AU2021308712B2 - Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules - Google Patents

Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules

Info

Publication number
AU2021308712B2
AU2021308712B2 AU2021308712A AU2021308712A AU2021308712B2 AU 2021308712 B2 AU2021308712 B2 AU 2021308712B2 AU 2021308712 A AU2021308712 A AU 2021308712A AU 2021308712 A AU2021308712 A AU 2021308712A AU 2021308712 B2 AU2021308712 B2 AU 2021308712B2
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AU
Australia
Prior art keywords
seq
btc
nos
antibody
amino acid
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Active
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AU2021308712A
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English (en)
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AU2021308712A1 (en
Inventor
Chad Eric BIGELOW
Ana Maria CARRION
James Edgar CHASTAIN
Kirk Lee CLARK
Bijan Alexandre ETEMAD-GILBERTSON
Joy Gispati GHOSH
Shawn Michael HANKS
Nicole Haubst
Ganesh Rajan IYER
Nina MOKER
Andrew Anh NGUYEN
Stephen Hendrick POOR
Yubin Qiu
Nalini Velamur RANGASWAMY
Michael Stefanidakis
Engin TOKSOZ
Michael Zbigniew TWAROG
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Novartis AG
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Novartis AG
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Publication of AU2021308712A1 publication Critical patent/AU2021308712A1/en
Application granted granted Critical
Publication of AU2021308712B2 publication Critical patent/AU2021308712B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AU2021308712A 2020-07-16 2021-07-14 Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules Active AU2021308712B2 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063052789P 2020-07-16 2020-07-16
US63/052,789 2020-07-16
US202163156709P 2021-03-04 2021-03-04
US63/156,709 2021-03-04
PCT/IB2021/056363 WO2022013787A1 (en) 2020-07-16 2021-07-14 Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2025287346 Division 2021-07-14

Publications (2)

Publication Number Publication Date
AU2021308712A1 AU2021308712A1 (en) 2023-02-02
AU2021308712B2 true AU2021308712B2 (en) 2025-10-09

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AU2021308712A Active AU2021308712B2 (en) 2020-07-16 2021-07-14 Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules

Country Status (20)

Country Link
US (3) US11524998B2 (enExample)
EP (1) EP4182025A1 (enExample)
JP (1) JP2023534214A (enExample)
CN (1) CN116323664A (enExample)
AU (1) AU2021308712B2 (enExample)
BR (1) BR112023000482A2 (enExample)
CA (1) CA3176556A1 (enExample)
CL (2) CL2023000084A1 (enExample)
CO (1) CO2023000112A2 (enExample)
CR (1) CR20230009A (enExample)
DO (1) DOP2023000005A (enExample)
EC (1) ECSP23001118A (enExample)
IL (1) IL299586A (enExample)
MX (1) MX2023000547A (enExample)
PE (1) PE20231093A1 (enExample)
PH (1) PH12023550015A1 (enExample)
TW (1) TW202216761A (enExample)
UY (1) UY39324A (enExample)
WO (1) WO2022013787A1 (enExample)
ZA (1) ZA202304787B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210021299A (ko) 2018-05-10 2021-02-25 리제너론 파아마슈티컬스, 인크. 고농도 vegf 수용체 융합 단백질 함유 제제
CR20230009A (es) * 2020-07-16 2023-01-25 Novartis Ag Anticuerpos anti-betacelulina, fragmentos de los mismos, y moléculas de unión multiespecíficas
WO2025119329A1 (zh) * 2023-12-07 2025-06-12 信达生物制药(苏州)有限公司 抗c5和htra1双特异性抗体及其用途

Citations (2)

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WO2014099997A1 (en) * 2012-12-18 2014-06-26 Novartis Ag Compositions and methods that utilize a peptide tag that binds to hyaluronan

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