JP3595607B2 - 安定な亜鉛インスリン類似化合物結晶の製造 - Google Patents

安定な亜鉛インスリン類似化合物結晶の製造 Download PDF

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Publication number
JP3595607B2
JP3595607B2 JP14732095A JP14732095A JP3595607B2 JP 3595607 B2 JP3595607 B2 JP 3595607B2 JP 14732095 A JP14732095 A JP 14732095A JP 14732095 A JP14732095 A JP 14732095A JP 3595607 B2 JP3595607 B2 JP 3595607B2
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JP
Japan
Prior art keywords
pro
lys
human insulin
solution
zinc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP14732095A
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English (en)
Japanese (ja)
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JPH08169899A (ja
Inventor
ジェフリー・クレイトン・ベイカー
ナンシー・デロリス・カーター
ブルース・ヒル・フランク
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Eli Lilly and Co
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Eli Lilly and Co
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Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPH08169899A publication Critical patent/JPH08169899A/ja
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Publication of JP3595607B2 publication Critical patent/JP3595607B2/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
JP14732095A 1994-06-16 1995-06-14 安定な亜鉛インスリン類似化合物結晶の製造 Expired - Lifetime JP3595607B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US260647 1994-06-16
US08/260,647 US5504188A (en) 1994-06-16 1994-06-16 Preparation of stable zinc insulin analog crystals

Publications (2)

Publication Number Publication Date
JPH08169899A JPH08169899A (ja) 1996-07-02
JP3595607B2 true JP3595607B2 (ja) 2004-12-02

Family

ID=22990041

Family Applications (1)

Application Number Title Priority Date Filing Date
JP14732095A Expired - Lifetime JP3595607B2 (ja) 1994-06-16 1995-06-14 安定な亜鉛インスリン類似化合物結晶の製造

Country Status (29)

Country Link
US (1) US5504188A (index.php)
EP (1) EP0692489B1 (index.php)
JP (1) JP3595607B2 (index.php)
KR (1) KR100369951B1 (index.php)
CN (1) CN1184234C (index.php)
AT (1) ATE233278T1 (index.php)
AU (1) AU697794B2 (index.php)
BR (1) BR9502798A (index.php)
CA (1) CA2151563C (index.php)
CO (1) CO4410205A1 (index.php)
CZ (1) CZ286066B6 (index.php)
DE (1) DE69529708T2 (index.php)
DK (1) DK0692489T3 (index.php)
ES (1) ES2188637T3 (index.php)
FI (1) FI952930A7 (index.php)
HU (1) HUT73495A (index.php)
IL (1) IL114152A (index.php)
IN (1) IN178919B (index.php)
MY (1) MY130551A (index.php)
NO (1) NO952334L (index.php)
NZ (1) NZ272358A (index.php)
PE (1) PE21896A1 (index.php)
PL (1) PL180968B1 (index.php)
RO (1) RO113529B1 (index.php)
RU (1) RU2156257C2 (index.php)
SI (1) SI0692489T1 (index.php)
TW (1) TW379228B (index.php)
YU (1) YU39595A (index.php)
ZA (1) ZA954942B (index.php)

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US5631347A (en) * 1995-06-07 1997-05-20 Eli Lilly And Company Reducing gelation of a fatty acid-acylated protein
US5869604A (en) * 1995-11-09 1999-02-09 Georgia Institute Of Technology Crystallization and purification of polypeptides
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Also Published As

Publication number Publication date
CO4410205A1 (es) 1997-01-09
PL309099A1 (en) 1995-12-27
DE69529708T2 (de) 2003-10-16
CN1184234C (zh) 2005-01-12
EP0692489A1 (en) 1996-01-17
FI952930L (fi) 1995-12-17
DE69529708D1 (de) 2003-04-03
FI952930A7 (fi) 1995-12-17
NO952334D0 (no) 1995-06-13
HUT73495A (en) 1996-08-28
ZA954942B (en) 1996-12-17
CA2151563A1 (en) 1995-12-17
EP0692489B1 (en) 2003-02-26
CZ286066B6 (cs) 2000-01-12
DK0692489T3 (da) 2003-03-31
NO952334L (no) 1995-12-18
ES2188637T3 (es) 2003-07-01
YU39595A (sh) 1997-08-22
MY130551A (en) 2007-06-29
PE21896A1 (es) 1996-06-15
ATE233278T1 (de) 2003-03-15
CZ154195A3 (en) 1996-02-14
CA2151563C (en) 2007-08-07
IL114152A (en) 1999-12-31
AU697794B2 (en) 1998-10-15
RO113529B1 (ro) 1998-08-28
CN1128271A (zh) 1996-08-07
IL114152A0 (en) 1995-10-31
KR100369951B1 (ko) 2003-03-28
AU2168195A (en) 1996-01-04
BR9502798A (pt) 1996-06-04
US5504188A (en) 1996-04-02
IN178919B (index.php) 1997-07-19
JPH08169899A (ja) 1996-07-02
NZ272358A (en) 1996-12-20
FI952930A0 (fi) 1995-06-14
SI0692489T1 (en) 2003-06-30
PL180968B1 (pl) 2001-05-31
KR960000922A (ko) 1996-01-25
RU2156257C2 (ru) 2000-09-20
HU9501715D0 (en) 1995-08-28
TW379228B (en) 2000-01-11
RU95110107A (ru) 1997-05-10

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