AU2021246526A1 - Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (AATD) - Google Patents

Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (AATD) Download PDF

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Publication number
AU2021246526A1
AU2021246526A1 AU2021246526A AU2021246526A AU2021246526A1 AU 2021246526 A1 AU2021246526 A1 AU 2021246526A1 AU 2021246526 A AU2021246526 A AU 2021246526A AU 2021246526 A AU2021246526 A AU 2021246526A AU 2021246526 A1 AU2021246526 A1 AU 2021246526A1
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Australia
Prior art keywords
alkyl
compound
pharmaceutically acceptable
compounds
cyano
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AU2021246526A
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Inventor
Emily Elizabeth ALLEN
Upul Keerthi Bandarage
Diane Marie BOUCHER
Michael John BOYD
Michael Aaron Brodney
Michael Philip Clark
Philip Noel Collier
Kevin Michael Cottrell
Veronique Damagnez
David D. Deininger
Hongbo Deng
Lev T.D. Fanning
Jr. Robert Francis Fimognari
Gabrielle Simone Fleming
Simon Giroux
Amy B. HALL
Dennis James Hurley
JR. Mac Arthur Johnson
Peter Jones
Brad Maxwell
John Patrick Maxwell
Philippe Marcel Nuhant
Steven M. Ronkin
Rebecca Jane Swett
Qing Tang
Timothy Lewis TAPLEY
Stephen A. Thomson
Nathan D. Waal
Jian Wang
Mariam ZAKY
Hu ZHANG
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of AU2021246526A1 publication Critical patent/AU2021246526A1/en
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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AU2021246526A 2020-04-03 2021-04-02 Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (AATD) Pending AU2021246526A1 (en)

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PCT/US2021/025614 WO2021203023A1 (en) 2020-04-03 2021-04-02 Indole derivatives as alpha-1 -antitrypsin modulators for treating alpha-1 -antitrypsin deficiency (aatd)

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Families Citing this family (6)

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CA3114672A1 (en) 2018-10-05 2020-04-23 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
US11884672B2 (en) 2019-05-14 2024-01-30 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin
JP7732999B2 (ja) * 2020-04-03 2025-09-02 バーテックス ファーマシューティカルズ インコーポレイテッド アルファ１－アンチトリプシンのモジュレーター
WO2022104353A1 (en) 2020-11-12 2022-05-19 Vertex Pharmaceuticals Incorporated Methods of monitoring alpha-1 antitrypsin (aat) deficiency by measuring polymerised aat
TW202440093A (zh) * 2023-03-06 2024-10-16 香港商英矽智能科技知識產權有限公司 Cdk8/19雙重抑制劑及其使用方法
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Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5639780A (en) * 1995-05-22 1997-06-17 Merck Frosst Canada, Inc. N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors
AU2002211901A1 (en) * 2000-10-10 2002-04-22 Smithkline Beecham Corporation Substituted indoles, pharmaceutical compositions containing such indoles and their use as PPAR-gamma binding agents
US6706423B2 (en) * 2001-12-27 2004-03-16 Lightronik Technology Inc. Organic EL device
US7223785B2 (en) * 2003-01-22 2007-05-29 Boehringer Ingelheim International Gmbh Viral polymerase inhibitors
US20070203209A1 (en) * 2005-08-18 2007-08-30 Wilmin Bartolini Useful indole compounds
BRPI0710527B8 (pt) * 2006-04-04 2021-05-25 Fibrogen Inc compostos de pirrolo- e tiazolo-piridina e composição farmacêutica que os compreende
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HUE025471T2 (hu) * 2008-04-16 2016-03-29 Karobio Ab Új ösztrogén receptor ligandumok
US20130167932A1 (en) * 2010-11-08 2013-07-04 Nec Corporation Indole compound, and photoelectric conversion dye using same, semiconductor electrode, photoelectric conversion element, and photoelectrochemical cell
JPWO2012111610A1 (ja) * 2011-02-14 2014-07-07 日本電気株式会社 チアゾール系化合物及びその用途
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