JP2555648B2 - ３−ピロリジニルチオ−１−アザビシクロ〔３．２．０〕ヘプト−２−エン−２−カルボン酸化合物 - Google Patents

３−ピロリジニルチオ−１−アザビシクロ〔３．２．０〕ヘプト−２−エン−２−カルボン酸化合物

Info

Publication number
JP2555648B2
JP2555648B2 JP62295902A JP29590287A JP2555648B2 JP 2555648 B2 JP2555648 B2 JP 2555648B2 JP 62295902 A JP62295902 A JP 62295902A JP 29590287 A JP29590287 A JP 29590287A JP 2555648 B2 JP2555648 B2 JP 2555648B2
Authority
JP
Japan
Prior art keywords
group
nitrobenzyloxycarbonyl
alkyl
pyrrolidine
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP62295902A
Other languages
English (en)
Japanese (ja)
Other versions
JPS63170379A (ja
Inventor
正好 村田
秀雄 津々美
啓二 松田
浩二 服部
尚志 中嶌
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868628060A external-priority patent/GB8628060D0/en
Priority claimed from GB878715825A external-priority patent/GB8715825D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of JPS63170379A publication Critical patent/JPS63170379A/ja
Application granted granted Critical
Publication of JP2555648B2 publication Critical patent/JP2555648B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cephalosporin Compounds (AREA)
JP62295902A 1986-11-24 1987-11-24 ３−ピロリジニルチオ−１−アザビシクロ〔３．２．０〕ヘプト−２−エン−２−カルボン酸化合物 Expired - Lifetime JP2555648B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB8628060 1986-11-24
GB868628060A GB8628060D0 (en) 1986-11-24 1986-11-24 Carboxylic acid compounds
GB878715825A GB8715825D0 (en) 1987-07-06 1987-07-06 3-pyrrolidinylthio-1-azabicyclo(3 2 0)hept-2-ene-2-carboxylic acid compounds
GB8715825 1987-07-06

Publications (2)

Publication Number Publication Date
JPS63170379A JPS63170379A (ja) 1988-07-14
JP2555648B2 true JP2555648B2 (ja) 1996-11-20

Family

ID=26291578

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62295902A Expired - Lifetime JP2555648B2 (ja) 1986-11-24 1987-11-24 ３−ピロリジニルチオ−１−アザビシクロ〔３．２．０〕ヘプト−２−エン−２−カルボン酸化合物

Country Status (6)

Country Link
US (3) US4921852A (forum.php)
EP (1) EP0272455B1 (forum.php)
JP (1) JP2555648B2 (forum.php)
DE (1) DE3784147T2 (forum.php)
ES (1) ES2053508T3 (forum.php)
GR (1) GR3007256T3 (forum.php)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4925838A (en) * 1988-03-18 1990-05-15 Fujisawa Pharmaceutical Company, Ltd. 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds
US4963544A (en) * 1988-05-23 1990-10-16 Fujisawa Pharmaceutical Company, Ltd. 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds
AU631671B2 (en) * 1989-08-04 1992-12-03 Banyu Pharmaceutical Co., Ltd. 2-(2-vinylpyrrolidinylthio)carbapenem derivatives
GB8923844D0 (en) * 1989-10-23 1989-12-13 Fujisawa Pharmaceutical Co Carbapenem compounds
US5112818A (en) * 1989-12-29 1992-05-12 Banyu Pharmaceutical Co., Ltd. 2-(2-cyclopropylpyrrolidin-4-ylthio)carbapenhem derivatives
TW198034B (forum.php) * 1990-03-27 1993-01-11 Manyu Seiyaku Kk
US5373002A (en) * 1990-03-27 1994-12-13 Banyu Pharmaceutical Co., Ltd. 2-(substituted pyrrolidinylthio) carbapenem derivatives
US5374720A (en) * 1990-03-27 1994-12-20 Banyu Pharmaceutical Co., Ltd. 2-(substituted pyrrolidinylthio)carbapenem derivatives
JPH0764846B2 (ja) * 1990-03-27 1995-07-12 萬有製薬株式会社 ２−（置換ピロリジニルチオ）カルバペネム誘導体
WO1993006102A1 (fr) * 1991-09-27 1993-04-01 Banyu Pharmaceutical Co., Ltd. Derive de 2-(pyrrolidinylthio substitue) carbapenem
JP3367104B2 (ja) * 1992-04-13 2003-01-14 藤沢薬品工業株式会社 抗菌剤としての置換された３−ピロリジニルチオ−カルバペネム化合物
KR940007029A (ko) * 1992-09-02 1994-04-26 손정삼 새로운 카바페넴 유도체 및 그의 제조방법
AU4912393A (en) * 1993-06-15 1994-12-22 Dong Kook Pharmaceutical Co., Ltd. 1-beta-methyl-2-thiolic carbapenem derivatives
DE4321444A1 (de) * 1993-06-28 1995-01-05 Bernd Prof Dr Clement Pharmazeutische Zubereitung
WO1995023150A1 (en) * 1994-02-25 1995-08-31 Banyu Pharmaceutical Co., Ltd. Carbapenem derivative
GB9507203D0 (en) * 1995-04-07 1995-05-31 Smithkline Beecham Plc Novel compounds
AU1682599A (en) * 1997-12-16 1999-07-05 Banyu Pharmaceutical Co., Ltd. Carbapenem derivatives
US6479478B1 (en) 1998-09-10 2002-11-12 Wyeth Lederle Japan, Ltd. Carbapenem compounds
KR100325375B1 (ko) * 2000-01-31 2002-03-06 박호군 이미다졸린 고리가 치환된 카바페넴 유도체
DK1340757T3 (da) * 2000-11-16 2007-02-12 Sankyo Co 1-methylcarbapenemderivater
CA2584485C (en) 2004-10-20 2013-12-31 Resverlogix Corp. Stilbenes and chalcones for the prevention and treatment of cardiovascular diseases
AU2006275514B2 (en) 2005-07-29 2012-04-05 Resverlogix Corp. Pharmaceutical compositions for the prevention and treatment of complex diseases and their delivery by insertable medical devices
CN101641339B (zh) 2007-02-01 2013-07-17 雷斯韦洛吉克斯公司 用于预防和治疗心血管疾病的化合物
CN101328179B (zh) * 2007-06-15 2011-01-12 山东轩竹医药科技有限公司 含有氧代氮杂环的巯基吡咯烷培南衍生物
PL2346837T3 (pl) 2008-06-26 2015-07-31 Resverlogix Corp Sposoby wytwarzania pochodnych chinazolinonu
EP2382194B1 (en) 2009-01-08 2014-03-12 Resverlogix Corp. Compounds for the prevention and treatment of cardiovascular disease
US9238640B2 (en) 2009-03-18 2016-01-19 Resverlogix Corp. Anti-inflammatory agents
EP3431086B1 (en) 2009-04-22 2020-06-17 Resverlogix Corp. Novel anti-inflammatory agents
US20130065874A1 (en) 2011-09-09 2013-03-14 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
HUE044986T2 (hu) 2011-11-01 2019-11-28 Resverlogix Corp Orális, azonnali felszabadulású készítmények szubsztituált kinazolinonokhoz
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
JP2016507496A (ja) 2012-12-21 2016-03-10 ゼニス・エピジェネティクス・コーポレイションＺｅｎｉｔｈ Ｅｐｉｇｅｎｅｔｉｃｓ Ｃｏｒｐ． ブロモドメイン阻害剤としての新規複素環式化合物
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
CA2906151A1 (en) 2013-03-15 2014-09-18 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274991A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
ES2800603T3 (es) 2013-09-09 2021-01-04 Merck Sharp & Dohme Tratamiento de infecciones con ceftolozano/tazobactam en sujetos con insuficiencia renal
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
JP6903585B2 (ja) 2015-03-13 2021-07-14 レスバーロジックス コーポレイション 補体関連疾患の治療のための組成物および治療方法
WO2021165927A1 (en) * 2020-02-21 2021-08-26 Wockhardt Bio Ag 2-cyanopyrroldines, -piperidines or -dazepines as hyperglycemic agents

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3766196A (en) * 1971-07-26 1973-10-16 Robins Co Inc A H 3-(2-pyridyl) pyrrolidines and pyrrolines
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
US4640915A (en) * 1982-03-29 1987-02-03 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives
JPS5916892A (ja) * 1982-07-19 1984-01-28 Sankyo Co Ltd カルバペネム−３−カルボン酸誘導体およびその製法
KR900006449B1 (ko) * 1982-08-24 1990-08-31 상꾜 가부시끼가이샤 아제티디논 화합물의 제조방법
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
DE3579888D1 (de) * 1984-11-08 1990-10-31 Sumitomo Pharma Carbapenemverbindungen und deren herstellung.
DE3821464A1 (de) * 1988-06-25 1989-12-28 Degussa Verfahren zur herstellung substituierter organyloxysilylfunktioneller, cyclischer thioharnstoffe und diese verbindungen

Also Published As

Publication number Publication date
US5138064A (en) 1992-08-11
DE3784147D1 (en) 1993-03-25
DE3784147T2 (de) 1993-06-03
JPS63170379A (ja) 1988-07-14
US4921852A (en) 1990-05-01
ES2053508T3 (es) 1994-08-01
US5420122A (en) 1995-05-30
EP0272455B1 (en) 1993-02-10
GR3007256T3 (forum.php) 1993-07-30
EP0272455A1 (en) 1988-06-29

Similar Documents

Publication Publication Date Title
JP2555648B2 (ja) ３−ピロリジニルチオ−１−アザビシクロ〔３．２．０〕ヘプト−２−エン−２−カルボン酸化合物
US5061804A (en) 3-pyrrolidinylthio-1-azabicyclo-(3.2.0)hept-2-ene-2-carboxylic acid derivatives and processes for the preparation thereof
JP2792103B2 (ja) ３―ピロリジニルチオ―１―アザビシクロ［３．２．０］ヘプト―２―エン―２―カルボン酸化合物
DE3587126T2 (de) Carbapenem-Derivate und sie enthaltende Zusammensetzung.
JP2748500B2 (ja) ３―アルケニル―１―アザビシクロ［３．２．０］ヘプト―２―エン―２―カルボン酸化合物
NL8105470A (nl) 1-sulfo 2-oxoazetidinederivaten, alsmede bereiding en toepassing daarvan.
DK161832B (da) Analogifremgangsmaade til fremstilling af 1-sulfo-2-azetidinonderivater eller farmaceutisk acceptable salte eller estere deraf
US7001897B2 (en) 1-methylcarbapenem derivatives
JPS60185786A (ja) ６―アルキリデンペネム誘導体及びその製法
CZ292623B6 (cs) Karbapenemové deriváty, antibakteriální činidlo s jejich obsahem a jejich meziproduktové sloučeniny
JP2012149079A (ja) ２位チオエテニル系カルバペネム誘導体
CZ122996A3 (en) 2-(pyrazol-3-yl)carbapenem derivatives, process of their preparation and pharmaceutical compositions containing thereof
WO2004067532A1 (ja) 新規カルバペネム誘導体
US5116833A (en) Antibiotic c-3 dithioacetal-substituted carbapenem compounds, compositions, and methods of use thereof
WO1992002521A1 (en) 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
JPH05105681A (ja) ２−（９−フルオレノニル）−カルバペネム
JPH02289571A (ja) ３―アルケニル―１―アザビシクロ［３．２．０］ヘプト―２―エン―２―カルボン酸誘導体およびその製造法、並びにそれを含む抗菌性薬剤
WO1994005667A1 (en) Carbapenem derivatives and processes for preparing the same
JPH0215081A (ja) ３―ピロリジニルチオ―１―アザビシクロ［３．２．０］ヘプト―２―エン―２―カルボン酸化合物およびその製造法
JP2006151815A (ja) 新規カルバペネム誘導体
JPH04234886A (ja) １−アザビシクロ［３．２．０］ヘプト−２−エン−２−カルボン酸化合物
JPH06116268A (ja) ３−置換オキシ−１−アザビシクロ［３．２．０］ヘプト−２−エン−２−カルボン酸化合物
JPH09165388A (ja) カルバペネム化合物、その製造法および剤
JPH07196662A (ja) 二環式化合物およびその製造法
JPWO2006109823A1 (ja) ２位チオエテニル系カルバペネム誘導体