DK0863155T3 - Suppression af T-celle-proliferation under anvendelse af peptidfragmenter af myelin basisk protein - Google Patents
Suppression af T-celle-proliferation under anvendelse af peptidfragmenter af myelin basisk proteinInfo
- Publication number
- DK0863155T3 DK0863155T3 DK98102522T DK98102522T DK0863155T3 DK 0863155 T3 DK0863155 T3 DK 0863155T3 DK 98102522 T DK98102522 T DK 98102522T DK 98102522 T DK98102522 T DK 98102522T DK 0863155 T3 DK0863155 T3 DK 0863155T3
- Authority
- DK
- Denmark
- Prior art keywords
- suppression
- cell proliferation
- peptide fragments
- basic protein
- myelin basic
- Prior art date
Links
- KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 title 1
- 102000047918 Myelin Basic Human genes 0.000 title 1
- 101710107068 Myelin basic protein Proteins 0.000 title 1
- 108010033276 Peptide Fragments Proteins 0.000 title 1
- 102000007079 Peptide Fragments Human genes 0.000 title 1
- 230000006052 T cell proliferation Effects 0.000 title 1
- 230000001629 suppression Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 125000001433 C-terminal amino-acid group Chemical group 0.000 abstract 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 1
- 230000006472 autoimmune response Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0008—Antigens related to auto-immune diseases; Preparations to induce self-tolerance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4713—Autoimmune diseases, e.g. Insulin-dependent diabetes mellitus, multiple sclerosis, rheumathoid arthritis, systemic lupus erythematosus; Autoantigens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Rehabilitation Therapy (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86531892A | 1992-04-09 | 1992-04-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0863155T3 true DK0863155T3 (da) | 2002-05-13 |
Family
ID=25345228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK98102522T DK0863155T3 (da) | 1992-04-09 | 1993-04-09 | Suppression af T-celle-proliferation under anvendelse af peptidfragmenter af myelin basisk protein |
Country Status (15)
| Country | Link |
|---|---|
| EP (2) | EP0863155B1 (enExample) |
| JP (1) | JP3434510B2 (enExample) |
| KR (1) | KR950700934A (enExample) |
| AT (2) | ATE212358T1 (enExample) |
| AU (1) | AU680824B2 (enExample) |
| BR (1) | BR9306272A (enExample) |
| CA (1) | CA2133749A1 (enExample) |
| DE (2) | DE69331501T2 (enExample) |
| DK (1) | DK0863155T3 (enExample) |
| ES (1) | ES2172044T3 (enExample) |
| HU (1) | HU219306B (enExample) |
| IL (1) | IL105347A0 (enExample) |
| NO (1) | NO317049B1 (enExample) |
| PT (1) | PT863155E (enExample) |
| WO (1) | WO1993021222A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5869054A (en) * | 1987-06-24 | 1999-02-09 | Autoimmune Inc. | Treatment of multiple sclerosis by oral administration of autoantigens |
| US5817629A (en) * | 1991-10-22 | 1998-10-06 | The Governors Of The University Of Alberta | Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients |
| US6252040B1 (en) | 1991-10-22 | 2001-06-26 | The Governors Of The University Of Alberta | Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients |
| HUT76099A (en) * | 1994-05-10 | 1997-06-30 | Immulogic Pharma Corp | Compositions and treatment for multiple sclerosis |
| PL324091A1 (en) * | 1994-10-25 | 1998-05-11 | Immulogic Pharma Corp | Compositions and procedure for treating sclerosis multiplex |
| US6251396B1 (en) | 1994-11-18 | 2001-06-26 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein |
| US6329499B1 (en) * | 1994-11-18 | 2001-12-11 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogues of human myelin basic protein |
| JPH10509714A (ja) | 1994-11-18 | 1998-09-22 | ニューロクライン バイオサイエンシーズ， インコーポレイテッド | ヒトミエリン塩基性タンパク質の９１位におけるペプチドアナログを用いる多発性硬化症の処置方法 |
| US6379670B1 (en) | 1994-11-18 | 2002-04-30 | Neurocrine Biosciences, Inc. | Methods for treatment of multiple sclerosis using peptide analogs of human myelin basic protein |
| WO1996028470A2 (en) * | 1995-03-09 | 1996-09-19 | Neurocrine Biosciences, Inc. | Peptide analogues of human myelin basic protein useful in treating multiple sclerosis |
| US5856446A (en) * | 1995-07-07 | 1999-01-05 | Autoimmune Inc. | Method of treating rheumatoid arthritis with low dose type II collagen |
| IL116559A (en) * | 1995-11-17 | 2005-11-20 | Yissum Res Dev Co | Chimeric protein consisting of a bacterial toxin and a myelin basic protein sequence |
| US6274136B1 (en) * | 1996-05-29 | 2001-08-14 | University Of Southern California | Construction and use of genes encoding pathogenic epitopes for treatment of autoimmune disease |
| CA2201841C (en) * | 1997-04-04 | 2010-01-26 | The Governors Of The University Of Alberta | Peptide specificity of anti-myelin basic protein and the administration of myelin basic protein peptides to multiple sclerosis patients |
| US20020072493A1 (en) | 1998-05-19 | 2002-06-13 | Yeda Research And Development Co. Ltd. | Activated T cells, nervous system-specific antigens and their uses |
| EP1080110A2 (en) * | 1998-05-19 | 2001-03-07 | Yeda Research And Development Co. Ltd. | Use of activated t cells, nervous system-specific antigens for treating disorders of the nevrous system |
| US7261896B2 (en) | 2000-05-24 | 2007-08-28 | United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health | Methods for preventing strokes by inducing tolerance to e-selectin |
| US20080107664A1 (en) | 2003-10-17 | 2008-05-08 | Zang Ying C Q | Method For Increasing Cd8+ Cytotoxic T Cell Responses And For Treating Multiple Sclerosis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995008572A1 (en) * | 1993-09-22 | 1995-03-30 | The Board Of Trustees For The Leland Stanford Junior University | Interaction of t-cell receptors and antigen in autoimmune disease |
| JPH10509714A (ja) * | 1994-11-18 | 1998-09-22 | ニューロクライン バイオサイエンシーズ， インコーポレイテッド | ヒトミエリン塩基性タンパク質の９１位におけるペプチドアナログを用いる多発性硬化症の処置方法 |
-
1993
- 1993-04-09 AT AT98102522T patent/ATE212358T1/de not_active IP Right Cessation
- 1993-04-09 DE DE69331501T patent/DE69331501T2/de not_active Expired - Lifetime
- 1993-04-09 AU AU42824/93A patent/AU680824B2/en not_active Ceased
- 1993-04-09 BR BR9306272A patent/BR9306272A/pt not_active Application Discontinuation
- 1993-04-09 IL IL105347A patent/IL105347A0/xx unknown
- 1993-04-09 WO PCT/US1993/003369 patent/WO1993021222A1/en not_active Ceased
- 1993-04-09 PT PT98102522T patent/PT863155E/pt unknown
- 1993-04-09 EP EP98102522A patent/EP0863155B1/en not_active Expired - Lifetime
- 1993-04-09 AT AT93912176T patent/ATE170874T1/de not_active IP Right Cessation
- 1993-04-09 JP JP51850993A patent/JP3434510B2/ja not_active Expired - Fee Related
- 1993-04-09 CA CA002133749A patent/CA2133749A1/en not_active Abandoned
- 1993-04-09 ES ES98102522T patent/ES2172044T3/es not_active Expired - Lifetime
- 1993-04-09 DE DE69320967T patent/DE69320967T2/de not_active Expired - Lifetime
- 1993-04-09 EP EP93912176A patent/EP0650498B1/en not_active Expired - Lifetime
- 1993-04-09 HU HU9402909A patent/HU219306B/hu not_active IP Right Cessation
- 1993-04-09 DK DK98102522T patent/DK0863155T3/da active
-
1994
- 1994-10-06 NO NO19943755A patent/NO317049B1/no not_active IP Right Cessation
- 1994-10-08 KR KR1019940703571A patent/KR950700934A/ko active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| ATE212358T1 (de) | 2002-02-15 |
| KR950700934A (ko) | 1995-02-20 |
| ATE170874T1 (de) | 1998-09-15 |
| JP3434510B2 (ja) | 2003-08-11 |
| WO1993021222A1 (en) | 1993-10-28 |
| DE69331501D1 (de) | 2002-03-14 |
| DE69320967D1 (de) | 1998-10-15 |
| HUT69169A (en) | 1995-08-28 |
| DE69320967T2 (de) | 1999-05-12 |
| KR100295606B1 (enExample) | 2001-10-22 |
| DE69331501T2 (de) | 2002-08-29 |
| BR9306272A (pt) | 1998-06-23 |
| CA2133749A1 (en) | 1993-10-28 |
| EP0650498B1 (en) | 1998-09-09 |
| NO317049B1 (no) | 2004-07-26 |
| HU219306B (en) | 2001-03-28 |
| AU4282493A (en) | 1993-11-18 |
| EP0650498A1 (en) | 1995-05-03 |
| IL105347A0 (en) | 1993-08-18 |
| PT863155E (pt) | 2002-07-31 |
| NO943755L (no) | 1994-12-02 |
| AU680824B2 (en) | 1997-08-14 |
| EP0650498A4 (en) | 1995-06-21 |
| NO943755D0 (no) | 1994-10-06 |
| EP0863155A1 (en) | 1998-09-09 |
| HU9402909D0 (en) | 1995-01-30 |
| ES2172044T3 (es) | 2002-09-16 |
| JPH08500083A (ja) | 1996-01-09 |
| EP0863155B1 (en) | 2002-01-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0863155T3 (da) | Suppression af T-celle-proliferation under anvendelse af peptidfragmenter af myelin basisk protein | |
| DK0670898T3 (da) | Interleukin-3 (IL-3)-mutantpolypeptider | |
| DK0792287T3 (da) | Peptidanaloger af humant basisk myelinprotein | |
| ATE430801T1 (de) | Von wd-40 abstammende peptide und ihre verwendung | |
| DE69838143D1 (de) | Antimikrobielle peptide | |
| DE60030450D1 (de) | Von MUC-1 abgeleitete Peptide | |
| DE69129865D1 (de) | Osteogene peptide | |
| GB8625435D0 (en) | Human apolipoprotein ai | |
| DE68927379D1 (de) | Plättchen blockierende peptide | |
| GB9606040D0 (en) | Active peptide | |
| DE69029377D1 (de) | Substituierungsanaloge von magaininpeptiden | |
| ATE154638T1 (de) | Mutanten von interleukin-3 | |
| Chauvet et al. | Characterization of porcine MSEL-neurophysin | |
| DK56995A (da) | Rekombinante lymphotoxin-varianter |