JP3434510B2 - ミエリン塩基性タンパク質のペプチドフラグメントを用いたｔ‐細胞増殖の抑制 - Google Patents

ミエリン塩基性タンパク質のペプチドフラグメントを用いたｔ‐細胞増殖の抑制

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Publication number
JP3434510B2
JP3434510B2 JP51850993A JP51850993A JP3434510B2 JP 3434510 B2 JP3434510 B2 JP 3434510B2 JP 51850993 A JP51850993 A JP 51850993A JP 51850993 A JP51850993 A JP 51850993A JP 3434510 B2 JP3434510 B2 JP 3434510B2
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JP
Japan
Prior art keywords
cells
mbp
cell
amino acid
peptide
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP51850993A
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English (en)
Japanese (ja)
Other versions
JPH08500083A (ja
Inventor
エル ウェイナー，ハワード
アレン ハフラー，デビッド
ミラー，アリエール
アル‐サバー，アーマッド
Original Assignee
オートイミューン インク
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Publication of JPH08500083A publication Critical patent/JPH08500083A/ja
Application granted granted Critical
Publication of JP3434510B2 publication Critical patent/JP3434510B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Rehabilitation Therapy (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP51850993A 1992-04-09 1993-04-09 ミエリン塩基性タンパク質のペプチドフラグメントを用いたｔ‐細胞増殖の抑制 Expired - Fee Related JP3434510B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US86531892A 1992-04-09 1992-04-09
US865,318 1992-04-09
PCT/US1993/003369 WO1993021222A1 (en) 1992-04-09 1993-04-09 Suppression of t-cell proliferation using peptide fragments of myelin basic protein

Publications (2)

Publication Number Publication Date
JPH08500083A JPH08500083A (ja) 1996-01-09
JP3434510B2 true JP3434510B2 (ja) 2003-08-11

Family

ID=25345228

Family Applications (1)

Application Number Title Priority Date Filing Date
JP51850993A Expired - Fee Related JP3434510B2 (ja) 1992-04-09 1993-04-09 ミエリン塩基性タンパク質のペプチドフラグメントを用いたｔ‐細胞増殖の抑制

Country Status (15)

Country Link
EP (2) EP0650498B1 (enExample)
JP (1) JP3434510B2 (enExample)
KR (1) KR950700934A (enExample)
AT (2) ATE212358T1 (enExample)
AU (1) AU680824B2 (enExample)
BR (1) BR9306272A (enExample)
CA (1) CA2133749A1 (enExample)
DE (2) DE69331501T2 (enExample)
DK (1) DK0863155T3 (enExample)
ES (1) ES2172044T3 (enExample)
HU (1) HU219306B (enExample)
IL (1) IL105347A0 (enExample)
NO (1) NO317049B1 (enExample)
PT (1) PT863155E (enExample)
WO (1) WO1993021222A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869054A (en) * 1987-06-24 1999-02-09 Autoimmune Inc. Treatment of multiple sclerosis by oral administration of autoantigens
US5817629A (en) * 1991-10-22 1998-10-06 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US6252040B1 (en) 1991-10-22 2001-06-26 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
JPH10500109A (ja) * 1994-05-10 1998-01-06 イミユロジク・フアーマシユーチカル・コーポレーシヨン 多発性硬化症のための組成物および治療方法
CZ122697A3 (en) * 1994-10-25 1997-09-17 Immulogic Pharma Corp Preparations and methods of treating disseminated sclerosis
US6379670B1 (en) 1994-11-18 2002-04-30 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
US6329499B1 (en) * 1994-11-18 2001-12-11 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein
AU721898B2 (en) * 1994-11-18 2000-07-20 Board Of Trustees Of The Leland Stanford Junior University Methods for treatment of multiple sclerosis using peptide analogues at position 91 of human myelin basic protein
US6251396B1 (en) 1994-11-18 2001-06-26 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
WO1996028470A2 (en) * 1995-03-09 1996-09-19 Neurocrine Biosciences, Inc. Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
US5856446A (en) * 1995-07-07 1999-01-05 Autoimmune Inc. Method of treating rheumatoid arthritis with low dose type II collagen
IL116559A (en) * 1995-11-17 2005-11-20 Yissum Res Dev Co Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence
US6274136B1 (en) * 1996-05-29 2001-08-14 University Of Southern California Construction and use of genes encoding pathogenic epitopes for treatment of autoimmune disease
CA2494338C (en) * 1997-04-04 2007-07-17 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US20020072493A1 (en) 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
WO1999060021A2 (en) * 1998-05-19 1999-11-25 Yeda Research And Development Co. Ltd. Use of activated t cells, nervous system-specific antigens for treating disorders of the nevrous system
WO2001089557A2 (en) 2000-05-24 2001-11-29 The United States Of America, As Represented By Secretary Of The Department Of Health & Human Services Methods for preventing strokes by inducing tolerance to e-selectin
JP2007509063A (ja) 2003-10-17 2007-04-12 ベイラー　カレッジ　オブ　メディスン Ｃｄ８＋細胞傷害性ｔ細胞応答を増大させる方法、および多発性硬化症を処置するための方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU695801B2 (en) * 1993-09-22 1998-08-20 Board Of Trustees Of The Leland Stanford Junior University Interaction of T-cell receptors and antigen in autoimmune disease
AU721898B2 (en) * 1994-11-18 2000-07-20 Board Of Trustees Of The Leland Stanford Junior University Methods for treatment of multiple sclerosis using peptide analogues at position 91 of human myelin basic protein

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
Ｉｍｍｕｎｏｌｏｇｙ Ｔｏｄａｙ，Ｖｏｌ．１２，Ｎｏ．８（１９９１），ｐ．２７７−２８２
Ｎａｔｕｒｅ，Ｖｏｌ．３４６（１９９０），ｐ．１８３−１８７
Ｓｃｉｅｎｃｅ，Ｖｏｌ．２４８（１９９０），ｐ．１０１６−１０１９
ＴＨＥ ＦＡＳＥＢ ＪＯＵＲＮＡＬ，Ｖｏｌ．４，Ｎｏ．７（１９９０），ｐ．Ａ１８５７，Ａｂｓｔｒａｃｔ Ｎｏ．９５６

Also Published As

Publication number Publication date
CA2133749A1 (en) 1993-10-28
DE69320967T2 (de) 1999-05-12
KR100295606B1 (enExample) 2001-10-22
WO1993021222A1 (en) 1993-10-28
NO943755D0 (no) 1994-10-06
ATE170874T1 (de) 1998-09-15
BR9306272A (pt) 1998-06-23
EP0650498A1 (en) 1995-05-03
HU9402909D0 (en) 1995-01-30
DE69331501T2 (de) 2002-08-29
DE69331501D1 (de) 2002-03-14
ES2172044T3 (es) 2002-09-16
DE69320967D1 (de) 1998-10-15
AU680824B2 (en) 1997-08-14
IL105347A0 (en) 1993-08-18
NO317049B1 (no) 2004-07-26
AU4282493A (en) 1993-11-18
PT863155E (pt) 2002-07-31
HU219306B (en) 2001-03-28
JPH08500083A (ja) 1996-01-09
DK0863155T3 (da) 2002-05-13
EP0650498A4 (en) 1995-06-21
EP0863155B1 (en) 2002-01-23
NO943755L (no) 1994-12-02
KR950700934A (ko) 1995-02-20
HUT69169A (en) 1995-08-28
ATE212358T1 (de) 2002-02-15
EP0650498B1 (en) 1998-09-09
EP0863155A1 (en) 1998-09-09

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