JP2011527675A5 - - Google Patents

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JP2011527675A5
JP2011527675A5 JP2011517424A JP2011517424A JP2011527675A5 JP 2011527675 A5 JP2011527675 A5 JP 2011527675A5 JP 2011517424 A JP2011517424 A JP 2011517424A JP 2011517424 A JP2011517424 A JP 2011517424A JP 2011527675 A5 JP2011527675 A5 JP 2011527675A5
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JP2011517424A
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English (en)
Japanese (ja)
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JP5775452B2 (ja
JP2011527675A (ja
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Priority claimed from PCT/US2009/004014 external-priority patent/WO2010005580A2/en
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Publication of JP2011527675A5 publication Critical patent/JP2011527675A5/ja
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JP2011517424A 2008-07-10 2009-07-09 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法 Expired - Fee Related JP5775452B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13448508P 2008-07-10 2008-07-10
US61/134,485 2008-07-10
PCT/US2009/004014 WO2010005580A2 (en) 2008-07-10 2009-07-09 Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015012415A Division JP2015108002A (ja) 2008-07-10 2015-01-26 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法

Publications (3)

Publication Number Publication Date
JP2011527675A JP2011527675A (ja) 2011-11-04
JP2011527675A5 true JP2011527675A5 (enExample) 2012-08-23
JP5775452B2 JP5775452B2 (ja) 2015-09-09

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JP2011517424A Expired - Fee Related JP5775452B2 (ja) 2008-07-10 2009-07-09 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法
JP2015012415A Pending JP2015108002A (ja) 2008-07-10 2015-01-26 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法

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JP2015012415A Pending JP2015108002A (ja) 2008-07-10 2015-01-26 肝細胞増殖因子（分散因子）活性の低分子モジュレーターの組成物および方法

Country Status (7)

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US (4) US8772326B2 (enExample)
EP (1) EP2313093A4 (enExample)
JP (2) JP5775452B2 (enExample)
CN (1) CN102149379A (enExample)
CA (1) CA2767331A1 (enExample)
IL (1) IL210544A (enExample)
WO (1) WO2010005580A2 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8772326B2 (en) 2008-07-10 2014-07-08 Anigion Biomedica Corp. Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity
BRPI1010706A2 (pt) 2009-06-12 2016-03-15 Sumitomo Rubber Ind veículo
JP6155187B2 (ja) 2010-03-30 2017-06-28 ヴァーセオン コーポレイション トロンビンの阻害剤としての多置換芳香族化合物
AU2011312333A1 (en) * 2010-10-05 2013-05-02 Angion Biomedica Corp. Methods of use of small molecule modulators of hepatocyte growth factor (scatter factor) activity
WO2014145986A1 (en) 2013-03-15 2014-09-18 Verseon, Inc. Multisubstituted aromatic compounds as serine protease inhibitors
ES2791749T3 (es) 2013-03-15 2020-11-05 Verseon Corp Halogenopirazoles como inhibidores de la trombina
KR20170048410A (ko) 2014-09-17 2017-05-08 베르선 코포레이션 세린 프로테아제 저해제로서의 피라졸릴-치환된 피리돈 화합물
AU2016224974B2 (en) 2015-02-27 2019-09-26 Verseon Corporation Substituted pyrazole compounds as serine protease inhibitors
US11413254B2 (en) * 2016-12-22 2022-08-16 Norbel Baby Co., Ltd. Application for (2R, 4R)-1,2,4-trihydroxyheptadec-16-yne in preparation of pharmaceutical composition for preventing or treating hepatic injury
CN114026085A (zh) 2019-04-11 2022-02-08 安吉昂生物医药公司 (e)-3-[2-(2-噻吩基)乙烯基]-1h-吡唑的固体形式
EP4051271A4 (en) * 2019-10-31 2023-11-29 Angion Biomedica Corp. IMPROVEMENT IN KIDNEY FUNCTION AFTER KIDNEY TRANSPLANT
CN119504599B (zh) * 2024-11-18 2025-09-26 安徽医科大学 一种用于治疗肾脏纤维化的吡唑类化合物及其应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE138770C (enExample)
JPS48713Y1 (enExample) 1967-12-19 1973-01-09
DD138770A1 (de) 1978-09-20 1979-11-21 Juergen Liebscher Verfahren zur herstellung von 5-styryl-pyrazolen und ihren vinylogen
US4806535A (en) * 1987-07-22 1989-02-21 Rorer Pharmaceutical Corporation Imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds and their use for increasing cardiatonic contractility
JPH02193994A (ja) 1989-01-23 1990-07-31 Kyowa Hakko Kogyo Co Ltd ピリダジノン誘導体
US6566098B1 (en) * 1990-09-14 2003-05-20 The United States Of America As Represented By The Department Of Health And Human Services DNA encoding truncated hepatocyte growth factor variants
JP3680114B2 (ja) * 1993-09-17 2005-08-10 敏一 中村 脳神経障害治療剤
US5837676A (en) * 1993-10-18 1998-11-17 Long Island Jewish Medical Center Use of scatter factor to enhance angiogenesis
US6498144B1 (en) * 1993-10-18 2002-12-24 North Shore - Long Island Jewish Research Institute Use of scatter factor to enhance angiogenesis
JP3818322B2 (ja) * 1994-04-28 2006-09-06 敏一 中村 コラーゲン分解促進剤
KR100765687B1 (ko) * 1995-08-29 2007-10-11 안제스에무지 가부시키가이샤 Ｈｇｆ 유전자를 함유하는 약제
US5830879A (en) * 1995-10-02 1998-11-03 St. Elizabeth's Medical Center Of Boston, Inc. Treatment of vascular injury using vascular endothelial growth factor
JPH11288112A (ja) 1998-04-06 1999-10-19 Mitsubishi Paper Mills Ltd 電子写真感光体
KR20010101675A (ko) * 1999-01-26 2001-11-14 우에노 도시오 2ｈ-프탈라진-1-온 유도체 및 그 유도체를 유효 성분으로하는 약제
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
US6437006B1 (en) * 1999-09-27 2002-08-20 American Cyanamid Company Pharmaceutical carrier formulation
AU1598801A (en) 1999-11-09 2001-06-06 Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The HGF-SF monoclonal antibody combinations
EP1274720A4 (en) * 2000-04-12 2004-08-18 Human Genome Sciences Inc FUSION PROTEINS CONTAINING ALBUMIN
AU7785401A (en) * 2000-06-29 2002-01-14 Long Island Jewish Res Inst Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof
DE10047486A1 (de) * 2000-09-26 2002-04-11 Bayer Ag Phenoxyphenyl Alkansulfonate
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
US6610726B2 (en) * 2001-06-29 2003-08-26 North Shore-Long Island Jewish Research Institute Compositions and agents for modulating cellular proliferation and angiogenesis
US6589997B2 (en) * 2001-06-29 2003-07-08 North Shore-Long Island Jewish Health System Small-molecule modulators of hepatocyte growth factor/scatter factor activities
US20030073692A1 (en) * 2001-08-07 2003-04-17 Pharmacia & Upjohn S.P.A. Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them
ATE397440T1 (de) * 2002-02-22 2008-06-15 Schering Corp Pharmazeutische zubereitungen von antineoplastischen wirkstoffen, insbesondere temozolomid, verfahren zu ihrer herstellung und deren verwendung
WO2004009599A1 (en) 2002-07-19 2004-01-29 Targacept, Inc. Five-membered heteroaromatic olefinic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of ncotinic cholinergic receptors
US7192976B2 (en) * 2002-12-21 2007-03-20 Angion Biomedica Corporation Small molecule modulators of hepatocyte growth factor (scatter factor) activity
FR2868519B1 (fr) * 2004-03-30 2006-06-16 Christian Muller Generateur thermique a materiau magneto-calorique et procede de generation de thermies
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
US7648978B2 (en) * 2004-09-28 2010-01-19 Angion Biomedica Corp. Small molecule modulators of cytokine activity
US20110230407A1 (en) * 2005-03-14 2011-09-22 Alexander Yuzhakov Hepatocyte growth factor pathway activators in demyelinating diseases and central nervous system trauma
US7879898B1 (en) 2006-02-14 2011-02-01 Angion Biomedica Corp. Hepatocyte growth factor pathway activators in chronic obstructive pulmonary disease
HRP20120346T1 (hr) * 2007-03-08 2012-05-31 Janssen Pharmaceutica N.V. Derivati kinolinona kao parp i tank inhibitori
WO2009064422A2 (en) 2007-11-13 2009-05-22 Angion Biomedica Corp. Hepatocyte growth factor pathway activators in fibrotic connective tissue diseases
US8772326B2 (en) 2008-07-10 2014-07-08 Anigion Biomedica Corp. Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity
US20110098304A1 (en) * 2008-10-22 2011-04-28 Bijoy Panicker Small molecule inhibitors of PARP activity
US20120190668A1 (en) 2009-08-12 2012-07-26 Oehlen Lambertus J W M Enhancement of cellular transplantation using small moleucle modulators of hepatocyte growth factor (scatter factor) activity
AU2011312333A1 (en) 2010-10-05 2013-05-02 Angion Biomedica Corp. Methods of use of small molecule modulators of hepatocyte growth factor (scatter factor) activity

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