ATE212358T1 - Unterdrückung der proliferation von t-zellen mittels peptidfragmenten des basischen proteins aus myelin - Google Patents

Unterdrückung der proliferation von t-zellen mittels peptidfragmenten des basischen proteins aus myelin

Info

Publication number
ATE212358T1
ATE212358T1 AT98102522T AT98102522T ATE212358T1 AT E212358 T1 ATE212358 T1 AT E212358T1 AT 98102522 T AT98102522 T AT 98102522T AT 98102522 T AT98102522 T AT 98102522T AT E212358 T1 ATE212358 T1 AT E212358T1
Authority
AT
Austria
Prior art keywords
myelin
suppression
cell proliferation
peptide fragments
basic protein
Prior art date
Application number
AT98102522T
Other languages
English (en)
Inventor
Howard M Weiner
Ariel Miller
David Allen Hafler
Ahmad Al-Sabbagh
Original Assignee
Autoimmune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Autoimmune Inc filed Critical Autoimmune Inc
Application granted granted Critical
Publication of ATE212358T1 publication Critical patent/ATE212358T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
AT98102522T 1992-04-09 1993-04-09 Unterdrückung der proliferation von t-zellen mittels peptidfragmenten des basischen proteins aus myelin ATE212358T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86531892A 1992-04-09 1992-04-09

Publications (1)

Publication Number Publication Date
ATE212358T1 true ATE212358T1 (de) 2002-02-15

Family

ID=25345228

Family Applications (2)

Application Number Title Priority Date Filing Date
AT93912176T ATE170874T1 (de) 1992-04-09 1993-04-09 Unterdrückung der t-zell proliferation mittels peptidfragmenten des myelin basischen protein
AT98102522T ATE212358T1 (de) 1992-04-09 1993-04-09 Unterdrückung der proliferation von t-zellen mittels peptidfragmenten des basischen proteins aus myelin

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT93912176T ATE170874T1 (de) 1992-04-09 1993-04-09 Unterdrückung der t-zell proliferation mittels peptidfragmenten des myelin basischen protein

Country Status (15)

Country Link
EP (2) EP0650498B1 (de)
JP (1) JP3434510B2 (de)
KR (1) KR950700934A (de)
AT (2) ATE170874T1 (de)
AU (1) AU680824B2 (de)
BR (1) BR9306272A (de)
CA (1) CA2133749A1 (de)
DE (2) DE69320967T2 (de)
DK (1) DK0863155T3 (de)
ES (1) ES2172044T3 (de)
HU (1) HU219306B (de)
IL (1) IL105347A0 (de)
NO (1) NO317049B1 (de)
PT (1) PT863155E (de)
WO (1) WO1993021222A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869054A (en) * 1987-06-24 1999-02-09 Autoimmune Inc. Treatment of multiple sclerosis by oral administration of autoantigens
US6252040B1 (en) * 1991-10-22 2001-06-26 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US5817629A (en) * 1991-10-22 1998-10-06 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
CZ329596A3 (en) * 1994-05-10 1997-05-14 Immulogic Pharma Corp Preparation for treating scattered sclerosis
HUT77047A (hu) * 1994-10-25 1998-03-02 Immulogic Pharmaceutical Corporation Szklerózis multiplex kezelésére szolgáló készítmények és kezelések
US6251396B1 (en) 1994-11-18 2001-06-26 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
AU721898B2 (en) 1994-11-18 2000-07-20 Board Of Trustees Of The Leland Stanford Junior University Methods for treatment of multiple sclerosis using peptide analogues at position 91 of human myelin basic protein
US6379670B1 (en) 1994-11-18 2002-04-30 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
US6329499B1 (en) * 1994-11-18 2001-12-11 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein
AU5360796A (en) * 1995-03-09 1996-10-02 Neurocrine Biosciences, Inc. Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
US5856446A (en) * 1995-07-07 1999-01-05 Autoimmune Inc. Method of treating rheumatoid arthritis with low dose type II collagen
IL116559A (en) * 1995-11-17 2005-11-20 Yissum Res Dev Co Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence
US6274136B1 (en) * 1996-05-29 2001-08-14 University Of Southern California Construction and use of genes encoding pathogenic epitopes for treatment of autoimmune disease
CA2201841C (en) * 1997-04-04 2010-01-26 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US20020072493A1 (en) 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
JP2003532618A (ja) * 1998-05-19 2003-11-05 イエダ リサーチ アンド デベロプメント カンパニイ リミテッド 細胞、神経系−特異的抗原およびそれらの用途
EP1286686B1 (de) 2000-05-24 2007-07-25 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY of the DEPARTMENT OF HEALTH AND HUMAN SERVICES E-selectin zur behandlung oder vorbeugung von schlaganfall
CN1893971A (zh) 2003-10-17 2007-01-10 贝勒医学院 用于增强cd8+细胞毒性t细胞应答和用于治疗多发性硬化的方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995008572A1 (en) * 1993-09-22 1995-03-30 The Board Of Trustees For The Leland Stanford Junior University Interaction of t-cell receptors and antigen in autoimmune disease
AU721898B2 (en) * 1994-11-18 2000-07-20 Board Of Trustees Of The Leland Stanford Junior University Methods for treatment of multiple sclerosis using peptide analogues at position 91 of human myelin basic protein

Also Published As

Publication number Publication date
NO943755D0 (no) 1994-10-06
ATE170874T1 (de) 1998-09-15
JPH08500083A (ja) 1996-01-09
DE69320967T2 (de) 1999-05-12
ES2172044T3 (es) 2002-09-16
EP0650498A1 (de) 1995-05-03
HUT69169A (en) 1995-08-28
KR950700934A (ko) 1995-02-20
IL105347A0 (en) 1993-08-18
EP0863155A1 (de) 1998-09-09
BR9306272A (pt) 1998-06-23
AU680824B2 (en) 1997-08-14
NO943755L (no) 1994-12-02
PT863155E (pt) 2002-07-31
DE69331501T2 (de) 2002-08-29
HU219306B (en) 2001-03-28
KR100295606B1 (de) 2001-10-22
EP0650498B1 (de) 1998-09-09
EP0863155B1 (de) 2002-01-23
DE69331501D1 (de) 2002-03-14
HU9402909D0 (en) 1995-01-30
DE69320967D1 (de) 1998-10-15
WO1993021222A1 (en) 1993-10-28
AU4282493A (en) 1993-11-18
NO317049B1 (no) 2004-07-26
DK0863155T3 (da) 2002-05-13
JP3434510B2 (ja) 2003-08-11
EP0650498A4 (de) 1995-06-21
CA2133749A1 (en) 1993-10-28

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee