DE69320967D1 - Unterdrückung der t-zell proliferation mittels peptidfragmenten des myelin basischen protein - Google Patents

Unterdrückung der t-zell proliferation mittels peptidfragmenten des myelin basischen protein

Info

Publication number
DE69320967D1
DE69320967D1 DE69320967T DE69320967T DE69320967D1 DE 69320967 D1 DE69320967 D1 DE 69320967D1 DE 69320967 T DE69320967 T DE 69320967T DE 69320967 T DE69320967 T DE 69320967T DE 69320967 D1 DE69320967 D1 DE 69320967D1
Authority
DE
Germany
Prior art keywords
suppression
cell proliferation
peptide fragments
basic protein
myeline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69320967T
Other languages
English (en)
Other versions
DE69320967T2 (de
Inventor
Howard Weiner
David Hafler
Ariel Miller
Ahmad Al-Sabbagh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Autoimmune Inc
Original Assignee
Autoimmune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Autoimmune Inc filed Critical Autoimmune Inc
Publication of DE69320967D1 publication Critical patent/DE69320967D1/de
Application granted granted Critical
Publication of DE69320967T2 publication Critical patent/DE69320967T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Rehabilitation Therapy (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69320967T 1992-04-09 1993-04-09 Unterdrückung der t-zell proliferation mittels peptidfragmenten des myelin basischen protein Expired - Lifetime DE69320967T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86531892A 1992-04-09 1992-04-09
PCT/US1993/003369 WO1993021222A1 (en) 1992-04-09 1993-04-09 Suppression of t-cell proliferation using peptide fragments of myelin basic protein

Publications (2)

Publication Number Publication Date
DE69320967D1 true DE69320967D1 (de) 1998-10-15
DE69320967T2 DE69320967T2 (de) 1999-05-12

Family

ID=25345228

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69331501T Expired - Lifetime DE69331501T2 (de) 1992-04-09 1993-04-09 Unterdrückung der Proliferation von T-Zellen mittels Peptidfragmenten des basischen Proteins aus Myelin
DE69320967T Expired - Lifetime DE69320967T2 (de) 1992-04-09 1993-04-09 Unterdrückung der t-zell proliferation mittels peptidfragmenten des myelin basischen protein

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69331501T Expired - Lifetime DE69331501T2 (de) 1992-04-09 1993-04-09 Unterdrückung der Proliferation von T-Zellen mittels Peptidfragmenten des basischen Proteins aus Myelin

Country Status (15)

Country Link
EP (2) EP0863155B1 (de)
JP (1) JP3434510B2 (de)
KR (1) KR950700934A (de)
AT (2) ATE212358T1 (de)
AU (1) AU680824B2 (de)
BR (1) BR9306272A (de)
CA (1) CA2133749A1 (de)
DE (2) DE69331501T2 (de)
DK (1) DK0863155T3 (de)
ES (1) ES2172044T3 (de)
HU (1) HU219306B (de)
IL (1) IL105347A0 (de)
NO (1) NO317049B1 (de)
PT (1) PT863155E (de)
WO (1) WO1993021222A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869054A (en) * 1987-06-24 1999-02-09 Autoimmune Inc. Treatment of multiple sclerosis by oral administration of autoantigens
US5817629A (en) * 1991-10-22 1998-10-06 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US6252040B1 (en) * 1991-10-22 2001-06-26 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
AU2470595A (en) * 1994-05-10 1995-11-29 Immulogic Pharmaceutical Corporation Compositions and treatment for multiple sclerosis
BR9509438A (pt) * 1994-10-25 1997-12-23 Immulogic Pharma Corp Composições e tratamento para a esclerose múltipla
US6329499B1 (en) * 1994-11-18 2001-12-11 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein
US6251396B1 (en) 1994-11-18 2001-06-26 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
EP1172376A1 (de) * 1994-11-18 2002-01-16 Neurocrine Biosciences, Inc. Peptidanaloge des menschlichen, basischen myelinproteins mit substitution an position 91 zur behandlung der multiplen sklerose
US6379670B1 (en) 1994-11-18 2002-04-30 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
AU5360796A (en) * 1995-03-09 1996-10-02 Neurocrine Biosciences, Inc. Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
US5856446A (en) * 1995-07-07 1999-01-05 Autoimmune Inc. Method of treating rheumatoid arthritis with low dose type II collagen
IL116559A (en) * 1995-11-17 2005-11-20 Yissum Res Dev Co Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence
US6274136B1 (en) * 1996-05-29 2001-08-14 University Of Southern California Construction and use of genes encoding pathogenic epitopes for treatment of autoimmune disease
CA2201841C (en) * 1997-04-04 2010-01-26 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US20020072493A1 (en) 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
JP2003532618A (ja) * 1998-05-19 2003-11-05 イエダ リサーチ アンド デベロプメント カンパニイ リミテッド 細胞、神経系−特異的抗原およびそれらの用途
PT1286686E (pt) 2000-05-24 2007-11-07 Us Health E-selectiva para o tratamento ou prevenção do acidente vascular cerebral
NZ546552A (en) 2003-10-17 2009-10-30 Baylor College Medicine A method for increasing CD8+ cytotoxic T cell reponses and for treating multiple sclerosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09502981A (ja) * 1993-09-22 1997-03-25 ザ ボード オブ トラスティーズ フォー ザ リーランド スタンフォード ジュニア ユニバーシティ 自己免疫疾患におけるｔ−細胞レセプターと抗原の相互作用
EP1172376A1 (de) * 1994-11-18 2002-01-16 Neurocrine Biosciences, Inc. Peptidanaloge des menschlichen, basischen myelinproteins mit substitution an position 91 zur behandlung der multiplen sklerose

Also Published As

Publication number Publication date
BR9306272A (pt) 1998-06-23
DE69331501D1 (de) 2002-03-14
NO943755D0 (no) 1994-10-06
HUT69169A (en) 1995-08-28
ATE212358T1 (de) 2002-02-15
DK0863155T3 (da) 2002-05-13
PT863155E (pt) 2002-07-31
WO1993021222A1 (en) 1993-10-28
AU680824B2 (en) 1997-08-14
NO317049B1 (no) 2004-07-26
HU9402909D0 (en) 1995-01-30
JP3434510B2 (ja) 2003-08-11
EP0650498A1 (de) 1995-05-03
KR100295606B1 (de) 2001-10-22
AU4282493A (en) 1993-11-18
EP0863155A1 (de) 1998-09-09
EP0863155B1 (de) 2002-01-23
HU219306B (en) 2001-03-28
CA2133749A1 (en) 1993-10-28
ES2172044T3 (es) 2002-09-16
EP0650498B1 (de) 1998-09-09
JPH08500083A (ja) 1996-01-09
NO943755L (no) 1994-12-02
KR950700934A (ko) 1995-02-20
ATE170874T1 (de) 1998-09-15
IL105347A0 (en) 1993-08-18
EP0650498A4 (de) 1995-06-21
DE69331501T2 (de) 2002-08-29
DE69320967T2 (de) 1999-05-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AUTOIMMUNE, INC., PASADENA, CALIF., US