CO6260137A2 - Compuesto de epoxi y metodo para fabricar el mismo - Google Patents

Compuesto de epoxi y metodo para fabricar el mismo

Info

Publication number
CO6260137A2
CO6260137A2 CO09122664A CO09122664A CO6260137A2 CO 6260137 A2 CO6260137 A2 CO 6260137A2 CO 09122664 A CO09122664 A CO 09122664A CO 09122664 A CO09122664 A CO 09122664A CO 6260137 A2 CO6260137 A2 CO 6260137A2
Authority
CO
Colombia
Prior art keywords
epoxy compound
manufacturing
manufacture
group
same
Prior art date
Application number
CO09122664A
Other languages
English (en)
Inventor
Hidestsugu Tsubouchi
Yoshikazu Haraguchi
Satoshi Hayakawa
Naoto Utsumi
Shinichi Taira
Yoshihisa Tanada
Nobuhisa Fujita
Kimiyoshi Annaka
Takuya Furuta
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of CO6260137A2 publication Critical patent/CO6260137A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención proporciona un producto intermedio novedoso para la fabricación de un compuesto de 2,3-dihidroimidazo[2,1-b]oxazol con un rendimiento alto y una pureza alta y un método de fabricación del producto intermedio. La presente invención proporciona un compuesto de epoxi representado por la fórmula general (2): en donde, R1 representa hidrógeno o un grupo alquilo inferior; y R2 representa un grupo piperidilo simbolizado por la fórmula general (A1) (en donde R3 representa un grupo fenoxi que tiene un grupo alcoxi inferior sustituido por halógeno sustituido en un grupo fenilo y similares) y similares; y n representa un número entero de 1 a 6, un método de fabricación del compuesto de epoxi y un método de fabricación de un compuesto de oxazol utilizando el compuesto de epoxi.
CO09122664A 2007-05-08 2009-10-30 Compuesto de epoxi y metodo para fabricar el mismo CO6260137A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2007123097 2007-05-08

Publications (1)

Publication Number Publication Date
CO6260137A2 true CO6260137A2 (es) 2011-03-22

Family

ID=39683776

Family Applications (1)

Application Number Title Priority Date Filing Date
CO09122664A CO6260137A2 (es) 2007-05-08 2009-10-30 Compuesto de epoxi y metodo para fabricar el mismo

Country Status (27)

Country Link
US (2) US8344148B2 (es)
EP (1) EP2144899B1 (es)
JP (1) JP4971343B2 (es)
KR (1) KR101191072B1 (es)
CN (1) CN101675044B (es)
AR (1) AR070301A1 (es)
AT (1) ATE536352T1 (es)
AU (1) AU2008250097B2 (es)
BR (1) BRPI0810780A2 (es)
CA (1) CA2686092C (es)
CO (1) CO6260137A2 (es)
CY (1) CY1112279T1 (es)
DK (1) DK2144899T3 (es)
ES (1) ES2375245T3 (es)
HK (1) HK1137023A1 (es)
HR (1) HRP20120091T1 (es)
IL (1) IL201976A (es)
MX (1) MX2009011888A (es)
MY (1) MY149301A (es)
NZ (1) NZ580918A (es)
PL (1) PL2144899T3 (es)
PT (1) PT2144899E (es)
RU (1) RU2459822C2 (es)
SI (1) SI2144899T1 (es)
TW (1) TWI432428B (es)
UA (1) UA99455C2 (es)
WO (1) WO2008140090A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102008053240A1 (de) 2008-10-25 2010-04-29 Saltigo Gmbh Herstellung von (N-Heterozyklyl)-Arylethern
TW201200523A (en) 2010-01-29 2012-01-01 Otsuka Pharma Co Ltd Synthetic intermediate of oxazole compound and method for producing the same
EP3067342A4 (en) * 2013-11-05 2017-07-12 Yokohama City University Superelastic material and energy storage material, energy absorption material, elastic material, actuator, and shape memory material that use said superelastic material
DK3119757T3 (en) 2014-03-17 2018-06-18 Pfizer DIACYLGYLERIC-ACYL TRANSFERASE-2 INHIBITORS TO USE IN THE TREATMENT OF METABOLIC AND RELATED DISEASES
BR112017015744A2 (pt) 2015-01-29 2018-03-13 Medshine Discovery Inc composto apresentando uma estrutura de fórmula (i), um sal farmaceuticamente aceitável do mesmo ou um isômero ótico do mesmo, composição farmacêutica e uso do composto de fórmula (i) para o tratamento e prevenção de mycobacterium tuberculosis ou outras infecções microbianas
EP3275862B1 (en) * 2015-03-27 2020-08-12 Otsuka Pharmaceutical Co., Ltd. Method for producing 1-(4-hydroxyphenyl)-4-(4-trifluoromethoxyphenoxy)piperidine or salt thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES512316A0 (es) * 1982-05-19 1983-02-01 Romikim S A Procedimiento de preparacion de la cis-1-acetil-4 4-4-(2,4-diclorofenil)-2-(1h-imidazol-1-ilmetil)-1,3-dioxolano-4-ilmetoxi-fenil piperacina.
AU1057401A (en) * 1999-11-11 2001-06-06 Senju Pharmaceutical Co., Ltd. Pancreatitis remedies
TWI347946B (en) * 2002-10-11 2011-09-01 Otsuka Pharma Co Ltd 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound
AR041605A1 (es) 2002-10-15 2005-05-26 Otsuka Pharma Co Ltd Compuesto 1- sustituido-4-nitroimidazol y metodo para preparar el mismo
ES2314460T3 (es) 2003-10-31 2009-03-16 Otsuka Pharmaceutical Co., Ltd. Compuestos de 2,3-dihidro-6-nitroimidazo (2,1-b)oxazol para el tratamiento de la tuberculosis.
JP4787529B2 (ja) * 2004-04-09 2011-10-05 大塚製薬株式会社 医薬組成物
JP2009269859A (ja) * 2008-05-08 2009-11-19 Otsuka Pharmaceut Co Ltd Ｎ−含有複素環化合物

Also Published As

Publication number Publication date
MX2009011888A (es) 2009-11-18
MY149301A (en) 2013-08-30
US20130072683A1 (en) 2013-03-21
US8552188B2 (en) 2013-10-08
CY1112279T1 (el) 2015-12-09
TWI432428B (zh) 2014-04-01
BRPI0810780A2 (pt) 2014-10-29
WO2008140090A1 (en) 2008-11-20
JP4971343B2 (ja) 2012-07-11
AU2008250097B2 (en) 2011-07-14
AR070301A1 (es) 2010-03-31
NZ580918A (en) 2011-09-30
IL201976A0 (en) 2010-06-16
CN101675044A (zh) 2010-03-17
ES2375245T3 (es) 2012-02-28
HRP20120091T1 (hr) 2012-02-29
EP2144899B1 (en) 2011-12-07
US20100217005A1 (en) 2010-08-26
CN101675044B (zh) 2012-10-03
IL201976A (en) 2015-05-31
TW200911793A (en) 2009-03-16
DK2144899T3 (da) 2012-02-13
ATE536352T1 (de) 2011-12-15
PL2144899T3 (pl) 2012-04-30
KR20090010943A (ko) 2009-01-30
EP2144899A1 (en) 2010-01-20
RU2009145273A (ru) 2011-06-20
RU2459822C2 (ru) 2012-08-27
KR101191072B1 (ko) 2012-10-15
SI2144899T1 (sl) 2012-03-30
PT2144899E (pt) 2011-12-27
CA2686092C (en) 2015-04-28
UA99455C2 (ru) 2012-08-27
AU2008250097A1 (en) 2008-11-20
HK1137023A1 (en) 2010-07-16
US8344148B2 (en) 2013-01-01
CA2686092A1 (en) 2008-11-20
JP2009534291A (ja) 2009-09-24

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