MXPA04004981A - Derivados de piperazina para uso como antagonistas del receptor ccr-3 en tratamiento de asma. - Google Patents
Derivados de piperazina para uso como antagonistas del receptor ccr-3 en tratamiento de asma.Info
- Publication number
- MXPA04004981A MXPA04004981A MXPA04004981A MXPA04004981A MXPA04004981A MX PA04004981 A MXPA04004981 A MX PA04004981A MX PA04004981 A MXPA04004981 A MX PA04004981A MX PA04004981 A MXPA04004981 A MX PA04004981A MX PA04004981 A MXPA04004981 A MX PA04004981A
- Authority
- MX
- Mexico
- Prior art keywords
- ccr
- asthma
- treatment
- receptor antagonists
- piperazine derivatives
- Prior art date
Links
- 102000004499 CCR3 Receptors Human genes 0.000 title abstract 2
- 108010017316 CCR3 Receptors Proteins 0.000 title abstract 2
- 208000006673 asthma Diseases 0.000 title abstract 2
- 150000004885 piperazines Chemical class 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title abstract 2
- 102100024167 C-C chemokine receptor type 3 Human genes 0.000 abstract 1
- 101710149862 C-C chemokine receptor type 3 Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
La presente invencion se refiere a derivados de piperazina de Formula (I), ver formula (I), en donde: R1-R4, A, L y X son como definen en la especificacion. Los compuestos son utiles como antagonistas del receptor CCR-3, y por lo tanto, pueden ser utilizados para el tratamiento de enfermedades mediadas por CCR-3 tale como el asma.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33465501P | 2001-11-30 | 2001-11-30 | |
PCT/EP2002/013217 WO2003045393A1 (en) | 2001-11-30 | 2002-11-25 | Piperazine derivatives for use as ccr-3 receptor antagonists in the treatment of asthma |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA04004981A true MXPA04004981A (es) | 2004-08-11 |
Family
ID=23308174
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA04004981A MXPA04004981A (es) | 2001-11-30 | 2002-11-25 | Derivados de piperazina para uso como antagonistas del receptor ccr-3 en tratamiento de asma. |
Country Status (16)
Country | Link |
---|---|
US (1) | US6906073B2 (es) |
EP (1) | EP1453514B1 (es) |
JP (1) | JP2005516903A (es) |
KR (1) | KR100586131B1 (es) |
CN (1) | CN1321115C (es) |
AR (1) | AR037459A1 (es) |
AT (1) | ATE367160T1 (es) |
AU (1) | AU2002352122A1 (es) |
BR (1) | BR0214582A (es) |
CA (1) | CA2467966A1 (es) |
DE (1) | DE60221275T2 (es) |
ES (1) | ES2290346T3 (es) |
MX (1) | MXPA04004981A (es) |
PL (1) | PL370746A1 (es) |
RU (1) | RU2004120063A (es) |
WO (1) | WO2003045393A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2004087685A2 (en) * | 2003-03-31 | 2004-10-14 | Janssen Pharmaceutica N.V. | Phospholipase c inhibitors for use in treating inflammatory disorders |
US7262197B2 (en) * | 2003-03-31 | 2007-08-28 | Janssen Pharmaceutica, N.V | Phospholipase C inhibitors for use in treating inflammatory disorders |
IN2006CH00378A (en) * | 2003-06-30 | 2007-05-11 | Sumitomo Chemical Co | Asymmetric urea compound and process for producing asymmetric compound by asymmetric conjugate addition reaction with the same as catalyst |
EP1748989A2 (en) * | 2004-05-12 | 2007-02-07 | ChemoCentryx Inc | Aryl sulfonamides |
US7517885B2 (en) * | 2005-06-29 | 2009-04-14 | Janssen Pharmaceutica N.V. | Substituted [4-(4-phenyl-piperazin-1-yl)-cyclohexyl]-urea compounds |
EP1948629A1 (en) * | 2005-10-31 | 2008-07-30 | Janssen Pharmaceutica N.V. | Substituted piperazines and piperidines as modulators of the neuropeptide y2 receptor |
US7776877B2 (en) | 2007-06-22 | 2010-08-17 | Chemocentryx, Inc. | N-(2-(hetaryl)aryl) arylsulfonamides and N-(2-(hetaryl) hetaryl arylsulfonamides |
WO2009006185A1 (en) * | 2007-07-03 | 2009-01-08 | Janssen Pharmaceutica, N.V. | Piperazinyl derivatives useful as modulators of the neuropeptide y2 receptor |
CA2735158C (en) * | 2008-08-29 | 2016-11-08 | Treventis Corporation | Compositions and methods of treating amyloid disease |
CN102459210B (zh) * | 2009-04-22 | 2015-09-02 | 埃克希金医药品有限公司 | 芳基磺酰胺ccr3拮抗剂 |
HUE038507T2 (hu) * | 2009-04-22 | 2018-10-29 | Sma Therapeutics Inc | 2,5-diszubsztituált arilszulfonamid CCR3-antagonisták |
MX2019011286A (es) | 2017-03-26 | 2019-12-19 | Takeda Pharmaceuticals Co | Carboxamidas heteroaromaticas sustituidas de piperidinilo y piperazinilo como moduladores de gpr6. |
EP3821947A1 (en) * | 2019-11-13 | 2021-05-19 | Libra Therapeutics, Inc. | Heterocyclic trpml1 agonists |
CN115087440A (zh) * | 2019-12-19 | 2022-09-20 | 卡斯玛治疗公司 | Trpml调节剂 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0592921A (ja) | 1991-05-17 | 1993-04-16 | Yamanouchi Pharmaceut Co Ltd | シクロヘキシルアルキルアミド および 該化合物を有効成分とするタキキニン抑制剤 |
DZ2376A1 (fr) * | 1996-12-19 | 2002-12-28 | Smithkline Beecham Plc | Dérivés de sulfonamides nouveaux procédé pour leurpréparation et compositions pharmaceutiques les c ontenant. |
US6339087B1 (en) * | 1997-08-18 | 2002-01-15 | Syntex (U.S.A.) Llc | Cyclic amine derivatives-CCR-3 receptor antagonists |
IL125658A0 (en) * | 1997-08-18 | 1999-04-11 | Hoffmann La Roche | Ccr-3 receptor antagonists |
CA2306811A1 (en) * | 1997-10-14 | 1999-04-22 | Yoshiyuki Aoki | Piperazine compounds and medicinal use thereof |
JP2002179651A (ja) * | 1998-06-19 | 2002-06-26 | Wakamoto Pharmaceut Co Ltd | ベンズアニリド誘導体及び医薬組成物 |
AU3126700A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
EP1158980B1 (en) | 1998-12-18 | 2005-08-24 | Bristol-Myers Squibb Pharma Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
WO2000035451A1 (en) | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
CN1206219C (zh) | 1998-12-18 | 2005-06-15 | 布里斯托尔-迈尔斯斯奎布药品公司 | 作为趋化因子受体活性调节剂的n-脲基烷基-哌啶化合物 |
AU2482100A (en) | 1998-12-18 | 2000-07-03 | Du Pont Pharmaceuticals Company | N-ureidoalkyl-piperidines as modulators of chemokine receptor activity |
-
2002
- 2002-11-25 WO PCT/EP2002/013217 patent/WO2003045393A1/en active IP Right Grant
- 2002-11-25 PL PL02370746A patent/PL370746A1/xx not_active Application Discontinuation
- 2002-11-25 CN CNB028239695A patent/CN1321115C/zh not_active Expired - Fee Related
- 2002-11-25 RU RU2004120063/04A patent/RU2004120063A/ru not_active Application Discontinuation
- 2002-11-25 BR BR0214582-0A patent/BR0214582A/pt not_active IP Right Cessation
- 2002-11-25 MX MXPA04004981A patent/MXPA04004981A/es not_active Application Discontinuation
- 2002-11-25 EP EP02787795A patent/EP1453514B1/en not_active Expired - Lifetime
- 2002-11-25 KR KR1020047008311A patent/KR100586131B1/ko not_active IP Right Cessation
- 2002-11-25 JP JP2003546895A patent/JP2005516903A/ja active Pending
- 2002-11-25 DE DE60221275T patent/DE60221275T2/de not_active Expired - Fee Related
- 2002-11-25 AU AU2002352122A patent/AU2002352122A1/en not_active Abandoned
- 2002-11-25 AT AT02787795T patent/ATE367160T1/de not_active IP Right Cessation
- 2002-11-25 ES ES02787795T patent/ES2290346T3/es not_active Expired - Lifetime
- 2002-11-25 CA CA002467966A patent/CA2467966A1/en not_active Abandoned
- 2002-11-28 AR ARP020104582A patent/AR037459A1/es not_active Application Discontinuation
- 2002-11-29 US US10/307,159 patent/US6906073B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
DE60221275D1 (de) | 2007-08-30 |
EP1453514B1 (en) | 2007-07-18 |
PL370746A1 (en) | 2005-05-30 |
US20030176441A1 (en) | 2003-09-18 |
ATE367160T1 (de) | 2007-08-15 |
CN1321115C (zh) | 2007-06-13 |
AR037459A1 (es) | 2004-11-10 |
KR20040065570A (ko) | 2004-07-22 |
CN1599611A (zh) | 2005-03-23 |
DE60221275T2 (de) | 2008-05-08 |
EP1453514A1 (en) | 2004-09-08 |
CA2467966A1 (en) | 2003-06-05 |
JP2005516903A (ja) | 2005-06-09 |
AU2002352122A1 (en) | 2003-06-10 |
ES2290346T3 (es) | 2008-02-16 |
KR100586131B1 (ko) | 2006-06-07 |
BR0214582A (pt) | 2004-11-03 |
WO2003045393A1 (en) | 2003-06-05 |
RU2004120063A (ru) | 2005-06-10 |
US6906073B2 (en) | 2005-06-14 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |