JP2006513221A5 - - Google Patents
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- Publication number
- JP2006513221A5 JP2006513221A5 JP2004563939A JP2004563939A JP2006513221A5 JP 2006513221 A5 JP2006513221 A5 JP 2006513221A5 JP 2004563939 A JP2004563939 A JP 2004563939A JP 2004563939 A JP2004563939 A JP 2004563939A JP 2006513221 A5 JP2006513221 A5 JP 2006513221A5
- Authority
- JP
- Japan
- Prior art keywords
- alkoxy
- hydroxy
- alkyl
- halogen
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 *c1ccc(C=Cc2n[n]cc2)cc1 Chemical compound *c1ccc(C=Cc2n[n]cc2)cc1 0.000 description 10
- FFTZWJNNDVASCO-HXGSSHHBSA-N C(/C=C/c1ccccc1)=C/c1n[nH]cc1 Chemical compound C(/C=C/c1ccccc1)=C/c1n[nH]cc1 FFTZWJNNDVASCO-HXGSSHHBSA-N 0.000 description 1
- YLKIXQUPYKAWAB-UHFFFAOYSA-N C(c1n[nH]cc1)=C/c1c(-c2ccccc2)nc2[s]cc[n]12 Chemical compound C(c1n[nH]cc1)=C/c1c(-c2ccccc2)nc2[s]cc[n]12 YLKIXQUPYKAWAB-UHFFFAOYSA-N 0.000 description 1
- PJLORFGDSVWAEC-UHFFFAOYSA-N C(c1n[nH]cc1)=C/c1ccc[o]1 Chemical compound C(c1n[nH]cc1)=C/c1ccc[o]1 PJLORFGDSVWAEC-UHFFFAOYSA-N 0.000 description 1
- FOHWAQGURRYJFK-UHFFFAOYSA-N C(c1n[nH]cc1)=C/c1ccc[s]1 Chemical compound C(c1n[nH]cc1)=C/c1ccc[s]1 FOHWAQGURRYJFK-UHFFFAOYSA-N 0.000 description 1
- NFLQSIIRRGMWIY-UHFFFAOYSA-N C(c1n[nH]cc1)=C/c1ccccc1 Chemical compound C(c1n[nH]cc1)=C/c1ccccc1 NFLQSIIRRGMWIY-UHFFFAOYSA-N 0.000 description 1
- NABHSXYZOUDRHL-NNIYNVSXSA-N C/C(/C(C(C1)C=CC1/C=C/c1ccc[o]1)=O)=C\C=C/[U] Chemical compound C/C(/C(C(C1)C=CC1/C=C/c1ccc[o]1)=O)=C\C=C/[U] NABHSXYZOUDRHL-NNIYNVSXSA-N 0.000 description 1
- ASEQLAXHASWYIT-OWOJBTEDSA-N C1C(/C=C/c2n[nH]cc2)N=NC1 Chemical compound C1C(/C=C/c2n[nH]cc2)N=NC1 ASEQLAXHASWYIT-OWOJBTEDSA-N 0.000 description 1
- GVKUQDGDOVVLFW-XJMFGXJGSA-N CC(C1N=C(/C=C/C2=CC=C[C@H]2C)C=C1)c1ccc[s]1 Chemical compound CC(C1N=C(/C=C/C2=CC=C[C@H]2C)C=C1)c1ccc[s]1 GVKUQDGDOVVLFW-XJMFGXJGSA-N 0.000 description 1
- IEMMBWWQXVXBEU-UHFFFAOYSA-N CC(c1ccc[o]1)=O Chemical compound CC(c1ccc[o]1)=O IEMMBWWQXVXBEU-UHFFFAOYSA-N 0.000 description 1
- XDOKUIJGTVJMBQ-VOTSOKGWSA-N CC1(C)C(/C=C/c2n[nH]cc2)C(C)=CCC1 Chemical compound CC1(C)C(/C=C/c2n[nH]cc2)C(C)=CCC1 XDOKUIJGTVJMBQ-VOTSOKGWSA-N 0.000 description 1
- PFBGETQWUQTYMC-QSUIBIRJSA-N C[C@H](/C=C\C(/C=C/C1OCCC1)=N)C(Cc(cc1)ccc1Cl)=O Chemical compound C[C@H](/C=C\C(/C=C/C1OCCC1)=N)C(Cc(cc1)ccc1Cl)=O PFBGETQWUQTYMC-QSUIBIRJSA-N 0.000 description 1
- LZWJXTNHDXYVTA-NSCUHMNNSA-N Cc1n[o]c(/C=C/c2n[nH]cc2)c1N Chemical compound Cc1n[o]c(/C=C/c2n[nH]cc2)c1N LZWJXTNHDXYVTA-NSCUHMNNSA-N 0.000 description 1
- WTLCERBYPIMJNW-SNAWJCMRSA-N Clc1cccc(Cl)c1/C=C/c1n[nH]cc1 Chemical compound Clc1cccc(Cl)c1/C=C/c1n[nH]cc1 WTLCERBYPIMJNW-SNAWJCMRSA-N 0.000 description 1
- KALNHHPDFLFWRP-WEVVVXLNSA-N NOc1ccc(CC(C2C=CC(/C=C/C3CCCC3)=NC2)=O)cc1 Chemical compound NOc1ccc(CC(C2C=CC(/C=C/C3CCCC3)=NC2)=O)cc1 KALNHHPDFLFWRP-WEVVVXLNSA-N 0.000 description 1
- VLZMIVFQQBXBTQ-VOTSOKGWSA-N NOc1ccc(CC(N2C=CC(/C=C/c3ccccc3)=CC2)=O)cc1 Chemical compound NOc1ccc(CC(N2C=CC(/C=C/c3ccccc3)=CC2)=O)cc1 VLZMIVFQQBXBTQ-VOTSOKGWSA-N 0.000 description 1
- YKFMMTOUODEEER-ONEGZZNKSA-N N[n]1c(/C=C/c2n[nH]cc2)ccc1 Chemical compound N[n]1c(/C=C/c2n[nH]cc2)ccc1 YKFMMTOUODEEER-ONEGZZNKSA-N 0.000 description 1
- MSNGHWNJGROJSW-SOFGYWHQSA-N O=C(C1C=C(/C=C/C2OC=CC2)C=C1)c1ccc[s]1 Chemical compound O=C(C1C=C(/C=C/C2OC=CC2)C=C1)c1ccc[s]1 MSNGHWNJGROJSW-SOFGYWHQSA-N 0.000 description 1
- NVHPHISBYYDWBI-JXMROGBWSA-N O=C(C1C=CC(/C=C/c2ccc[o]2)=CC1)c1ccc[o]1 Chemical compound O=C(C1C=CC(/C=C/c2ccc[o]2)=CC1)c1ccc[o]1 NVHPHISBYYDWBI-JXMROGBWSA-N 0.000 description 1
- UNHJCDSXJJHSQQ-GQCTYLIASA-N O=C(C1C=CC(/C=C/c2ccc[o]2)=CNC1)C1=CSCC1 Chemical compound O=C(C1C=CC(/C=C/c2ccc[o]2)=CNC1)C1=CSCC1 UNHJCDSXJJHSQQ-GQCTYLIASA-N 0.000 description 1
- GKHHPICNPBDGTO-VOTSOKGWSA-N O=C(c1c[s]cc1)N(C1)C=CC1/C=C/c1ccccc1 Chemical compound O=C(c1c[s]cc1)N(C1)C=CC1/C=C/c1ccccc1 GKHHPICNPBDGTO-VOTSOKGWSA-N 0.000 description 1
- HESBHQPOAFXLSA-AATRIKPKSA-N O=Cc1ccc(/C=C/c2n[nH]cc2)cc1 Chemical compound O=Cc1ccc(/C=C/c2n[nH]cc2)cc1 HESBHQPOAFXLSA-AATRIKPKSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43553302P | 2002-12-21 | 2002-12-21 | |
| US60/435,533 | 2002-12-21 | ||
| US10/740,708 | 2003-12-18 | ||
| US10/740,708 US7192976B2 (en) | 2002-12-21 | 2003-12-18 | Small molecule modulators of hepatocyte growth factor (scatter factor) activity |
| PCT/US2003/040917 WO2004058721A2 (en) | 2002-12-21 | 2003-12-19 | Pyrazole derivatives modulators of hepatocyte growth factor (scatter factor) activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010186703A Division JP5755417B2 (ja) | 2002-12-21 | 2010-08-23 | 肝細胞増殖因子（分散因子）活性のピラゾール誘導体モジュレーター |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006513221A JP2006513221A (ja) | 2006-04-20 |
| JP2006513221A5 true JP2006513221A5 (enExample) | 2007-02-15 |
| JP5160019B2 JP5160019B2 (ja) | 2013-03-13 |
Family
ID=32685400
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004563939A Expired - Fee Related JP5160019B2 (ja) | 2002-12-21 | 2003-12-19 | 肝細胞増殖因子（分散因子）活性のピラゾール誘導体モジュレーター |
| JP2010186703A Expired - Fee Related JP5755417B2 (ja) | 2002-12-21 | 2010-08-23 | 肝細胞増殖因子（分散因子）活性のピラゾール誘導体モジュレーター |
| JP2015016424A Pending JP2015078246A (ja) | 2002-12-21 | 2015-01-30 | 肝細胞増殖因子（分散因子）活性のピラゾール誘導体モジュレーター |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010186703A Expired - Fee Related JP5755417B2 (ja) | 2002-12-21 | 2010-08-23 | 肝細胞増殖因子（分散因子）活性のピラゾール誘導体モジュレーター |
| JP2015016424A Pending JP2015078246A (ja) | 2002-12-21 | 2015-01-30 | 肝細胞増殖因子（分散因子）活性のピラゾール誘導体モジュレーター |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US7192976B2 (enExample) |
| EP (2) | EP1572199B1 (enExample) |
| JP (3) | JP5160019B2 (enExample) |
| CN (1) | CN1747730B (enExample) |
| AU (1) | AU2003301224C1 (enExample) |
| CA (1) | CA2511199C (enExample) |
| DK (2) | DK1572199T3 (enExample) |
| HU (1) | HUE030700T2 (enExample) |
| IL (1) | IL169316A (enExample) |
| WO (1) | WO2004058721A2 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192976B2 (en) * | 2002-12-21 | 2007-03-20 | Angion Biomedica Corporation | Small molecule modulators of hepatocyte growth factor (scatter factor) activity |
| US20110230407A1 (en) * | 2005-03-14 | 2011-09-22 | Alexander Yuzhakov | Hepatocyte growth factor pathway activators in demyelinating diseases and central nervous system trauma |
| US7879898B1 (en) | 2006-02-14 | 2011-02-01 | Angion Biomedica Corp. | Hepatocyte growth factor pathway activators in chronic obstructive pulmonary disease |
| CN102149379A (zh) * | 2008-07-10 | 2011-08-10 | 安吉翁生物医药有限公司 | 调节肝细胞生长因子(分散因子)活性的方法和肝细胞生长因子(分散因子)活性的小分子调节剂组合物 |
| WO2010068287A2 (en) * | 2008-12-11 | 2010-06-17 | Angion Biomedica Corp. | Small molecule modulators of hepatocyte growth factor (scatter factor) activity |
| WO2011006072A2 (en) * | 2009-07-10 | 2011-01-13 | Northwestern University | Cardioprotective role of hepatic cells and hepatocyte secretory factors in myocardial ischemia |
| WO2011019400A2 (en) * | 2009-08-12 | 2011-02-17 | Angion Biomedica Corp. | Enhancement of cellular transplantation using small molecule modulators hepatocyte growth factor (scatter factor) activity |
| SG10201502484SA (en) | 2010-03-30 | 2015-05-28 | Verseon Corp | Multisubstituted aromatic compounds as inhibitors of thrombin |
| EP2624830A4 (en) * | 2010-10-05 | 2014-03-19 | Angion Biomedica Corp | METHODS OF USING SMALL MOLECULE MODULATORS OF GROWTH FACTOR ACTIVITY (DISPERSION FACTOR) OF LIVER CELLS |
| CN103582490B (zh) * | 2011-04-02 | 2015-09-30 | 华盛顿州立大学 | 作为治疗剂的肝细胞生长因子模拟物 |
| US8754044B2 (en) | 2011-05-03 | 2014-06-17 | Northwestern University | Neuroprotection by hepatic cells and hepatocyte secretory factors |
| UY34200A (es) * | 2011-07-21 | 2013-02-28 | Bayer Ip Gmbh | 3-(fluorovinil)pirazoles y su uso |
| DK2968297T3 (en) | 2013-03-15 | 2019-01-07 | Verseon Inc | MULTI-SUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS |
| WO2014149139A2 (en) | 2013-03-15 | 2014-09-25 | Verseon, Inc. | Halogenopyrazoles as inhibitors of thrombin |
| JP2017528486A (ja) | 2014-09-17 | 2017-09-28 | ヴァーセオン コーポレイション | セリンプロテアーゼ阻害剤としてのピラゾリル置換ピリドン化合物 |
| ES2931460T3 (es) | 2015-02-27 | 2022-12-29 | Verseon Int Corporation | Compuestos de pirazol sustituido como inhibidores de serina proteasa |
| MX2021012250A (es) | 2019-04-11 | 2022-01-18 | Angion Biomedica Corp | Formas solidas de (e)-3-[2-(2-tienil)vinil]-1h-pirazol. |
| US20230000828A1 (en) * | 2019-10-31 | 2023-01-05 | Angion Biomedica Corp. | Improving renal function after kidney transplantation |
| WO2021183774A1 (en) * | 2020-03-12 | 2021-09-16 | Angion Biomedica Corp. | Treating acute respiratory distress |
| EP4228626A2 (en) * | 2020-10-14 | 2023-08-23 | Angion Biomedica Corp. | Preparation of terevalefim and formulations thereof |
| AU2021371026A1 (en) * | 2020-11-02 | 2023-06-15 | LeonaBio, Inc. | Bicyclic compounds and uses thereof for the treatment of diseases |
| WO2022217070A1 (en) * | 2021-04-09 | 2022-10-13 | Angion Biomedica Corp. | Hgf/sf mimetic compounds |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE138770C (enExample) * | ||||
| JPS48713Y1 (enExample) | 1967-12-19 | 1973-01-09 | ||
| JPS48713U (enExample) | 1971-05-22 | 1973-01-08 | ||
| DD138770A1 (de) * | 1978-09-20 | 1979-11-21 | Juergen Liebscher | Verfahren zur herstellung von 5-styryl-pyrazolen und ihren vinylogen |
| JPH02193994A (ja) | 1989-01-23 | 1990-07-31 | Kyowa Hakko Kogyo Co Ltd | ピリダジノン誘導体 |
| FR2669633B1 (fr) * | 1990-11-23 | 1993-01-22 | Adir | Nouveaux derives de la benzoselenazolinone, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| US5837676A (en) * | 1993-10-18 | 1998-11-17 | Long Island Jewish Medical Center | Use of scatter factor to enhance angiogenesis |
| US6498144B1 (en) * | 1993-10-18 | 2002-12-24 | North Shore - Long Island Jewish Research Institute | Use of scatter factor to enhance angiogenesis |
| US5476076A (en) * | 1994-12-06 | 1995-12-19 | Zhou; Zhishan | Internal combustion piston engine utilizing interference movable fit technology |
| JPH11288112A (ja) | 1998-04-06 | 1999-10-19 | Mitsubishi Paper Mills Ltd | 電子写真感光体 |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| WO2001034650A1 (en) * | 1999-11-09 | 2001-05-17 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Heatlh And Human Services | Hgf-sf monoclonal antibody combinations |
| JP4993834B2 (ja) | 2000-06-29 | 2012-08-08 | ノース ショア−ロング アイランド ジューイッシュ ヘルス システム | 細胞増殖および血管形成の調節物質、その使用方法および特定方法 |
| US6589997B2 (en) * | 2001-06-29 | 2003-07-08 | North Shore-Long Island Jewish Health System | Small-molecule modulators of hepatocyte growth factor/scatter factor activities |
| US6610726B2 (en) * | 2001-06-29 | 2003-08-26 | North Shore-Long Island Jewish Research Institute | Compositions and agents for modulating cellular proliferation and angiogenesis |
| AU2002313690A1 (en) | 2002-07-19 | 2004-02-09 | Targacept, Inc. | Five-membered heteroaromatic olefinic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of ncotinic cholinergic receptors |
| US7192976B2 (en) | 2002-12-21 | 2007-03-20 | Angion Biomedica Corporation | Small molecule modulators of hepatocyte growth factor (scatter factor) activity |
-
2003
- 2003-12-18 US US10/740,708 patent/US7192976B2/en not_active Expired - Lifetime
- 2003-12-19 EP EP03814306.1A patent/EP1572199B1/en not_active Expired - Lifetime
- 2003-12-19 JP JP2004563939A patent/JP5160019B2/ja not_active Expired - Fee Related
- 2003-12-19 DK DK03814306.1T patent/DK1572199T3/da active
- 2003-12-19 DK DK10011181.4T patent/DK2292227T3/en active
- 2003-12-19 CA CA2511199A patent/CA2511199C/en not_active Expired - Lifetime
- 2003-12-19 CN CN2003801095507A patent/CN1747730B/zh not_active Expired - Fee Related
- 2003-12-19 EP EP10011181.4A patent/EP2292227B1/en not_active Expired - Lifetime
- 2003-12-19 AU AU2003301224A patent/AU2003301224C1/en not_active Ceased
- 2003-12-19 WO PCT/US2003/040917 patent/WO2004058721A2/en not_active Ceased
- 2003-12-19 HU HUE10011181A patent/HUE030700T2/en unknown
-
2004
- 2004-12-29 US US11/025,373 patent/US7265112B2/en not_active Expired - Lifetime
- 2004-12-29 US US11/024,615 patent/US7250437B2/en not_active Expired - Lifetime
-
2005
- 2005-06-21 IL IL169316A patent/IL169316A/en active IP Right Grant
-
2007
- 2007-08-13 US US11/891,618 patent/US8580834B2/en not_active Expired - Fee Related
-
2010
- 2010-08-23 JP JP2010186703A patent/JP5755417B2/ja not_active Expired - Fee Related
-
2013
- 2013-10-07 US US14/047,907 patent/US9663471B2/en not_active Expired - Fee Related
-
2015
- 2015-01-30 JP JP2015016424A patent/JP2015078246A/ja active Pending
-
2019
- 2019-01-11 US US16/245,373 patent/US20190382348A1/en not_active Abandoned
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