JP3874306B2 - （ｓ）−３−（アミノメチル）−５−メチルヘキサン酸を製造する方法 - Google Patents

（ｓ）−３−（アミノメチル）−５−メチルヘキサン酸を製造する方法 Download PDF

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Publication number
JP3874306B2
JP3874306B2 JP50055997A JP50055997A JP3874306B2 JP 3874306 B2 JP3874306 B2 JP 3874306B2 JP 50055997 A JP50055997 A JP 50055997A JP 50055997 A JP50055997 A JP 50055997A JP 3874306 B2 JP3874306 B2 JP 3874306B2
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JP
Japan
Prior art keywords
aminomethyl
acid
methylhexanoic acid
water
methylhexanoic
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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JP50055997A
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English (en)
Japanese (ja)
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JPH11506726A (ja
JPH11506726A5 (enExample
Inventor
グロート，トツド・マイケル
ハツカビー，ブライアン・キース
ムルハーン，トマス
ソービーライ，デニス・マーテイン
タイタス，ロバート・ダニエル
Original Assignee
ワーナー−ランバート・コンパニー
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Publication of JPH11506726A publication Critical patent/JPH11506726A/ja
Publication of JPH11506726A5 publication Critical patent/JPH11506726A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/34—Preparation of optical isomers by separation of optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/10—Formation of amino groups in compounds containing carboxyl groups with simultaneously increasing the number of carbon atoms in the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C07C255/22—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton containing cyano groups and at least two carboxyl groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Seasonings (AREA)
JP50055997A 1995-06-07 1996-05-13 （ｓ）−３−（アミノメチル）−５−メチルヘキサン酸を製造する方法 Expired - Lifetime JP3874306B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/474,874 US5637767A (en) 1995-06-07 1995-06-07 Method of making (S)-3-(aminomethyl)-5-methylhexanoic acid
US08/474,874 1995-06-07
PCT/US1996/006819 WO1996040617A1 (en) 1995-06-07 1996-05-13 Method of making (s)-3-(aminomethyl)-5-methylhexanoic acid

Publications (3)

Publication Number Publication Date
JPH11506726A JPH11506726A (ja) 1999-06-15
JPH11506726A5 JPH11506726A5 (enExample) 2004-07-08
JP3874306B2 true JP3874306B2 (ja) 2007-01-31

Family

ID=23885291

Family Applications (1)

Application Number Title Priority Date Filing Date
JP50055997A Expired - Lifetime JP3874306B2 (ja) 1995-06-07 1996-05-13 （ｓ）−３−（アミノメチル）−５−メチルヘキサン酸を製造する方法

Country Status (18)

Country Link
US (4) US5637767A (enExample)
EP (1) EP0830338B1 (enExample)
JP (1) JP3874306B2 (enExample)
AT (1) ATE210628T1 (enExample)
CA (1) CA2219150C (enExample)
CZ (2) CZ291147B6 (enExample)
DE (1) DE69617948T2 (enExample)
DK (1) DK0830338T3 (enExample)
EE (1) EE04053B1 (enExample)
ES (1) ES2170231T3 (enExample)
GE (1) GEP19991870B (enExample)
HU (2) HU228194B1 (enExample)
NZ (2) NZ308319A (enExample)
PL (3) PL185425B1 (enExample)
PT (1) PT830338E (enExample)
SI (1) SI0830338T1 (enExample)
SK (2) SK282865B6 (enExample)
WO (1) WO1996040617A1 (enExample)

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PT1727620E (pt) * 2004-03-12 2007-11-05 Warner Lambert Co Ligandos de biofosfina c1-simétricos e a sua utilização na síntese assimétrica da pregabalina
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CN1972904B (zh) * 2004-06-21 2011-02-02 沃尼尔·朗伯有限责任公司 普瑞巴林和相关化合物的制备
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WO2007127309A2 (en) * 2006-04-24 2007-11-08 Teva Pharmaceutical Industries Ltd. Processes for the synthesis of 3-isobutylglutaric acid
WO2007139933A2 (en) * 2006-05-24 2007-12-06 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
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WO2007143152A2 (en) * 2006-05-31 2007-12-13 Teva Pharmaceutical Industries Ltd. Preparation of (s)-pregabalin-nitrile
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WO2008062460A2 (en) * 2006-10-06 2008-05-29 Cadila Healthcare Limited Crystalline forms of pregabalin
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WO2008138874A1 (en) * 2007-05-09 2008-11-20 Chemo Ibérica, S.A. Process for preparing (s)-pregabalin by optical resolution of racemic pregabalin
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WO2009044409A2 (en) * 2007-10-01 2009-04-09 Natco Pharma Limited Novel resolution process for pregabalin
WO2009046309A2 (en) * 2007-10-03 2009-04-09 Teva Pharmaceutical Industries Ltd. Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
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CN101910112B (zh) * 2008-01-02 2012-11-14 浙江九洲药业股份有限公司 S-3-氨甲基-5-甲基己酸拆分工艺
US20110144383A1 (en) * 2008-02-18 2011-06-16 Matrix Laboratories Limited Process for preparing (s)-3-(aminomethyl)-5-methylhexanoic acid
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CN101585778B (zh) * 2008-05-19 2014-08-13 上海臣邦医药科技有限公司 一种普瑞巴林制备方法
SI2294207T1 (sl) * 2008-05-21 2013-01-31 Sandoz Ag Postopek za stereoselektivno encimatsko hidrolizo estra 5-metil-3-nitrometil-heksanojske kisline
US20110190393A1 (en) * 2008-06-03 2011-08-04 Generics (Uk) Limited Novel and efficient method for the synthesis of an amino acid
WO2009158343A1 (en) * 2008-06-23 2009-12-30 Teva Pharmaceutical Industries, Ltd. Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
WO2010061403A2 (en) * 2008-11-26 2010-06-03 Ind-Swift Laboratories Limited Process to prepare highly pure (s)-pregabalin
WO2010070593A2 (en) 2008-12-19 2010-06-24 Pfizer Ireland Pharmaceuticals Malonate esters
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JP6482465B2 (ja) 2012-11-07 2019-03-13 ハイカル リミテッド プレガバリンの調製方法
CN103980144B (zh) * 2014-05-16 2018-08-17 浙江华海药业股份有限公司 一种普瑞巴林中间体母液的套用方法
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CN104649919B (zh) * 2015-02-10 2021-02-12 浙江华海药业股份有限公司 一种小颗粒普瑞巴林的制备方法
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CN105175276A (zh) * 2015-07-25 2015-12-23 安徽东凯生物科技有限公司 一种光学纯(r)-3-氨甲酰甲基-5-甲基己酸的合成方法
CN105085290A (zh) * 2015-08-18 2015-11-25 太仓运通生物化工有限公司 一种合成普瑞巴林的方法
CN105061234A (zh) * 2015-08-18 2015-11-18 太仓运通生物化工有限公司 一种制备普瑞巴林的方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN111333529A (zh) * 2018-12-19 2020-06-26 北京万全德众医药生物技术有限公司 普瑞巴林的一种制备方法
CN109942446B (zh) * 2019-04-17 2021-09-07 黄冈鲁班药业股份有限公司 一种普瑞巴林的制备方法
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CN116041214B (zh) * 2022-11-15 2025-04-22 奥锐特药业股份有限公司 一种普瑞巴林中间体的制备方法及其应用

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Also Published As

Publication number Publication date
MX9708652A (es) 1998-06-30
AU700091B2 (en) 1998-12-24
SK282865B6 (sk) 2003-01-09
PL185425B1 (pl) 2003-05-30
DE69617948T2 (de) 2002-06-13
PT830338E (pt) 2002-04-29
PL185560B1 (pl) 2003-06-30
US5637767A (en) 1997-06-10
CA2219150A1 (en) 1996-12-19
US5840956A (en) 1998-11-24
EP0830338A1 (en) 1998-03-25
CA2219150C (en) 2008-11-18
HUP9802504A3 (en) 2000-06-28
HU229957B1 (hu) 2015-03-30
ATE210628T1 (de) 2001-12-15
HU228194B1 (en) 2013-01-28
SK164597A3 (en) 1998-05-06
JPH11506726A (ja) 1999-06-15
CZ291147B6 (cs) 2002-12-11
WO1996040617A1 (en) 1996-12-19
US20010016665A1 (en) 2001-08-23
NZ501628A (en) 2001-09-28
US6046353A (en) 2000-04-04
PL185557B1 (pl) 2003-06-30
EP0830338B1 (en) 2001-12-12
EE9700320A (et) 1998-06-15
HU0500934D0 (en) 2005-12-28
AU5792196A (en) 1996-12-30
GEP19991870B (en) 1999-12-06
NZ308319A (en) 2000-02-28
PL323795A1 (en) 1998-04-27
ES2170231T3 (es) 2002-08-01
DK0830338T3 (da) 2002-04-02
SI0830338T1 (en) 2002-04-30
CZ384697A3 (cs) 1998-03-18
HUP9802504A2 (hu) 1999-02-01
SK283507B6 (sk) 2003-08-05
DE69617948D1 (de) 2002-01-24
CZ296895B6 (cs) 2006-07-12
EE04053B1 (et) 2003-06-16

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