AR125238A1 - Inhibidores de khk - Google Patents

Inhibidores de khk

Info

Publication number
AR125238A1
AR125238A1 ARP220100751A ARP220100751A AR125238A1 AR 125238 A1 AR125238 A1 AR 125238A1 AR P220100751 A ARP220100751 A AR P220100751A AR P220100751 A ARP220100751 A AR P220100751A AR 125238 A1 AR125238 A1 AR 125238A1
Authority
AR
Argentina
Prior art keywords
disease
kidney
syndrome
fibrosis
renal
Prior art date
Application number
ARP220100751A
Other languages
English (en)
Spanish (es)
Inventor
James L Bachman
Daniel H Byun
Christopher T Clark
Petr Jansa
Joshua A Kaplan
Zachary A Kasun
Jennifer R Lo
Megan E Neubig
Nathaniel H Stanley
Kirk L Stevens
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of AR125238A1 publication Critical patent/AR125238A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10Spiro-condensed systems
    • C07D491/107Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D491/00Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/20Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D493/00Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D495/00Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/20Spiro-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D513/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ARP220100751A 2021-03-29 2022-03-29 Inhibidores de khk AR125238A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US202163167331P 2021-03-29 2021-03-29

Publications (1)

Publication Number Publication Date
AR125238A1 true AR125238A1 (es) 2023-06-28

Family

ID=81388962

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP220100751A AR125238A1 (es) 2021-03-29 2022-03-29 Inhibidores de khk

Country Status (12)

Country Link
US (2) US12410160B2 (https=)
EP (2) EP4313967B1 (https=)
JP (2) JP7705475B2 (https=)
KR (1) KR20230158542A (https=)
CN (1) CN117120429A (https=)
AR (1) AR125238A1 (https=)
AU (2) AU2022252182B2 (https=)
CA (1) CA3214961A1 (https=)
ES (1) ES3061522T3 (https=)
PL (1) PL4313967T3 (https=)
TW (2) TWI855308B (https=)
WO (1) WO2022212194A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230098069A (ko) * 2021-12-24 2023-07-03 주식회사 엘지화학 (s)-2-(2-메틸아제티딘-1-일)피리미딘 유도체 및 이를 포함하는 약제학적 조성물
JP2025534728A (ja) * 2022-10-24 2025-10-17 ユーハン・コーポレイション ジメチル-2,3-ジヒドロ-1h-インデン誘導体の改良された製造方法
WO2024125482A1 (zh) * 2022-12-13 2024-06-20 华领医药技术(上海)有限公司 作为己酮糖激酶抑制剂的化合物、其用途以及包含其的组合物
WO2025184056A1 (en) * 2024-02-26 2025-09-04 Miralogx Llc Synthetic cannabinoid analogs, pharmaceutical compositions and methods of treating anxiety and other disorders
WO2025250674A1 (en) * 2024-05-30 2025-12-04 Miralogx Llc Synthetic cannabinoid analogs, pharmaceutical compositions and methods of treating neurological disorders and other conditions

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5041443A (en) * 1989-02-21 1991-08-20 Dainippon Pharmaceutical Co., Ltd. Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof
US5137890A (en) 1990-02-14 1992-08-11 Ortho Pharmaceutical Corporation 4-phenyl tetrahydropyrido(4,3-d)pyrimidines
GB0100620D0 (en) 2001-01-10 2001-02-21 Vernalis Res Ltd Chemical cokpounds V
ES2305744T3 (es) * 2003-03-12 2008-11-01 Millennium Pharmaceuticals, Inc. Derivados de quinazolina como inhibidores e tgf-beta.
BRPI0415683A (pt) * 2003-11-03 2006-12-19 Warner Lambert Co inibidores da reabsorção de norepinefrina para o tratamento de distúrbios do sistema nervoso central
CN101277700B (zh) 2005-08-04 2013-02-20 詹森药业有限公司 作为5-羟色胺受体调节剂的嘧啶化合物
US7851468B2 (en) * 2006-05-15 2010-12-14 Cephalon, Inc. Substituted pyrazolo[3,4-d]pyrimidines
EP2209785A1 (en) * 2007-10-05 2010-07-28 S*BIO Pte Ltd 2-morpholinylpurines as inhibitors of pi3k
US8829011B2 (en) 2008-10-29 2014-09-09 Janssen Pharmaceutica Nv 2-aminopyrimidine compounds as serotonin receptor modulators
US8586582B2 (en) * 2008-11-11 2013-11-19 Xcovery Holding Company, Llc PI3K/mTOR kinase inhibitors
TWI491606B (zh) 2009-07-13 2015-07-11 Gilead Sciences Inc 調節細胞凋亡信號之激酶的抑制劑
JP2013525370A (ja) 2010-04-22 2013-06-20 ヤンセン ファーマシューティカ エヌ.ベー. ケトヘキソキナーゼ阻害剤として有用なインダゾール化合物
EP2545964A1 (en) 2011-07-13 2013-01-16 Phenex Pharmaceuticals AG Novel FXR (NR1H4) binding and activity modulating compounds
LT2776038T (lt) 2011-11-11 2018-04-25 Gilead Apollo, Llc Acc inhibitoriai ir jų panaudojimas
UY34573A (es) 2012-01-27 2013-06-28 Gilead Sciences Inc Inhibidor de la quinasa que regula la señal de la apoptosis
CN103467482B (zh) * 2012-04-10 2017-05-10 上海璎黎药业有限公司 稠合嘧啶类化合物,其制备方法,中间体,组合物和应用
EP3197448B1 (en) 2014-09-24 2019-04-24 Gilead Sciences, Inc. Methods of treating liver disease
TWI685491B (zh) 2014-12-23 2020-02-21 美商基利科學股份有限公司 製備5-(4-環丙基-1h-咪唑-1-基)-n-(6-(4-異丙基-4h-1,2,4-三唑-3-基)吡啶-2-基)-2-氟-4-甲基苯甲醯胺之方法
MA41252A (fr) 2014-12-23 2017-10-31 Gilead Sciences Inc Formes solides d'un inhibiteur d'ask 1
JP2018501276A (ja) 2015-01-09 2018-01-18 ギリアド アポロ, エルエルシー 非アルコール性脂肪肝疾患の処置のためのacc阻害剤併用療法
US20190137505A1 (en) * 2015-08-10 2019-05-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona Biomarkers of methylglyoxal and related methods thereof
SI3397631T1 (sl) 2015-12-29 2022-01-31 Pfizer Inc. Substituirani 3-azabiciklo(3.1.0)heksani kot zaviralci ketoheksokinaze
CN119977993A (zh) 2016-03-02 2025-05-13 吉利德阿波罗公司 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法
EP4273132A3 (en) 2017-03-03 2024-01-10 Gilead Sciences, Inc. Processes for preparing acc inhibitors and solid forms thereof
US11083720B2 (en) 2017-03-17 2021-08-10 Regents Of The University Of Colorado, A Body Corporate Indazole inhibitors of fructokinase (KHK) and methods of use in treating KHK-mediated disorders or diseases
WO2018183342A1 (en) 2017-03-28 2018-10-04 Gilead Sciences, Inc. Methods of treating liver disease
PT3600309T (pt) 2017-03-28 2022-10-03 Gilead Sciences Inc Combinações terapêuticas para o tratamento de doenças hepáticas
AU2018250614A1 (en) 2017-04-12 2019-10-17 Gilead Sciences, Inc. Methods of treating liver disease
KR102419458B1 (ko) 2017-10-06 2022-07-12 길리애드 사이언시즈, 인코포레이티드 Acc 억제제를 포함하는 조합 요법
US12161621B2 (en) 2018-07-16 2024-12-10 The Regents Of The University Of Colorado Methods for fructokinase mediation of alcohol craving and alcohol induced liver disease
TWI714231B (zh) 2018-09-04 2020-12-21 美商美國禮來大藥廠 2,6-二胺基吡啶化合物
KR102558308B1 (ko) 2018-09-27 2023-07-24 주식회사 엘지화학 3-아자바이사이클로[3,1,1]헵탄 유도체 및 이를 포함하는 약제학적 조성물
PH12021551635A1 (en) * 2019-01-29 2022-05-02 Shandong Xuanzhu Pharma Co Ltd Hexone glucokinase inhibitor and use thereof
CA3233305A1 (en) 2019-02-19 2020-08-27 Gilead Sciences, Inc. Solid forms of fxr agonists
WO2020185685A1 (en) 2019-03-08 2020-09-17 The Regents Of The University Of California Compositions and methods for treating acne
CN114007602A (zh) 2019-04-17 2022-02-01 科罗拉多研究合作伙伴有限责任公司 治疗果糖相关病症或疾病的新型化合物和使用方法
CN111978296A (zh) 2019-05-22 2020-11-24 山东轩竹医药科技有限公司 己酮糖激酶抑制剂及其用途
TWI750685B (zh) 2019-06-17 2021-12-21 美商美國禮來大藥廠 二取代吡唑化合物
EP4083034A4 (en) 2019-12-24 2023-12-06 Hangzhou Zhongmeihuadong Pharmaceutical Co., Ltd. ASSOCIATION WITH CHAD-INHIBITING EFFECT
CN114846008B (zh) 2019-12-25 2024-05-28 杭州中美华东制药有限公司 具有果糖激酶(khk)抑制作用的嘧啶类化合物
WO2021162943A1 (en) 2020-02-13 2021-08-19 Eli Lilly And Company 2-[2-methylazetidin-1-yl]-4-phenyl-6-(trifluoromethyl)-pyrimidine compounds
CN111423420A (zh) 2020-04-30 2020-07-17 广州博济医药生物技术股份有限公司 作为己酮糖激酶抑制剂的并环化合物
CN114181198B (zh) 2020-09-15 2025-07-15 山东轩竹医药科技有限公司 嘧啶衍生物类己酮糖激酶抑制剂及其用途
EP4269404A4 (en) * 2020-12-25 2024-12-04 Xizang Haisco Pharmaceutical Co., Ltd. KETOHEXOKINASE INHIBITORS AND USE THEREOF
CN114805312A (zh) 2021-01-29 2022-07-29 上海拓界生物医药科技有限公司 一种己酮糖激酶抑制剂及其制备方法
CN114989143A (zh) 2021-03-02 2022-09-02 山东轩竹医药科技有限公司 并环类己酮糖激酶抑制剂及其用途
WO2022211595A1 (ko) 2021-04-01 2022-10-06 주식회사 엘지화학 옥사디아졸 화합물 및 이를 포함하는 약제학적 조성물

Also Published As

Publication number Publication date
TWI855308B (zh) 2024-09-11
KR20230158542A (ko) 2023-11-20
JP2025032196A (ja) 2025-03-11
WO2022212194A1 (en) 2022-10-06
PL4313967T3 (pl) 2026-04-20
TW202448875A (zh) 2024-12-16
EP4313967B1 (en) 2025-11-12
US12410160B2 (en) 2025-09-09
CA3214961A1 (en) 2022-10-06
TW202246253A (zh) 2022-12-01
EP4681774A2 (en) 2026-01-21
AU2022252182B2 (en) 2025-02-20
CN117120429A (zh) 2023-11-24
AU2022252182A1 (en) 2023-09-28
JP2024512646A (ja) 2024-03-19
ES3061522T3 (en) 2026-04-06
EP4313967A1 (en) 2024-02-07
EP4313967C0 (en) 2025-11-12
US20230079863A1 (en) 2023-03-16
JP7778900B2 (ja) 2025-12-02
JP7705475B2 (ja) 2025-07-09
EP4681774A3 (en) 2026-03-25
AU2025203602A1 (en) 2025-06-05
US20260092053A1 (en) 2026-04-02

Similar Documents

Publication Publication Date Title
AR125238A1 (es) Inhibidores de khk
ECSP17004665A (es) Ácidos grasos novedosos y su uso en la conjugación con biomoléculas
MX2022004942A (es) Anticuerpos humanizados contra el ligando 1a de tipo tnf (tl1a) y usos de los mismos.
AR123156A1 (es) Agonistas de glp-1r y sus usos
MX2021012492A (es) Agonistas de glp-1r y usos de los mismos.
PE20251598A1 (es) Analogos de incretina y sus usos
MX2018014743A (es) Metodo para tratar fibrosis hepatica.
HRP20200881T1 (hr) Antitijela koja vežu beta-klotho domenu 2 i postupci njihove uporabe
CU24540B1 (es) 3-azabiciclo[3.1.0]hexanos sustituidos como inhibidores de cetohexoquinasa
PE20220377A1 (es) Compuestos de pirazol disustituidos como inhibidores de cetohexoquinasa
DOP2021000027A (es) Compuestos de 2,6-diaminopiridina
PE20171622A1 (es) Formulacion de relacion fija de insulina glargina/lixisenatida
EA201592020A1 (ru) Новая композиция для неалкогольной жировой болезни печени (нажбп)
AR084215A1 (es) Bifidobacterium cect 7765 y su uso en la prevencion y/o tratamiento del sobrepeso, la obesidad y patologias asociadas
EA201391262A1 (ru) Композиция, способ лечения и диагностики стеатоза печени как самостоятельного заболевания или в комбинации с инфекцией гепатита с
BRPI0412380A (pt) compostos de benzenossulfonilamino e composições farmacêuticas que contêm esses compostos
PH12019550226A1 (en) Apoptosis signal-regulating kinase 1 inhibitors and methods of use thereof
MX2020011225A (es) Tetrazol que contiene inhibidores de la cinasa 1 reguladora de la señal de apoptosis y métodos de uso de los mismos.
AR125400A1 (es) Compuestos de péptidos similares al glucagón
ZA202304148B (en) Preparation of benzimidazolone derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors
ZA202304150B (en) Preparation of oxindole derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors
EA202092057A1 (ru) Защитные композиции для печени и терапевтические применения
CL2025001515A1 (es) Uso de finerenona para tratar la enfermedad renal crónica en la diabetes mellitus tipo i.
MX2022007929A (es) Coagonistas de triazol grapados de los receptores de glucagon y glp-1.
AR132060A1 (es) Compuestos heterocíclicos como antagonistas de sting

Legal Events

Date Code Title Description
FA Abandonment or withdrawal