JP2688363B2 - 医薬活性物質の投与物及び又は投薬物を製造する方法 - Google Patents
医薬活性物質の投与物及び又は投薬物を製造する方法Info
- Publication number
- JP2688363B2 JP2688363B2 JP63504858A JP50485888A JP2688363B2 JP 2688363 B2 JP2688363 B2 JP 2688363B2 JP 63504858 A JP63504858 A JP 63504858A JP 50485888 A JP50485888 A JP 50485888A JP 2688363 B2 JP2688363 B2 JP 2688363B2
- Authority
- JP
- Japan
- Prior art keywords
- printing
- active substance
- pad
- dosage form
- printing medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013543 active substance Substances 0.000 title claims abstract description 30
- 238000004519 manufacturing process Methods 0.000 title claims description 15
- 239000002552 dosage form Substances 0.000 title abstract description 7
- 238000000034 method Methods 0.000 claims abstract description 54
- 238000007639 printing Methods 0.000 claims abstract description 49
- 239000003814 drug Substances 0.000 claims abstract description 21
- 238000007649 pad printing Methods 0.000 claims abstract description 8
- 239000000758 substrate Substances 0.000 claims description 19
- 229940079593 drug Drugs 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 5
- 229940126585 therapeutic drug Drugs 0.000 claims description 2
- 238000000576 coating method Methods 0.000 description 23
- 239000011248 coating agent Substances 0.000 description 18
- 239000000853 adhesive Substances 0.000 description 10
- 230000001070 adhesive effect Effects 0.000 description 10
- 229940124597 therapeutic agent Drugs 0.000 description 9
- 239000000463 material Substances 0.000 description 8
- 239000011505 plaster Substances 0.000 description 8
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 4
- 239000010408 film Substances 0.000 description 4
- 229960002715 nicotine Drugs 0.000 description 4
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 4
- 238000009826 distribution Methods 0.000 description 3
- 239000011159 matrix material Substances 0.000 description 3
- 230000001360 synchronised effect Effects 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- 239000012298 atmosphere Substances 0.000 description 2
- 239000013039 cover film Substances 0.000 description 2
- 238000005530 etching Methods 0.000 description 2
- 238000001704 evaporation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229920006267 polyester film Polymers 0.000 description 2
- 238000007761 roller coating Methods 0.000 description 2
- 238000009495 sugar coating Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 229920002323 Silicone foam Polymers 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 240000003834 Triticum spelta Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 239000011149 active material Substances 0.000 description 1
- 239000008186 active pharmaceutical agent Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 238000007606 doctor blade method Methods 0.000 description 1
- 229940088679 drug related substance Drugs 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000011253 protective coating Substances 0.000 description 1
- 239000013514 silicone foam Substances 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 230000037384 skin absorption Effects 0.000 description 1
- 231100000274 skin absorption Toxicity 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000013271 transdermal drug delivery Methods 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
- B41F—PRINTING MACHINES OR PRESSES
- B41F17/00—Printing apparatus or machines of special types or for particular purposes, not otherwise provided for
- B41F17/001—Pad printing apparatus or machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/10—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of compressed tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7084—Transdermal patches having a drug layer or reservoir, and one or more separate drug-free skin-adhesive layers, e.g. between drug reservoir and skin, or surrounding the drug reservoir; Liquid-filled reservoir patches
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Laminated Bodies (AREA)
- Record Information Processing For Printing (AREA)
- Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3727232.2 | 1987-08-14 | ||
| DE19873727232 DE3727232A1 (de) | 1987-08-14 | 1987-08-14 | Verfahren zur herstellung einer darreichungs- und/oder dosierungsform fuer arzneimittelwirkstoffe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH02500193A JPH02500193A (ja) | 1990-01-25 |
| JP2688363B2 true JP2688363B2 (ja) | 1997-12-10 |
Family
ID=6333827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63504858A Expired - Lifetime JP2688363B2 (ja) | 1987-08-14 | 1988-06-16 | 医薬活性物質の投与物及び又は投薬物を製造する方法 |
Country Status (28)
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4230589C1 (de) * | 1992-09-12 | 1994-02-03 | Lohmann Therapie Syst Lts | Dosierverfahren für leicht flüchtige oder thermolabile Substanzen in flüssiger Form zur Herstellung von u.a. flächigen Arzneiformen, insbesondere zur Herstellung von transdermalen oder dermalen therapeutischen Systemen |
| DE4302445A1 (de) * | 1993-01-29 | 1994-08-11 | Lohmann Therapie Syst Lts | Tampondruckverfahren |
| DE4400769C2 (de) * | 1994-01-13 | 1996-07-18 | Lohmann Therapie Syst Lts | Verfahren und Vorrichtung zur Herstellung einer flächigen Darreichungsform mit einer Arzneimittelwirkstoffe enthaltenden Zubereitung |
| DE69531488T2 (de) * | 1994-03-07 | 2004-06-17 | Theratech Inc., Salt Lake City | Medikament enthaltende, adhesive, zusammenbaubare, transdermale abgabevorrichtung |
| DE69506122D1 (de) * | 1994-09-30 | 1998-12-24 | Becton Dickinson Co | Verfahren zur herstellung und verpackung von iontophoretischen pflastern und denselben, um die stabilität und die lagerstabilität zu verbessern |
| US5688523A (en) * | 1995-03-31 | 1997-11-18 | Minnesota Mining And Manufacturing Company | Method of making a pressure sensitive skin adhesive sheet material |
| DE19708674C2 (de) * | 1996-03-25 | 2002-02-07 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit einer wirkstoffhaltigen Filmschicht und einer löslichen Trennschicht, sowie ein Verfahren zu dessen Herstellung |
| HU225734B1 (en) * | 1999-07-28 | 2007-07-30 | Zoltan Dardai | Multilayer plaster for introducing peptidaceous pharmacons in living organisms and process for producing thereof |
| DE10110391A1 (de) | 2001-03-03 | 2002-09-26 | Lohmann Therapie Syst Lts | Hochflexibles Nikotin transdermales therapeutisches System mit Nikotin als Wirkstoff |
| WO2003024373A1 (en) * | 2001-09-14 | 2003-03-27 | 3M Innovative Properties Company | Non-contact printing method for making a medical pressure sensitive adhesive article |
| ITMI20020672A1 (it) * | 2002-03-29 | 2003-09-29 | Gamma Croma Spa | Processo di applicazione di un prodotto cosmetico decorativo su un prodotto cosmetico di base |
| US20050244402A1 (en) * | 2004-04-30 | 2005-11-03 | Villanueva Julie M | Absorption of pain-causing agents |
| US8609198B2 (en) * | 2004-07-21 | 2013-12-17 | Hewlett-Packard Development Company, L.P. | Pharmaceutical dose form with a patterned coating and method of making the same |
| DE102005010255A1 (de) * | 2005-03-07 | 2006-09-14 | Lts Lohmann Therapie-Systeme Ag | Faserfreies transdermales therapeutisches System und Verfahren zu seiner Herstellung |
| IL177071A0 (en) * | 2005-08-01 | 2006-12-10 | Nitto Denko Corp | Method of preparing a nicotine transdermal preparation |
| US20100272799A1 (en) * | 2009-04-27 | 2010-10-28 | Joshi Hemant N | Coating technology to produce a combination solid dosage form |
| CN102883888B (zh) * | 2010-03-12 | 2015-07-08 | 株式会社御牧工程 | 图像形成装置和图像形成方法 |
| CN103287082B (zh) * | 2013-06-25 | 2016-04-20 | 苏州速腾电子科技有限公司 | 一种移印头机构 |
| EP2946775A1 (de) | 2014-05-20 | 2015-11-25 | LTS LOHMANN Therapie-Systeme AG | Lavendelöl enthaltendes transdermales therapeutisches System |
| US10549521B2 (en) * | 2016-05-02 | 2020-02-04 | Benjamin S. Adner | Thermally controlled pad print ink transfer arrangement |
| DE102017104026A1 (de) | 2017-02-27 | 2018-08-30 | Lts Lohmann Therapie-Systeme Ag | Nicotin enthaltendes transparentes transdermales therapeutisches System |
| DE102019117310A1 (de) * | 2019-06-27 | 2020-12-31 | Lts Lohmann Therapie-Systeme Ag | Verfahren zur Herstellung von Wirkstoffverabreichungssystemen mittels Tampondruckverfahren |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2865810A (en) * | 1955-10-07 | 1958-12-23 | Jr Roy Y Sanders | Marked pharmaceutical tablet and method of marking the same |
| US3015609A (en) * | 1960-07-29 | 1962-01-02 | Jr Roy Y Sanders | Marked pharmaceutical tablet and method of marking the same |
| US3910183A (en) * | 1974-02-28 | 1975-10-07 | Parke Davis & Co | Apparatus for offset printing capsules |
| US4548825A (en) * | 1978-11-15 | 1985-10-22 | Boehringer Ingelheim Gmbh | Method for ink-jet printing on uncoated tablets or uncoated tablet cores |
| DE2849495C3 (de) * | 1978-11-15 | 1982-05-13 | Voss, Gunther M., 8918 Diessen | Anwendung eines Tintenstrahldruckers zum Beschriften oder Bedrucken von Arzneimittelformlingen |
| US4409264A (en) * | 1981-04-01 | 1983-10-11 | Northern Engraving Corporation | Boss formation using low surface energy dams |
| DE3423328A1 (de) * | 1984-06-23 | 1986-01-02 | Beiersdorf Ag, 2000 Hamburg | Selbstklebendes pflaster |
| DE3423293C2 (de) * | 1984-06-23 | 1995-08-24 | Lohmann Therapie Syst Lts | Selbstklebendes Pflaster |
| AT385592B (de) * | 1985-08-28 | 1988-04-25 | Fink Karl | Schmelzofen |
| US4849246A (en) * | 1985-10-09 | 1989-07-18 | Wolfgang Schmidt | Process for producing an administration or dosage form for drugs, reagents or other active ingredients |
| US4743249A (en) * | 1986-02-14 | 1988-05-10 | Ciba-Geigy Corp. | Dermal and transdermal patches having a discontinuous pattern adhesive layer |
-
1987
- 1987-08-14 DE DE19873727232 patent/DE3727232A1/de not_active Ceased
-
1988
- 1988-06-16 KR KR1019890700139A patent/KR960013702B1/ko not_active Expired - Lifetime
- 1988-06-16 HU HU883863A patent/HU204204B/hu unknown
- 1988-06-16 AT AT88109691T patent/ATE80997T1/de not_active IP Right Cessation
- 1988-06-16 JP JP63504858A patent/JP2688363B2/ja not_active Expired - Lifetime
- 1988-06-16 ES ES198888109691T patent/ES2034035T3/es not_active Expired - Lifetime
- 1988-06-16 DE DE8888109691T patent/DE3875026D1/de not_active Expired - Lifetime
- 1988-06-16 AU AU19357/88A patent/AU623597B2/en not_active Expired
- 1988-06-16 WO PCT/DE1988/000366 patent/WO1989001328A1/de active IP Right Grant
- 1988-06-16 EP EP88109691A patent/EP0303025B1/de not_active Expired - Lifetime
- 1988-06-30 ZA ZA884670A patent/ZA884670B/xx unknown
- 1988-06-30 NZ NZ225242A patent/NZ225242A/xx unknown
- 1988-07-02 MY MYPI88000734A patent/MY103741A/en unknown
- 1988-07-19 CA CA000572416A patent/CA1333455C/en not_active Expired - Lifetime
- 1988-07-19 PL PL1988273790A patent/PL157820B1/pl unknown
- 1988-07-20 IL IL87160A patent/IL87160A/xx not_active IP Right Cessation
- 1988-07-28 PT PT88138A patent/PT88138B/pt not_active IP Right Cessation
- 1988-08-05 IE IE239188A patent/IE62262B1/en not_active IP Right Cessation
- 1988-08-10 DD DD88318827A patent/DD272792A5/de not_active IP Right Cessation
- 1988-08-12 SI SI8811567A patent/SI8811567A8/sl unknown
- 1988-08-12 CZ CS885590A patent/CZ283152B6/cs not_active IP Right Cessation
- 1988-08-12 SK SK5590-88A patent/SK559088A3/sk unknown
- 1988-08-12 YU YU156788A patent/YU46705B/sh unknown
-
1989
- 1989-01-16 NO NO890186A patent/NO177376C/no not_active IP Right Cessation
- 1989-04-13 FI FI891774A patent/FI95653C/fi active IP Right Grant
- 1989-04-14 DK DK198901833A patent/DK175276B1/da not_active IP Right Cessation
-
1991
- 1991-08-13 US US07/746,296 patent/US5110599A/en not_active Expired - Lifetime
-
1992
- 1992-02-12 US US07/834,483 patent/US5264224A/en not_active Expired - Lifetime
- 1992-10-02 HR HRP-1567/88A patent/HRP920834B1/xx not_active IP Right Cessation
- 1992-10-27 GR GR920402418T patent/GR3006089T3/el unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
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