A JPH08507533A (ja) 1996-08-13
JP4258575B2 true JP4258575B2 (ja) 2009-04-30

Family

ID=21854619

Family Applications (1)

Application Number Title Priority Date Filing Date
JP52034194A Expired - Lifetime JP4258575B2 (ja) 1993-03-12 1994-03-11 新規ａ８３５４３化合物及びそれらの製造法

Country Status (14)

Country Link
US (3) US5840861A (index.php)
EP (1) EP0688332B1 (index.php)
JP (1) JP4258575B2 (index.php)
AT (1) ATE150758T1 (index.php)
AU (1) AU685107B2 (index.php)
BR (1) BR9406587A (index.php)
CA (1) CA2156194C (index.php)
DE (1) DE69402308T2 (index.php)
DK (1) DK0688332T3 (index.php)
ES (1) ES2099604T3 (index.php)
FI (1) FI107266B (index.php)
IL (1) IL108979A (index.php)
TW (1) TW294672B (index.php)
WO (1) WO1994020518A1 (index.php)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU711185B2 (en) * 1995-06-14 1999-10-07 Dow Agrosciences Llc Synthetic modification to spinosyn compounds
DE19823396A1 (de) * 1998-05-26 1999-12-02 Bayer Ag Synergistische insektizide Mischungen
DE19823397B4 (de) 1998-05-26 2011-07-28 Bayer CropScience AG, 40789 Verwendung von Spinosynen zum Einsatz als Bodeninsektizide
CA2337789C (en) 1998-07-02 2010-10-26 Eli Lilly And Company Formulations for controlling human lice
US6933318B1 (en) 1999-08-12 2005-08-23 Eli Lilly And Company Topical organic ectoparasiticidal formulations
AU6606400A (en) * 1999-08-12 2001-03-13 Eli Lilly And Company Topical treatment for insect pests in companion animals
US6927210B1 (en) 1999-08-12 2005-08-09 Eli Lilly And Company Ectoparasiticidal aqueous suspension formulations of spinosyns
PT1207756E (pt) 1999-08-12 2006-07-31 Lilly Co Eli Utilizacao de espinosade ou de uma formulacao que compreende espinosade
JP2003508050A (ja) 1999-08-27 2003-03-04 バイエル アクチェンゲゼルシャフト スピノシン生合成の酵素活性をコードする核酸
BRPI0013963B1 (pt) * 1999-09-13 2017-01-24 Dow Agrosciences Llc macrolídeos pesticidas
AUPQ441699A0 (en) 1999-12-02 2000-01-06 Eli Lilly And Company Pour-on formulations
AUPQ634300A0 (en) * 2000-03-20 2000-04-15 Eli Lilly And Company Synergistic formulations
US6585990B1 (en) 2001-03-05 2003-07-01 Dow Agrosciences, Llc Compositions and devices using a spinosyn compound for control of insects
DK1373290T3 (da) * 2001-03-21 2014-12-01 Dow Agrosciences Llc Pesticidale spinosynderivater
US20040147766A1 (en) * 2001-03-29 2004-07-29 Marc Stadler Intermediates for producing spinosyns
AR033022A1 (es) 2001-03-30 2003-12-03 Dow Agrosciences Llc Genes biosinteticos para la produccion de insecticida de butenilespinosina
US6727228B2 (en) 2001-04-25 2004-04-27 Johnson & Johnson Consumer Companies, Inc. Pediculicidal and ovacidal treatment compositions and methods for killing head lice and their eggs
DE10135550A1 (de) * 2001-07-20 2003-01-30 Bayer Cropscience Ag Verfahren zum Herstellen von neuen Spinosyn-Derivaten
WO2003024223A1 (en) 2001-09-17 2003-03-27 Eli Lilly And Company Pesticidal formulations
TWI330183B (index.php) * 2001-10-22 2010-09-11 Eisai R&D Man Co Ltd
CN1633237B (zh) 2002-02-19 2010-05-26 道农业科学公司 新的产生spinosyn的聚酮合酶
US20070049631A1 (en) * 2003-11-04 2007-03-01 Akzo Nobel N.V. Ectoparasiticidal formulations of spinosyms and azole pesticides
EP1849363A1 (en) * 2006-03-09 2007-10-31 Cheminova A/S Synergistic combination of glutamate- and GABA-gated chloride agonist pesticide and at least one of Vitamin E or Niacin
RU2513723C2 (ru) * 2008-02-12 2014-04-20 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи Пестицидные композиции
CN101560477B (zh) * 2008-04-16 2012-04-25 上海医药工业研究院 发酵多杀菌素产生菌的培养基
US9514283B2 (en) 2008-07-09 2016-12-06 Baxter International Inc. Dialysis system having inventory management including online dextrose mixing
CN102202506B (zh) 2008-09-22 2015-07-29 克里斯廷·克里蒂考 刺糖多孢菌素防污组合物、其使用方法、以及受到保护而免于附着污损生物的制品
US8268975B2 (en) 2009-04-03 2012-09-18 Dow Agrosciences Llc Demulsification compositions, systems and methods for demulsifying and separating aqueous emulsions
TW201041508A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041510A (en) 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041509A (en) * 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity
TW201041507A (en) * 2009-04-30 2010-12-01 Dow Agrosciences Llc Pesticide compositions exhibiting enhanced activity and methods for preparing same
CA2764526A1 (en) 2009-06-24 2010-12-29 Christine Kritikou The use of spinosyns and spinosyn compositions against diseases caused by protozoans, viral infections and cancer
CA2798886A1 (en) 2010-05-11 2011-11-17 Dow Agrosciences Llc Saccharopolyspora spinosa with modified spnk
WO2012085683A1 (en) 2010-12-22 2012-06-28 Entarco Sa The use of spinosyns and spinosyn compositions as local anesthetics and as antiarrhythmic agents
WO2012141754A2 (en) * 2010-12-29 2012-10-18 Dow Agrosciences Llc Methods of controlling insects
EP2520653B1 (en) 2011-05-03 2017-03-29 Dow AgroSciences LLC Integration of genes into the chromosome of saccharopolyspora spinosa
US8741603B2 (en) 2011-05-03 2014-06-03 Agrigenetics Inc. Enhancing spinosyn production with oxygen binding proteins
US9404107B2 (en) 2011-05-03 2016-08-02 Dow Agrosciences Llc Integration of genes into the chromosome of Saccharopolyspora spinosa
US9631195B2 (en) 2011-12-28 2017-04-25 Dow Agrosciences Llc Identification and characterization of the spinactin biosysnthesis gene cluster from spinosyn producing saccharopolyspora spinosa
CA2863498C (en) 2012-02-06 2017-10-03 Merial Limited Parasiticidal oral veterinary compositions comprising systemically-acting active agents, methods and uses thereof
JO3626B1 (ar) 2012-02-23 2020-08-27 Merial Inc تركيبات موضعية تحتوي على فيبرونيل و بيرميثرين و طرق استخدامها
AU2012233000B2 (en) * 2012-09-28 2016-01-21 Elanco New Zealand Ectoparasitic Treatment Method and Composition
AU2015247463B2 (en) 2014-04-17 2018-03-29 Basf, Se Use of malononitrile compounds for protecting animals from parasites
US10045979B2 (en) 2014-05-19 2018-08-14 Merial Inc. Anthelmintic compounds
AU2015276941B2 (en) 2014-06-19 2018-07-19 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising indole derivatives, methods and uses thereof
WO2016022520A1 (en) 2014-08-05 2016-02-11 Kyung-An Han Composition and methods for modulation of the octopamine receptor and its homologs
UY36570A (es) 2015-02-26 2016-10-31 Merial Inc Formulaciones inyectables de acción prolongada que comprenden un agente activo isoxazolina, métodos y usos de las mismas
DK3298027T3 (da) 2015-05-20 2021-08-09 Boehringer Ingelheim Animal Health Usa Inc Anthelmintiske depsipeptidforbindelser
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
US11382949B2 (en) 2016-11-16 2022-07-12 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
JP7350659B2 (ja) 2017-06-06 2023-09-26 ザイマージェン インコーポレイテッド Ｓａｃｃｈａｒｏｐｏｌｙｓｐｏｒａ ｓｐｉｎｏｓａの改良のためのハイスループット（ＨＴＰ）ゲノム操作プラットフォーム
BR112021000257A2 (pt) 2018-07-09 2021-04-06 Boehringer Ingelheim Animal Health USA Inc. Compostos heterocíclicos anti-helmínticos
US10730901B2 (en) 2018-07-27 2020-08-04 Aperta Biosciences, Llc Spinosyn formulations for treatment of demodex-induced ocular and facial conditions
CN113260419A (zh) 2018-11-20 2021-08-13 勃林格殷格翰动物保健美国公司 吲唑基氰基乙基氨基化合物、其组合物、其制备方法和其使用方法
NZ776819A (en) 2019-01-16 2023-04-28 Boehringer Ingelheim Animal Health Usa Inc Topical compositions comprising a neonicotinoid and a macrocyclic lactone, methods and uses thereof
CN113825543B (zh) 2019-03-19 2024-09-06 勃林格殷格翰动物保健有限公司 驱虫的氮杂-苯并噻吩和氮杂-苯并呋喃化合物
CN110734467B (zh) * 2019-09-10 2021-08-27 北大方正集团有限公司 一种从发酵液中提取纯化多杀霉素的方法
BR112022024156A2 (pt) 2020-05-29 2023-02-14 Boehringer Ingelheim Animal Health Usa Inc Compostos heterocílicos antelmínticos

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2881162A (en) * 1953-11-16 1959-04-07 Abbott Lab Recovery process
US3725385A (en) * 1970-11-02 1973-04-03 Abbott Lab Process for the demethylation of 3-amino macrolides
US4206206A (en) * 1977-03-24 1980-06-03 Kowa Company, Ltd. Antibiotics of the KA-6606 series and pharmaceutical compositions thereof
AU520409B2 (en) * 1977-05-25 1982-01-28 Commonwealth Scientific And Industrial Research Organisation Controlled release composition
US4213966A (en) * 1977-06-02 1980-07-22 E. R. Squibb & Sons, Inc. Method for isolating polyether antibiotics
US4148883A (en) * 1977-08-18 1979-04-10 Pfizer Inc. Antibiotics produced by new species of nocardia
US4224314A (en) * 1979-03-02 1980-09-23 Pfizer Inc. Antibiotics produced by species of Nocardia
JPS5943929B2 (ja) * 1979-08-13 1984-10-25 サッポロビール株式会社 多糖体ｒｂｓ物質，その製法およびそれを有効成分とする抗腫瘍性剤
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
PL124267B1 (en) * 1979-09-12 1983-01-31 Lilly Co Eli Device for use in the masseter/galea part of a ruminant's gaster
US4251511A (en) * 1979-10-02 1981-02-17 The Upjohn Company Antibiotic and fermentation process of preparing
US4321329A (en) * 1979-10-02 1982-03-23 The Upjohn Company Saccharopolyspora culture
US4293651A (en) * 1979-10-02 1981-10-06 The Upjohn Company Process for producing antibiotic using saccharopolyspora
EP0043197A1 (en) * 1980-07-02 1982-01-06 Beecham Group Plc Beta-Lactam antibiotic, its preparation and use
US4425430A (en) * 1980-07-15 1984-01-10 Kowa Company, Ltd. Process for production of antibiotics and novel antibiotics produced thereby
US4448970A (en) * 1981-02-19 1984-05-15 The Upjohn Company Nargenicin derivatives
IT1195299B (it) * 1981-11-27 1988-10-12 Pierrel Spa Procedimento chimico di sintesi per la preparazione di antibiotici macrolidici
FR2517697B1 (fr) * 1981-12-08 1987-07-10 Toyo Jozo Kk Nouveaux aminoglycosides antibiotiques appeles saccharocines et leur production
JPS58189114A (ja) * 1982-04-30 1983-11-04 Ss Pharmaceut Co Ltd 抗潰瘍剤
US4508647A (en) * 1982-07-26 1985-04-02 Bristol-Myers Company Antitumor antibiotics BBM-2040A and BBM-2040B
IT1194181B (it) * 1983-03-30 1988-09-14 Erba Farmitalia Procedimento migliorato per la purificazione della tilosina
US4530835A (en) * 1983-07-08 1985-07-23 Warner-Lambert Company CL-1577 Antibiotic compounds and their production
US4560509A (en) * 1983-11-16 1985-12-24 Eli Lilly And Company Antibiotic A39079 factor S-1
JPS625990A (ja) * 1985-06-20 1987-01-12 Sumitomo Chem Co Ltd 抗生物質およびその製造方法
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
JPS62226925A (ja) * 1986-03-28 1987-10-05 Ss Pharmaceut Co Ltd 抗マイコプラズマ剤
US4831016A (en) * 1986-10-31 1989-05-16 Merck & Co., Inc. Reduced avermectin derivatives
US5003056A (en) * 1987-12-24 1991-03-26 Nippon Kayaku Kabushiki Kaisha Antibiotic NK86-0279, process for production of the same and application of the same
PE5591A1 (es) * 1988-12-19 1991-02-15 Lilly Co Eli Un nuevo grupo de compuestos de macrolida
US5362634A (en) * 1989-10-30 1994-11-08 Dowelanco Process for producing A83543 compounds
US5028536A (en) * 1989-03-15 1991-07-02 Bristol-Myers Squibb Company Antitumor antibiotic BMY-41339
JPH05504469A (ja) * 1989-10-30 1993-07-15 ダウエランコ Ａ８３５４３回収方法
US5202242A (en) * 1991-11-08 1993-04-13 Dowelanco A83543 compounds and processes for production thereof
US5227295A (en) * 1991-11-08 1993-07-13 Dowelanco Process for isolating A83543 and its components
CN1073483A (zh) * 1991-11-08 1993-06-23 道伊兰科公司 一种发酵杀虫剂化合物及其制备方法

Also Published As

Publication number Publication date
CA2156194C (en) 2008-01-08
WO1994020518A1 (en) 1994-09-15
TW294672B (index.php) 1997-01-01
IL108979A (en) 1999-09-22
FI954246A0 (fi) 1995-09-11
DE69402308D1 (de) 1997-04-30
US5840861A (en) 1998-11-24
EP0688332A1 (en) 1995-12-27
US5670486A (en) 1997-09-23
AU6518794A (en) 1994-09-26
FI954246L (fi) 1995-09-11
ES2099604T3 (es) 1997-05-16
CA2156194A1 (en) 1994-09-15
JPH08507533A (ja) 1996-08-13
IL108979A0 (en) 1994-06-24
DK0688332T3 (da) 1997-10-13
BR9406587A (pt) 1996-01-02
EP0688332B1 (en) 1997-03-26
US5670364A (en) 1997-09-23
ATE150758T1 (de) 1997-04-15
AU685107B2 (en) 1998-01-15
FI107266B (fi) 2001-06-29
DE69402308T2 (de) 1997-10-23

Similar Documents

Publication Publication Date Title
JP4258575B2 (ja) 新規ａ８３５４３化合物及びそれらの製造法
US5631155A (en) Saccharopolyspora spinosa strain
US5202242A (en) A83543 compounds and processes for production thereof
JP2535080B2 (ja) マクロライド化合物
AU666900B2 (en) New A83543 compounds and process for production thereof
EP0170006B1 (en) Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
JP4666861B2 (ja) 有害生物防除性マクロライド
CZ286032B6 (cs) Polycyklická sloučenina, způsob její výroby, farmaceutický prostředek a biologicky čistá kultura
US5317030A (en) Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
US5198464A (en) Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
JPH0649090A (ja) アベルメクチン化合物を１４ａ−位置でグリコシル化する方法
MXPA94003509A (en) Procedure for the production of demaccured compounds, product obtained and compositioninsecticide or acaric
RO106065B1 (ro) Compusi macrolidici cu activitate insecticida si miticida si procedeu de preparare a lor

Legal Events

Date Code Title Description
A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20040324

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20040517

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20040623

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20040817

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20041115

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20050330

RD02 Notification of acceptance of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7422

Effective date: 20081031

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20081128

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20090127

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120220

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20120220

Year of fee payment: 3

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130220

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20130220

Year of fee payment: 4

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140220

Year of fee payment: 5

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term