ES2095255T3 - Analogos de sustitucion de peptidos magainina. - Google Patents
Analogos de sustitucion de peptidos magainina.Info
- Publication number
- ES2095255T3 ES2095255T3 ES90909538T ES90909538T ES2095255T3 ES 2095255 T3 ES2095255 T3 ES 2095255T3 ES 90909538 T ES90909538 T ES 90909538T ES 90909538 T ES90909538 T ES 90909538T ES 2095255 T3 ES2095255 T3 ES 2095255T3
- Authority
- ES
- Spain
- Prior art keywords
- magainina
- analogs
- peptides
- substitution
- magainin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000006467 substitution reaction Methods 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 125000000539 amino acid group Chemical group 0.000 abstract 2
- 101500009721 Xenopus laevis Magainin-2 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 108091005128 magainin I Proteins 0.000 abstract 1
- OFIZOVDANLLTQD-ZVNXOKPXSA-N magainin i Chemical compound C([C@H](NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(O)=O)C1=CC=CC=C1 OFIZOVDANLLTQD-ZVNXOKPXSA-N 0.000 abstract 1
- COLNVLDHVKWLRT-QMMMGPOBSA-N phenylalanine group Chemical group N[C@@H](CC1=CC=CC=C1)C(=O)O COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
UN COMPUESTO QUE CONSTA DE MAGAININA I O MAGAININA II, EN DONDE AL MENOS SE PUEDE HACER UNA SUSTITUCION DE ALGUNOS RESIDUOS AMINOACIDOS POR OTROS RESIDUOSAMINOACIDOS, DICHOS PEPTIDOS SE CONOCEN CON EL NOMBRE DE SUSTITUCIONES ANALOGAS. ADEMAS A TALES SUSTITUCIONES, SE PUEDE INCLUIR DENTRO DEL CAMPO DE LA INVENCION SUSTANCIAS ANALOGAS DONDE AL MENOS UNO DE LOS RESIDUOS DEL AMINOACIDO 15 Y 23 PUEDEN SER TAMBIEN SUPRIMIDOS, Y EN DONDE LAS SUSTITUCIONES SE REALIZARON EN LA CADENA PEPTIDICA RESTANTE. SE HA DEMOSTRADO QUE CIERTAS SUSTITUCIONES ANALOGAS DENTRO DEL CAMPO DE LA PRESENTE INVENCION POSEEN ACTIVIDAD BIOLOGICA AUMENTADA.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37675489A | 1989-07-07 | 1989-07-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2095255T3 true ES2095255T3 (es) | 1997-02-16 |
Family
ID=23486335
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES90909538T Expired - Lifetime ES2095255T3 (es) | 1989-07-07 | 1990-06-28 | Analogos de sustitucion de peptidos magainina. |
Country Status (16)
| Country | Link |
|---|---|
| EP (4) | EP0751149A3 (es) |
| JP (1) | JP2854970B2 (es) |
| CN (1) | CN1055480C (es) |
| AT (1) | ATE146188T1 (es) |
| AU (1) | AU650236B2 (es) |
| CA (1) | CA2020663C (es) |
| DE (1) | DE69029377T2 (es) |
| DK (1) | DK0437556T3 (es) |
| ES (1) | ES2095255T3 (es) |
| IE (1) | IE63842B1 (es) |
| IL (1) | IL94939A (es) |
| PH (4) | PH30054A (es) |
| PT (1) | PT94625B (es) |
| SG (1) | SG47913A1 (es) |
| WO (1) | WO1991000869A1 (es) |
| ZA (1) | ZA905203B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2854970B2 (ja) * | 1989-07-07 | 1999-02-10 | スクリップス クリニック アンド リサーチ ファウンデーション | マガイニンペプチドの置換アナログ |
| US5221664A (en) * | 1990-04-23 | 1993-06-22 | Magainin Pharmaaceuticals Inc. | Composition and treatment with biologically active peptides and toxic cations |
| AU648140B2 (en) * | 1991-02-01 | 1994-04-14 | Virtual Drug Development, Inc. | Reverse antimicrobial peptides and antimicrobial compositions |
| EP0590044A4 (en) * | 1991-06-12 | 1996-06-12 | Magainin Pharma | Composition and treatment with biologically active peptides having c-terminal substitutions |
| US5424290A (en) * | 1992-10-26 | 1995-06-13 | Magainin Pharmaceuticals Inc. | Biologically active peptides and uses therefor |
| US5773413A (en) * | 1993-06-04 | 1998-06-30 | Demeter Biotechnologies, Ltd. | Method of combating mammalian neoplasias, and lytic peptides therefor |
| US5561107A (en) * | 1993-06-04 | 1996-10-01 | Demeter Biotechnologies, Ltd. | Method of enhancing wound healing by stimulating fibroblast and keratinocyte growth in vivo, utilizing amphipathic peptides |
| CN101928340A (zh) * | 2009-12-24 | 2010-12-29 | 深圳市圣西马生物技术有限公司 | 一组抗菌肽衍生物及其应用 |
| CN104710523B (zh) * | 2013-12-11 | 2017-12-29 | 华东理工大学 | 对铜绿假单胞菌具有抗菌性能的Magainin肽修饰物及其制备方法 |
| CA2989311A1 (en) * | 2015-07-02 | 2017-01-05 | Dana-Farber Cancer Institute, Inc. | Stabilized anti-microbial peptides |
| EP3423075B1 (en) | 2016-02-29 | 2024-04-03 | Dana-Farber Cancer Institute, Inc. | Stapled intracellular-targeting antimicrobial peptides to treat infection |
| JP7305614B2 (ja) * | 2017-07-19 | 2023-07-10 | デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド | 抗生物質耐性細菌感染症の処置のための安定化抗菌ペプチド |
| CN111892646B (zh) * | 2020-08-13 | 2023-05-02 | 中国人民解放军军事科学院军事医学研究院 | 抗菌肽衍生物及其在制备抗细菌感染药物中的应用 |
| CN112625092B (zh) * | 2021-01-13 | 2023-03-28 | 兰州大学 | 一种基于polybia-MPI的抗菌多肽化合物及其合成与应用 |
| CN114634553B (zh) * | 2022-04-27 | 2024-03-08 | 贵州医科大学 | 阳离子肽c9及其应用 |
| CN120081951B (zh) * | 2025-03-06 | 2025-09-30 | 辽宁波尔莱特农牧实业集团有限公司 | 一种抗菌肽Magainin 2-hEGF融合蛋白及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE106896T1 (de) * | 1987-03-04 | 1994-06-15 | Us Health | Neue synthetische bioaktive verbindungen und verfahren zur herstellung bioaktiver wirkungen. |
| US4810777A (en) * | 1987-03-04 | 1989-03-07 | The United States Of America As Represented By The Department Of Health And Human Services | Antimicrobial compounds |
| JP2854970B2 (ja) * | 1989-07-07 | 1999-02-10 | スクリップス クリニック アンド リサーチ ファウンデーション | マガイニンペプチドの置換アナログ |
-
1990
- 1990-06-28 JP JP2509660A patent/JP2854970B2/ja not_active Expired - Fee Related
- 1990-06-28 SG SG1996005217A patent/SG47913A1/en unknown
- 1990-06-28 WO PCT/US1990/003675 patent/WO1991000869A1/en not_active Ceased
- 1990-06-28 DE DE69029377T patent/DE69029377T2/de not_active Expired - Fee Related
- 1990-06-28 AT AT90909538T patent/ATE146188T1/de not_active IP Right Cessation
- 1990-06-28 EP EP96201385A patent/EP0751149A3/en not_active Ceased
- 1990-06-28 AU AU59454/90A patent/AU650236B2/en not_active Ceased
- 1990-06-28 EP EP90909538A patent/EP0437556B1/en not_active Expired - Lifetime
- 1990-06-28 DK DK90909538.2T patent/DK0437556T3/da active
- 1990-06-28 ES ES90909538T patent/ES2095255T3/es not_active Expired - Lifetime
- 1990-06-28 EP EP96201384A patent/EP0751148A3/en not_active Ceased
- 1990-06-28 EP EP96201383A patent/EP0761684A3/en not_active Ceased
- 1990-07-02 IL IL9493990A patent/IL94939A/en active IP Right Grant
- 1990-07-03 ZA ZA905203A patent/ZA905203B/xx unknown
- 1990-07-06 IE IE247690A patent/IE63842B1/en not_active IP Right Cessation
- 1990-07-06 PT PT94625A patent/PT94625B/pt not_active IP Right Cessation
- 1990-07-06 CA CA002020663A patent/CA2020663C/en not_active Expired - Lifetime
- 1990-07-06 PH PH40802A patent/PH30054A/en unknown
- 1990-07-06 CN CN90106803A patent/CN1055480C/zh not_active Expired - Fee Related
-
1992
- 1992-12-21 PH PH45486A patent/PH30219A/en unknown
- 1992-12-21 PH PH45487A patent/PH30410A/en unknown
- 1992-12-21 PH PH45488A patent/PH30218A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU650236B2 (en) | 1994-06-16 |
| JP2854970B2 (ja) | 1999-02-10 |
| EP0437556A1 (en) | 1991-07-24 |
| DK0437556T3 (da) | 1996-12-30 |
| EP0437556B1 (en) | 1996-12-11 |
| AU5945490A (en) | 1991-02-06 |
| PT94625A (pt) | 1991-03-20 |
| EP0437556A4 (en) | 1992-05-20 |
| CN1049166A (zh) | 1991-02-13 |
| EP0751148A3 (en) | 1997-07-02 |
| WO1991000869A1 (en) | 1991-01-24 |
| EP0751149A2 (en) | 1997-01-02 |
| CA2020663A1 (en) | 1991-01-08 |
| DE69029377T2 (de) | 1997-06-19 |
| CN1055480C (zh) | 2000-08-16 |
| CA2020663C (en) | 1999-12-07 |
| EP0751148A2 (en) | 1997-01-02 |
| ATE146188T1 (de) | 1996-12-15 |
| SG47913A1 (en) | 1998-04-17 |
| IL94939A (en) | 1996-12-05 |
| EP0751149A3 (en) | 1997-07-02 |
| ZA905203B (en) | 1991-05-29 |
| PH30218A (en) | 1997-02-05 |
| JPH04506801A (ja) | 1992-11-26 |
| EP0761684A2 (en) | 1997-03-12 |
| IE63842B1 (en) | 1995-06-14 |
| IL94939A0 (en) | 1991-06-10 |
| IE902476A1 (en) | 1991-02-13 |
| EP0761684A3 (en) | 1997-07-02 |
| PH30410A (en) | 1997-05-09 |
| DE69029377D1 (de) | 1997-01-23 |
| PH30054A (en) | 1996-11-08 |
| PT94625B (pt) | 1997-03-31 |
| PH30219A (en) | 1997-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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