ZA202304787B - Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules - Google Patents

Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules

Info

Publication number
ZA202304787B
ZA202304787B ZA2023/04787A ZA202304787A ZA202304787B ZA 202304787 B ZA202304787 B ZA 202304787B ZA 2023/04787 A ZA2023/04787 A ZA 2023/04787A ZA 202304787 A ZA202304787 A ZA 202304787A ZA 202304787 B ZA202304787 B ZA 202304787B
Authority
ZA
South Africa
Prior art keywords
antibodies
specific binding
binding molecules
betacellulin
fragments
Prior art date
Application number
ZA2023/04787A
Other languages
English (en)
Inventor
Chad Eric Bigelow
Ana Maria Carrion
James Edgar Chastain
Kirk Lee Clark
Bijan Alexandre Etemad-Gilbertson
Joy Gispati Ghosh
Shawn Michael Hanks
Nicole Haubst
Ganesh Rajan Iyer
Nina Moker
Andrew Anh Nguyen
Stephen Hendrick Poor
Yubin Qiu
Nalini Velamur Rangaswamy
Michael Stefanidakis
Engin Toksoz
Michael Zbigniew Twarog
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA202304787B publication Critical patent/ZA202304787B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA2023/04787A 2020-07-16 2023-04-25 Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules ZA202304787B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063052789P 2020-07-16 2020-07-16
US202163156709P 2021-03-04 2021-03-04
PCT/IB2021/056363 WO2022013787A1 (en) 2020-07-16 2021-07-14 Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules

Publications (1)

Publication Number Publication Date
ZA202304787B true ZA202304787B (en) 2025-10-29

Family

ID=76971949

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2023/04787A ZA202304787B (en) 2020-07-16 2023-04-25 Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules

Country Status (20)

Country Link
US (3) US11524998B2 (enExample)
EP (1) EP4182025A1 (enExample)
JP (1) JP2023534214A (enExample)
CN (1) CN116323664A (enExample)
AU (1) AU2021308712B2 (enExample)
BR (1) BR112023000482A2 (enExample)
CA (1) CA3176556A1 (enExample)
CL (2) CL2023000084A1 (enExample)
CO (1) CO2023000112A2 (enExample)
CR (1) CR20230009A (enExample)
DO (1) DOP2023000005A (enExample)
EC (1) ECSP23001118A (enExample)
IL (1) IL299586A (enExample)
MX (1) MX2023000547A (enExample)
PE (1) PE20231093A1 (enExample)
PH (1) PH12023550015A1 (enExample)
TW (1) TW202216761A (enExample)
UY (1) UY39324A (enExample)
WO (1) WO2022013787A1 (enExample)
ZA (1) ZA202304787B (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ770284A (en) 2018-05-10 2025-11-28 Regeneron Pharma High concentration vegf receptor fusion protein containing formulations
PH12023550015A1 (en) * 2020-07-16 2024-03-11 Novartis Ag Anti-betacellulin antibodies, fragments thereof, and multi-specific binding molecules
WO2025119329A1 (zh) * 2023-12-07 2025-06-12 信达生物制药(苏州)有限公司 抗c5和htra1双特异性抗体及其用途

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