JP2023534214A - 抗ベータセルリン抗体、その断片、及び多重特異性結合分子 - Google Patents

抗ベータセルリン抗体、その断片、及び多重特異性結合分子 Download PDF

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Publication number
JP2023534214A
JP2023534214A JP2023501589A JP2023501589A JP2023534214A JP 2023534214 A JP2023534214 A JP 2023534214A JP 2023501589 A JP2023501589 A JP 2023501589A JP 2023501589 A JP2023501589 A JP 2023501589A JP 2023534214 A JP2023534214 A JP 2023534214A
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eye
seq
nos
btc
binding
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JPWO2022013787A5 (enExample
Inventor
エリック ビグロー，チャド
マリア キャリオン，アナ
エドガー チャステイン，ジェームズ
リー クラーク，カーク
アレクサンドル エトマッド－ギルバートソン，ビジャン
ギスパティ ゴーシュ，ジョイ
マイケル ハンクス，ショーン
ハブスト，ニコル
ラジャン アイヤー，ガネシュ
モカー，ニーナ
アイン グエン，アンドリュー
ヘンドリック プーア，ステファン
チョウ，ユビン
ベラムーア ランガスワーミィ，ナリーニ
ステファニダキス，マイケル
トクソ，エンゲン
ズビグニエフ トワログ，マイケル
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ノバルティス アーゲー
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Publication of JP2023534214A publication Critical patent/JP2023534214A/ja
Publication of JPWO2022013787A5 publication Critical patent/JPWO2022013787A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2023501589A 2020-07-16 2021-07-14 抗ベータセルリン抗体、その断片、及び多重特異性結合分子 Pending JP2023534214A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063052789P 2020-07-16 2020-07-16
US63/052,789 2020-07-16
US202163156709P 2021-03-04 2021-03-04
US63/156,709 2021-03-04
PCT/IB2021/056363 WO2022013787A1 (en) 2020-07-16 2021-07-14 Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules

Publications (2)

Publication Number Publication Date
JP2023534214A true JP2023534214A (ja) 2023-08-08
JPWO2022013787A5 JPWO2022013787A5 (enExample) 2024-07-24

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Country Status (20)

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US (3) US11524998B2 (enExample)
EP (1) EP4182025A1 (enExample)
JP (1) JP2023534214A (enExample)
CN (1) CN116323664A (enExample)
AU (1) AU2021308712B2 (enExample)
BR (1) BR112023000482A2 (enExample)
CA (1) CA3176556A1 (enExample)
CL (2) CL2023000084A1 (enExample)
CO (1) CO2023000112A2 (enExample)
CR (1) CR20230009A (enExample)
DO (1) DOP2023000005A (enExample)
EC (1) ECSP23001118A (enExample)
IL (1) IL299586A (enExample)
MX (1) MX2023000547A (enExample)
PE (1) PE20231093A1 (enExample)
PH (1) PH12023550015A1 (enExample)
TW (1) TW202216761A (enExample)
UY (1) UY39324A (enExample)
WO (1) WO2022013787A1 (enExample)
ZA (1) ZA202304787B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ770284A (en) 2018-05-10 2025-11-28 Regeneron Pharma High concentration vegf receptor fusion protein containing formulations
PH12023550015A1 (en) * 2020-07-16 2024-03-11 Novartis Ag Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules
WO2025119329A1 (zh) * 2023-12-07 2025-06-12 信达生物制药(苏州)有限公司 抗c5和htra1双特异性抗体及其用途

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JP2011525359A (ja) * 2008-06-25 2011-09-22 エスバテック、アン アルコン バイオメディカル リサーチ ユニット、エルエルシー Ｖｅｇｆを阻害する安定かつ可溶性の抗体
WO2014175444A1 (ja) * 2013-04-26 2014-10-30 千葉県 抗ｎｌｒｒ１抗体
JP2016502850A (ja) * 2012-12-18 2016-02-01 ノバルティス アーゲー ヒアルロナンに結合するペプチドタグを使用する組成物及び方法
JP2018531005A (ja) * 2015-09-23 2018-10-25 ジェネンテック， インコーポレイテッド 抗ｖｅｇｆ抗体の最適化変異体
JP2020514376A (ja) * 2017-03-22 2020-05-21 ジェネンテック， インコーポレイテッド 眼障害の治療のために最適化された抗体組成物

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