JP2024028825A5 - - Google Patents

Download PDF

Info

Publication number
JP2024028825A5
JP2024028825A5 JP2023204069A JP2023204069A JP2024028825A5 JP 2024028825 A5 JP2024028825 A5 JP 2024028825A5 JP 2023204069 A JP2023204069 A JP 2023204069A JP 2023204069 A JP2023204069 A JP 2023204069A JP 2024028825 A5 JP2024028825 A5 JP 2024028825A5
Authority
JP
Japan
Prior art keywords
residue
viral segment
viral
influenza virus
vector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2023204069A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024028825A (ja
JP7754912B2 (ja
Filing date
Publication date
Priority claimed from PCT/US2020/014659 external-priority patent/WO2020167432A2/en
Application filed filed Critical
Publication of JP2024028825A publication Critical patent/JP2024028825A/ja
Publication of JP2024028825A5 publication Critical patent/JP2024028825A5/ja
Application granted granted Critical
Publication of JP7754912B2 publication Critical patent/JP7754912B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2023204069A 2019-01-23 2023-12-01 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異 Active JP7754912B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962795821P 2019-01-23 2019-01-23
US62/795,821 2019-01-23
PCT/US2020/014659 WO2020167432A2 (en) 2019-01-23 2020-01-22 Mutations that confer genetic stability to additional genes in influenza viruses
JP2021542525A JP2022527235A (ja) 2019-01-23 2020-01-22 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2021542525A Division JP2022527235A (ja) 2019-01-23 2020-01-22 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異

Publications (3)

Publication Number Publication Date
JP2024028825A JP2024028825A (ja) 2024-03-05
JP2024028825A5 true JP2024028825A5 (enExample) 2024-06-19
JP7754912B2 JP7754912B2 (ja) 2025-10-15

Family

ID=71069917

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021542525A Withdrawn JP2022527235A (ja) 2019-01-23 2020-01-22 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異
JP2023204069A Active JP7754912B2 (ja) 2019-01-23 2023-12-01 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2021542525A Withdrawn JP2022527235A (ja) 2019-01-23 2020-01-22 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異

Country Status (4)

Country Link
US (2) US11241492B2 (enExample)
EP (1) EP3914295A2 (enExample)
JP (2) JP2022527235A (enExample)
WO (1) WO2020167432A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
JP2014527799A (ja) 2011-08-26 2014-10-23 ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション 変異型pb2遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
WO2017143236A1 (en) 2016-02-19 2017-08-24 Yoshihiro Kawaoka Improved influenza b virus replication for vaccine development
US11197926B2 (en) 2017-10-25 2021-12-14 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
JP7783047B2 (ja) 2018-08-07 2025-12-09 ウィスコンシン アルムニ リサーチ ファンデイション 組換えの生物学的に封じ込められたフィロウイルスワクチン
JP7655849B2 (ja) 2018-08-20 2025-04-02 ウィスコンシン アルムニ リサーチ ファンデイション ヘマグルチニン(ha)タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター
JP2022527235A (ja) 2019-01-23 2022-06-01 義裕 河岡 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異
EP3921413A1 (en) 2019-02-08 2021-12-15 Wisconsin Alumni Research Foundation (WARF) Humanized cell line
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
JP2023511444A (ja) 2020-01-24 2023-03-17 ウィスコンシン アルムニ リサーチ ファンデイション 安定化されたnaを有する組換えインフルエンザウイルス
WO2021195410A1 (en) 2020-03-25 2021-09-30 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
CN117098551A (zh) * 2020-11-17 2023-11-21 维瓦尔第生物科学有限公司 编码截短的ns1蛋白和sars-cov受体结合域的流感病毒

Family Cites Families (89)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4071618A (en) 1974-09-03 1978-01-31 Research Foundation For Microbial Diseases Of Osaka University Process for preparing virus disease live vaccines
JPS57136528A (en) 1981-02-09 1982-08-23 Hayashibara Biochem Lab Inc Preparation of viral vaccine
NZ219515A (en) 1987-02-10 1989-09-27 Wellcome Found Fusion proteins comprising influenza virus ha and a nonnatural antigenic epitope
US5854037A (en) 1989-08-28 1998-12-29 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand RNA virus expression systems and vaccines
US5166057A (en) 1989-08-28 1992-11-24 The Mount Sinai School Of Medicine Of The City University Of New York Recombinant negative strand rna virus expression-systems
US5840520A (en) 1989-08-28 1998-11-24 Aviron Recombinant negative strand RNA virus expression systems
US5919676A (en) 1993-06-24 1999-07-06 Advec, Inc. Adenoviral vector system comprising Cre-loxP recombination
PT702085E (pt) 1994-07-18 2004-04-30 Karl Klaus Conzelmann Virus de arn de cadeia negativa nao segmentada infeccioso recombinante
WO1996010631A1 (en) 1994-09-30 1996-04-11 St. Jude Children's Research Hospital Nucleic acid encoding mutant matrix proteins useful for attenuation or enhancement of influenza a virus
US5716821A (en) 1994-09-30 1998-02-10 Uab Research Foundation Prevention and treatment of respiratory tract disease
WO1996010400A1 (en) 1994-09-30 1996-04-11 The Uab Research Foundation Gene therapy vectors and vaccines based on non-segmented negatives stranded rna viruses
ATE181112T1 (de) 1995-08-09 1999-06-15 Schweiz Serum & Impfinst Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren
US6037348A (en) 1996-02-09 2000-03-14 Eli Lilly And Company Inhibition of viral replication
DE19612967A1 (de) 1996-04-01 1997-10-02 Behringwerke Ag Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren
DE19612966B4 (de) 1996-04-01 2009-12-10 Novartis Vaccines And Diagnostics Gmbh & Co. Kg MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren
US5994526A (en) 1996-06-21 1999-11-30 Plant Genetic Systems Gene expression in plants
EP2112220A3 (en) 1996-07-15 2010-01-06 The Government of the United States of America, as represented by The Department of Health and Human Services Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences
TW570803B (en) 1997-04-09 2004-01-11 Duphar Int Res Influenza vaccine
BR9809456B1 (pt) 1997-05-23 2011-06-28 molécula isolada de polinucleotìdeo, composição de célula ou isenta de célula, partìcula de piv infeciosa, atenuada e imunogênica, e, composição imunogênica.
ES2255181T3 (es) 1997-08-05 2006-06-16 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw. Antigeno inmunoprotector contra la gripe y su uso en vacunacion.
US6169175B1 (en) 1997-08-06 2001-01-02 Centers For Disease Control And Prevention Preparation and use of recombinant influenza A virus M2 construct vaccines
KR100281676B1 (ko) 1997-11-29 2001-04-02 신동권 신규한독감생백신바이러스
US6146642A (en) 1998-09-14 2000-11-14 Mount Sinai School Of Medicine, Of The City University Of New York Recombinant new castle disease virus RNA expression systems and vaccines
US6544785B1 (en) 1998-09-14 2003-04-08 Mount Sinai School Of Medicine Of New York University Helper-free rescue of recombinant negative strand RNA viruses
EP1035209A1 (en) 1999-03-06 2000-09-13 ARTEMIS Pharmaceuticals GmbH Stable recombinant influenza viruses free of helper viruses
US8715940B2 (en) 1999-04-06 2014-05-06 Wisconsin Alumni Research Foundation Method of making recombinant influenza virus
EP2345716B1 (en) 1999-04-06 2015-01-14 Wisconsin Alumni Research Foundation Recombinant influenza viruses for vaccines and gene therapy
US6492169B1 (en) 1999-05-18 2002-12-10 Crucell Holland, B.V. Complementing cell lines
US6686168B1 (en) 1999-11-04 2004-02-03 Zymogenetics, Inc. Cell surface display of proteins by recombinant host cells
US7192759B1 (en) 1999-11-26 2007-03-20 Crucell Holland B.V. Production of vaccines
DE60142506D1 (de) 2000-03-03 2010-08-19 Chemo Sero Therapeut Res Inst In serumfreier kultur verwendbare zelle, kultursuspension und verfahren zur virusproduktion als impfstoff unter verwendung der zelle
AU5533601A (en) 2000-04-14 2001-10-30 Wisconsin Alumni Res Found Viruses comprising mutation ion channel protein
DE60137345D1 (de) 2000-04-28 2009-02-26 St Jude Childrens Res Hospital Dna-transfektionssystem zur erzeugung von infektiösen negativsträngigen rna virus
EP1201760A1 (en) 2000-10-30 2002-05-02 ARTEMIS Pharmaceuticals GmbH Influenza virus vector for human dendritic cells
EP1233059A1 (en) 2001-02-09 2002-08-21 ARTEMIS Pharmaceuticals GmbH Influenza viruses with enhanced transcriptional and replicational capacities
WO2002068632A2 (en) 2001-02-23 2002-09-06 Wisconsin Alumni Research Foundation Methods to identify mutant cells with altered sialic acid
DE10144906B4 (de) 2001-09-12 2013-11-28 Novartis Vaccines And Diagnostics Gmbh Verfahren zur großtechnischen Herstellung von Impfstoffen
US6951752B2 (en) 2001-12-10 2005-10-04 Bexter Healthcare S.A. Method for large scale production of virus antigen
HUE050222T2 (hu) 2002-02-13 2020-11-30 Wisconsin Alumni Res Found Szignál influenzavírus-vektorok pakolására
WO2003076462A1 (en) 2002-03-08 2003-09-18 Crucell Holland B.V. Use of recombinant trypsin for vaccine production
CN103540613A (zh) 2002-04-26 2014-01-29 米迪缪尼有限公司 制备流感病毒的多质粒系统
US7465456B2 (en) 2002-04-26 2008-12-16 Medimmune, Llc Multi plasmid system for the production of influenza virus
US20050158342A1 (en) 2003-12-23 2005-07-21 Medimmune, Inc. Multi plasmid system for the production of influenza virus
PT2287288E (pt) 2002-07-09 2012-12-10 Baxter Int Meio isento de proteína animal para cultura de células
CA2522081C (en) 2003-04-23 2013-01-29 Wisconsin Alumni Research Foundation Recombinant influenza viruses holding a mutation in a transmembrane protein gene
JP2006525815A (ja) 2003-05-28 2006-11-16 ウィスコンシン・アラムナイ・リサーチ・ファウンデイション Poliiプロモーターおよびリボザイムを有する組換えインフルエンザベクター
JP5215561B2 (ja) 2003-05-28 2013-06-19 ウィスコンシン アルムニ リサーチ ファンデイション ワクチン及び遺伝子治療のための高力価組換えインフルエンザ・ウイルス
CA2816222A1 (en) 2003-06-16 2005-03-03 Medimmune Vaccines, Inc. Influenza hemagglutinin and neuraminidase variants
US7037707B2 (en) 2003-09-04 2006-05-02 St. Jude Children's Research Hospital Method for generating influenza viruses and vaccines
JP2005245302A (ja) 2004-03-04 2005-09-15 Kanazawa Univ Tlo Inc 組換えインフルエンザウイルスおよびそれを用いたワクチン
NZ551640A (en) 2004-05-20 2010-05-28 Id Biomedical Corp Process for the production of an influenza vaccine
EP2578229B1 (en) 2004-09-09 2013-07-10 Novartis Vaccines and Diagnostics GmbH Decreasing potential iatrogenic risks associated with vaccine antigens
JP2008520248A (ja) 2004-11-19 2008-06-19 ウィスコンシン・アラムナイ・リサーチ・ファウンデイション タンデム転写ユニットを有する組換えインフルエンザベクター
CN101189326B (zh) 2004-12-23 2013-06-12 米迪缪尼有限公司 用于病毒增殖的非致瘤性mdck细胞系
AU2005318087B2 (en) 2004-12-24 2011-04-21 Abbott Biologicals B.V. Rescue of influenza virus
ES2527503T3 (es) 2005-03-08 2015-01-26 Medimmune, Llc Virus influenza reordenantes
EP1945778B1 (en) 2005-10-17 2012-12-26 MedImmune, LLC Methods of increasing influenza virus replication
HUE049580T2 (hu) 2006-01-27 2020-09-28 Seqirus Uk Ltd Hemagglutinint és mátrixfehérjéket tartalmazó, influenza elleni oltóanyagok
AU2014202470B2 (en) 2006-03-31 2016-08-04 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
AU2012204138B2 (en) 2006-03-31 2014-02-06 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
WO2007126810A2 (en) 2006-03-31 2007-11-08 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses for vaccines
EP2022849A4 (en) 2006-05-11 2010-10-06 Chemo Sero Therapeut Res Inst METHOD FOR PROLIFERATION OF INFLUENZA VIRUS
US7507411B2 (en) 2006-06-23 2009-03-24 University Of Saskatchewan Attenuated influenza NS1 variants
JP2010500034A (ja) 2006-08-09 2010-01-07 メッドイミューン バクシーンズ,インコーポレイティド インフルエンザ赤血球凝集素変異体およびノイラミニダーゼ変異体
EP2069480B1 (en) 2006-09-15 2014-03-19 MedImmune, LLC Mdck cell lines supporting viral growth to high titers and bioreactor process using the same
PL2121011T3 (pl) 2006-12-06 2014-10-31 Novartis Ag Szczepionki zawierające antygeny czterech szczepów wirusa grypy
JP5666905B2 (ja) 2007-06-18 2015-02-12 メディミューン,エルエルシー ヘマグルチニンポリペプチド中に変化を有するインフルエンザbウイルス
WO2008156778A2 (en) 2007-06-18 2008-12-24 Tokiko Watanabe Influenza m2 protein mutant viruses as live influenza attenuated vaccines
CN101784283A (zh) 2007-06-27 2010-07-21 诺华有限公司 低添加流感疫苗
WO2009014919A2 (en) * 2007-07-13 2009-01-29 Iowa State University Research Foundation, Inc. H2n3 influenza a viruses and methods of use
BRPI0915487A2 (pt) 2008-07-11 2017-06-27 Medimmune Inc hemaglutina de nfluenza e variantes de neuraminidase
JP5845178B2 (ja) 2009-07-16 2016-01-20 クルセル ホランド ベー ヴェー ワクチン生産のためのポリオウイルスの高力価での生産
WO2011056591A1 (en) 2009-10-26 2011-05-12 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in vero cells
GB0919117D0 (en) 2009-10-30 2009-12-16 Glaxosmithkline Biolog Sa Process
EP2599864B1 (en) * 2009-11-20 2017-08-02 Danisco US Inc. Beta-glucosidase variants with improved properties
US10130697B2 (en) 2010-03-23 2018-11-20 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
GB201011502D0 (en) 2010-07-08 2010-08-25 Glaxosmithkline Biolog Sa Novel process
WO2012033236A1 (ko) 2010-09-06 2012-03-15 에스케이케미칼 주식회사 무혈청 배양 및 부유 배양에 적응된 mdck 세포주 및 상기 세포를 사용하여 백신용 바이러스를 제조하는 방법
US9284533B2 (en) 2011-06-24 2016-03-15 Flugen, Inc. Influenza virus mutants and uses therefor
CN102304495A (zh) 2011-09-08 2012-01-04 中国农业科学院上海兽医研究所 高效表达ha蛋白的重组流感病毒及其制备方法和应用
US8877560B2 (en) 2012-07-17 2014-11-04 Lite-On Technology Corp. Method for assembling heat generating element and heat dissipating element, pressure sensitive element, and power supplying unit
BR112015030582A2 (pt) 2013-06-06 2017-08-29 Novartis Ag Segmento de hemaglutinina da gripe quimérico e de neuraminidase quimérico, proteína de hemaglutinina quimérica, vírus da gripe rearranjado, métodos para preparação de um vírus da gripe rearranjado e para preparação de uma vacina e sistema de expressão
WO2015009743A1 (en) 2013-07-15 2015-01-22 Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs
US10053671B2 (en) 2014-06-20 2018-08-21 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
US9890363B2 (en) 2015-07-06 2018-02-13 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
WO2017143236A1 (en) 2016-02-19 2017-08-24 Yoshihiro Kawaoka Improved influenza b virus replication for vaccine development
JP2018064493A (ja) * 2016-10-19 2018-04-26 京都府公立大学法人 Mdck細胞を用いたインフルエンザウイルスの増殖方法
JP2022527235A (ja) 2019-01-23 2022-06-01 義裕 河岡 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異

Similar Documents

Publication Publication Date Title
JP2024028825A5 (enExample)
JP2024091645A5 (enExample)
JP2015119730A5 (enExample)
EP1820853B1 (en) Recombinant influenza viruses for vaccines and gene therapy
US9023603B2 (en) Recombinant influenza viruses for vaccines and gene therapy
US8673613B2 (en) Influenza B viruses having alterations in the hemaglutinin polypeptide
CN110218246B (zh) Anp32蛋白在宿主体内维持流感病毒聚合酶活性中的应用
CN1826407B (zh) 用于疫苗和基因治疗的高滴度重组流感病毒
ES2395813T3 (es) Obtención de un virus de la gripe
JP2024177515A5 (enExample)
JP2016521553A5 (enExample)
JP2013236638A (ja) インフルエンザウイルス製造用マルチプラスミド系
RU2008101367A (ru) Способы и композиции для экспрессии отрицательной смысловой вирусной рнк в собачьих клетках
CN104073513B (zh) 甲型流感病毒疫苗哺乳动物细胞适应株的获得方法和适应位点
TWI396741B (zh) 非洲綠猴腎細胞培養之流感病毒及疫苗
JPWO2020167432A5 (enExample)
CN105985413A (zh) 新的甲型流感病毒哺乳动物细胞适应株及其制备和应用
JP2004514415A (ja) インフルエンザA/Udorn/72(H3N2)ゲノムのヌクレオチド配列
CN109136199B (zh) 一种表达h5亚型ha的复制缺陷型重组h9n2禽流感病毒
KR102694347B1 (ko) 저병원성 h9n2 계통 조류 인플루엔자 재조합 바이러스 및 이를 포함하는 백신 조성물
CN114075567A (zh) 优化的表达新型冠状病毒抗原的核苷酸序列及其应用
CN110106192A (zh) 一种具有低受体结合活性的高致病性h7n9禽流感病毒抗原及其制备方法
HK1133442B (en) Influenza b viruses having alterations in the hemaglutinin polypeptide
HK1148778B (en) Recombinant influenza viruses for vaccines and gene therapy