AR069700A1 - Derivados de azetidina,composiciones farmaceuticas que los comprenden, metodo de preparacion, intermediarios de sintesis,y usos de los mismos en el tratamiento o prevencion de trastornos psiquiatricos , del sistema inmune y gastrointestinales, entre otros. - Google Patents

Derivados de azetidina,composiciones farmaceuticas que los comprenden, metodo de preparacion, intermediarios de sintesis,y usos de los mismos en el tratamiento o prevencion de trastornos psiquiatricos , del sistema inmune y gastrointestinales, entre otros.

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Publication number
AR069700A1
AR069700A1 ARP080105459A ARP080105459A AR069700A1 AR 069700 A1 AR069700 A1 AR 069700A1 AR P080105459 A ARP080105459 A AR P080105459A AR P080105459 A ARP080105459 A AR P080105459A AR 069700 A1 AR069700 A1 AR 069700A1
Authority
AR
Argentina
Prior art keywords
alkyl group
group
haloalkyl
alkyl
hydrogen atom
Prior art date
Application number
ARP080105459A
Other languages
English (en)
Inventor
Jean-Francois Sabuco
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40935338&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR069700(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from FR0708830A external-priority patent/FR2925051B1/fr
Priority claimed from FR0802492A external-priority patent/FR2930941B1/fr
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of AR069700A1 publication Critical patent/AR069700A1/es

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    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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Abstract

Procedimiento de preparacion e intermediarios de síntesis. Reivindicacion 1: Compuesto de formula (1) en la que: R representa un grupo alquilo C1-6, haloalquilo C1-6; R' representa un grupo NR4R5, OR8; A y B, si están presentes, representan independientemente uno del otro, uno o dos átomos de carbono, estando estos átomos de carbono sustituidos con uno o varios hidrogenos, grupos alquilo C1-6; estando el o los grupos alquilo C1-6 opcionalmente sustituidos con uno o varios grupos hidroxi, alcoxi C1-6, haloalquilo C1-6, alquilo C1-6S(O)p, NR4R5, CONR4R5; A+B representan como máximo dos carbonos; R1 representa un átomo de hidrogeno o un grupo alquilo C1-6; R2 y R3 representan, independientemente entre sí, un átomo de hidrogeno, un grupo alquilo C1-6; estando el grupo alquilo C1-6 opcionalmente sustituido con uno o varios grupos hidroxi, alcoxi C1-6, haloalquilo C1-6, alquilo C1-6S(O)p, NR4R5, CONR4R5; R4 y R5 representan independientemente el uno del otro, un átomo de hidrogeno, un grupo alquilo C1-6, o forman juntos, con el átomo de nitrogeno al que están unidos, un heterociclo de tipo azetidina, pirrolidina, piperidina, azepán, piperacina, homopiperacina, morfolina, tiomorfolina, tiomorfolina S-oxido, tiomorfolina S-dioxido, estando este heterociclo sustituido opcionalmente con un grupo alquilo C1-6; R6 y R7 representan cada uno un grupo fenilo, sustituido opcionalmente con uno o varios átomos o grupos elegidos entre un átomo de hidrogeno, un halogeno, un grupo alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6 o ciano; Y representa un átomo de hidrogeno, un halogeno, un grupo alquilo C1-6, haloalquilo C1-6, alcoxi C1-6, haloalcoxi C1-6, alquilo C1-6S(O)p o ciano; R8 representa un átomo de hidrogeno, un grupo alquilo C1-6, un grupo haloalquilo C1-6, un grupo alilo, un grupo fenilalquilo C1-6, estando el grupo fenilo sustituido opcionalmente con 1 o 2 grupos O-metilo; p representa un numero entero elegido entre 0, 1 o 2 en el estado de base o de sal de adicion a un ácido o a una base.
ARP080105459A 2007-12-18 2008-12-16 Derivados de azetidina,composiciones farmaceuticas que los comprenden, metodo de preparacion, intermediarios de sintesis,y usos de los mismos en el tratamiento o prevencion de trastornos psiquiatricos , del sistema inmune y gastrointestinales, entre otros. AR069700A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0708830A FR2925051B1 (fr) 2007-12-18 2007-12-18 Derives d'azetidines,leur preparation et leur application en therapeutique
FR0802492A FR2930941B1 (fr) 2008-05-06 2008-05-06 Derives d'azetidines, leur preparation et leur application en therapeutique

Publications (1)

Publication Number Publication Date
AR069700A1 true AR069700A1 (es) 2010-02-10

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ARP080105459A AR069700A1 (es) 2007-12-18 2008-12-16 Derivados de azetidina,composiciones farmaceuticas que los comprenden, metodo de preparacion, intermediarios de sintesis,y usos de los mismos en el tratamiento o prevencion de trastornos psiquiatricos , del sistema inmune y gastrointestinales, entre otros.

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US (2) US8445478B2 (es)
EP (1) EP2234966B1 (es)
JP (1) JP5460614B2 (es)
KR (1) KR20100098563A (es)
CN (1) CN101945852B (es)
AR (1) AR069700A1 (es)
AU (1) AU2008351943B2 (es)
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SI (1) SI2234966T1 (es)
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UA103319C2 (en) 2008-05-06 2013-10-10 Глаксосмитклайн Ллк Thiazole- and oxazole-benzene sulfonamide compounds
FR2946650B1 (fr) * 2009-06-16 2011-08-19 Sanofi Aventis Esters derives d'azetidines, leur preparation et leur application en therapeutique.
US9440948B2 (en) 2010-09-03 2016-09-13 University Of Florida Research Foundation, Inc. Nicotine compounds and analogs thereof, synthetic methods of making compounds, and methods of use
GB201321601D0 (en) * 2013-12-06 2014-01-22 Canbex Therapeutics Ltd Modulator
US11003343B2 (en) * 2014-01-06 2021-05-11 Lett.rs LLC Electronic personal signature generation and distribution for personal communication

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FR2814678B1 (fr) * 2000-10-04 2002-12-20 Aventis Pharma Sa Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite
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EA010583B1 (ru) * 2003-05-01 2008-10-30 Вернэлис Рисёч Лимитед Производные азетидинкарбоксамида и их применение при лечении нарушений, опосредованных св1 рецепторами
PE20071092A1 (es) * 2005-12-08 2007-12-10 Aventis Pharma Inc Composicion farmaceutica que comprende un antagonista de cb1 y un agente antisicotico
CN101437398A (zh) * 2006-03-10 2009-05-20 詹里恩探索公司 用于治疗肥胖症的大麻素受体拮抗剂/反向激动剂

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CN101945852A (zh) 2011-01-12
EA201070758A1 (ru) 2011-02-28
CY1114991T1 (el) 2016-12-14
KR20100098563A (ko) 2010-09-07
MA32019B1 (fr) 2011-01-03
CA2709863A1 (fr) 2009-09-03
AU2008351943A1 (en) 2009-09-03
WO2009106708A2 (fr) 2009-09-03
EA019315B1 (ru) 2014-02-28
BRPI0822054A2 (pt) 2015-06-23
PL2234966T3 (pl) 2014-02-28
DK2234966T3 (da) 2014-01-06
US8445478B2 (en) 2013-05-21
HRP20131168T1 (hr) 2014-01-03
AU2008351943B2 (en) 2013-12-19
EP2234966A2 (fr) 2010-10-06
CO6290755A2 (es) 2011-06-20
CL2008003780A1 (es) 2010-04-09
SI2234966T1 (sl) 2014-01-31
JP5460614B2 (ja) 2014-04-02
PT2234966E (pt) 2013-12-19
ES2439258T3 (es) 2014-01-22
IL206420A0 (en) 2010-12-30
TW200930360A (en) 2009-07-16
CN101945852B (zh) 2014-05-07
US20130237513A1 (en) 2013-09-12
UY31548A1 (es) 2009-08-03
HK1152038A1 (en) 2012-02-17
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PE20091270A1 (es) 2009-09-23
US20110009377A1 (en) 2011-01-13
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PA8808101A1 (es) 2009-07-23
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