JP2023520400A5 - - Google Patents
Info
- Publication number
- JP2023520400A5 JP2023520400A5 JP2022559587A JP2022559587A JP2023520400A5 JP 2023520400 A5 JP2023520400 A5 JP 2023520400A5 JP 2022559587 A JP2022559587 A JP 2022559587A JP 2022559587 A JP2022559587 A JP 2022559587A JP 2023520400 A5 JP2023520400 A5 JP 2023520400A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cyano
- compound
- tautomer
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063004717P | 2020-04-03 | 2020-04-03 | |
| US63/004,717 | 2020-04-03 | ||
| PCT/US2021/025614 WO2021203023A1 (en) | 2020-04-03 | 2021-04-02 | Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023520400A JP2023520400A (ja) | 2023-05-17 |
| JP2023520400A5 true JP2023520400A5 (enExample) | 2024-04-10 |
Family
ID=75919370
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022559587A Pending JP2023520400A (ja) | 2020-04-03 | 2021-04-02 | アルファ－１－アンチトリプシン欠損症（ａａｔｄ）を治療するためのアルファ－１－アンチトリプシンモジュレーターとしてのインドール誘導体 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20230159502A1 (enExample) |
| EP (1) | EP4132908A1 (enExample) |
| JP (1) | JP2023520400A (enExample) |
| KR (1) | KR20220165260A (enExample) |
| CN (1) | CN115916748A (enExample) |
| AR (1) | AR121745A1 (enExample) |
| AU (1) | AU2021246526A1 (enExample) |
| BR (1) | BR112022019792A2 (enExample) |
| CA (1) | CA3177531A1 (enExample) |
| IL (1) | IL296920A (enExample) |
| MX (1) | MX2022011829A (enExample) |
| TW (1) | TWI908788B (enExample) |
| WO (1) | WO2021203023A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3114672A1 (en) | 2018-10-05 | 2020-04-23 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
| US11884672B2 (en) | 2019-05-14 | 2024-01-30 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
| JP7732999B2 (ja) * | 2020-04-03 | 2025-09-02 | バーテックス ファーマシューティカルズ インコーポレイテッド | アルファ１－アンチトリプシンのモジュレーター |
| WO2022104353A1 (en) | 2020-11-12 | 2022-05-19 | Vertex Pharmaceuticals Incorporated | Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat |
| TW202440093A (zh) * | 2023-03-06 | 2024-10-16 | 香港商英矽智能科技知識產權有限公司 | Cdk8/19雙重抑制劑及其使用方法 |
| EP4687883A2 (en) * | 2023-04-05 | 2026-02-11 | Caraway Therapeutics, Inc. | Modulators of trpml, their compositions and methods of use |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639780A (en) * | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
| AU2002211901A1 (en) * | 2000-10-10 | 2002-04-22 | Smithkline Beecham Corporation | Substituted indoles, pharmaceutical compositions containing such indoles and their use as PPAR-gamma binding agents |
| US6706423B2 (en) * | 2001-12-27 | 2004-03-16 | Lightronik Technology Inc. | Organic EL device |
| US7223785B2 (en) * | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US20070203209A1 (en) * | 2005-08-18 | 2007-08-30 | Wilmin Bartolini | Useful indole compounds |
| BRPI0710527B8 (pt) * | 2006-04-04 | 2021-05-25 | Fibrogen Inc | compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende |
| SG176477A1 (en) * | 2006-08-07 | 2011-12-29 | Ironwood Pharmaceuticals Inc | Indole compounds |
| GB0803017D0 (en) * | 2008-02-19 | 2008-03-26 | Glaxo Group Ltd | Compounds |
| HUE025471T2 (hu) * | 2008-04-16 | 2016-03-29 | Karobio Ab | Új ösztrogén receptor ligandumok |
| US20130167932A1 (en) * | 2010-11-08 | 2013-07-04 | Nec Corporation | Indole compound, and photoelectric conversion dye using same, semiconductor electrode, photoelectric conversion element, and photoelectrochemical cell |
| JPWO2012111610A1 (ja) * | 2011-02-14 | 2014-07-07 | 日本電気株式会社 | チアゾール系化合物及びその用途 |
| MX2020013853A (es) * | 2018-06-22 | 2021-05-27 | Ucl Business Ltd | Compuestos innovadores. |
| TWI748194B (zh) * | 2018-06-28 | 2021-12-01 | 德商菲尼克斯 Ｆｘｒ有限責任公司 | 含有雙環核心部分之新穎lxr調節劑 |
| AU2021246104A1 (en) * | 2020-04-03 | 2022-10-20 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
-
2021
- 2021-04-02 IL IL296920A patent/IL296920A/en unknown
- 2021-04-02 BR BR112022019792A patent/BR112022019792A2/pt unknown
- 2021-04-02 CA CA3177531A patent/CA3177531A1/en active Pending
- 2021-04-02 JP JP2022559587A patent/JP2023520400A/ja active Pending
- 2021-04-02 KR KR1020227038045A patent/KR20220165260A/ko active Pending
- 2021-04-02 MX MX2022011829A patent/MX2022011829A/es unknown
- 2021-04-02 EP EP21725849.0A patent/EP4132908A1/en active Pending
- 2021-04-02 AU AU2021246526A patent/AU2021246526A1/en active Pending
- 2021-04-02 CN CN202180039837.5A patent/CN115916748A/zh active Pending
- 2021-04-02 WO PCT/US2021/025614 patent/WO2021203023A1/en not_active Ceased
- 2021-04-02 US US17/916,484 patent/US20230159502A1/en active Pending
- 2021-04-05 AR ARP210100866A patent/AR121745A1/es unknown
- 2021-04-06 TW TW110112401A patent/TWI908788B/zh active