JP2023521351A5 - - Google Patents
Info
- Publication number
- JP2023521351A5 JP2023521351A5 JP2022561072A JP2022561072A JP2023521351A5 JP 2023521351 A5 JP2023521351 A5 JP 2023521351A5 JP 2022561072 A JP2022561072 A JP 2022561072A JP 2022561072 A JP2022561072 A JP 2022561072A JP 2023521351 A5 JP2023521351 A5 JP 2023521351A5
- Authority
- JP
- Japan
- Prior art keywords
- oxo
- diazepana
- benzenacyclotetradecafan
- dimethoxy
- dioxa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063006629P | 2020-04-07 | 2020-04-07 | |
| US63/006,629 | 2020-04-07 | ||
| PCT/EP2021/059096 WO2021204896A1 (en) | 2020-04-07 | 2021-04-07 | Macrocyclic diamine derivatives as ent inhibitors for the treatment of cancers, and combination thereof with adenosine receptor antagonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023521351A JP2023521351A (ja) | 2023-05-24 |
| JP2023521351A5 true JP2023521351A5 (https=) | 2024-04-17 |
| JP7784041B2 JP7784041B2 (ja) | 2025-12-11 |
Family
ID=75441913
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022561072A Active JP7784041B2 (ja) | 2020-04-07 | 2021-04-07 | がんの治療のためのｅｎｔ阻害剤としての大環状ジアミン誘導体、及びそれとアデノシン受容体拮抗薬との組合せ |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20230203058A1 (https=) |
| EP (1) | EP4132933A1 (https=) |
| JP (1) | JP7784041B2 (https=) |
| KR (1) | KR20230007369A (https=) |
| CN (2) | CN116535365A (https=) |
| AR (1) | AR121777A1 (https=) |
| AU (1) | AU2021253634A1 (https=) |
| BR (1) | BR112022020324A2 (https=) |
| CA (1) | CA3179526A1 (https=) |
| CL (1) | CL2022002772A1 (https=) |
| IL (1) | IL297127A (https=) |
| MX (1) | MX2022012558A (https=) |
| PH (1) | PH12022552981A1 (https=) |
| TW (1) | TW202204365A (https=) |
| WO (1) | WO2021204896A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN118076610A (zh) * | 2021-10-06 | 2024-05-24 | Iteos比利时公司 | 具有ent1抑制活性的大环化合物 |
| KR20240089211A (ko) * | 2021-10-06 | 2024-06-20 | 아이테오스 벨지움 에스에이 | Ent1 억제 활성을 갖는 마크로시클릭 화합물의 제조 방법 |
| US20260069604A1 (en) * | 2022-06-01 | 2026-03-12 | Duke University | Novel equilibrative nucleoside transporter inhibitors and methods of making and using same |
| CN115417766B (zh) * | 2022-08-31 | 2024-05-17 | 天津药明康德新药开发有限公司 | 一种3-羟基-4,5二甲氧基苯甲酸叔丁酯的合成方法 |
| CN115650936B (zh) * | 2022-10-26 | 2024-11-01 | 天津药明康德新药开发有限公司 | 一种(叔丁基(3)-1,4-二氮杂卓-1-丙基)氨基甲酸酯的制备方法 |
| TW202444377A (zh) * | 2023-03-22 | 2024-11-16 | 比利時商艾托斯比利時公司 | 包括ent1抑制劑之鹽、結晶形式及水合物與溶劑合物的硫酸氫複合物 |
| TW202523332A (zh) | 2023-11-14 | 2025-06-16 | 比利時商艾托斯比利時公司 | Ｅｎｔ１抑制劑與檢查點抑制劑組合 |
| WO2025126110A1 (en) | 2023-12-15 | 2025-06-19 | iTeos Belgium SA | Ent1 inhibitors in combination with bispecific antibodies |
| WO2025163520A1 (en) | 2024-01-30 | 2025-08-07 | iTeos Belgium SA | Ent1 inhibitors for use in the treatment of diseases with increased adenosine levels |
| WO2025202864A1 (en) | 2024-03-25 | 2025-10-02 | iTeos Belgium SA | Ent1 inhibitors in combination with oncolytic viruses and their use in the treatment of cancer |
| WO2026038162A1 (en) | 2024-08-15 | 2026-02-19 | iTeos Belgium SA | Pharmaceutical compositions of ent1 inhibitors |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1646390B1 (en) * | 2003-07-22 | 2008-10-08 | Cv Therapeutics, Inc. | A1 adenosine receptor antagonists |
| JO3126B1 (ar) * | 2007-11-14 | 2017-09-20 | Janssen Pharmaceutica Nv | مثبطات ناقل نيوكليوسيد متوازن اي ان تي 1 |
| GB0906579D0 (en) | 2009-04-16 | 2009-05-20 | Vernalis R&D Ltd | Pharmaceuticals, compositions and methods of making and using the same |
| US9291747B2 (en) | 2010-02-08 | 2016-03-22 | Essilor International (Compagnie Generale D'optique) | Optical article comprising an anti-reflecting coating having anti-fogging properties |
| ES2365960B1 (es) | 2010-03-31 | 2012-06-04 | Palobiofarma, S.L | Nuevos antagonistas de los receptores de adenosina. |
| MA39822A (fr) * | 2014-04-03 | 2018-02-06 | Janssen Pharmaceutica Nv | Dérivés de pyrimidine bicycle |
| MX380313B (es) * | 2016-02-04 | 2025-03-12 | Univ Johns Hopkins | Rapadocinas, inhibidores de transportador 1 de nucleósido equilibrador y usos de los mismos. |
| US10131670B2 (en) * | 2016-12-16 | 2018-11-20 | Cystic Fibrosis Foundation Therapeutics, Inc. | Bicyclic heteroaryl derivatives as CFTR potentiators |
| HUE064141T2 (hu) | 2017-01-20 | 2024-02-28 | Arcus Biosciences Inc | Azolopirimidin rákkal összefüggõ rendellenességek kezelésére |
| TWI801372B (zh) | 2017-03-30 | 2023-05-11 | 比利時商艾特歐斯比利時有限公司 | 作為a2a抑制劑的硫胺甲酸酯衍生物以及用於癌症治療的方法 |
-
2021
- 2021-04-07 KR KR1020227038825A patent/KR20230007369A/ko active Pending
- 2021-04-07 AU AU2021253634A patent/AU2021253634A1/en active Pending
- 2021-04-07 BR BR112022020324A patent/BR112022020324A2/pt unknown
- 2021-04-07 MX MX2022012558A patent/MX2022012558A/es unknown
- 2021-04-07 CA CA3179526A patent/CA3179526A1/en active Pending
- 2021-04-07 JP JP2022561072A patent/JP7784041B2/ja active Active
- 2021-04-07 CN CN202310367239.1A patent/CN116535365A/zh active Pending
- 2021-04-07 IL IL297127A patent/IL297127A/en unknown
- 2021-04-07 PH PH1/2022/552981A patent/PH12022552981A1/en unknown
- 2021-04-07 WO PCT/EP2021/059096 patent/WO2021204896A1/en not_active Ceased
- 2021-04-07 EP EP21717829.2A patent/EP4132933A1/en active Pending
- 2021-04-07 AR ARP210100908A patent/AR121777A1/es unknown
- 2021-04-07 CN CN202180040635.2A patent/CN115768773A/zh active Pending
- 2021-04-07 TW TW110112556A patent/TW202204365A/zh unknown
- 2021-04-07 US US17/917,462 patent/US20230203058A1/en active Pending
-
2022
- 2022-10-07 CL CL2022002772A patent/CL2022002772A1/es unknown
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