MX2022011829A - Derivados de indol como moduladores de alfa-1-antitripsina para tratar la deficiencia de alfa-1-antitripsina (aatd). - Google Patents

Derivados de indol como moduladores de alfa-1-antitripsina para tratar la deficiencia de alfa-1-antitripsina (aatd).

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Publication number
MX2022011829A
MX2022011829A MX2022011829A MX2022011829A MX2022011829A MX 2022011829 A MX2022011829 A MX 2022011829A MX 2022011829 A MX2022011829 A MX 2022011829A MX 2022011829 A MX2022011829 A MX 2022011829A MX 2022011829 A MX2022011829 A MX 2022011829A
Authority
MX
Mexico
Prior art keywords
alpha
antitrypsin
aatd
modulators
indole derivatives
Prior art date
Application number
MX2022011829A
Other languages
English (en)
Spanish (es)
Inventor
Hongbo Deng
Dennis James Hurley
Peter Jones
Jian Wang
Kevin Michael Cottrell
Nathan D Waal
John Patrick Maxwell
Steven M Ronkin
Simon Giroux
David D Deininger
Michael Aaron Brodney
Mariam Zaky
Philippe Marcel Nuhant
Qing Tang
Upul Keerthi Bandarage
Veronique Damagnez
Jr Robert Francis Fimognari
Jr Mac Arthur Johnson
Rebecca Jane Swett
Timothy Lewis Tapley
Stephen A Thomson
Michael John Boyd
Michael Philip Clark
Gabrielle Simone Fleming
Brad Maxwell
Emily Elizabeth Allen
Hu Zhang
Philip Noel Collier
Diane Marie Boucher
Lev T D Fanning
Amy B Hall
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MX2022011829A publication Critical patent/MX2022011829A/es

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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • C07—ORGANIC CHEMISTRY
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
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    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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MX2022011829A 2020-04-03 2021-04-02 Derivados de indol como moduladores de alfa-1-antitripsina para tratar la deficiencia de alfa-1-antitripsina (aatd). MX2022011829A (es)

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US202063004717P 2020-04-03 2020-04-03
PCT/US2021/025614 WO2021203023A1 (en) 2020-04-03 2021-04-02 Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)

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MX2022011829A true MX2022011829A (es) 2022-12-15

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US (1) US20230159502A1 (enExample)
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