JP2024509818A5 - - Google Patents
Info
- Publication number
- JP2024509818A5 JP2024509818A5 JP2023553045A JP2023553045A JP2024509818A5 JP 2024509818 A5 JP2024509818 A5 JP 2024509818A5 JP 2023553045 A JP2023553045 A JP 2023553045A JP 2023553045 A JP2023553045 A JP 2023553045A JP 2024509818 A5 JP2024509818 A5 JP 2024509818A5
- Authority
- JP
- Japan
- Prior art keywords
- section
- compound
- compound according
- item
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025036310A JP7797723B2 (ja) | 2021-03-10 | 2025-03-07 | 哺乳動物ｓｌｃ６ａ１９機能の小分子阻害剤 |
| JP2025088466A JP7731021B1 (ja) | 2021-03-10 | 2025-05-28 | 哺乳動物ｓｌｃ６ａ１９機能の小分子阻害剤 |
| JP2025135673A JP2026000898A (ja) | 2021-03-10 | 2025-08-18 | 哺乳動物ｓｌｃ６ａ１９機能の小分子阻害剤 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163159271P | 2021-03-10 | 2021-03-10 | |
| US63/159,271 | 2021-03-10 | ||
| US202163226551P | 2021-07-28 | 2021-07-28 | |
| US63/226,551 | 2021-07-28 | ||
| US202163234487P | 2021-08-18 | 2021-08-18 | |
| US63/234,487 | 2021-08-18 | ||
| US202163292815P | 2021-12-22 | 2021-12-22 | |
| US63/292,815 | 2021-12-22 | ||
| US202263308790P | 2022-02-10 | 2022-02-10 | |
| US63/308,790 | 2022-02-10 | ||
| PCT/US2022/019513 WO2022192370A1 (en) | 2021-03-10 | 2022-03-09 | Small molecule inhibitors of mammalian slc6a19 function |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025036310A Division JP7797723B2 (ja) | 2021-03-10 | 2025-03-07 | 哺乳動物ｓｌｃ６ａ１９機能の小分子阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2024509818A JP2024509818A (ja) | 2024-03-05 |
| JP2024509818A5 true JP2024509818A5 (https=) | 2025-02-19 |
| JP7649386B2 JP7649386B2 (ja) | 2025-03-19 |
Family
ID=83227044
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023553045A Active JP7649386B2 (ja) | 2021-03-10 | 2022-03-09 | 哺乳動物ｓｌｃ６ａ１９機能の小分子阻害剤 |
| JP2025036310A Active JP7797723B2 (ja) | 2021-03-10 | 2025-03-07 | 哺乳動物ｓｌｃ６ａ１９機能の小分子阻害剤 |
| JP2025088466A Active JP7731021B1 (ja) | 2021-03-10 | 2025-05-28 | 哺乳動物ｓｌｃ６ａ１９機能の小分子阻害剤 |
| JP2025135673A Pending JP2026000898A (ja) | 2021-03-10 | 2025-08-18 | 哺乳動物ｓｌｃ６ａ１９機能の小分子阻害剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025036310A Active JP7797723B2 (ja) | 2021-03-10 | 2025-03-07 | 哺乳動物ｓｌｃ６ａ１９機能の小分子阻害剤 |
| JP2025088466A Active JP7731021B1 (ja) | 2021-03-10 | 2025-05-28 | 哺乳動物ｓｌｃ６ａ１９機能の小分子阻害剤 |
| JP2025135673A Pending JP2026000898A (ja) | 2021-03-10 | 2025-08-18 | 哺乳動物ｓｌｃ６ａ１９機能の小分子阻害剤 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US20240208923A1 (https=) |
| EP (1) | EP4304586A4 (https=) |
| JP (4) | JP7649386B2 (https=) |
| KR (1) | KR20230162935A (https=) |
| AU (1) | AU2022234302A1 (https=) |
| CA (1) | CA3209914A1 (https=) |
| CL (1) | CL2023002581A1 (https=) |
| CO (1) | CO2023013218A2 (https=) |
| CR (1) | CR20230467A (https=) |
| DO (1) | DOP2023000178A (https=) |
| EC (1) | ECSP23075523A (https=) |
| IL (1) | IL305262A (https=) |
| MX (1) | MX2023010467A (https=) |
| PE (2) | PE20260125A1 (https=) |
| PY (1) | PY2216888A (https=) |
| TN (1) | TN2023000216A1 (https=) |
| UY (1) | UY39667A (https=) |
| WO (1) | WO2022192370A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4304586A4 (en) | 2021-03-10 | 2025-04-02 | Jnana Therapeutics Inc. | SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION |
| CN117813307A (zh) | 2021-08-18 | 2024-04-02 | 新锐思生物制药股份有限公司 | 白介素-1受体相关激酶的双官能降解物及其治疗用途 |
| JP2025500308A (ja) * | 2021-12-22 | 2025-01-09 | ジュニャーナ セラピューティクス インコーポレイテッド | 哺乳類ｓｌｃ６ａ１９機能の小分子阻害剤 |
| AU2023342603A1 (en) * | 2022-09-14 | 2025-04-17 | Jnana Therapeutics Inc. | Dosing regimen for treating pku with a piperidine inhibitor of slc6a19 function |
| EP4622960A1 (en) * | 2022-11-22 | 2025-10-01 | Maze Therapeutics, Inc. | Inhibitors of solute carrier family 6a member 19 (slc6a19) and methods of use thereof |
| EP4626420A1 (en) * | 2022-11-30 | 2025-10-08 | Jnana Therapeutics Inc. | Crystalline forms of a piperidine inhibitor of slc6a19 function |
| KR20260022325A (ko) * | 2023-06-14 | 2026-02-19 | 제이나나 테라퓨틱스 인코포레이티드 | Slc6a19 기능의 피페리딘 억제제 |
| CN121399098A (zh) | 2023-06-30 | 2026-01-23 | 赛诺菲 | 取代的环状化合物以及治疗苯丙酮尿症和其他氨基酸尿症的方法 |
| CN121666235A (zh) * | 2023-08-11 | 2026-03-13 | 杰那医疗公司 | Slc6a19功能的含双环杂芳基的哌啶抑制剂 |
| TW202515556A (zh) * | 2023-08-17 | 2025-04-16 | 美商杰那醫療公司 | Ｓｌｃ６ａ１９功能之含萘基哌啶抑制劑 |
| WO2025049658A1 (en) * | 2023-08-30 | 2025-03-06 | Agios Pharmaceuticals, Inc. | 4-pyrazolo[1,5-a]pyridin-2-yl-4,5,6,7-tetrahydro-1 h-imidazo[4,5-c]pyridine derivatives as mutant pah protein stabilizers for the treatment of phenylketonuria |
| US20250346567A1 (en) * | 2024-05-13 | 2025-11-13 | Pfizer Inc. | Substituted pyridine and phenyl compounds |
| WO2026038155A1 (en) * | 2024-08-16 | 2026-02-19 | Pfizer Inc. | Substituted pyridine compounds |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6750348B1 (en) | 1999-03-24 | 2004-06-15 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds |
| FR2793248B1 (fr) | 1999-05-03 | 2001-06-29 | Adir | Nouveaux derives de 2,3-methano-aminoacides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2000076512A1 (en) | 1999-06-11 | 2000-12-21 | Merck & Co., Inc. | Cyclopentyl modulators of chemokine receptor activity |
| US6894063B2 (en) * | 2000-09-14 | 2005-05-17 | Schering Corporation | Substituted urea neuropeptide Y Y5 Receptor antagonists |
| WO2003037894A1 (en) | 2001-11-02 | 2003-05-08 | Glaxo Group Limited | 4-(5-membered)-heteroaryl acyl pyrrolidine derivatives as hcv inhibitors |
| US20040142416A1 (en) | 2002-04-30 | 2004-07-22 | Laipis Philip J. | Treatment for phenylketonuria |
| WO2007030761A2 (en) * | 2005-09-08 | 2007-03-15 | Smithkline Beecham Corporation | Acyclic 1,4-diamines and uses thereof |
| WO2007115232A2 (en) | 2006-03-30 | 2007-10-11 | Chemocentryx, Inc. | Cxcr4 modulators |
| US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| BRPI0721451A2 (pt) | 2007-03-13 | 2014-03-25 | Arete Therapeutics Inc | Compostos de 4-piperidiniluréia como inibidores de epóxido hidrolase solúvel |
| FR2944206B1 (fr) | 2009-04-09 | 2012-12-28 | Sanofi Aventis | Applications therapeutiques dans le domaine cardiovasculaire de derives de quinazolinedione |
| WO2011060397A1 (en) | 2009-11-16 | 2011-05-19 | Schering Corporation | Substituted amino heterocycles useful as hiv antagonists |
| WO2011060396A1 (en) | 2009-11-16 | 2011-05-19 | Schering Corporation | Aliphatic amines based heterocycles useful as hiv entry blockers |
| WO2012113103A1 (en) | 2011-02-25 | 2012-08-30 | Helsinn Healthcare S.A. | Asymmetric ureas and medical uses thereof |
| CN104470914A (zh) | 2012-06-20 | 2015-03-25 | 桑多斯股份公司 | 替拉瑞韦和波普瑞韦或者其药学上可接受的盐或溶剂合物和中间产物包括经Mukaiyama羟醛加成制备的β-氨基酸的合成 |
| WO2014144130A2 (en) * | 2013-03-15 | 2014-09-18 | Als Mountain Llc | Pharmaceutical composition comprising an ampk activator and a serotonergic agent and methods of use thereof |
| US9783504B2 (en) * | 2013-07-09 | 2017-10-10 | Dana-Farber Cancer Institute, Inc. | Kinase inhibitors for the treatment of disease |
| TWI703130B (zh) | 2014-03-07 | 2020-09-01 | 瑞士商赫爾辛保健股份有限公司 | 對位取代的不對稱脲及其醫療用途 |
| WO2016095089A1 (en) | 2014-12-15 | 2016-06-23 | Merck Sharp & Dohme Corp. | Erk inhibitors |
| AR103297A1 (es) | 2014-12-30 | 2017-05-03 | Forma Therapeutics Inc | Pirrolo y pirazolopirimidinas como inhibidores de la proteasa 7 específica de ubiquitina |
| CN117050032A (zh) * | 2016-12-15 | 2023-11-14 | 阿瑞雅德制药公司 | 作为c-kit抑制剂的氨基噻唑化合物 |
| WO2019040106A2 (en) * | 2017-08-21 | 2019-02-28 | Acadia Pharmaceuticals Inc. | COMPOUNDS, RELATED SALTS AND METHODS FOR THE TREATMENT OF DISEASES |
| WO2019046303A1 (en) * | 2017-08-28 | 2019-03-07 | The Trustees Of Columbia University In The City Of New York | METHOD FOR PREDICTING PATIENT RESPONSE TO SLC MODULATOR PROCESSING |
| TWI834637B (zh) | 2018-03-01 | 2024-03-11 | 日商武田藥品工業有限公司 | 六氫吡啶基-3-(芳氧基)丙醯胺及丙酸酯 |
| GB201809050D0 (en) | 2018-06-01 | 2018-07-18 | E Therapeutics Plc | Modulators of tryptophan catabolism |
| EP3866798A4 (en) | 2018-10-15 | 2022-07-13 | Dana-Farber Cancer Institute, Inc. | ENHANCED TRANSCRIPTIONAL ASSOCIATED DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND THEIR USES |
| CN111978311B (zh) | 2019-05-21 | 2024-05-31 | 中国科学院上海有机化学研究所 | 一类细胞程序性坏死抑制剂及其制备方法和用途 |
| AU2020308862B2 (en) | 2019-06-28 | 2026-03-26 | Research Triangle Institute | Urea derivatives as CB1 allosteric modulators |
| BR112022010895A2 (pt) | 2019-12-04 | 2022-09-06 | Omeros Corp | Composto, composição farmacêutica, e, método para tratar uma doença ou distúrbio associado à serina protease-2 associada à lectina de ligação ao manan |
| BR112023015061A2 (pt) | 2021-01-27 | 2023-10-03 | Corteva Agriscience Llc | Compostos antiparasitários |
| KR20230169979A (ko) | 2021-03-10 | 2023-12-18 | 다이스 몰레큘스 에스브이, 인크. | 알파 v 베타 6 및 알파 v 베타 1 인테그린 억제제 및 그의 용도 |
| EP4304586A4 (en) | 2021-03-10 | 2025-04-02 | Jnana Therapeutics Inc. | SMALL MOLECULE INHIBITORS OF MAMMALIAN SLC6A19 FUNCTION |
| TW202309022A (zh) | 2021-04-13 | 2023-03-01 | 美商努法倫特公司 | 用於治療具egfr突變之癌症之胺基取代雜環 |
| MX2024000357A (es) | 2021-07-07 | 2024-02-12 | Incyte Corp | Compuestos triciclicos como inhibidores de homologo de oncogen viral de sarcoma de rata kirsten (kras). |
| EP4376840A4 (en) | 2021-07-28 | 2025-05-21 | Nura Bio, Inc. | SUBSTITUTED PYRIDINE DERIVATIVES AS SARM1 INHIBITORS |
| TW202321229A (zh) | 2021-08-18 | 2023-06-01 | 美商富曼西公司 | 殺真菌的取代的雜環化合物 |
| WO2023023532A2 (en) | 2021-08-18 | 2023-02-23 | Chemocentryx, Inc. | Aryl sulfonyl (hydroxy) piperidines as ccr6 inhibitors |
| CN117813307A (zh) | 2021-08-18 | 2024-04-02 | 新锐思生物制药股份有限公司 | 白介素-1受体相关激酶的双官能降解物及其治疗用途 |
| WO2023079294A1 (en) | 2021-11-05 | 2023-05-11 | Sitryx Therapeutics Limited | Phthalazine derivatives as pyruvate kinase modulators |
| JP2025500308A (ja) | 2021-12-22 | 2025-01-09 | ジュニャーナ セラピューティクス インコーポレイテッド | 哺乳類ｓｌｃ６ａ１９機能の小分子阻害剤 |
| EP4452982A1 (en) | 2021-12-22 | 2024-10-30 | Incyte Corporation | Salts and solid forms of an fgfr inhibitor and processes of preparing thereof |
| US20250163022A1 (en) | 2021-12-22 | 2025-05-22 | Synnovation Therapeutics, Inc. | Parp1 inhibitors |
| EP4452980A1 (en) | 2021-12-22 | 2024-10-30 | Chiesi Farmaceutici S.p.A. | Triazolone derivative salt as neutrophil elastase inhibitor |
| MX2024007744A (es) | 2021-12-22 | 2024-07-01 | Sitryx Therapeutics Ltd | Derivados de ftalazina como moduladores de piruvato quinasa. |
| EP4452253A4 (en) | 2021-12-23 | 2026-04-15 | The Katholieke Univ Leuven | 2-PYRAZOLE, ANILINES AND RELATED ANALOGUES TO INHIBIT YAP/TAZ-TEAD |
| WO2024015574A1 (en) | 2022-07-14 | 2024-01-18 | Jnana Therapeutics Inc. | Small molecule inhibitors of mammalian slc6a19 function |
| EP4554584A2 (en) | 2022-07-14 | 2025-05-21 | Jnana Therapeutics Inc. | Small molecule inhibitors of mammalian slc6a19 function |
| JP2025531160A (ja) | 2022-09-14 | 2025-09-19 | ジュニャーナ セラピューティクス インコーポレイテッド | Ｓｌｃ６ａ１９機能のスピロ置換ピペリジン阻害剤及び他のピペリジン阻害剤によるｐｋｕの処置 |
| WO2024059005A1 (en) | 2022-09-14 | 2024-03-21 | Jnana Therapeutics Inc. | Treating pku with correctors of mammalian slc6a19 function |
| AU2023342603A1 (en) | 2022-09-14 | 2025-04-17 | Jnana Therapeutics Inc. | Dosing regimen for treating pku with a piperidine inhibitor of slc6a19 function |
| EP4622960A1 (en) | 2022-11-22 | 2025-10-01 | Maze Therapeutics, Inc. | Inhibitors of solute carrier family 6a member 19 (slc6a19) and methods of use thereof |
| EP4626420A1 (en) | 2022-11-30 | 2025-10-08 | Jnana Therapeutics Inc. | Crystalline forms of a piperidine inhibitor of slc6a19 function |
| KR20260022325A (ko) | 2023-06-14 | 2026-02-19 | 제이나나 테라퓨틱스 인코포레이티드 | Slc6a19 기능의 피페리딘 억제제 |
| CN121666235A (zh) | 2023-08-11 | 2026-03-13 | 杰那医疗公司 | Slc6a19功能的含双环杂芳基的哌啶抑制剂 |
| TW202515556A (zh) | 2023-08-17 | 2025-04-16 | 美商杰那醫療公司 | Ｓｌｃ６ａ１９功能之含萘基哌啶抑制劑 |
-
2022
- 2022-03-09 EP EP22767877.8A patent/EP4304586A4/en active Pending
- 2022-03-09 PE PE2025002437A patent/PE20260125A1/es unknown
- 2022-03-09 CR CR20230467A patent/CR20230467A/es unknown
- 2022-03-09 WO PCT/US2022/019513 patent/WO2022192370A1/en not_active Ceased
- 2022-03-09 IL IL305262A patent/IL305262A/en unknown
- 2022-03-09 JP JP2023553045A patent/JP7649386B2/ja active Active
- 2022-03-09 US US18/281,138 patent/US20240208923A1/en active Pending
- 2022-03-09 TN TNP/2023/000216A patent/TN2023000216A1/en unknown
- 2022-03-09 KR KR1020237032431A patent/KR20230162935A/ko active Pending
- 2022-03-09 AU AU2022234302A patent/AU2022234302A1/en active Pending
- 2022-03-09 CA CA3209914A patent/CA3209914A1/en active Pending
- 2022-03-09 PE PE2023002500A patent/PE20231987A1/es unknown
- 2022-03-09 MX MX2023010467A patent/MX2023010467A/es unknown
- 2022-03-10 PY PY202202216888A patent/PY2216888A/es unknown
- 2022-03-10 UY UY0001039667A patent/UY39667A/es unknown
-
2023
- 2023-08-31 CL CL2023002581A patent/CL2023002581A1/es unknown
- 2023-09-04 DO DO2023000178A patent/DOP2023000178A/es unknown
- 2023-10-03 CO CONC2023/0013218A patent/CO2023013218A2/es unknown
- 2023-10-05 EC ECSENADI202375523A patent/ECSP23075523A/es unknown
-
2024
- 2024-12-11 US US18/977,370 patent/US12319668B2/en active Active
-
2025
- 2025-03-07 JP JP2025036310A patent/JP7797723B2/ja active Active
- 2025-05-09 US US19/203,913 patent/US20260001859A1/en active Pending
- 2025-05-28 JP JP2025088466A patent/JP7731021B1/ja active Active
- 2025-05-30 US US19/224,188 patent/US12595244B2/en active Active
- 2025-05-30 US US19/224,208 patent/US20250289798A1/en active Pending
- 2025-08-18 JP JP2025135673A patent/JP2026000898A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024509818A5 (https=) | ||
| JP6907173B2 (ja) | スルファモイル−アリールアミド及びｂ型肝炎の治療のための薬剤としてのその使用 | |
| CN106573898B (zh) | 治疗和预防乙型肝炎病毒感染的新的哒嗪酮和三嗪酮 | |
| JP2021534124A5 (https=) | ||
| JP2021511360A5 (https=) | ||
| JP7811768B2 (ja) | ピロール化合物 | |
| JP2023521351A5 (https=) | ||
| JP2025510074A5 (https=) | ||
| JP2007504160A5 (https=) | ||
| JP2005514420A5 (https=) | ||
| JP2025500308A5 (https=) | ||
| RU2394028C2 (ru) | Производные бензилтриазолона в качестве ненуклеозидных ингибиторов обратной транскриптазы | |
| JP2023543254A5 (https=) | ||
| JP2024507139A5 (https=) | ||
| JP2022533939A5 (https=) | ||
| JP2021533206A5 (https=) | ||
| JP2022526450A (ja) | Ｃｄ４０－ｃｄ１５４結合の阻害剤 | |
| JP2024509760A5 (https=) | ||
| FI4225753T3 (fi) | Voimakkaita ja selektiivisiä yhdisteitä serotoniini 1b -reseptorin modulaattoreina | |
| JP2021534254A5 (ja) | 心臓弁疾患を治療するための医薬組成物 | |
| WO1993020065A1 (fr) | Nouveau derive d'imidazole, son utilisation pharmaceutique, et intermediaire associe | |
| JP2018065817A (ja) | 抗ウイルス活性を有するメタンチオン化合物 | |
| JP2021523178A5 (https=) | ||
| CA2630040A1 (en) | Heterocycle-substituted 3-alkyl azetidine derivatives | |
| JPS5840552B2 (ja) | １，４− ベンゾジオキサンノ アミンユウドウタイノセイホウ |