ES2172044T3 - Supresion de la proliferacion de celulas t usando fragmentos peptidicos de proteina basica de mielina. - Google Patents

Supresion de la proliferacion de celulas t usando fragmentos peptidicos de proteina basica de mielina.

Info

Publication number
ES2172044T3
ES2172044T3 ES98102522T ES98102522T ES2172044T3 ES 2172044 T3 ES2172044 T3 ES 2172044T3 ES 98102522 T ES98102522 T ES 98102522T ES 98102522 T ES98102522 T ES 98102522T ES 2172044 T3 ES2172044 T3 ES 2172044T3
Authority
ES
Spain
Prior art keywords
myeline
proliferation
suppression
protein
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98102522T
Other languages
English (en)
Inventor
Howard M Weiner
Ariel Miller
David Allen Hafler
Ahmad Al-Sabbagh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Autoimmune Inc
Original Assignee
Autoimmune Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Autoimmune Inc filed Critical Autoimmune Inc
Application granted granted Critical
Publication of ES2172044T3 publication Critical patent/ES2172044T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens

Abstract

PEPTIDOS DERIVADOS DEL FRAGMENTO 84-102 DE LA HMBP POR DELECION DE UNO A CUATRO AMINOACIDOS N-TERMINALES Y/O UNO A OCHO AMINOACIDOS C-TERMINALES Y QUE CONTIENEN UN RESIDUO ALANINA EN POSICION 85,86,87,88,89,90,91,92,93,94,95,96,97,98 O 99. ESTOS PEPTIDOS SON UTILES PARA SUPRIMIR LAS RESPUESTAS AUTOINMUNES.
ES98102522T 1992-04-09 1993-04-09 Supresion de la proliferacion de celulas t usando fragmentos peptidicos de proteina basica de mielina. Expired - Lifetime ES2172044T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US86531892A 1992-04-09 1992-04-09

Publications (1)

Publication Number Publication Date
ES2172044T3 true ES2172044T3 (es) 2002-09-16

Family

ID=25345228

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98102522T Expired - Lifetime ES2172044T3 (es) 1992-04-09 1993-04-09 Supresion de la proliferacion de celulas t usando fragmentos peptidicos de proteina basica de mielina.

Country Status (15)

Country Link
EP (2) EP0863155B1 (es)
JP (1) JP3434510B2 (es)
KR (1) KR950700934A (es)
AT (2) ATE170874T1 (es)
AU (1) AU680824B2 (es)
BR (1) BR9306272A (es)
CA (1) CA2133749A1 (es)
DE (2) DE69331501T2 (es)
DK (1) DK0863155T3 (es)
ES (1) ES2172044T3 (es)
HU (1) HU219306B (es)
IL (1) IL105347A0 (es)
NO (1) NO317049B1 (es)
PT (1) PT863155E (es)
WO (1) WO1993021222A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869054A (en) * 1987-06-24 1999-02-09 Autoimmune Inc. Treatment of multiple sclerosis by oral administration of autoantigens
US6252040B1 (en) 1991-10-22 2001-06-26 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US5817629A (en) * 1991-10-22 1998-10-06 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
PL317197A1 (en) * 1994-05-10 1997-03-17 Immulogic Pharma Corp Compositions for and method of treating sclerosis multiplex
PL324091A1 (en) * 1994-10-25 1998-05-11 Immulogic Pharma Corp Compositions and procedure for treating sclerosis multiplex
US6379670B1 (en) 1994-11-18 2002-04-30 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
US6329499B1 (en) * 1994-11-18 2001-12-11 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein
US6251396B1 (en) 1994-11-18 2001-06-26 Neurocrine Biosciences, Inc. Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein
JPH10509714A (ja) * 1994-11-18 1998-09-22 ニューロクライン バイオサイエンシーズ， インコーポレイテッド ヒトミエリン塩基性タンパク質の９１位におけるペプチドアナログを用いる多発性硬化症の処置方法
AU5360796A (en) * 1995-03-09 1996-10-02 Neurocrine Biosciences, Inc. Peptide analogues of human myelin basic protein useful in treating multiple sclerosis
US5856446A (en) * 1995-07-07 1999-01-05 Autoimmune Inc. Method of treating rheumatoid arthritis with low dose type II collagen
IL116559A (en) * 1995-11-17 2005-11-20 Yissum Res Dev Co Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence
US6274136B1 (en) * 1996-05-29 2001-08-14 University Of Southern California Construction and use of genes encoding pathogenic epitopes for treatment of autoimmune disease
CA2201841C (en) * 1997-04-04 2010-01-26 The Governors Of The University Of Alberta Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients
US20020072493A1 (en) 1998-05-19 2002-06-13 Yeda Research And Development Co. Ltd. Activated T cells, nervous system-specific antigens and their uses
WO1999060021A2 (en) * 1998-05-19 1999-11-25 Yeda Research And Development Co. Ltd. Use of activated t cells, nervous system-specific antigens for treating disorders of the nevrous system
ATE367823T1 (de) 2000-05-24 2007-08-15 Us Health E-selectin zur behandlung oder vorbeugung von schlaganfall
US20080107664A1 (en) 2003-10-17 2008-05-08 Zang Ying C Q Method For Increasing Cd8+ Cytotoxic T Cell Responses And For Treating Multiple Sclerosis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0720622A1 (en) * 1993-09-22 1996-07-10 The Board Of Trustees Of The Leland Stanford Junior University Interaction of t-cell receptors and antigen in autoimmune disease
JPH10509714A (ja) * 1994-11-18 1998-09-22 ニューロクライン バイオサイエンシーズ， インコーポレイテッド ヒトミエリン塩基性タンパク質の９１位におけるペプチドアナログを用いる多発性硬化症の処置方法

Also Published As

Publication number Publication date
IL105347A0 (en) 1993-08-18
PT863155E (pt) 2002-07-31
KR950700934A (ko) 1995-02-20
EP0650498B1 (en) 1998-09-09
CA2133749A1 (en) 1993-10-28
DE69320967T2 (de) 1999-05-12
WO1993021222A1 (en) 1993-10-28
KR100295606B1 (es) 2001-10-22
EP0650498A1 (en) 1995-05-03
AU4282493A (en) 1993-11-18
EP0650498A4 (en) 1995-06-21
DE69331501T2 (de) 2002-08-29
AU680824B2 (en) 1997-08-14
EP0863155A1 (en) 1998-09-09
DE69320967D1 (de) 1998-10-15
NO943755D0 (no) 1994-10-06
NO317049B1 (no) 2004-07-26
EP0863155B1 (en) 2002-01-23
JPH08500083A (ja) 1996-01-09
DE69331501D1 (de) 2002-03-14
HU219306B (en) 2001-03-28
BR9306272A (pt) 1998-06-23
DK0863155T3 (da) 2002-05-13
ATE170874T1 (de) 1998-09-15
NO943755L (no) 1994-12-02
HU9402909D0 (en) 1995-01-30
HUT69169A (en) 1995-08-28
JP3434510B2 (ja) 2003-08-11
ATE212358T1 (de) 2002-02-15

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