JP2016521553A5 - - Google Patents
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- JP2016521553A5 JP2016521553A5 JP2016517733A JP2016517733A JP2016521553A5 JP 2016521553 A5 JP2016521553 A5 JP 2016521553A5 JP 2016517733 A JP2016517733 A JP 2016517733A JP 2016517733 A JP2016517733 A JP 2016517733A JP 2016521553 A5 JP2016521553 A5 JP 2016521553A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- segment
- influenza
- nucleotide
- position corresponding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 206010022000 influenza Diseases 0.000 claims description 84
- 239000002773 nucleotide Substances 0.000 claims description 82
- 125000003729 nucleotide group Chemical group 0.000 claims description 82
- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 claims description 44
- 230000001086 cytosolic effect Effects 0.000 claims description 39
- 241000712461 unidentified influenza virus Species 0.000 claims description 37
- 229930024421 Adenine Natural products 0.000 claims description 34
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 claims description 34
- 229960000643 adenine Drugs 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 33
- 101710154606 Hemagglutinin Proteins 0.000 claims description 31
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 31
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 31
- 101710176177 Protein A56 Proteins 0.000 claims description 31
- 102000005348 Neuraminidase Human genes 0.000 claims description 28
- 108010006232 Neuraminidase Proteins 0.000 claims description 28
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims description 28
- 239000000185 hemagglutinin Substances 0.000 claims description 27
- 229940113082 thymine Drugs 0.000 claims description 22
- 108010076504 Protein Sorting Signals Proteins 0.000 claims description 21
- 241000700605 Viruses Species 0.000 claims description 21
- 229960005486 vaccine Drugs 0.000 claims description 17
- 210000004027 cell Anatomy 0.000 claims description 16
- UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 claims description 16
- 229940104302 cytosine Drugs 0.000 claims description 14
- 208000037797 influenza A Diseases 0.000 claims description 14
- 208000037798 influenza B Diseases 0.000 claims description 10
- 230000003612 virological effect Effects 0.000 claims description 7
- 108091092724 Noncoding DNA Proteins 0.000 claims description 5
- 241000712431 Influenza A virus Species 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 108020004414 DNA Proteins 0.000 claims description 2
- 241000713196 Influenza B virus Species 0.000 claims description 2
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 2
- 239000004472 Lysine Substances 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 210000000991 chicken egg Anatomy 0.000 claims description 2
- 230000002779 inactivation Effects 0.000 claims description 2
- 210000004962 mammalian cell Anatomy 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 2
- 210000003501 vero cell Anatomy 0.000 claims description 2
- 210000002845 virion Anatomy 0.000 claims description 2
- 239000000277 virosome Substances 0.000 claims description 2
- 229940126581 whole-virion vaccine Drugs 0.000 claims description 2
- 230000001419 dependent effect Effects 0.000 claims 1
- 108700026244 Open Reading Frames Proteins 0.000 description 3
- 230000035931 haemagglutination Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361832091P | 2013-06-06 | 2013-06-06 | |
| US61/832,091 | 2013-06-06 | ||
| EP13179013 | 2013-08-01 | ||
| EP13179013.1 | 2013-09-26 | ||
| PCT/IB2014/062030 WO2014195920A2 (en) | 2013-06-06 | 2014-06-06 | Influenza virus reassortment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016521553A JP2016521553A (ja) | 2016-07-25 |
| JP2016521553A5 true JP2016521553A5 (enExample) | 2017-07-20 |
Family
ID=48900885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016517733A Ceased JP2016521553A (ja) | 2013-06-06 | 2014-06-06 | インフルエンザウイルス再集合 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US10329537B2 (enExample) |
| EP (1) | EP3004332A2 (enExample) |
| JP (1) | JP2016521553A (enExample) |
| KR (1) | KR20160014657A (enExample) |
| CN (1) | CN105722976A (enExample) |
| AU (1) | AU2014276418A1 (enExample) |
| BR (1) | BR112015030582A2 (enExample) |
| CA (1) | CA2914604A1 (enExample) |
| HK (1) | HK1222882A1 (enExample) |
| MX (1) | MX2015016755A (enExample) |
| SG (1) | SG11201509985XA (enExample) |
| WO (1) | WO2014195920A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2813347T3 (es) | 2009-10-26 | 2021-03-23 | Wisconsin Alumni Res Found | Virus recombinantes de la influenza de alto título con replicación mejorada en células Vero |
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| ES2655051T3 (es) | 2011-08-26 | 2018-02-16 | Wisconsin Alumni Research Foundation | Virus de la gripe con segmento génico PB2 mutante como vacunas vivas atenuadas |
| AU2014290203B2 (en) * | 2013-07-15 | 2020-12-24 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in MDCK or vero cells or eggs |
| US10053671B2 (en) | 2014-06-20 | 2018-08-21 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| AU2016281904B2 (en) | 2015-06-26 | 2022-08-11 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| AU2017221444B2 (en) * | 2016-02-19 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza B virus replication for vaccine development |
| KR102477492B1 (ko) * | 2016-07-15 | 2022-12-13 | 잇판사이단호진한다이비세이부쯔뵤우겐큐우카이 | 리소턴트 인플루엔자 바이러스 작출 방법 |
| US11197926B2 (en) | 2017-10-25 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized HA for replication in eggs |
| WO2019086463A1 (en) | 2017-10-30 | 2019-05-09 | Baxalta GmbH | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| CN108048476B (zh) * | 2017-11-21 | 2020-09-08 | 浙江迪福润丝生物科技有限公司 | 一种制备区分免疫和感染动物h9亚型禽流感疫苗株的方法及应用 |
| CN108018300B (zh) * | 2017-11-21 | 2020-08-28 | 浙江迪福润丝生物科技有限公司 | 区分免疫和感染动物h7亚型禽流感疫苗株及其制备方法和应用 |
| LT3768846T (lt) * | 2018-03-21 | 2023-08-10 | Aldevron, L.L.C. | Virusiniai ir nevirusiniai nanoplazmidiniai vektoriai su patobulinta gamyba |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| US11389523B2 (en) | 2018-08-20 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein |
| EP3914295A2 (en) | 2019-01-23 | 2021-12-01 | Yoshihiro Kawaoka | Mutations that confer genetic stability to additional genes in influenza viruses |
| CN113874496A (zh) | 2019-02-08 | 2021-12-31 | 威斯康星校友研究基金会(Warf) | 人源化细胞系 |
| WO2020223699A1 (en) | 2019-05-01 | 2020-11-05 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| JP7627911B2 (ja) | 2019-08-27 | 2025-02-07 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵内複製のための安定化されたｈａを持つ組換えインフルエンザウイルス |
| WO2021150874A1 (en) | 2020-01-24 | 2021-07-29 | Wisconsin Alumni Research Foundation (Warf) | Recombinant influenza viruses with stabilized na |
| WO2021195410A1 (en) | 2020-03-25 | 2021-09-30 | Wisconsin Alumni Research Foundation (Warf) | Recombinant multivalent influenza viruses |
| CN113527443B (zh) * | 2020-04-16 | 2023-03-07 | 中国科学院微生物研究所 | 甲型流感病毒pb1蛋白t细胞表位多肽片段及其应用 |
| EP4323382A4 (en) * | 2021-04-15 | 2025-06-18 | Biorchestra Co., Ltd. | POLYNUCLEOTIDES FOR ENHANCED PROTEIN EXPRESSION AND USES THEREOF |
| CN114058742B (zh) * | 2022-01-18 | 2022-04-22 | 广州科方生物技术股份有限公司 | 一种引物探针组合物、包含其的试剂盒及其检测方法 |
| TW202408543A (zh) * | 2022-05-31 | 2024-03-01 | 日商Ｖｌｐ醫療日本股份有限公司 | 改良疫苗設計發展 |
| CN116144612B (zh) * | 2022-12-08 | 2023-11-10 | 广州医科大学附属第一医院（广州呼吸中心） | 重组乙型流感病毒及其制备方法与应用 |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
| AU5543294A (en) | 1993-10-29 | 1995-05-22 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
| DE19612966B4 (de) | 1996-04-01 | 2009-12-10 | Novartis Vaccines And Diagnostics Gmbh & Co. Kg | MDCK-Zellen und Verfahren zur Vermehrung von Influenzaviren |
| DE19612967A1 (de) | 1996-04-01 | 1997-10-02 | Behringwerke Ag | Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren |
| TW570803B (en) | 1997-04-09 | 2004-01-11 | Duphar Int Res | Influenza vaccine |
| US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
| AR025750A1 (es) | 1999-09-24 | 2002-12-11 | Smithkline Beecham Biolog | Vacunas |
| WO2001064846A1 (fr) | 2000-03-03 | 2001-09-07 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Cellule utilisable pour culture sans serum et culture en suspension, et procede de production de virus pour vaccin utilisant cette cellule |
| GB0024089D0 (en) | 2000-10-02 | 2000-11-15 | Smithkline Beecham Biolog | Novel compounds |
| WO2002067983A1 (en) | 2001-02-23 | 2002-09-06 | Glaxosmithkline Biologicals S.A. | Novel vaccine |
| US20040071734A1 (en) | 2001-02-23 | 2004-04-15 | Nathalie Garcon | Novel vaccine |
| TWI228420B (en) | 2001-05-30 | 2005-03-01 | Smithkline Beecham Pharma Gmbh | Novel vaccine composition |
| US7566458B2 (en) * | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| WO2005097181A1 (en) | 2004-04-05 | 2005-10-20 | Pfizer Products Inc. | Microfluidized oil-in-water emulsions and vaccine compositions |
| WO2005113756A1 (en) | 2004-05-14 | 2005-12-01 | Glaxosmithkline Biologicals S.A. | Method |
| US20080254067A1 (en) | 2004-05-20 | 2008-10-16 | Id Biomedical Corporation | Process for the Production of an Influenza Vaccine |
| CN103555670B (zh) | 2004-12-23 | 2015-08-12 | 米迪缪尼有限公司 | 用于病毒增殖的非致瘤性mdck细胞系 |
| US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
| CA2613283A1 (en) | 2005-06-21 | 2007-01-04 | Medimmune Vaccines, Inc. | Methods and compositions for expressing a heterologous protease |
| US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
| ES2359214T5 (es) | 2005-11-01 | 2014-10-08 | Novartis Vaccines And Diagnostics Gmbh | Vacunas virales derivadas de células con niveles reducidos de ADN celular residual por tratamiento con beta-propiolactona |
| BRPI0618254A2 (pt) | 2005-11-04 | 2011-08-23 | Novartis Vaccines & Diagnostic | emulsões com agente tensoativo de fase aquosa livre para fornecer adjuvante às vacinas contra influenza dividido |
| FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
| JP5491173B2 (ja) | 2006-04-19 | 2014-05-14 | メディミューン，エルエルシー | イヌ細胞中でマイナス鎖ウイルスｒｎａを発現させるための方法および組成物 |
| PT2086582E (pt) | 2006-10-12 | 2013-01-25 | Glaxosmithkline Biolog Sa | Vacina compreendendo uma emulsão adjuvante óleo em água |
| CN101553252A (zh) | 2006-12-06 | 2009-10-07 | 诺华有限公司 | 包含来自于四株流感病毒的抗原的疫苗 |
| EP2045323A1 (en) | 2007-10-05 | 2009-04-08 | Avir Green Hills Biotechnology Research Development Trade Ag | Linear expression constructs for production of influenza virus particles |
| EP2401384B1 (en) | 2009-05-21 | 2012-10-03 | Novartis AG | Reverse genetics using non-endogenous pol i promoters |
| JP5871796B2 (ja) * | 2009-06-24 | 2016-03-01 | メディカゴ インコーポレイテッド | ヘマグルチニンを含むキメラインフルエンザウイルス様粒子 |
| CN102666860B (zh) | 2009-07-31 | 2015-06-17 | 诺华股份有限公司 | 反向遗传系统 |
| SI2491117T1 (sl) | 2009-10-20 | 2014-03-31 | Novartis Ag | Izboljšani postopki reverzne genetike za pridobivanje virusov |
| ES2628301T3 (es) * | 2012-03-02 | 2017-08-02 | Seqirus UK Limited | Recombinación de virus de gripe |
| BR112015002268A2 (pt) * | 2012-08-03 | 2017-11-07 | Sanofi Pasteur | produção de vírus influenza infecciosos |
-
2014
- 2014-06-06 JP JP2016517733A patent/JP2016521553A/ja not_active Ceased
- 2014-06-06 SG SG11201509985XA patent/SG11201509985XA/en unknown
- 2014-06-06 CN CN201480044797.3A patent/CN105722976A/zh active Pending
- 2014-06-06 BR BR112015030582A patent/BR112015030582A2/pt not_active Application Discontinuation
- 2014-06-06 MX MX2015016755A patent/MX2015016755A/es unknown
- 2014-06-06 KR KR1020157035931A patent/KR20160014657A/ko not_active Withdrawn
- 2014-06-06 EP EP14733369.4A patent/EP3004332A2/en not_active Withdrawn
- 2014-06-06 HK HK16110972.3A patent/HK1222882A1/zh unknown
- 2014-06-06 CA CA2914604A patent/CA2914604A1/en not_active Abandoned
- 2014-06-06 US US14/896,348 patent/US10329537B2/en active Active
- 2014-06-06 WO PCT/IB2014/062030 patent/WO2014195920A2/en not_active Ceased
- 2014-06-06 AU AU2014276418A patent/AU2014276418A1/en not_active Abandoned
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