JP2025032196A5 - - Google Patents
Info
- Publication number
- JP2025032196A5 JP2025032196A5 JP2024211090A JP2024211090A JP2025032196A5 JP 2025032196 A5 JP2025032196 A5 JP 2025032196A5 JP 2024211090 A JP2024211090 A JP 2024211090A JP 2024211090 A JP2024211090 A JP 2024211090A JP 2025032196 A5 JP2025032196 A5 JP 2025032196A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- cycloalkyl
- membered
- haloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163167331P | 2021-03-29 | 2021-03-29 | |
| US63/167,331 | 2021-03-29 | ||
| PCT/US2022/021912 WO2022212194A1 (en) | 2021-03-29 | 2022-03-25 | Khk inhibitors |
| JP2023560087A JP7705475B2 (ja) | 2021-03-29 | 2022-03-25 | Ｋｈｋ阻害剤 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023560087A Division JP7705475B2 (ja) | 2021-03-29 | 2022-03-25 | Ｋｈｋ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2025032196A JP2025032196A (ja) | 2025-03-11 |
| JP2025032196A5 true JP2025032196A5 (https=) | 2025-09-04 |
| JP7778900B2 JP7778900B2 (ja) | 2025-12-02 |
Family
ID=81388962
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023560087A Active JP7705475B2 (ja) | 2021-03-29 | 2022-03-25 | Ｋｈｋ阻害剤 |
| JP2024211090A Active JP7778900B2 (ja) | 2021-03-29 | 2024-12-04 | Ｋｈｋ阻害剤 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023560087A Active JP7705475B2 (ja) | 2021-03-29 | 2022-03-25 | Ｋｈｋ阻害剤 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US12410160B2 (https=) |
| EP (2) | EP4313967B1 (https=) |
| JP (2) | JP7705475B2 (https=) |
| KR (1) | KR20230158542A (https=) |
| CN (1) | CN117120429A (https=) |
| AR (1) | AR125238A1 (https=) |
| AU (2) | AU2022252182B2 (https=) |
| CA (1) | CA3214961A1 (https=) |
| ES (1) | ES3061522T3 (https=) |
| PL (1) | PL4313967T3 (https=) |
| TW (2) | TWI855308B (https=) |
| WO (1) | WO2022212194A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20230098069A (ko) * | 2021-12-24 | 2023-07-03 | 주식회사 엘지화학 | (s)-2-(2-메틸아제티딘-1-일)피리미딘 유도체 및 이를 포함하는 약제학적 조성물 |
| JP2025534728A (ja) * | 2022-10-24 | 2025-10-17 | ユーハン・コーポレイション | ジメチル－２，３－ジヒドロ－１ｈ－インデン誘導体の改良された製造方法 |
| WO2024125482A1 (zh) * | 2022-12-13 | 2024-06-20 | 华领医药技术（上海）有限公司 | 作为己酮糖激酶抑制剂的化合物、其用途以及包含其的组合物 |
| WO2025184056A1 (en) * | 2024-02-26 | 2025-09-04 | Miralogx Llc | Synthetic cannabinoid analogs, pharmaceutical compositions and methods of treating anxiety and other disorders |
| WO2025250674A1 (en) * | 2024-05-30 | 2025-12-04 | Miralogx Llc | Synthetic cannabinoid analogs, pharmaceutical compositions and methods of treating neurological disorders and other conditions |
Family Cites Families (47)
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| US5041443A (en) * | 1989-02-21 | 1991-08-20 | Dainippon Pharmaceutical Co., Ltd. | Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof |
| US5137890A (en) | 1990-02-14 | 1992-08-11 | Ortho Pharmaceutical Corporation | 4-phenyl tetrahydropyrido(4,3-d)pyrimidines |
| GB0100620D0 (en) | 2001-01-10 | 2001-02-21 | Vernalis Res Ltd | Chemical cokpounds V |
| ES2305744T3 (es) * | 2003-03-12 | 2008-11-01 | Millennium Pharmaceuticals, Inc. | Derivados de quinazolina como inhibidores e tgf-beta. |
| BRPI0415683A (pt) * | 2003-11-03 | 2006-12-19 | Warner Lambert Co | inibidores da reabsorção de norepinefrina para o tratamento de distúrbios do sistema nervoso central |
| CN101277700B (zh) | 2005-08-04 | 2013-02-20 | 詹森药业有限公司 | 作为5-羟色胺受体调节剂的嘧啶化合物 |
| US7851468B2 (en) * | 2006-05-15 | 2010-12-14 | Cephalon, Inc. | Substituted pyrazolo[3,4-d]pyrimidines |
| EP2209785A1 (en) * | 2007-10-05 | 2010-07-28 | S*BIO Pte Ltd | 2-morpholinylpurines as inhibitors of pi3k |
| US8829011B2 (en) | 2008-10-29 | 2014-09-09 | Janssen Pharmaceutica Nv | 2-aminopyrimidine compounds as serotonin receptor modulators |
| US8586582B2 (en) * | 2008-11-11 | 2013-11-19 | Xcovery Holding Company, Llc | PI3K/mTOR kinase inhibitors |
| TWI491606B (zh) | 2009-07-13 | 2015-07-11 | Gilead Sciences Inc | 調節細胞凋亡信號之激酶的抑制劑 |
| JP2013525370A (ja) | 2010-04-22 | 2013-06-20 | ヤンセン ファーマシューティカ エヌ．ベー． | ケトヘキソキナーゼ阻害剤として有用なインダゾール化合物 |
| EP2545964A1 (en) | 2011-07-13 | 2013-01-16 | Phenex Pharmaceuticals AG | Novel FXR (NR1H4) binding and activity modulating compounds |
| LT2776038T (lt) | 2011-11-11 | 2018-04-25 | Gilead Apollo, Llc | Acc inhibitoriai ir jų panaudojimas |
| UY34573A (es) | 2012-01-27 | 2013-06-28 | Gilead Sciences Inc | Inhibidor de la quinasa que regula la señal de la apoptosis |
| CN103467482B (zh) * | 2012-04-10 | 2017-05-10 | 上海璎黎药业有限公司 | 稠合嘧啶类化合物，其制备方法，中间体，组合物和应用 |
| EP3197448B1 (en) | 2014-09-24 | 2019-04-24 | Gilead Sciences, Inc. | Methods of treating liver disease |
| TWI685491B (zh) | 2014-12-23 | 2020-02-21 | 美商基利科學股份有限公司 | 製備５-（４-環丙基-１ｈ-咪唑-１-基）-ｎ-（６-（４-異丙基-４ｈ-１,２,４-三唑-３-基）吡啶-２-基）-２-氟-４-甲基苯甲醯胺之方法 |
| MA41252A (fr) | 2014-12-23 | 2017-10-31 | Gilead Sciences Inc | Formes solides d'un inhibiteur d'ask 1 |
| JP2018501276A (ja) | 2015-01-09 | 2018-01-18 | ギリアド アポロ， エルエルシー | 非アルコール性脂肪肝疾患の処置のためのａｃｃ阻害剤併用療法 |
| US20190137505A1 (en) * | 2015-08-10 | 2019-05-09 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Biomarkers of methylglyoxal and related methods thereof |
| SI3397631T1 (sl) | 2015-12-29 | 2022-01-31 | Pfizer Inc. | Substituirani 3-azabiciklo(3.1.0)heksani kot zaviralci ketoheksokinaze |
| CN119977993A (zh) | 2016-03-02 | 2025-05-13 | 吉利德阿波罗公司 | 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法 |
| EP4273132A3 (en) | 2017-03-03 | 2024-01-10 | Gilead Sciences, Inc. | Processes for preparing acc inhibitors and solid forms thereof |
| US11083720B2 (en) | 2017-03-17 | 2021-08-10 | Regents Of The University Of Colorado, A Body Corporate | Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases |
| WO2018183342A1 (en) | 2017-03-28 | 2018-10-04 | Gilead Sciences, Inc. | Methods of treating liver disease |
| PT3600309T (pt) | 2017-03-28 | 2022-10-03 | Gilead Sciences Inc | Combinações terapêuticas para o tratamento de doenças hepáticas |
| AU2018250614A1 (en) | 2017-04-12 | 2019-10-17 | Gilead Sciences, Inc. | Methods of treating liver disease |
| KR102419458B1 (ko) | 2017-10-06 | 2022-07-12 | 길리애드 사이언시즈, 인코포레이티드 | Acc 억제제를 포함하는 조합 요법 |
| US12161621B2 (en) | 2018-07-16 | 2024-12-10 | The Regents Of The University Of Colorado | Methods for fructokinase mediation of alcohol craving and alcohol induced liver disease |
| TWI714231B (zh) | 2018-09-04 | 2020-12-21 | 美商美國禮來大藥廠 | 2,6-二胺基吡啶化合物 |
| KR102558308B1 (ko) | 2018-09-27 | 2023-07-24 | 주식회사 엘지화학 | 3-아자바이사이클로[3,1,1]헵탄 유도체 및 이를 포함하는 약제학적 조성물 |
| PH12021551635A1 (en) * | 2019-01-29 | 2022-05-02 | Shandong Xuanzhu Pharma Co Ltd | Hexone glucokinase inhibitor and use thereof |
| CA3233305A1 (en) | 2019-02-19 | 2020-08-27 | Gilead Sciences, Inc. | Solid forms of fxr agonists |
| WO2020185685A1 (en) | 2019-03-08 | 2020-09-17 | The Regents Of The University Of California | Compositions and methods for treating acne |
| CN114007602A (zh) | 2019-04-17 | 2022-02-01 | 科罗拉多研究合作伙伴有限责任公司 | 治疗果糖相关病症或疾病的新型化合物和使用方法 |
| CN111978296A (zh) | 2019-05-22 | 2020-11-24 | 山东轩竹医药科技有限公司 | 己酮糖激酶抑制剂及其用途 |
| TWI750685B (zh) | 2019-06-17 | 2021-12-21 | 美商美國禮來大藥廠 | 二取代吡唑化合物 |
| EP4083034A4 (en) | 2019-12-24 | 2023-12-06 | Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. | ASSOCIATION WITH CHAD-INHIBITING EFFECT |
| CN114846008B (zh) | 2019-12-25 | 2024-05-28 | 杭州中美华东制药有限公司 | 具有果糖激酶(khk)抑制作用的嘧啶类化合物 |
| WO2021162943A1 (en) | 2020-02-13 | 2021-08-19 | Eli Lilly And Company | 2-[2-methylazetidin-1-yl]-4-phenyl-6-(trifluoromethyl)-pyrimidine compounds |
| CN111423420A (zh) | 2020-04-30 | 2020-07-17 | 广州博济医药生物技术股份有限公司 | 作为己酮糖激酶抑制剂的并环化合物 |
| CN114181198B (zh) | 2020-09-15 | 2025-07-15 | 山东轩竹医药科技有限公司 | 嘧啶衍生物类己酮糖激酶抑制剂及其用途 |
| EP4269404A4 (en) * | 2020-12-25 | 2024-12-04 | Xizang Haisco Pharmaceutical Co., Ltd. | KETOHEXOKINASE INHIBITORS AND USE THEREOF |
| CN114805312A (zh) | 2021-01-29 | 2022-07-29 | 上海拓界生物医药科技有限公司 | 一种己酮糖激酶抑制剂及其制备方法 |
| CN114989143A (zh) | 2021-03-02 | 2022-09-02 | 山东轩竹医药科技有限公司 | 并环类己酮糖激酶抑制剂及其用途 |
| WO2022211595A1 (ko) | 2021-04-01 | 2022-10-06 | 주식회사 엘지화학 | 옥사디아졸 화합물 및 이를 포함하는 약제학적 조성물 |
-
2022
- 2022-03-25 CA CA3214961A patent/CA3214961A1/en active Pending
- 2022-03-25 CN CN202280024429.7A patent/CN117120429A/zh active Pending
- 2022-03-25 WO PCT/US2022/021912 patent/WO2022212194A1/en not_active Ceased
- 2022-03-25 ES ES22719399T patent/ES3061522T3/es active Active
- 2022-03-25 KR KR1020237035032A patent/KR20230158542A/ko active Pending
- 2022-03-25 AU AU2022252182A patent/AU2022252182B2/en active Active
- 2022-03-25 EP EP22719399.2A patent/EP4313967B1/en active Active
- 2022-03-25 US US17/704,440 patent/US12410160B2/en active Active
- 2022-03-25 JP JP2023560087A patent/JP7705475B2/ja active Active
- 2022-03-25 PL PL22719399.2T patent/PL4313967T3/pl unknown
- 2022-03-25 EP EP25206447.2A patent/EP4681774A3/en active Pending
- 2022-03-28 TW TW111111557A patent/TWI855308B/zh active
- 2022-03-28 TW TW113132589A patent/TW202448875A/zh unknown
- 2022-03-29 AR ARP220100751A patent/AR125238A1/es not_active Application Discontinuation
-
2024
- 2024-12-04 JP JP2024211090A patent/JP7778900B2/ja active Active
-
2025
- 2025-05-19 AU AU2025203602A patent/AU2025203602A1/en active Pending
- 2025-08-22 US US19/307,911 patent/US20260092053A1/en active Pending
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