MX2022007929A - Coagonistas de triazol grapados de los receptores de glucagon y glp-1. - Google Patents
Coagonistas de triazol grapados de los receptores de glucagon y glp-1.Info
- Publication number
- MX2022007929A MX2022007929A MX2022007929A MX2022007929A MX2022007929A MX 2022007929 A MX2022007929 A MX 2022007929A MX 2022007929 A MX2022007929 A MX 2022007929A MX 2022007929 A MX2022007929 A MX 2022007929A MX 2022007929 A MX2022007929 A MX 2022007929A
- Authority
- MX
- Mexico
- Prior art keywords
- glp
- glucagon
- agonists
- receptors
- stapled
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los péptidos grapados de la presente invención, y las sales farmacéuticamente aceptables de los mismos, son los coagonistas de los receptores de glucagon y GLP-1, y pueden ser útiles en el tratamiento, la prevención y la supresión de las enfermedades mediadas por el receptor de glucagon y el receptor de GLP-1, los que incluyen, pero no se limitan a, los trastornos metabólicos tales como la diabetes, la enfermedad del hígado graso no alcohólico (NAFLD, por sus siglas en inglés), la esteatohepatitis no alcohólica (NASH, por sus siglas en inglés) y la obesidad.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19425098.1A EP3842061A1 (en) | 2019-12-23 | 2019-12-23 | Stapled triazole co-agonists of the glucagon and glp-1 receptors |
PCT/US2020/065796 WO2021133644A1 (en) | 2019-12-23 | 2020-12-18 | Stapled triazole co-agonists of the glucagon and glp-1 receptors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022007929A true MX2022007929A (es) | 2022-09-29 |
Family
ID=69326342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022007929A MX2022007929A (es) | 2019-12-23 | 2020-12-18 | Coagonistas de triazol grapados de los receptores de glucagon y glp-1. |
Country Status (10)
Country | Link |
---|---|
US (1) | US20230063794A1 (es) |
EP (2) | EP3842061A1 (es) |
JP (1) | JP2023508349A (es) |
KR (1) | KR20220119475A (es) |
CN (1) | CN115226391A (es) |
AU (1) | AU2020412677A1 (es) |
BR (1) | BR112022012499A2 (es) |
CA (1) | CA3162800A1 (es) |
MX (1) | MX2022007929A (es) |
WO (1) | WO2021133644A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL310838A (en) * | 2021-08-27 | 2024-04-01 | Univ Yale | Molecular assemblies of extracellular proteins |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
AR008789A1 (es) | 1996-07-31 | 2000-02-23 | Bayer Corp | Piridinas y bifenilos substituidos |
US6268343B1 (en) * | 1996-08-30 | 2001-07-31 | Novo Nordisk A/S | Derivatives of GLP-1 analogs |
AU6691798A (en) | 1997-03-07 | 1998-09-22 | Metabasis Therapeutics, Inc. | Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase |
WO1998039344A1 (en) | 1997-03-07 | 1998-09-11 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
ES2210728T3 (es) | 1997-03-07 | 2004-07-01 | Metabasis Therapeutics, Inc. | Nuevos inhibidores bencimidazol de la fructosa-1, 6-bifosfatasa. |
US6613942B1 (en) | 1997-07-01 | 2003-09-02 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
JP2003514508A (ja) | 1997-07-01 | 2003-04-15 | ノボ ノルディスク アクティーゼルスカブ | グルカゴン拮抗剤/逆作用剤 |
DK1112275T3 (da) | 1998-09-09 | 2003-11-24 | Metabasis Therapeutics Inc | Hidtil ukendte heteroaromatiske inhibitorer for fructose-1,6-bisphosphatase |
DE60023492T2 (de) | 1999-05-17 | 2006-07-20 | Novo Nordisk A/S | Glucagon antagonisten/inverse agonisten |
US6677136B2 (en) * | 2000-05-03 | 2004-01-13 | Amgen Inc. | Glucagon antagonists |
JP2004513076A (ja) | 2000-07-25 | 2004-04-30 | メルク エンド カムパニー インコーポレーテッド | 糖尿病治療で有用なn−置換インドール類 |
JP4181408B2 (ja) | 2001-01-30 | 2008-11-12 | メルク エンド カムパニー インコーポレーテッド | 肥満、糖尿病及び脂質異常を治療するためのアシルスルファミド類 |
GB0121709D0 (en) | 2001-09-07 | 2001-10-31 | Imp College Innovations Ltd | Food inhibition agent |
AR040241A1 (es) | 2002-06-10 | 2005-03-23 | Merck & Co Inc | Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia |
MXPA05002303A (es) | 2002-08-29 | 2005-06-08 | Merck & Co Inc | Indoles con actividad antidiabetica. |
JP4340232B2 (ja) | 2002-08-29 | 2009-10-07 | メルク エンド カムパニー インコーポレーテッド | 抗糖尿病活性を有するインドール類 |
JO2397B1 (en) | 2002-12-20 | 2007-06-17 | ميرك شارب اند دوم كوربوريشن | Terazol derivatives as beta-hydroxy steroid dihydrogenase-1 inhibitors |
GB0300571D0 (en) | 2003-01-10 | 2003-02-12 | Imp College Innovations Ltd | Modification of feeding behaviour |
WO2004066963A2 (en) | 2003-01-17 | 2004-08-12 | Merck & Co., Inc. | N-cyclohexylaminocarbonyl benzenesulfonamide derivatives |
US8546326B2 (en) * | 2005-06-06 | 2013-10-01 | Camurus Ab | Glp-1 analogue formulations |
PT1891105E (pt) | 2005-06-13 | 2012-06-27 | Imp Innovations Ltd | Análogos de oxintomodulina e seus efeitos sobre o comportamento da alimentação |
US8175737B2 (en) | 2006-07-19 | 2012-05-08 | Freescale Semiconductor, Inc. | Method and apparatus for designing and integrated circuit |
WO2009000087A1 (en) | 2007-06-28 | 2008-12-31 | Merck Frosst Canada Ltd. | Substituted fused pyrimidines as antagonists of gpr105 activity |
KR101404781B1 (ko) | 2007-06-28 | 2014-06-12 | 가부시키가이샤 한도오따이 에네루기 켄큐쇼 | 반도체 장치의 제조 방법 |
JP2010533712A (ja) | 2007-07-19 | 2010-10-28 | メルク・シャープ・エンド・ドーム・コーポレイション | 抗糖尿病化合物としてのベータカルボリン誘導体 |
WO2009042053A2 (en) | 2007-09-21 | 2009-04-02 | Merck & Co., Inc. | Neuromedin u receptor agonists and uses thereof |
EA019203B9 (ru) | 2008-06-17 | 2014-03-31 | Индиана Юниверсити Рисерч Энд Текнолоджи Корпорейшн | Коагонисты глюкагонового рецептора/glp-1-рецептора |
WO2010096052A1 (en) | 2009-02-19 | 2010-08-26 | Merck Sharp & Dohme Corp. | Oxyntomodulin analogs |
EP2512503A4 (en) | 2009-12-18 | 2013-08-21 | Univ Indiana Res & Tech Corp | COAGONISTS OF GLUCAGON / GLP-1 RECEPTOR |
RS56173B1 (sr) | 2011-06-22 | 2017-11-30 | Univ Indiana Res & Tech Corp | Koagonisti receptora za glukagon/glp-1 receptora |
BR112013032717A2 (pt) | 2011-06-22 | 2017-01-24 | Univ Indiana Res & Tech Corp | coagonistas do receptor de glucagon/glp-1 |
CA2935026C (en) * | 2014-01-15 | 2018-11-13 | Fyziologicky Ustav Akademie Ved Cr, V.V.I. | Lipidated prolactin-releasing peptides for lowering blood glucose |
CA2964379C (en) | 2014-10-24 | 2023-08-15 | Merck Sharp & Dohme Corp. | Co-agonists of the glucagon and glp-1 receptors |
WO2017074798A2 (en) * | 2015-10-27 | 2017-05-04 | Merck Sharp & Dohme Corp. | Long-acting co-agonists of the glucagon and glp-1 receptors |
WO2017189342A1 (en) * | 2016-04-26 | 2017-11-02 | Merck Sharp & Dohme Corp. | Insulin dimer-incretin conjugates |
EP3700550A4 (en) | 2017-09-25 | 2022-02-23 | Merck Sharp & Dohme Corp. | LONG-ACTING CO-AGONISTS OF GLUCAGON AND GLP-1 RECEPTORS |
CN109836488B (zh) * | 2017-11-24 | 2022-08-23 | 浙江道尔生物科技有限公司 | 一种治疗代谢疾病的胰高血糖素类似物 |
-
2019
- 2019-12-23 EP EP19425098.1A patent/EP3842061A1/en not_active Withdrawn
-
2020
- 2020-12-18 JP JP2022538471A patent/JP2023508349A/ja active Pending
- 2020-12-18 AU AU2020412677A patent/AU2020412677A1/en active Pending
- 2020-12-18 WO PCT/US2020/065796 patent/WO2021133644A1/en unknown
- 2020-12-18 MX MX2022007929A patent/MX2022007929A/es unknown
- 2020-12-18 KR KR1020227025623A patent/KR20220119475A/ko unknown
- 2020-12-18 US US17/785,287 patent/US20230063794A1/en active Pending
- 2020-12-18 CA CA3162800A patent/CA3162800A1/en active Pending
- 2020-12-18 EP EP20904872.7A patent/EP4081243A4/en active Pending
- 2020-12-18 BR BR112022012499A patent/BR112022012499A2/pt unknown
- 2020-12-18 CN CN202080096783.1A patent/CN115226391A/zh active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4081243A1 (en) | 2022-11-02 |
EP3842061A1 (en) | 2021-06-30 |
EP4081243A4 (en) | 2024-01-10 |
WO2021133644A1 (en) | 2021-07-01 |
CN115226391A (zh) | 2022-10-21 |
US20230063794A1 (en) | 2023-03-02 |
AU2020412677A1 (en) | 2022-07-14 |
JP2023508349A (ja) | 2023-03-02 |
BR112022012499A2 (pt) | 2022-09-06 |
KR20220119475A (ko) | 2022-08-29 |
CA3162800A1 (en) | 2021-07-01 |
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