JP2023501620A5 - - Google Patents

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Publication number
JP2023501620A5
JP2023501620A5 JP2022527835A JP2022527835A JP2023501620A5 JP 2023501620 A5 JP2023501620 A5 JP 2023501620A5 JP 2022527835 A JP2022527835 A JP 2022527835A JP 2022527835 A JP2022527835 A JP 2022527835A JP 2023501620 A5 JP2023501620 A5 JP 2023501620A5
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JP
Japan
Prior art keywords
formula
disease
phenyl
piperidine
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022527835A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023501620A (ja
Filing date
Publication date
Priority claimed from EP19208888.8A external-priority patent/EP3821947A1/en
Application filed filed Critical
Publication of JP2023501620A publication Critical patent/JP2023501620A/ja
Publication of JP2023501620A5 publication Critical patent/JP2023501620A5/ja
Pending legal-status Critical Current

Links

JP2022527835A 2019-11-13 2020-11-12 複素環式ｔｒｐｍｌ１アゴニスト Pending JP2023501620A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19208888.8 2019-11-13
EP19208888.8A EP3821947A1 (en) 2019-11-13 2019-11-13 Heterocyclic trpml1 agonists
PCT/IB2020/060659 WO2021094974A1 (en) 2019-11-13 2020-11-12 Heterocyclic trpml1 agonists

Publications (2)

Publication Number Publication Date
JP2023501620A JP2023501620A (ja) 2023-01-18
JP2023501620A5 true JP2023501620A5 (https=) 2023-11-13

Family

ID=68581425

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022527835A Pending JP2023501620A (ja) 2019-11-13 2020-11-12 複素環式ｔｒｐｍｌ１アゴニスト

Country Status (5)

Country Link
US (1) US20230010299A1 (https=)
EP (2) EP3821947A1 (https=)
JP (1) JP2023501620A (https=)
CA (1) CA3158079A1 (https=)
WO (1) WO2021094974A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202136219A (zh) * 2019-12-19 2021-10-01 美商卡司馬療法公司 Trpml調節劑
CN116390759A (zh) * 2020-08-03 2023-07-04 卡斯玛治疗公司 Tfeb激活和溶酶体生物发生的方法以及用于其的组合物
US12590063B2 (en) * 2020-09-07 2026-03-31 Sumitomo Pharma Co., Ltd. Phenol derivative
US20240254083A1 (en) * 2021-05-12 2024-08-01 Libra Therapeutics, Inc. Heterocyclic trpml1 agonists and uses thereof
KR20250048243A (ko) * 2022-07-07 2025-04-08 리브라 테라퓨틱스, 인크. 옥사졸 trpml1 작용제 및 이의 용도
CN117659017A (zh) * 2022-08-25 2024-03-08 北京华益健康药物研究中心 Trpml1/2调节剂化合物、药物组合物及其制备方法和应用
TW202535364A (zh) * 2024-01-08 2025-09-16 美商利布拉醫療公司 噻唑trpml1促效劑及其用途

Family Cites Families (17)

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JPS62291656A (ja) * 1986-06-10 1987-12-18 Konica Corp 色素画像の安定性が改良されたハロゲン化銀写真感光材料
AUPO395396A0 (en) * 1996-12-02 1997-01-02 Fujisawa Pharmaceutical Co., Ltd. Benzamide derivatives
JP2002179651A (ja) * 1998-06-19 2002-06-26 Wakamoto Pharmaceut Co Ltd ベンズアニリド誘導体及び医薬組成物
ES2247298T3 (es) * 2001-01-23 2006-03-01 Eli Lilly And Company Derivados de piperazina y piperidina como agonistas del receptor de melanocortina.
MXPA04004981A (es) * 2001-11-30 2004-08-11 Hoffmann La Roche Derivados de piperazina para uso como antagonistas del receptor ccr-3 en tratamiento de asma.
US6977265B2 (en) * 2001-11-30 2005-12-20 Roche Palo Alto Llc Piperidine CCR-3 receptor antagonists
US20040204422A1 (en) * 2003-04-14 2004-10-14 Abbott Gmbh & Co. Kg. N-[(Piperazinyl)hetaryl]arylsulfonamide compounds
GB0412072D0 (en) * 2004-05-28 2004-06-30 Syngenta Participations Ag Chemical compounds
ZA200709817B (en) * 2005-04-21 2009-02-25 Serono Lab 2,3 substituted pyrazine sulfonmides as inhibitors of CRTH2
JP2009534380A (ja) * 2006-04-20 2009-09-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ｃ−ｆｍｓキナーゼインヒビター
US8080541B2 (en) * 2009-08-27 2011-12-20 Hoffman-La Roche Inc. Carbocyclic GlyT-1 receptor antagonists
US8987307B2 (en) * 2011-03-03 2015-03-24 Hoffmann-La Roche Inc. 3-amino-pyridines as GPBAR1 agonists
CN105753814A (zh) * 2015-01-01 2016-07-13 成都贝斯凯瑞生物科技有限公司 取代氮杂环衍生物及其应用
US10851084B2 (en) 2016-06-29 2020-12-01 Lysoway Therapeutics, Inc. Piperazine derivatives as TRPML modulators
WO2019063996A1 (en) * 2017-09-27 2019-04-04 Exonate Limited INHIBITORS OF SRPK1
WO2019201283A1 (en) * 2018-04-20 2019-10-24 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
WO2021041866A1 (en) * 2019-08-30 2021-03-04 The Regents Of The University Of Michigan Small molecule agonists of mucolipin 1 and uses thereof

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