BR112022019792A2 - Derivados de indol como moduladores de alfa-1-antitripsina para tratamento da deficiência de alfa-1-antitripsina (aatd) - Google Patents

Derivados de indol como moduladores de alfa-1-antitripsina para tratamento da deficiência de alfa-1-antitripsina (aatd)

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Publication number
BR112022019792A2
BR112022019792A2 BR112022019792A BR112022019792A BR112022019792A2 BR 112022019792 A2 BR112022019792 A2 BR 112022019792A2 BR 112022019792 A BR112022019792 A BR 112022019792A BR 112022019792 A BR112022019792 A BR 112022019792A BR 112022019792 A2 BR112022019792 A2 BR 112022019792A2
Authority
BR
Brazil
Prior art keywords
alpha
antytripsin
aatd
modulators
deficiency
Prior art date
Application number
BR112022019792A
Other languages
English (en)
Portuguese (pt)
Inventor
Giroux Simon
Philip Clark Michael
Aaron Brodney Michael
Marcel Nuhant Philippe
Elizabeth Allen Emily
Francis Fimognari Robert Jr
Zaky Mariam
John Boyd Michael
D Deininger David
Zhang Hu
Deng Hongbo
Noel Collier Philip
Maxwell Brad
D Waal Nathan
M Ronkin Steven
Tang Qing
Wang Jian
Jones Peter
Simone Fleming Gabrielle
T D Fanning Lev
Marie Boucher Diane
James Hurley Dennis
B Hall Amy
Patrick Maxwell John
Arthur Johnson Mac Jr
Lewis Tapley Timothy
Jane Swett Rebecca
Damagnez Veronique
A Thomson Stephen
Keerthi Bandarage Upul
Michael Cottrell Kevin
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of BR112022019792A2 publication Critical patent/BR112022019792A2/pt

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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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BR112022019792A 2020-04-03 2021-04-02 Derivados de indol como moduladores de alfa-1-antitripsina para tratamento da deficiência de alfa-1-antitripsina (aatd) BR112022019792A2 (pt)

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US202063004717P 2020-04-03 2020-04-03
PCT/US2021/025614 WO2021203023A1 (en) 2020-04-03 2021-04-02 Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)

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