|
WO2002053558A1
(en)
|
2001-01-02 |
2002-07-11 |
F.Hoffman-La Roche Ag |
Quinazolone derivatives as alpha 1a/b adrenergic receptor antagonists
|
|
WO2002088079A2
(en)
|
2001-05-01 |
2002-11-07 |
Bristol-Myers Squibb Company |
Dual inhibitors of pde 7 and pde 4
|
|
US7105667B2
(en)
|
2001-05-01 |
2006-09-12 |
Bristol-Myers Squibb Co. |
Fused heterocyclic compounds and use thereof
|
|
AU2002331621B2
(en)
|
2001-08-15 |
2008-06-05 |
Icos Corporation |
2H-phthalazin-1-ones and methods for use thereof
|
|
GB0310726D0
(en)
|
2003-05-09 |
2003-06-11 |
Merck Sharp & Dohme |
Therapeutic agents
|
|
US7928107B2
(en)
|
2004-09-02 |
2011-04-19 |
Vertex Pharmaceuticals Incorporated |
Quinazolines useful as modulators of ion channels
|
|
ES2336603T3
(es)
|
2005-07-21 |
2010-04-14 |
F. Hoffmann-La Roche Ag |
Compuestos de pirido(2,3-d)pirimidina-2,4-diamina como inhibidores de ptp1b.
|
|
US20080051387A1
(en)
|
2006-06-09 |
2008-02-28 |
Yuelian Xu |
Tetrahydropyrido[3,4-d]pyrimidines and related analogues
|
|
WO2008009078A2
(en)
|
2006-07-20 |
2008-01-24 |
Gilead Sciences, Inc. |
4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
|
|
EP2518063B1
(en)
*
|
2006-12-21 |
2017-02-01 |
Sloan-Kettering Institute For Cancer Research |
Pyridazinones and furan-containing compounds
|
|
WO2008103470A2
(en)
|
2007-02-21 |
2008-08-28 |
Trustees Of Columbia University In The City Of New York |
Oncogenic-ras-signal dependent lethal compounds
|
|
US20100298289A1
(en)
|
2007-10-09 |
2010-11-25 |
Ucb Pharma, S.A. |
Heterobicyclic compounds as histamine h4-receptor antagonists
|
|
CA2729045A1
(en)
|
2008-07-31 |
2010-02-04 |
Philippe Bergeron |
Pyrimidine compounds, compositions and methods of use
|
|
WO2010120996A1
(en)
|
2009-04-17 |
2010-10-21 |
Wyeth Llc |
5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
|
|
JP2012524800A
(ja)
|
2009-04-22 |
2012-10-18 |
ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ |
モノアシルグリセロールリパーゼ阻害剤としてのアゼチジニルジアミド
|
|
EP2518064A1
(en)
|
2009-12-25 |
2012-10-31 |
Mochida Pharmaceutical Co., Ltd. |
Novel aryl urea derivative
|
|
JP2013516422A
(ja)
|
2009-12-30 |
2013-05-13 |
アビラ セラピューティクス, インコーポレイテッド |
タンパク質のリガンド−指向性共有的修飾
|
|
EP2836482B1
(en)
|
2012-04-10 |
2019-12-25 |
The Regents of The University of California |
Compositions and methods for treating cancer
|
|
US9695133B2
(en)
|
2012-07-13 |
2017-07-04 |
The Trustees Of Columbia University In The City Of New York |
Quinazolinone-based oncogenic-RAS-selective lethal compounds and their use
|
|
US9745319B2
(en)
|
2013-03-15 |
2017-08-29 |
Araxes Pharma Llc |
Irreversible covalent inhibitors of the GTPase K-Ras G12C
|
|
US9227978B2
(en)
|
2013-03-15 |
2016-01-05 |
Araxes Pharma Llc |
Covalent inhibitors of Kras G12C
|
|
CA2904393A1
(en)
|
2013-03-15 |
2014-09-25 |
Araxes Pharma Llc |
Covalent inhibitors of kras g12c
|
|
JO3805B1
(ar)
|
2013-10-10 |
2021-01-31 |
Araxes Pharma Llc |
مثبطات كراس جي12سي
|
|
EP3055290B1
(en)
|
2013-10-10 |
2019-10-02 |
Araxes Pharma LLC |
Inhibitors of kras g12c
|
|
MA40074A
(fr)
|
2014-05-30 |
2015-12-03 |
Univ Columbia |
Composés liant ras multivalents
|
|
WO2016025650A1
(en)
|
2014-08-13 |
2016-02-18 |
Celgene Avilomics Research, Inc. |
Combinations of an erk inhibitor and a cdk4/6 inhibitor and related methods
|
|
CN107074824B
(zh)
|
2014-09-05 |
2021-01-08 |
基因泰克公司 |
作为用于治疗癌症的pcaf和gcn5抑制剂的式(i)的酞嗪衍生物
|
|
JO3556B1
(ar)
|
2014-09-18 |
2020-07-05 |
Araxes Pharma Llc |
علاجات مدمجة لمعالجة السرطان
|
|
WO2016049565A1
(en)
|
2014-09-25 |
2016-03-31 |
Araxes Pharma Llc |
Compositions and methods for inhibition of ras
|
|
JP2017528498A
(ja)
|
2014-09-25 |
2017-09-28 |
アラクセス ファーマ エルエルシー |
Kras g12c変異体タンパク質のインヒビター
|
|
WO2016049568A1
(en)
|
2014-09-25 |
2016-03-31 |
Araxes Pharma Llc |
Methods and compositions for inhibition of ras
|
|
WO2016130460A2
(en)
|
2015-02-09 |
2016-08-18 |
The Johns Hopkins University |
Phthalazinone pyrazole derivatives for treating retinal degenerative disease
|
|
US10017540B2
(en)
|
2015-03-11 |
2018-07-10 |
California Institute Of Technology |
Cyclic peptide binder against oncogenic K-Ras
|
|
ES2898765T3
(es)
|
2015-04-10 |
2022-03-08 |
Araxes Pharma Llc |
Compuestos de quinazolina sustituidos y métodos de uso de los mismos
|
|
US10428064B2
(en)
|
2015-04-15 |
2019-10-01 |
Araxes Pharma Llc |
Fused-tricyclic inhibitors of KRAS and methods of use thereof
|
|
US10421764B2
(en)
|
2015-04-24 |
2019-09-24 |
H. Lee Moffitt Cancer Center And Research Institute, Inc. |
Mutant KRas inhibitors
|
|
AU2016258192B2
(en)
|
2015-05-06 |
2021-07-29 |
Leidos Biomedical Research, Inc. |
K-Ras modulators
|
|
US10144724B2
(en)
|
2015-07-22 |
2018-12-04 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use thereof
|
|
CN108513588A
(zh)
|
2015-09-24 |
2018-09-07 |
Ionis制药公司 |
Kras表达的调节剂
|
|
EP3356359B1
(en)
|
2015-09-28 |
2021-10-20 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058728A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
EP3356347A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
EP3356351A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
EP3356349A1
(en)
|
2015-09-28 |
2018-08-08 |
Araxes Pharma LLC |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058902A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2017058805A1
(en)
|
2015-09-28 |
2017-04-06 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
WO2017070256A2
(en)
|
2015-10-19 |
2017-04-27 |
Araxes Pharma Llc |
Method for screening inhibitors of ras
|
|
EP3365686A4
(en)
|
2015-10-22 |
2019-03-27 |
The Scripps Research Institute |
REACTIVE CYSTEINSONS AND USES THEREOF
|
|
WO2017080980A1
(en)
|
2015-11-09 |
2017-05-18 |
Astrazeneca Ab |
Dihydropyrrolopyrazinone derivatives useful in the treatment of cancer
|
|
WO2017079864A1
(en)
|
2015-11-12 |
2017-05-18 |
Hangzhou Yier Biotech Co., Ltd. |
Treatment of cancers related to chronically active ras
|
|
KR20180081596A
(ko)
|
2015-11-16 |
2018-07-16 |
아락세스 파마 엘엘씨 |
치환된 헤테로사이클릭 그룹을 포함하는 2-치환된 퀴나졸린 화합물 및 이의 사용 방법
|
|
US9988357B2
(en)
|
2015-12-09 |
2018-06-05 |
Araxes Pharma Llc |
Methods for preparation of quinazoline derivatives
|
|
WO2017172979A1
(en)
*
|
2016-03-30 |
2017-10-05 |
Araxes Pharma Llc |
Substituted quinazoline compounds and methods of use
|
|
US20170283445A1
(en)
|
2016-04-05 |
2017-10-05 |
University Of South Carolina |
Small Molecule Inhibitors Selective For Polo-Like Kinase Proteins
|
|
KR102444509B1
(ko)
|
2016-05-18 |
2022-09-19 |
미라티 테라퓨틱스, 인크. |
Kras g12c 억제제
|
|
US10646488B2
(en)
|
2016-07-13 |
2020-05-12 |
Araxes Pharma Llc |
Conjugates of cereblon binding compounds and G12C mutant KRAS, HRAS or NRAS protein modulating compounds and methods of use thereof
|
|
WO2018064510A1
(en)
|
2016-09-29 |
2018-04-05 |
Araxes Pharma Llc |
Inhibitors of kras g12c mutant proteins
|
|
EP3523289A1
(en)
|
2016-10-07 |
2019-08-14 |
Araxes Pharma LLC |
Heterocyclic compounds as inhibitors of ras and methods of use thereof
|
|
US12150934B2
(en)
|
2016-11-30 |
2024-11-26 |
Bantam Pharmaceutical, Llc |
Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
|
|
CA3081983A1
(en)
|
2016-11-30 |
2018-06-07 |
Bantam Pharmaceutical, Llc |
Substituted pyrazole compounds and methods of using them for treatment of hyperproliferative diseases
|
|
KR20190095355A
(ko)
|
2016-12-15 |
2019-08-14 |
더 리젠츠 오브 더 유니버시티 오브 캘리포니아 |
암의 치료를 위한 조성물 및 방법
|
|
EP3558979B1
(en)
|
2016-12-22 |
2021-02-17 |
Boehringer Ingelheim International GmbH |
Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors
|
|
CN110366550A
(zh)
|
2016-12-22 |
2019-10-22 |
美国安进公司 |
作为用于治疗肺癌、胰腺癌或结直肠癌的KRAS G12C抑制剂的苯并异噻唑、异噻唑并[3,4-b]吡啶、喹唑啉、酞嗪、吡啶并[2,3-d]哒嗪和吡啶并[2,3-d]嘧啶衍生物
|
|
US10344026B2
(en)
|
2017-01-18 |
2019-07-09 |
Nantbio, Inc. |
Compositions and methods of targeting mutant K-ras
|
|
WO2018140513A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
1-(3-(6-(3-hydroxynaphthalen-1-yl)benzofuran-2-yl)azetidin-1yl)prop-2-en-1-one derivatives and similar compounds as kras g12c modulators for treating cancer
|
|
JP7327802B2
(ja)
|
2017-01-26 |
2023-08-16 |
アラクセス ファーマ エルエルシー |
縮合ヘテロ-ヘテロ二環式化合物およびその使用方法
|
|
EP3573954A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
Fused bicyclic benzoheteroaromatic compounds and methods of use thereof
|
|
EP3573966A1
(en)
|
2017-01-26 |
2019-12-04 |
Araxes Pharma LLC |
Fused n-heterocyclic compounds and methods of use thereof
|
|
US11136308B2
(en)
|
2017-01-26 |
2021-10-05 |
Araxes Pharma Llc |
Substituted quinazoline and quinazolinone compounds and methods of use thereof
|
|
WO2018140599A1
(en)
|
2017-01-26 |
2018-08-02 |
Araxes Pharma Llc |
Benzothiophene and benzothiazole compounds and methods of use thereof
|
|
JOP20190186A1
(ar)
|
2017-02-02 |
2019-08-01 |
Astellas Pharma Inc |
مركب كينازولين
|
|
EP3612526A2
(en)
|
2017-04-20 |
2020-02-26 |
The Regents of the University of California |
K-ras modulators
|
|
US10745385B2
(en)
|
2017-05-25 |
2020-08-18 |
Araxes Pharma Llc |
Covalent inhibitors of KRAS
|
|
AU2018329920B2
(en)
|
2017-09-08 |
2022-12-01 |
Amgen Inc. |
Inhibitors of KRAS G12C and methods of using the same
|
|
LT3710439T
(lt)
|
2017-11-15 |
2023-05-10 |
Mirati Therapeutics, Inc. |
Kras g12c inhibitoriai
|
|
US11285156B2
(en)
|
2018-06-12 |
2022-03-29 |
Amgen Inc. |
Substituted piperazines as KRAS G12C inhibitors
|
|
EP3832583A4
(en)
|
2018-07-31 |
2021-12-08 |
Honda Motor Co., Ltd. |
PERFORMANCE FORECAST SYSTEM, PERFORMANCE FORECAST DEVICE, PERFORMANCE FORECAST METHOD, PROGRAM AND STORAGE MEDIUM
|
|
CN109413550B
(zh)
|
2018-09-30 |
2021-03-09 |
华为技术有限公司 |
音频播放电路和终端
|
|
PE20260440A1
(es)
|
2018-11-09 |
2026-02-19 |
Hoffmann La Roche |
Compuestos de anillo fusionado
|
|
CN111193490B
(zh)
|
2018-11-14 |
2025-05-13 |
天津大学 |
散热结构、带散热结构的体声波谐振器、滤波器和电子设备
|
|
MX2021002804A
(es)
|
2018-12-05 |
2021-07-15 |
Mirati Therapeutics Inc |
Terapias de combinacion.
|
|
WO2020123395A1
(en)
*
|
2018-12-10 |
2020-06-18 |
Ideaya Biosciences, Inc. |
2-oxoquinazoline derivatives as methionine adenosyltransferase 2a inhibitors
|
|
EP3908283A4
(en)
|
2019-01-10 |
2022-10-12 |
Mirati Therapeutics, Inc. |
KRAS G12C INHIBITORS
|
|
US20220193242A1
(en)
|
2019-02-07 |
2022-06-23 |
The Regents Of The University Of California |
Immunophilin-dependent inhibitors and uses thereof
|
|
US20220221355A1
(en)
|
2019-02-11 |
2022-07-14 |
Mesomat Inc. |
Sensing fibers for structural health monitoring
|
|
KR102747104B1
(ko)
|
2019-02-18 |
2024-12-27 |
한국과학기술연구원 |
단백질 키나아제 저해 활성을 갖는 신규한 피리도[3,4-d]피리미딘-8-온 유도체 및 이를 포함하는 암의 예방, 개선 또는 치료용 약학 조성물
|
|
CN114026116A
(zh)
|
2019-02-20 |
2022-02-08 |
弗雷德哈钦森癌症研究中心 |
Ras新抗原特异性结合蛋白及其用途
|
|
GB201902392D0
(en)
|
2019-02-21 |
2019-04-10 |
Cambridge Entpr Ltd |
Modular binding proteins
|
|
WO2020176693A2
(en)
|
2019-02-26 |
2020-09-03 |
Cell Response, Inc. |
Methods for treating map3k8 positive cancers
|
|
MX2021010323A
(es)
*
|
2019-03-01 |
2021-12-10 |
Revolution Medicines Inc |
Compuestos bicíclicos de heterociclilo y usos de este.
|
|
WO2020177629A1
(zh)
|
2019-03-01 |
2020-09-10 |
劲方医药科技(上海)有限公司 |
螺环取代的嘧啶并环类化合物,其制法与医药上的用途
|
|
US12117170B2
(en)
|
2019-03-05 |
2024-10-15 |
Questor Technology Inc. |
Gas incinerator system
|
|
KR102934231B1
(ko)
|
2019-03-05 |
2026-03-06 |
아스트라제네카 아베 |
항암제로 유용한 융합 삼환식 화합물
|
|
EP3941938A1
(en)
|
2019-03-06 |
2022-01-26 |
Dana-Farber Cancer Institute, Inc. |
T cell receptors specific to b-cell maturation antigen for treatment of cancer
|
|
US20220160714A1
(en)
|
2019-03-22 |
2022-05-26 |
Icahn School Of Medicine At Mount Sinai |
Methods for treating colorectal cancer
|
|
BR112021018739A2
(pt)
|
2019-03-29 |
2022-05-03 |
Dicerna Pharmaceuticals Inc |
Composições e métodos para o tratamento de doenças ou distúrbios associados a kras
|
|
CA3134825A1
(en)
|
2019-03-29 |
2020-10-08 |
Kura Oncology, Inc. |
Methods of treating squamous cell carcinomas with farnesyltransferase inhibitors
|
|
KR102222693B1
(ko)
|
2019-04-04 |
2021-03-04 |
금정제약 주식회사 |
H-rev107 유래 펩타이드의 신규한 용도
|
|
WO2020214537A1
(en)
|
2019-04-15 |
2020-10-22 |
Tosk, Inc. |
Modulators of ras gtpase
|
|
US20200335182A1
(en)
|
2019-04-16 |
2020-10-22 |
Uratim Ltd. |
Method and apparatus for facilitating the binding of biological macromolecules with the use of gluing molecular agents with applications in RAS mutations and related conditions
|
|
KR20220012255A
(ko)
|
2019-04-28 |
2022-02-03 |
젠플리트 테라퓨틱스 (상하이) 아이엔씨. |
옥사아자퀴나졸린-7(8h)-케톤 화합물, 이의 제조 방법 및 이의 약학적 응용
|
|
US11518758B2
(en)
|
2019-05-10 |
2022-12-06 |
Deciphera Pharmaceuticals, Llc |
Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof
|
|
PE20220597A1
(es)
|
2019-05-10 |
2022-04-22 |
Deciphera Pharmaceuticals Llc |
Inhibidores de la autofagia de fenilaminopirimidina amida y metodos de uso de estos
|
|
EP3969449B1
(en)
|
2019-05-13 |
2025-02-12 |
Novartis AG |
New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
|
|
US11879013B2
(en)
|
2019-05-14 |
2024-01-23 |
Janssen Biotech, Inc. |
Combination therapies with bispecific anti-EGFR/c-Met antibodies and third generation EGFR tyrosine kinase inhibitors
|
|
EP3738593A1
(en)
|
2019-05-14 |
2020-11-18 |
Amgen, Inc |
Dosing of kras inhibitor for treatment of cancers
|
|
JP7502337B2
(ja)
|
2019-05-20 |
2024-06-18 |
カリフォルニア インスティチュート オブ テクノロジー |
Kras g12cインヒビター及びその使用
|
|
WO2020236947A1
(en)
|
2019-05-21 |
2020-11-26 |
Amgen Inc. |
Solid state forms
|
|
CN114437065A
(zh)
|
2019-05-21 |
2022-05-06 |
益方生物科技(上海)股份有限公司 |
杂环化合物,其制备方法和用途
|
|
AU2020277398B2
(en)
|
2019-05-21 |
2026-01-29 |
Amgen Inc. |
Solid state forms
|
|
WO2020234103A1
(en)
|
2019-05-21 |
2020-11-26 |
Bayer Aktiengesellschaft |
Identification and use of kras inhibitors
|
|
US12577278B2
(en)
|
2019-06-07 |
2026-03-17 |
Emory University |
KRAS G12V mutant binds to JAK1, inhibitors, pharmaceutical compositions, and methods related thereto
|
|
CA3141405A1
(en)
|
2019-06-12 |
2020-12-17 |
H. Charles Manning |
Amino acid transport inhibitors and the uses thereof
|
|
CN114269715A
(zh)
|
2019-06-12 |
2022-04-01 |
范德比尔特大学 |
作为氨基酸转运抑制剂的二苄基胺
|
|
WO2021000885A1
(zh)
|
2019-07-01 |
2021-01-07 |
江苏恒瑞医药股份有限公司 |
喹唑啉酮类衍生物、其制备方法及其在医药上的应用
|
|
JP7756069B6
(ja)
|
2019-08-02 |
2025-11-27 |
上海済▲ユウ▼医薬科技股▲フン▼有限公司 |
四環式化合物、その調製と使用の方法
|
|
CN112341457A
(zh)
|
2019-08-07 |
2021-02-09 |
北京加科思新药研发有限公司 |
Kras突变蛋白抑制剂
|
|
CN114174298B
(zh)
|
2019-08-14 |
2023-08-01 |
正大天晴药业集团南京顺欣制药有限公司 |
哒嗪酮并嘧啶类衍生物及其医药用途
|
|
CN112390797A
(zh)
|
2019-08-15 |
2021-02-23 |
微境生物医药科技(上海)有限公司 |
新型螺环类K-Ras G12C抑制剂
|
|
WO2021031952A1
(zh)
|
2019-08-16 |
2021-02-25 |
劲方医药科技(上海)有限公司 |
氧代六元环并嘧啶类化合物,其制法与医药上的用途
|
|
MX2022002108A
(es)
|
2019-08-22 |
2022-03-17 |
Univ Michigan Regents |
Metodo para tratar canceres asociados con kras.
|
|
CN114269735B
(zh)
|
2019-08-26 |
2024-02-23 |
南京创济生物医药有限公司 |
二氢或四氢喹唑啉类化合物及其中间体、制备方法和应用
|
|
MX2022002465A
(es)
*
|
2019-08-29 |
2022-05-19 |
Mirati Therapeutics Inc |
Inhibidores de kras g12d.
|
|
EP3819300A4
(en)
|
2019-09-06 |
2021-11-24 |
Wellmarker Bio Co., Ltd. |
THERAPEUTIC COMPOSITION BASED ON BIOMARKERS
|
|
WO2021043322A1
(zh)
|
2019-09-06 |
2021-03-11 |
正大天晴药业集团南京顺欣制药有限公司 |
氮杂环庚烷并嘧啶类衍生物及其医药用途
|
|
WO2021050732A1
(en)
|
2019-09-10 |
2021-03-18 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods of treating kras mutant cancers
|
|
US20230002371A1
(en)
|
2019-09-13 |
2023-01-05 |
Biotheryx, Inc. |
Ras protein degraders, pharmaceutical compositions thereof, and their therapeutic applications
|
|
US20220402916A1
(en)
|
2019-09-18 |
2022-12-22 |
Merck Sharp & Dohme Corp. |
Small molecule inhibitors of kras g12c mutant
|
|
WO2021052499A1
(zh)
|
2019-09-20 |
2021-03-25 |
上海济煜医药科技有限公司 |
稠合吡啶酮类化合物及其制备方法和应用
|
|
CN114502165A
(zh)
|
2019-09-23 |
2022-05-13 |
苏州浦合医药科技有限公司 |
Shp2抑制剂及其用途
|
|
WO2021061749A1
(en)
|
2019-09-24 |
2021-04-01 |
Mirati Therapeutics, Inc. |
Combination therapies
|
|
TW202115062A
(zh)
|
2019-09-25 |
2021-04-16 |
大陸商北京加科思新藥研發有限公司 |
Kras突變蛋白抑制劑
|
|
WO2021058018A1
(en)
|
2019-09-29 |
2021-04-01 |
Beigene, Ltd. |
Inhibitors of kras g12c
|
|
WO2021063346A1
(zh)
|
2019-09-30 |
2021-04-08 |
上海迪诺医药科技有限公司 |
Kras g12c抑制剂及其应用
|
|
CN114555586B
(zh)
|
2019-10-10 |
2023-06-23 |
信达生物制药(苏州)有限公司 |
Krasg12c蛋白抑制剂及其制备方法和用途
|
|
US20240139193A1
(en)
|
2019-10-15 |
2024-05-02 |
Amgen Inc. |
Combination therapy of kras inhibitor and shp2 inhibitor for treatment of cancers
|
|
JP6754125B1
(ja)
|
2019-10-15 |
2020-09-09 |
学校法人東京理科大学 |
Brap2作用増強剤
|
|
CN112694475B
(zh)
|
2019-10-23 |
2025-09-23 |
苏州泽璟生物制药股份有限公司 |
环烷基类和杂环烷基类抑制剂及其制备方法和应用
|
|
US12331035B2
(en)
|
2019-10-23 |
2025-06-17 |
Sk Biopharmaceuticals Co., Ltd. |
Bicyclic compound and use thereof
|
|
EP4048671B1
(en)
|
2019-10-24 |
2026-03-18 |
Amgen Inc. |
Pyridopyrimidine derivatives useful as kras g12c and kras g12d inhibitors in the treatment of cancer
|
|
UA129778C2
(uk)
|
2019-10-28 |
2025-07-30 |
Мерк Шарп Енд Доум Елелсі |
Низькомолекулярні інгібітори g12c-мутантного kras
|
|
JP7601869B2
(ja)
|
2019-10-30 |
2024-12-17 |
▲勁▼方医▲薬▼科技(上海)有限公司 |
置換された複素環-環系化合物、その調製方法及び医薬への応用
|
|
US20230023023A1
(en)
|
2019-10-31 |
2023-01-26 |
Taiho Pharmaceutical Co., Ltd. |
4-aminobut-2-enamide derivatives and salts thereof
|
|
WO2021084765A1
(en)
|
2019-10-31 |
2021-05-06 |
Taiho Pharmaceutical Co., Ltd |
4-aminobut-2-enamide derivatives and salts thereof
|
|
TW202132316A
(zh)
|
2019-11-04 |
2021-09-01 |
美商銳新醫藥公司 |
Ras抑制劑
|
|
CN113286794B
(zh)
|
2019-11-04 |
2024-03-12 |
北京加科思新药研发有限公司 |
Kras突变蛋白抑制剂
|
|
IL322454A
(en)
|
2019-11-04 |
2025-09-01 |
Revolution Medicines Inc |
ras inhibitors
|
|
AU2020377925A1
(en)
|
2019-11-04 |
2022-05-05 |
Revolution Medicines, Inc. |
Ras inhibitors
|
|
CN112778301A
(zh)
|
2019-11-07 |
2021-05-11 |
苏州泽璟生物制药股份有限公司 |
四氢吡啶并嘧啶类抑制剂及其制备方法和应用
|
|
BR112022007535A2
(pt)
|
2019-11-07 |
2022-07-12 |
Chugai Pharmaceutical Co Ltd |
Composto peptídico cíclico tendo ação inibitória de kras
|
|
CA3156359A1
(en)
|
2019-11-08 |
2021-05-14 |
Adrian Liam Gill |
Bicyclic heteroaryl compounds and uses thereof
|
|
CN114630832A
(zh)
|
2019-11-15 |
2022-06-14 |
四川海思科制药有限公司 |
一种嘧啶并环衍生物及其在医药上的应用
|
|
EP4065231A1
(en)
|
2019-11-27 |
2022-10-05 |
Revolution Medicines, Inc. |
Covalent ras inhibitors and uses thereof
|
|
CN113614080B
(zh)
|
2019-11-29 |
2022-06-28 |
苏州信诺维医药科技股份有限公司 |
Kras g12c抑制剂化合物及其用途
|
|
WO2021106231A1
(en)
|
2019-11-29 |
2021-06-03 |
Taiho Pharmaceutical Co., Ltd. |
A compound having inhibitory activity against kras g12d mutation
|
|
EP4067343A4
(en)
|
2019-11-29 |
2024-01-03 |
Taiho Pharmaceutical Co., Ltd. |
NEW PHENOLIC COMPOUND OR SALT THEREOF
|
|
WO2021109737A1
(zh)
|
2019-12-02 |
2021-06-10 |
上海璎黎药业有限公司 |
一种含氧杂环化合物、其制备方法及应用
|
|
WO2021113595A1
(en)
|
2019-12-06 |
2021-06-10 |
Beta Pharma, Inc. |
Phosphorus derivatives as kras inhibitors
|
|
WO2021120045A1
(en)
|
2019-12-18 |
2021-06-24 |
InventisBio Co., Ltd. |
Heterocyclic compounds, preparation methods and uses thereof
|
|
WO2021126799A1
(en)
|
2019-12-18 |
2021-06-24 |
Merck Sharp & Dohme Corp. |
Macrocyclic peptides as potent inhibitors of k-ras g12d mutant
|
|
WO2021121397A1
(zh)
|
2019-12-19 |
2021-06-24 |
首药控股(北京)股份有限公司 |
取代的炔基杂环化合物
|
|
CN114761408B
(zh)
|
2019-12-19 |
2023-09-15 |
贝达药业股份有限公司 |
Kras g12c抑制剂及其在医药上的应用
|
|
IL293962B2
(en)
|
2019-12-19 |
2025-10-01 |
Jacobio Pharmaceuticals Co Ltd |
Mutant KRAS protein inhibitors
|
|
TR201920922A2
(tr)
|
2019-12-20 |
2020-06-22 |
Ankara Ueniversitesi |
3/4-((2E,6E)-3,7,11-Trimetildodeka-2,6,10-trieniltiyo)benzamid Türevi Bileşikler
|
|
CA3164995A1
(en)
|
2019-12-20 |
2021-06-24 |
Erasca, Inc. |
Tricyclic pyridones and pyrimidones
|
|
JP7850663B2
(ja)
|
2019-12-27 |
2026-04-23 |
ウィゲン・バイオメディシン・テクノロジー・(シャンハイ)・カンパニー・リミテッド |
スピロ環含有キナゾリン化合物
|
|
CN113045565A
(zh)
|
2019-12-27 |
2021-06-29 |
微境生物医药科技(上海)有限公司 |
新型K-Ras G12C抑制剂
|
|
WO2021139678A1
(zh)
|
2020-01-07 |
2021-07-15 |
广州百霆医药科技有限公司 |
吡啶并嘧啶类kras g12c突变蛋白抑制剂
|
|
WO2021139748A1
(en)
|
2020-01-08 |
2021-07-15 |
Ascentage Pharma (Suzhou) Co., Ltd. |
Spirocyclic tetrahydroquinazolines
|
|
US20210269434A1
(en)
|
2020-01-10 |
2021-09-02 |
Incyte Corporation |
Tricyclic compounds as inhibitors of kras
|
|
WO2021143693A1
(zh)
|
2020-01-13 |
2021-07-22 |
苏州泽璟生物制药股份有限公司 |
芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用
|
|
KR102382613B1
(ko)
|
2020-01-15 |
2022-04-06 |
한국과학기술연구원 |
단백질 키나아제 저해 활성을 갖는 7-아미노-3,4-디히드로피리미도피리미딘-2-온 유도체 및 이를 포함하는 치료용 약학 조성물
|
|
KR102396930B1
(ko)
|
2020-01-15 |
2022-05-12 |
한국과학기술연구원 |
피리도[3,4-d]피리미딘 유도체 및 이를 포함하는 치료용 약학 조성물
|
|
WO2021150613A1
(en)
|
2020-01-20 |
2021-07-29 |
Incyte Corporation |
Spiro compounds as inhibitors of kras
|
|
CN115003668A
(zh)
|
2020-01-21 |
2022-09-02 |
南京明德新药研发有限公司 |
作为kras抑制剂的大环类化合物
|
|
GB202001344D0
(en)
|
2020-01-31 |
2020-03-18 |
Redx Pharma Plc |
Ras Inhibitors
|
|
CN115135650A
(zh)
|
2020-02-20 |
2022-09-30 |
贝达医药公司 |
作为kras抑制剂的吡啶并嘧啶衍生物
|
|
CN114845997B
(zh)
|
2020-02-24 |
2024-03-29 |
上海喆邺生物科技有限公司 |
芳香类化合物及其在制备抗肿瘤药物中的应用
|
|
CN113637005B
(zh)
|
2020-02-24 |
2024-05-24 |
泰励生物科技(上海)有限公司 |
用于癌症治疗的kras抑制剂
|
|
US20210292330A1
(en)
|
2020-02-28 |
2021-09-23 |
Erasca, Inc. |
Pyrrolidine-fused heterocycles
|
|
CN114901663B
(zh)
|
2020-03-02 |
2024-07-02 |
上海喆邺生物科技有限公司 |
一类芳香杂环类化合物及其在药物中的应用
|
|
KR20210111711A
(ko)
|
2020-03-03 |
2021-09-13 |
웰마커바이오 주식회사 |
Kras 돌연변이 및 활성화된 ron이 존재하는 암의 예방 또는 치료용 약학 조성물
|
|
WO2021178741A1
(en)
|
2020-03-05 |
2021-09-10 |
The Regents Of The University Of Michigan |
Inhibitors of egfr, kras, braf, and other targets and use of the same
|
|
CN115397413A
(zh)
|
2020-03-05 |
2022-11-25 |
密歇根大学董事会 |
Egfr、kras、braf和其他靶标的抑制剂及其用途
|
|
AU2021233058B2
(en)
|
2020-03-12 |
2024-05-16 |
D3 Bio(Wuxi) Co., Ltd |
Pyrimidoheterocyclic compounds and application thereof
|
|
TW202144345A
(zh)
|
2020-03-17 |
2021-12-01 |
大陸商北京加科思新藥研發有限公司 |
Kras突變蛋白抑制劑
|
|
CA3170068A1
(en)
|
2020-03-25 |
2021-09-30 |
Yuli Xie |
Spiro ring-containing quinazoline compound
|
|
WO2021197499A1
(zh)
|
2020-04-03 |
2021-10-07 |
南京明德新药研发有限公司 |
八氢吡嗪并二氮杂萘啶二酮类化生物
|
|
CN115803030A
(zh)
|
2020-04-06 |
2023-03-14 |
阿维纳斯企业公司 |
用于kras靶向降解的化合物和方法
|
|
TW202144338A
(zh)
|
2020-04-08 |
2021-12-01 |
大陸商江蘇恆瑞醫藥股份有限公司 |
嘧啶并二環類衍生物、其製備方法及其在醫藥上的應用
|
|
AU2021254794A1
(en)
|
2020-04-16 |
2022-12-15 |
Incyte Corporation |
Fused tricyclic KRAS inhibitors
|
|
WO2021216770A1
(en)
|
2020-04-22 |
2021-10-28 |
Accutar Biotechnology Inc. |
Substituted tetrahydroquinazoline compounds as kras inhibitors
|
|
US20230242586A1
(en)
|
2020-04-23 |
2023-08-03 |
The Regents Of The University Of California |
Ras inhibitors and uses thereof
|
|
WO2021215544A1
(en)
|
2020-04-24 |
2021-10-28 |
Taiho Pharmaceutical Co., Ltd. |
Kras g12d protein inhibitors
|
|
CA3177261A1
(en)
|
2020-04-29 |
2021-11-04 |
Shanghai Ringene Biopharma Co., Ltd. |
Benzothiazolyl biaryl compound, and preparation method and use
|
|
CN115135636B
(zh)
|
2020-04-29 |
2024-08-23 |
北京泰德制药股份有限公司 |
喹喔啉酮衍生物作为kras g12c突变蛋白的不可逆抑制剂
|
|
WO2021219072A1
(zh)
|
2020-04-30 |
2021-11-04 |
上海科州药物研发有限公司 |
作为kras抑制剂的杂环化合物的制备及其应用方法
|
|
US11739102B2
(en)
|
2020-05-13 |
2023-08-29 |
Incyte Corporation |
Fused pyrimidine compounds as KRAS inhibitors
|
|
CN113666923A
(zh)
|
2020-05-15 |
2021-11-19 |
苏州泽璟生物制药股份有限公司 |
烷氧基烷基取代杂环基类抑制剂及其制备方法和应用
|
|
WO2021236475A1
(en)
|
2020-05-18 |
2021-11-25 |
Asinex Corporation |
Compounds that inhibit asparagine synthetase and their methods of use
|
|
TWI799871B
(zh)
|
2020-05-27 |
2023-04-21 |
大陸商勁方醫藥科技(上海)有限公司 |
三環并環類化合物,其製法與醫藥上的用途
|
|
CA3180314A1
(en)
|
2020-05-29 |
2021-12-02 |
John Graeme HODGSON |
Methods of treating cancer in patients with an anomalous kras gene or deletions within chromosome 9
|
|
JP7808058B2
(ja)
|
2020-06-02 |
2026-01-28 |
ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング |
がんを治療するための縮合環化2-アミノ-3-シアノチオフェン及び誘導体
|
|
WO2021244603A1
(en)
|
2020-06-04 |
2021-12-09 |
Shanghai Antengene Corporation Limited |
Inhibitors of kras g12c protein and uses thereof
|
|
US20230202981A1
(en)
|
2020-06-04 |
2023-06-29 |
Baskaran Pillai |
Novel small molecules for targeted degradation of untargetable kras in cancer therapy
|
|
WO2021248083A1
(en)
|
2020-06-05 |
2021-12-09 |
Sparcbio Llc |
Heterocyclic compounds and methods of use thereof
|
|
WO2021248079A1
(en)
|
2020-06-05 |
2021-12-09 |
Sparcbio Llc |
Heterocyclic compounds and methods of use thereof
|
|
US20230023009A1
(en)
|
2020-06-05 |
2023-01-26 |
Sparcbio Llc |
Heterocyclic compounds and methods of use thereof
|
|
WO2021248082A1
(en)
|
2020-06-05 |
2021-12-09 |
Sparcbio Llc |
Heterocyclic compounds and methods of use thereof
|
|
US20230026856A1
(en)
|
2020-06-05 |
2023-01-26 |
Sparcbio Llc |
Heterocyclic compounds and methods of use thereof
|
|
WO2021252339A1
(en)
|
2020-06-08 |
2021-12-16 |
Accutar Biotechnology, Inc. |
Substituted purine-2,6-dione compounds as kras inhibitors
|
|
WO2021249563A1
(zh)
|
2020-06-12 |
2021-12-16 |
苏州泽璟生物制药股份有限公司 |
芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用
|
|
US20230227466A1
(en)
|
2020-06-18 |
2023-07-20 |
Shy Therapeutics, Llc |
Substituted thienopyrimidines that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
|
|
WO2021259331A1
(zh)
|
2020-06-24 |
2021-12-30 |
南京明德新药研发有限公司 |
八元含n杂环类化合物
|
|
WO2022002102A1
(en)
|
2020-06-30 |
2022-01-06 |
InventisBio Co., Ltd. |
Quinazoline compounds, preparation methods and uses thereof
|
|
WO2022015375A1
(en)
|
2020-07-16 |
2022-01-20 |
Mirati Therapeutics, Inc. |
Kras g12d inhibitors
|
|
WO2022017339A1
(zh)
|
2020-07-20 |
2022-01-27 |
江苏恒瑞医药股份有限公司 |
稠合哒嗪类衍生物、其制备方法及其在医药上的应用
|
|
JP7584815B2
(ja)
|
2020-08-02 |
2024-11-18 |
上▲海▼▲哲▼▲イェ▼生物科技有限公司 |
抗腫瘍薬物における芳香族化合物及びその用途
|
|
EP4192585A4
(en)
|
2020-08-04 |
2024-08-21 |
Mirati Therapeutics, Inc. |
Kras g12d inhibitors
|
|
WO2022028492A1
(en)
|
2020-08-05 |
2022-02-10 |
Beigene, Ltd. |
Imidazotriazine and pyrrolopyrimidine derivatives as kras g12c inhibitors
|
|
US20230303551A1
(en)
|
2020-08-13 |
2023-09-28 |
Albert Einstein College Of Medicine |
N-cyclyl-sulfonamides useful for inhibiting raf
|
|
CN113999226B
(zh)
|
2020-12-22 |
2023-01-06 |
上海科州药物研发有限公司 |
作为kras抑制剂的杂环化合物的制备及其应用方法
|
|
WO2022236578A1
(en)
*
|
2021-05-10 |
2022-11-17 |
Nikang Therapeutics, Inc. |
Exocyclic amino quinazoline derivatives as kras inhibitors
|
|
BR112023025869A2
(pt)
|
2021-06-10 |
2024-02-27 |
Redx Pharma Plc |
Derivados de quinazolina úteis como inibidores de ras
|
|
US20240409558A1
(en)
|
2021-09-13 |
2024-12-12 |
Biomea Fusion, Inc. |
Irreversible inhibitors of kras
|