JP2016521553A - インフルエンザウイルス再集合 - Google Patents

インフルエンザウイルス再集合 Download PDF

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Publication number
JP2016521553A
JP2016521553A JP2016517733A JP2016517733A JP2016521553A JP 2016521553 A JP2016521553 A JP 2016521553A JP 2016517733 A JP2016517733 A JP 2016517733A JP 2016517733 A JP2016517733 A JP 2016517733A JP 2016521553 A JP2016521553 A JP 2016521553A
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seq
influenza
segment
strain
virus
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JP2016521553A5 (enExample
Inventor
ピーター メイソン，
ピーター メイソン，
ピラダ スッパピパット，
ピラダ スッパピパット，
ラウル ゴミラ，
ラウル ゴミラ，
フィリップ ドルミッチャー，
フィリップ ドルミッチャー，
Original Assignee
ノバルティス アーゲー
ノバルティス アーゲー
シンセティック ジェノミクス ヴァクシンズ， インコーポレーテッド
シンセティック ジェノミクス ヴァクシンズ， インコーポレーテッド
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Publication of JP2016521553A publication Critical patent/JP2016521553A/ja
Publication of JP2016521553A5 publication Critical patent/JP2016521553A5/ja
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    • C—CHEMISTRY; METALLURGY
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16141—Use of virus, viral particle or viral elements as a vector
    • C12N2760/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16151—Methods of production or purification of viral material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16161—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16211—Influenzavirus B, i.e. influenza B virus
    • C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01018—Exo-alpha-sialidase (3.2.1.18), i.e. trans-sialidase

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  • Life Sciences & Earth Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2016517733A 2013-06-06 2014-06-06 インフルエンザウイルス再集合 Ceased JP2016521553A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361832091P 2013-06-06 2013-06-06
US61/832,091 2013-06-06
EP13179013 2013-08-01
EP13179013.1 2013-09-26
PCT/IB2014/062030 WO2014195920A2 (en) 2013-06-06 2014-06-06 Influenza virus reassortment

Publications (2)

Publication Number Publication Date
JP2016521553A true JP2016521553A (ja) 2016-07-25
JP2016521553A5 JP2016521553A5 (enExample) 2017-07-20

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JP2016517733A Ceased JP2016521553A (ja) 2013-06-06 2014-06-06 インフルエンザウイルス再集合

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US (1) US10329537B2 (enExample)
EP (1) EP3004332A2 (enExample)
JP (1) JP2016521553A (enExample)
KR (1) KR20160014657A (enExample)
CN (1) CN105722976A (enExample)
AU (1) AU2014276418A1 (enExample)
BR (1) BR112015030582A2 (enExample)
CA (1) CA2914604A1 (enExample)
HK (1) HK1222882A1 (enExample)
MX (1) MX2015016755A (enExample)
SG (1) SG11201509985XA (enExample)
WO (1) WO2014195920A2 (enExample)

Cited By (14)

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JP2020010711A (ja) * 2013-07-15 2020-01-23 ウィスコンシン アルムニ リサーチ ファンデイション Ｍｄｃｋ、ベロ細胞又は卵内で増強された複製を有する高力価の組換えインフルエンザウイルス
US11046934B2 (en) 2014-06-20 2021-06-29 Wisconsin Alumni Research Foundation (Warf) Mutations that confer genetic stability to additional genes in influenza viruses
JP2021518150A (ja) * 2018-03-21 2021-08-02 ネイチャー テクノロジー コーポレーション 生成が改良されたウイルス及び非ウイルスのナノプラスミドベクター
US11390649B2 (en) 2019-05-01 2022-07-19 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
US11807872B2 (en) 2019-08-27 2023-11-07 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
US11851648B2 (en) 2019-02-08 2023-12-26 Wisconsin Alumni Research Foundation (Warf) Humanized cell line
US12076387B2 (en) 2010-03-23 2024-09-03 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
US12144857B2 (en) 2018-08-20 2024-11-19 Wisconsin Alumni Research Foundation (Warf) Vectors for eliciting immune responses to non-dominant epitopes in the hemagglutinin (HA) protein
US12251436B2 (en) 2017-10-25 2025-03-18 Wisconsin Alumni Research Foundation (Warf) Recombinant influenza viruses with stabilized HA for replication in eggs
US12290562B2 (en) 2020-03-25 2025-05-06 Wisconsin Alumni Research Foundation (Warf) Recombinant multivalent influenza viruses
US12343390B2 (en) 2018-08-07 2025-07-01 Wisconsin Alumni Research Foundation (Warf) Recombinant biologically contained filovirus vaccine
US12365880B2 (en) 2020-01-24 2025-07-22 The University Of Tokyo Recombinant influenza viruses with stabilized NA
US12364748B2 (en) 2016-02-19 2025-07-22 Wisconsin Alumni Research Foundation (Warf) Influenza B virus replication for vaccine development
US12410409B2 (en) 2011-08-26 2025-09-09 Wisconsin Alumni Research Foundation (Warf) Influenza viruses with mutant PB2 gene segment as live attenuated vaccines

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WO2011056591A1 (en) 2009-10-26 2011-05-12 Warf - Wisconsin Alumni Research Foundation High titer recombinant influenza viruses with enhanced replication in vero cells
US10633422B2 (en) 2015-06-01 2020-04-28 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA
BR112017028011A2 (pt) 2015-06-26 2018-08-28 Seqirus Uk Ltd vacinas de gripe correspondentes antigenicamente
US9890363B2 (en) 2015-07-06 2018-02-13 Wisconsin Alumni Research Foundation (Warf) Influenza virus replication for vaccine development
JP6335399B1 (ja) * 2016-07-15 2018-05-30 一般財団法人阪大微生物病研究会 リアソータントインフルエンザウイルス作出方法
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CN108048476B (zh) * 2017-11-21 2020-09-08 浙江迪福润丝生物科技有限公司 一种制备区分免疫和感染动物h9亚型禽流感疫苗株的方法及应用
CN108018300B (zh) 2017-11-21 2020-08-28 浙江迪福润丝生物科技有限公司 区分免疫和感染动物h7亚型禽流感疫苗株及其制备方法和应用
JP2022527235A (ja) 2019-01-23 2022-06-01 義裕 河岡 インフルエンザウイルスにおける付加的遺伝子に遺伝的安定性を付与する突然変異
CN113527443B (zh) * 2020-04-16 2023-03-07 中国科学院微生物研究所 甲型流感病毒pb1蛋白t细胞表位多肽片段及其应用
US20240209035A1 (en) * 2021-04-15 2024-06-27 Biorchestra Co., Ltd. Polynucleotides capable of enhanced protein expression and uses thereof
CN114058742B (zh) * 2022-01-18 2022-04-22 广州科方生物技术股份有限公司 一种引物探针组合物、包含其的试剂盒及其检测方法
WO2023234300A1 (en) * 2022-05-31 2023-12-07 Vlp Therapeutics Japan, Inc. Modified vaccine design developments
CN116144612B (zh) * 2022-12-08 2023-11-10 广州医科大学附属第一医院（广州呼吸中心） 重组乙型流感病毒及其制备方法与应用

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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12076387B2 (en) 2010-03-23 2024-09-03 Wisconsin Alumni Research Foundation (Warf) Vaccines comprising mutant attenuated influenza viruses
US12410409B2 (en) 2011-08-26 2025-09-09 Wisconsin Alumni Research Foundation (Warf) Influenza viruses with mutant PB2 gene segment as live attenuated vaccines
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AU2014276418A1 (en) 2016-01-21
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