HRP20120091T1 - Epoksi spoj i postupak za njegovu proizvodnju - Google Patents
Epoksi spoj i postupak za njegovu proizvodnju Download PDFInfo
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- HRP20120091T1 HRP20120091T1 HR20120091T HRP20120091T HRP20120091T1 HR P20120091 T1 HRP20120091 T1 HR P20120091T1 HR 20120091 T HR20120091 T HR 20120091T HR P20120091 T HRP20120091 T HR P20120091T HR P20120091 T1 HRP20120091 T1 HR P20120091T1
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- Prior art keywords
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- phenyl
- lower alkyl
- halogen
- substituted lower
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- 150000001875 compounds Chemical class 0.000 title claims abstract 9
- 239000004593 Epoxy Substances 0.000 title claims abstract 6
- 238000004519 manufacturing process Methods 0.000 title claims 3
- 238000000034 method Methods 0.000 title claims 3
- 125000000217 alkyl group Chemical group 0.000 claims abstract 46
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 39
- 125000001424 substituent group Chemical group 0.000 claims abstract 28
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 10
- 150000003839 salts Chemical class 0.000 claims abstract 9
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 6
- 229910052736 halogen Inorganic materials 0.000 claims abstract 6
- 150000002367 halogens Chemical class 0.000 claims abstract 5
- -1 piperazyl group Chemical group 0.000 claims abstract 5
- 125000003277 amino group Chemical group 0.000 claims abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims abstract 4
- 125000003386 piperidinyl group Chemical group 0.000 claims abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- WPVZKVNCGYZPAQ-FQEVSTJZSA-N 1-(4-chlorophenyl)-4-[4-[[(2r)-2-methyloxiran-2-yl]methoxy]phenyl]piperazine Chemical compound C=1C=C(N2CCN(CC2)C=2C=CC(Cl)=CC=2)C=CC=1OC[C@@]1(C)CO1 WPVZKVNCGYZPAQ-FQEVSTJZSA-N 0.000 claims 1
- IGFBGNHNWFKBRS-IBGZPJMESA-N 1-(4-chlorophenyl)-4-[4-[[(2r)-oxiran-2-yl]methoxy]phenyl]piperazine Chemical compound C1=CC(Cl)=CC=C1N1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 IGFBGNHNWFKBRS-IBGZPJMESA-N 0.000 claims 1
- VROZDUDKUZGDFC-QHCPKHFHSA-N 1-[4-[[(2R)-2-methyloxiran-2-yl]methoxy]phenyl]-4-[3-[4-(trifluoromethoxy)phenyl]prop-2-enyl]piperazine Chemical compound C=1C=C(N2CCN(CC=CC=3C=CC(OC(F)(F)F)=CC=3)CC2)C=CC=1OC[C@@]1(C)CO1 VROZDUDKUZGDFC-QHCPKHFHSA-N 0.000 claims 1
- JPXTYHMPPOZFFB-QFIPXVFZSA-N 1-[4-[[(2R)-oxiran-2-yl]methoxy]phenyl]-4-[3-[4-(trifluoromethoxy)phenyl]prop-2-enyl]piperazine Chemical compound C1=CC(OC(F)(F)F)=CC=C1C=CCN1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 JPXTYHMPPOZFFB-QFIPXVFZSA-N 0.000 claims 1
- GSWKAUPDNWHGDX-NRFANRHFSA-N 1-[4-[[(2r)-2-methyloxiran-2-yl]methoxy]phenyl]-4-[4-(trifluoromethoxy)phenoxy]piperidine Chemical compound C=1C=C(N2CCC(CC2)OC=2C=CC(OC(F)(F)F)=CC=2)C=CC=1OC[C@@]1(C)CO1 GSWKAUPDNWHGDX-NRFANRHFSA-N 0.000 claims 1
- PVGHVBZCRXTUEE-QFIPXVFZSA-N 1-[4-[[(2r)-2-methyloxiran-2-yl]methoxy]phenyl]-4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidine Chemical compound C=1C=C(N2CCC(CC2)OCC=2C=CC(OC(F)(F)F)=CC=2)C=CC=1OC[C@@]1(C)CO1 PVGHVBZCRXTUEE-QFIPXVFZSA-N 0.000 claims 1
- PDWDJZNJOXCSCC-QFIPXVFZSA-N 1-[4-[[(2r)-2-methyloxiran-2-yl]methoxy]phenyl]-4-[[4-(trifluoromethoxy)phenyl]methyl]piperidine Chemical compound C=1C=C(N2CCC(CC=3C=CC(OC(F)(F)F)=CC=3)CC2)C=CC=1OC[C@@]1(C)CO1 PDWDJZNJOXCSCC-QFIPXVFZSA-N 0.000 claims 1
- ZBCHTXWIWJNCIA-QFIPXVFZSA-N 1-[4-[[(2r)-2-methyloxiran-2-yl]methoxy]phenyl]-4-[[4-(trifluoromethyl)phenoxy]methyl]piperidine Chemical compound C=1C=C(N2CCC(COC=3C=CC(=CC=3)C(F)(F)F)CC2)C=CC=1OC[C@@]1(C)CO1 ZBCHTXWIWJNCIA-QFIPXVFZSA-N 0.000 claims 1
- UFSOFSKPBYRGID-FQEVSTJZSA-N 1-[4-[[(2r)-oxiran-2-yl]methoxy]phenyl]-4-[4-(trifluoromethoxy)phenoxy]piperidine Chemical compound C1=CC(OC(F)(F)F)=CC=C1OC1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 UFSOFSKPBYRGID-FQEVSTJZSA-N 0.000 claims 1
- QADQISDMQZKVIY-NRFANRHFSA-N 1-[4-[[(2r)-oxiran-2-yl]methoxy]phenyl]-4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidine Chemical compound C1=CC(OC(F)(F)F)=CC=C1COC1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 QADQISDMQZKVIY-NRFANRHFSA-N 0.000 claims 1
- NVBADBIVWJJSRI-NRFANRHFSA-N 1-[4-[[(2r)-oxiran-2-yl]methoxy]phenyl]-4-[[4-(trifluoromethoxy)phenyl]methyl]piperidine Chemical compound C1=CC(OC(F)(F)F)=CC=C1CC1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 NVBADBIVWJJSRI-NRFANRHFSA-N 0.000 claims 1
- PNOUQWXAUPCBJQ-NRFANRHFSA-N 1-[4-[[(2r)-oxiran-2-yl]methoxy]phenyl]-4-[[4-(trifluoromethyl)phenoxy]methyl]piperidine Chemical compound C1=CC(C(F)(F)F)=CC=C1OCC1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 PNOUQWXAUPCBJQ-NRFANRHFSA-N 0.000 claims 1
- LSWCZCBNHGSJFW-QHCPKHFHSA-N 4-[(4-chlorophenyl)methoxymethyl]-1-[4-[[(2r)-2-methyloxiran-2-yl]methoxy]phenyl]piperidine Chemical compound C=1C=C(N2CCC(COCC=3C=CC(Cl)=CC=3)CC2)C=CC=1OC[C@@]1(C)CO1 LSWCZCBNHGSJFW-QHCPKHFHSA-N 0.000 claims 1
- AEVBBWAFVMGCMP-QFIPXVFZSA-N 4-[(4-chlorophenyl)methoxymethyl]-1-[4-[[(2r)-oxiran-2-yl]methoxy]phenyl]piperidine Chemical compound C1=CC(Cl)=CC=C1COCC1CCN(C=2C=CC(OC[C@@H]3OC3)=CC=2)CC1 AEVBBWAFVMGCMP-QFIPXVFZSA-N 0.000 claims 1
- LWMPFIOTEAXAGV-UHFFFAOYSA-N piperidin-1-amine Chemical compound NN1CCCCC1 LWMPFIOTEAXAGV-UHFFFAOYSA-N 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oncology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Epoksi spoj ili njegova sol, prikazan općom formulom (2): naznačen time, da R1 predstavlja vodik ili skupinu niži alkil; R2 predstavlja piperidinilnu skupinu prikazanu općom formulom (A1): (u kojoj R3 predstavlja: (A1a) fenoksi skupinu s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini, (A1b) fenoksi-supstituiranu skupinu niži alkil s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini, (A1c) fenil-supstituiranu skupinu niži alkoksi niži alkil s halogenom (halogenima) kao supstituentom (supstituentima) na fenilnoj skupini, (A1d) fenil-supstituiranu skupinu niži alkil s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini, (A1e) amino skupinu koja ima fenilnu skupinu s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini, te skupinu niži alkil, ili (A1f) fenil-supstituiranu skupinu niži alkoksi s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini), ili piperazilnu skupinu prikazanu općom formulom (A2): (u kojoj R4 predstavlja: (A2a) fenil-supstituiranu skupinu niži alkenil s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini, ili (A2b) halogen-supstituiranu fenilnu skupinu); a n predstavlja cijeli broj od 1 do 6. Odrednica niži označava skupinu s 1 do 6 atoma ugljika u slučaju alkilne ili alkoksi skupine te skupinu s 2 do 6 atoma ugljika u slučaju alkenilne skupine. Patent sadrži još 3 patentna zahtjeva.
Claims (4)
1. Epoksi spoj ili njegova sol, prikazan općom formulom (2):
[image]
naznačen time, da
R1 predstavlja vodik ili skupinu niži alkil;
R2 predstavlja piperidinilnu skupinu prikazanu općom formulom (A1):
[image]
(u kojoj R3 predstavlja:
(A1a) fenoksi skupinu s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini,
(A1b) fenoksi-supstituiranu skupinu niži alkil s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini,
(A1c) fenil-supstituiranu skupinu niži alkoksi niži alkil s halogenom (halogenima) kao supstituentom (supstituentima) na fenilnoj skupini,
(A1d) fenil-supstituiranu skupinu niži alkil s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini,
(A1e) amino skupinu koja ima fenilnu skupinu s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini, te skupinu niži alkil, ili
(A1f) fenil-supstituiranu skupinu niži alkoksi s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini), ili piperazilnu skupinu prikazanu općom formulom (A2):
[image]
(u kojoj R4 predstavlja:
(A2a) fenil-supstituiranu skupinu niži alkenil s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini, ili
(A2b) halogen-supstituiranu fenilnu skupinu); a n predstavlja cijeli broj od 1 do 6. Odrednica niži označava skupinu s 1 do 6 atoma ugljika u slučaju alkilne ili alkoksi skupine te skupinu s 2 do 6 atoma ugljika u slučaju alkenilne skupine.
2. Epoksi spoj ili njegove soli u skladu s patentnim zahtjevom 1, naznačen time, da je odabran iz skupine koju čine:
1) (R)-1-[4-(2,3-epoksi-2-metilpropoksi)fenil]-4-(4-trifluormetoksifenoksi)piperidin;
2) (R)-1-[4-(2,3-epoksipropoksi)fenil]-4-(4-trifluormetoksifenoksi)piperidin;
3) (R)-1-[4-(2,3-epoksi-2-metilpropoksi)fenil]-4-(4-trifluormetilfenoksimetil)piperidin;
4) (R)-1-[4-(2,3-epoksipropoksi)fenil]-4-(4-trifluormetilfenoksimetil)piperidin;
5) (R)-1-[4-(2,3-epoksi-2-metilpropoksi)fenil]-4-[3-(4-trifluormetoksifenil)-2-propenil]piperazin;
6) (R)-1-[4-(2,3-epoksipropoksi) fenil]-4-[3-(4-trifluormetoksifenil)-2-propenil]piperazin;
7) (R)-4-(4-klorbenziloksimetil)-1-[4-(2,3-epoksi-2-metilpropoksi)fenil]piperidin;
8) (R)-4-(4-klorbenziloksimetil)-1-[4-(2,3-epoksipropoksi)fenil]piperidin;
9) (R)-1-[4-(2,3-epoksi-2-metilpropoksi)fenil]-4-(4-trifluormetoksibenzil)piperidin;
10) (R)-1-[4-(2,3-epoksipropoksi)fenil]-4-(4-trifluormetoksibenzil)piperidin;
11) (R)-1-[4-(2,3-epoksi-2-metilpropoksi)fenil]-4-[N-metil-N-(4-trifluormetoksifenil)]aminopiperidin;
12) (R)-4-[N-metil-N-(4-trifluormetoksifenil)]amino-1-[4-(2,3-epoksipropoksi)fenil]piperidin;
13) (R)-1-(4-klorfenil)-4-[4-(2,3-epoksi-2-metilpropoksi) fenil] piperazin;
14) (R)-1-(4-klorfenil)-4-[4-(2,3-epoksipropoksi)fenil]piperazin;
15) (R)-1-[4-(2,3-epoksi-2-metilpropoksi)fenil]-4-(4-trifluormetoksibenziloksi)piperidin; i
16) (R)-1-(4-(oksiranilmetoksi)fenil)-4-(4-(trifluormetoksi) benziloksi) piperidin.
3. Postupak za proizvodnju epoksi spoja ili njegove soli, prikazanog općom formulom (2):
[image]
u kojem su R1, R2 i n definirani jednako kao u nastavku, naznačen time, da se odvija reakcijom spoja ili njegove soli, prikazanog općom formulom (3):
[image]
u kojoj
R1 predstavlja vodik ili skupinu niži alkil; n predstavlja cijeli broj od 1 do 6; i
X2 predstavlja halogen ili skupinu koja uzrokuje reakciju supstitucije poput halogena, sa spojem ili njegovom soli, prikazanim općom formulom (4):
[image]
u kojoj R2 predstavlja piperidinilnu skupinu prikazanu općom formulom (A1):
[image]
(u kojoj R3 predstavlja:
(A1a) fenoksi skupinu s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini,
(A1b) fenoksi-supstituiranu skupinu niži alkil s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini,
(A1c) fenil-supstituiranu skupinu niži alkoksi niži alkil s halogenom (halogenima) kao supstituentom (supstituentima) na fenilnoj skupini,
(A1d) fenil-supstituiranu skupinu niži alkil s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini,
(A1e) amino skupinu koja ima fenilnu skupinu s fenilnom skupinom s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini, te skupinu niži alkil, ili
(A1f) fenil-supstituiranu skupinu niži alkoksi s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini), ili piperazilnu skupinu prikazanu općom formulom (A2):
[image]
(u kojoj R4 predstavlja:
(A2a) fenil-supstituiranu skupinu niži alkenil s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini, ili
(A2b) halogen-supstituiranu fenilnu skupinu).
4. Postupak za proizvodnju oksazolnog spoja ili njegove soli prikazanog općom formulom (1):
[image]
u kojem su R1, R2 i n definirani jednako kao u nastavku, naznačen time, da se odvija reakcijom spoja ili njegove soli, prikazanog općom formulom (5):
[image]
u kojoj X1 predstavlja atom halogena, s epoksi spojem ili njegovom soli, prikazanim općom formulom (2):
[image]
u kojoj R1 predstavlja vodik ili skupinu niži alkil; R2 predstavlja piperidinilnu skupinu prikazanu općom formulom (A1):
[image]
(u kojoj R3 predstavlja:
(A1a) fenoksi skupinu s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (supstituentima) na fenilnoj skupini,
(A1b) fenoksi-supstituiranu skupinu niži alkil s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (s) na fenilnoj skupini,
(A1c) fenil-supstituiranu skupinu niži alkoksi niži alkil s halogenom (halogenima) kao supstituentom (supstituentima) na fenilnoj skupini,
(A1d) fenil-supstituiranu skupinu niži alkil s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (s) na fenilnoj skupini,
(A1e) amino skupinu koja ima fenilnu skupinu s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (s) na fenilnoj skupini, te skupinu niži alkil, ili
(A1f) fenil-supstituiranu skupinu niži alkoksi s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (s) na fenilnoj skupini), ili piperazilnu skupinu prikazanu općom formulom (A2):
[image]
(u kojoj R4 predstavlja:
(A2a) fenil-supstituiranu skupinu niži alkenil s halogen-supstituiranom skupinom (skupinama) niži alkil kao supstituentom (s) na fenilnoj skupini, ili
(A2b) halogen-supstituiranu fenilnu skupinu); a
n predstavlja cijeli broj od 1 do 6.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2007123097 | 2007-05-08 | ||
| PCT/JP2008/058798 WO2008140090A1 (en) | 2007-05-08 | 2008-05-07 | Epoxy compound and method for manufacturing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20120091T1 true HRP20120091T1 (hr) | 2012-02-29 |
Family
ID=39683776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20120091T HRP20120091T1 (hr) | 2007-05-08 | 2012-01-26 | Epoksi spoj i postupak za njegovu proizvodnju |
Country Status (27)
| Country | Link |
|---|---|
| US (2) | US8344148B2 (hr) |
| EP (1) | EP2144899B1 (hr) |
| JP (1) | JP4971343B2 (hr) |
| KR (1) | KR101191072B1 (hr) |
| CN (1) | CN101675044B (hr) |
| AR (1) | AR070301A1 (hr) |
| AT (1) | ATE536352T1 (hr) |
| AU (1) | AU2008250097B2 (hr) |
| BR (1) | BRPI0810780A2 (hr) |
| CA (1) | CA2686092C (hr) |
| CO (1) | CO6260137A2 (hr) |
| CY (1) | CY1112279T1 (hr) |
| DK (1) | DK2144899T3 (hr) |
| ES (1) | ES2375245T3 (hr) |
| HK (1) | HK1137023A1 (hr) |
| HR (1) | HRP20120091T1 (hr) |
| IL (1) | IL201976A (hr) |
| MX (1) | MX2009011888A (hr) |
| MY (1) | MY149301A (hr) |
| NZ (1) | NZ580918A (hr) |
| PL (1) | PL2144899T3 (hr) |
| PT (1) | PT2144899E (hr) |
| RU (1) | RU2459822C2 (hr) |
| SI (1) | SI2144899T1 (hr) |
| TW (1) | TWI432428B (hr) |
| UA (1) | UA99455C2 (hr) |
| WO (1) | WO2008140090A1 (hr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102008053240A1 (de) | 2008-10-25 | 2010-04-29 | Saltigo Gmbh | Herstellung von (N-Heterozyklyl)-Arylethern |
| TW201200523A (en) * | 2010-01-29 | 2012-01-01 | Otsuka Pharma Co Ltd | Synthetic intermediate of oxazole compound and method for producing the same |
| WO2015068712A1 (ja) * | 2013-11-05 | 2015-05-14 | 公立大学法人横浜市立大学 | 超弾性材料、ならびに当該超弾性材料を用いた、エネルギー貯蔵材料、エネルギー吸収材料、弾性材料、アクチュエータおよび形状記憶材料 |
| CR20160405A (es) | 2014-03-17 | 2016-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
| EP3252059A4 (en) | 2015-01-29 | 2018-07-11 | Medshine Discovery Inc. | Anti-pulmonary tuberculosis nitroimidazole derivative |
| LT3275862T (lt) * | 2015-03-27 | 2020-09-25 | Otsuka Pharmaceutical Co., Ltd. | 1-(4-hidroksifenil)-4-(4-trifluormetoksifenoksi)piperidino arba jo druskos gamybos būdas |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES512316A0 (es) * | 1982-05-19 | 1983-02-01 | Romikim S A | Procedimiento de preparacion de la cis-1-acetil-4 4-4-(2,4-diclorofenil)-2-(1h-imidazol-1-ilmetil)-1,3-dioxolano-4-ilmetoxi-fenil piperacina. |
| AU1057401A (en) * | 1999-11-11 | 2001-06-06 | Senju Pharmaceutical Co., Ltd. | Pancreatitis remedies |
| AR041198A1 (es) * | 2002-10-11 | 2005-05-04 | Otsuka Pharma Co Ltd | Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen |
| EP2644599B1 (en) * | 2002-10-15 | 2014-12-10 | Otsuka Pharmaceutical Co., Ltd. | Method for preparing a 2-halo-4-nitroimidazole compound |
| KR100851802B1 (ko) * | 2003-10-31 | 2008-08-13 | 오쓰까 세이야꾸 가부시키가이샤 | 결핵의 치료를 위한2,3-디히드로-6-니트로이미다조[2,1-ｂ]옥사졸 화합물 |
| JP4787529B2 (ja) * | 2004-04-09 | 2011-10-05 | 大塚製薬株式会社 | 医薬組成物 |
| JP2009269859A (ja) * | 2008-05-08 | 2009-11-19 | Otsuka Pharmaceut Co Ltd | Ｎ−含有複素環化合物 |
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- 2008-05-07 JP JP2008536669A patent/JP4971343B2/ja active Active
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- 2008-05-07 CA CA2686092A patent/CA2686092C/en not_active Expired - Fee Related
- 2008-05-07 TW TW097116853A patent/TWI432428B/zh not_active IP Right Cessation
- 2008-05-07 AT AT08764285T patent/ATE536352T1/de active
- 2008-05-07 WO PCT/JP2008/058798 patent/WO2008140090A1/en active Application Filing
- 2008-05-07 DK DK08764285.6T patent/DK2144899T3/da active
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