JP2571904B2 - 抗虚血剤としての２−（４−ヒドロキシピペリジノ）−１−アルカノール誘導体 - Google Patents

抗虚血剤としての２−（４−ヒドロキシピペリジノ）−１−アルカノール誘導体

Info

Publication number
JP2571904B2
JP2571904B2 JP5502784A JP50278493A JP2571904B2 JP 2571904 B2 JP2571904 B2 JP 2571904B2 JP 5502784 A JP5502784 A JP 5502784A JP 50278493 A JP50278493 A JP 50278493A JP 2571904 B2 JP2571904 B2 JP 2571904B2
Authority
JP
Japan
Prior art keywords
carbon atoms
alkyl
group
hydroxy
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP5502784A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06504293A (ja
Inventor
ウエルチ，ウイラード・マコーワン・ジユニア
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Original Assignee
Pfizer Corp Belgium
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium filed Critical Pfizer Corp Belgium
Publication of JPH06504293A publication Critical patent/JPH06504293A/ja
Application granted granted Critical
Publication of JP2571904B2 publication Critical patent/JP2571904B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP5502784A 1991-07-17 1992-06-19 抗虚血剤としての２−（４−ヒドロキシピペリジノ）−１−アルカノール誘導体 Expired - Lifetime JP2571904B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US73157791A 1991-07-17 1991-07-17
US731.577 1991-07-17

Publications (2)

Publication Number Publication Date
JPH06504293A JPH06504293A (ja) 1994-05-19
JP2571904B2 true JP2571904B2 (ja) 1997-01-16

Family

ID=24940103

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5502784A Expired - Lifetime JP2571904B2 (ja) 1991-07-17 1992-06-19 抗虚血剤としての２−（４−ヒドロキシピペリジノ）−１−アルカノール誘導体

Country Status (22)

Country Link
EP (1) EP0594729A1 (enExample)
JP (1) JP2571904B2 (enExample)
KR (1) KR0165003B1 (enExample)
CN (1) CN1043759C (enExample)
AU (1) AU655840B2 (enExample)
BR (1) BR9206272A (enExample)
CA (1) CA2113568A1 (enExample)
CZ (1) CZ284133B6 (enExample)
EG (1) EG20048A (enExample)
FI (2) FI940192L (enExample)
HU (1) HUT70528A (enExample)
IE (1) IE922311A1 (enExample)
IL (1) IL102473A (enExample)
MX (1) MX9204190A (enExample)
NO (1) NO180445C (enExample)
NZ (1) NZ243580A (enExample)
PL (1) PL169884B1 (enExample)
PT (1) PT100689B (enExample)
RU (1) RU2065859C1 (enExample)
TW (1) TW201732B (enExample)
WO (1) WO1993002052A1 (enExample)
ZA (1) ZA925306B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
WO1994010166A1 (en) * 1992-10-30 1994-05-11 Pfizer Inc. Neuroprotective 3,4-dihydro-2(1h)-quinolone compounds
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
US6978166B2 (en) 1994-10-07 2005-12-20 Saint Louis University System for use in displaying images of a body part
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
CA2220649C (en) * 1996-12-03 2007-02-13 F. Hoffmann-La Roche Ag 4-hydroxy-piperidine derivatives
EP1182193A4 (en) * 1999-04-09 2002-09-11 Mochida Pharm Co Ltd REMEDIES FOR NEUROGENIC PAIN
TWI254043B (en) * 1999-06-08 2006-05-01 Hoffmann La Roche Ethanesulfonyl-piperidine derivatives having good affinity to N-methyl-D-aspartate (NMDA) receptor
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
WO2001030330A2 (en) 1999-10-29 2001-05-03 Merck Sharp & Dohme Limited Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
UA75392C2 (en) 2001-02-23 2006-04-17 Merck & Co Inc N-substituted non-aryl heterocyclic antagonists nmda/nr2b
CA2443108A1 (en) 2001-04-03 2002-10-17 Merck & Co. Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
WO2004048326A1 (ja) 2002-11-25 2004-06-10 Mochida Pharmaceutical Co., Ltd. ４−ヒドロキシピペリジン誘導体を有効成分とする呼吸器疾患治療剤
JP2007508288A (ja) * 2003-10-08 2007-04-05 ファイザー株式会社 縮合ラクタム化合物
TWI409289B (zh) 2010-09-02 2013-09-21 Taiwan Union Technology Corp 由氮氧雜環化合物所製得之聚合物之穩態溶液及其製法與用途
AU2021297823A1 (en) * 2020-06-23 2023-02-16 Biohaven Therapeutics Ltd. Topical formulations of (1S)-1-phenyl-2-pyridin-2-ylethanamine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
FR2546166B1 (fr) * 1983-05-19 1985-10-25 Synthelabo Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
ES2098248T3 (es) * 1989-05-17 1997-05-01 Pfizer Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.
US5306723A (en) * 1990-05-10 1994-04-26 Pfizer Inc. Neuroprotective indolone and related derivatives

Also Published As

Publication number Publication date
FI981956L (fi) 1998-09-11
NO940144D0 (no) 1994-01-14
WO1993002052A1 (en) 1993-02-04
PT100689A (pt) 1993-10-29
IL102473A0 (en) 1993-01-14
PT100689B (pt) 1999-06-30
NO180445B (no) 1997-01-13
TW201732B (enExample) 1993-03-11
HU9400136D0 (en) 1994-05-30
NZ243580A (en) 1994-10-26
FI981956A0 (fi) 1998-09-11
RU2065859C1 (ru) 1996-08-27
CZ284133B6 (cs) 1998-08-12
HUT70528A (en) 1995-10-30
KR0165003B1 (en) 1999-01-15
PL169884B1 (pl) 1996-09-30
FI940192A0 (fi) 1994-01-14
CN1068566A (zh) 1993-02-03
MX9204190A (es) 1993-01-01
NO940144L (no) 1994-01-14
FI940192A7 (fi) 1994-01-14
ZA925306B (en) 1994-01-17
IL102473A (en) 1997-07-13
FI981956A7 (fi) 1998-09-11
AU655840B2 (en) 1995-01-12
CN1043759C (zh) 1999-06-23
AU2322592A (en) 1993-02-23
NO180445C (no) 1997-04-23
BR9206272A (pt) 1995-04-11
FI940192L (fi) 1994-01-14
EG20048A (en) 1997-03-27
CA2113568A1 (en) 1993-02-04
JPH06504293A (ja) 1994-05-19
CZ400892A3 (en) 1994-03-16
IE922311A1 (en) 1993-01-27
EP0594729A1 (en) 1994-05-04

Similar Documents

Publication Publication Date Title
JP2571904B2 (ja) 抗虚血剤としての２−（４−ヒドロキシピペリジノ）−１−アルカノール誘導体
US5432175A (en) Pyridine and pyridine N-oxide derivatives of diaryl methyl piperidines or piperazines, and compositions and methods of use thereof
JP2000512296A (ja) セロトニン再取込み阻害
IL109234A (en) Indole derivatives, their preparation and pharmaceutical compositions containing them
US6153641A (en) Pharmaceutically active compounds
HK109695A (en) 1-indolylalkyl-4-(alkoxy-pyrimidinyl)piperazines
FR2662696A2 (fr) Antagonistes de la serotonine, leur preparation et medicaments les contenant.
JP5894164B2 (ja) クロメン誘導体
EP0411912A2 (en) Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders
JPH0375542B2 (enExample)
JP3687899B2 (ja) アミノアルキルフェノール誘導体および関連化合物
JPH02300184A (ja) インドール誘導体
KR100235506B1 (ko) 5-아미노-5,6,7,8-테트라하이드로퀴놀린 및 관련화합물,이의 제조방법 및 약제로서의 이의 용도
US6255322B1 (en) 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
JPH0377191B2 (enExample)
JPH09504014A (ja) カルシウムチャネル拮抗薬としてのアミン誘導体類
KR100255619B1 (ko) 신규한 피페리딘 유도체 및 이의 제조방법
JP5546463B2 (ja) キノロン化合物を含む薬剤
JP2956788B2 (ja) スピロイソインドリン化合物、その製造方法、それを含有する神経症を治療するための医薬およびそれを製造するための中間体
US5512566A (en) Tricyclic compounds having affinity for the 5-HT1A receptor
JPH03184978A (ja) 新規なモルホリン誘導体およびこれらの誘導体を含有する医薬組成物
JPH0525140A (ja) ベンズイミダゾール誘導体
JPS62267269A (ja) ピラゾ−ル−３−アミン類
JPH08268949A (ja) ジフェニルメチレン誘導体
KR20240109240A (ko) 베타 아드레날린 작용제 및 이의 사용 방법