JP2011527675A5 - - Google Patents
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- JP2011527675A5 JP2011527675A5 JP2011517424A JP2011517424A JP2011527675A5 JP 2011527675 A5 JP2011527675 A5 JP 2011527675A5 JP 2011517424 A JP2011517424 A JP 2011517424A JP 2011517424 A JP2011517424 A JP 2011517424A JP 2011527675 A5 JP2011527675 A5 JP 2011527675A5
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- JP
- Japan
- Prior art keywords
- alkoxy
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- hydroxy
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 0 *C(*)(CC1)CCC1C=C[C@@]1NNC=C1 Chemical compound *C(*)(CC1)CCC1C=C[C@@]1NNC=C1 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13448508P | 2008-07-10 | 2008-07-10 | |
| US61/134,485 | 2008-07-10 | ||
| PCT/US2009/004014 WO2010005580A2 (en) | 2008-07-10 | 2009-07-09 | Methods and compositions of small molecule modulators of hepatocyte growth factor (scatter factor) activity |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015012415A Division JP2015108002A (ja) | 2008-07-10 | 2015-01-26 | 肝細胞増殖因子(分散因子)活性の低分子モジュレーターの組成物および方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011527675A JP2011527675A (ja) | 2011-11-04 |
| JP2011527675A5 true JP2011527675A5 (enExample) | 2012-08-23 |
| JP5775452B2 JP5775452B2 (ja) | 2015-09-09 |
Family
ID=41507639
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517424A Expired - Fee Related JP5775452B2 (ja) | 2008-07-10 | 2009-07-09 | 肝細胞増殖因子(分散因子)活性の低分子モジュレーターの組成物および方法 |
| JP2015012415A Pending JP2015108002A (ja) | 2008-07-10 | 2015-01-26 | 肝細胞増殖因子(分散因子)活性の低分子モジュレーターの組成物および方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015012415A Pending JP2015108002A (ja) | 2008-07-10 | 2015-01-26 | 肝細胞増殖因子(分散因子)活性の低分子モジュレーターの組成物および方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US8772326B2 (enExample) |
| EP (1) | EP2313093A4 (enExample) |
| JP (2) | JP5775452B2 (enExample) |
| CN (1) | CN102149379A (enExample) |
| CA (1) | CA2767331A1 (enExample) |
| IL (1) | IL210544A (enExample) |
| WO (1) | WO2010005580A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102149379A (zh) | 2008-07-10 | 2011-08-10 | 安吉翁生物医药有限公司 | 调节肝细胞生长因子(分散因子)活性的方法和肝细胞生长因子(分散因子)活性的小分子调节剂组合物 |
| CN102802969A (zh) | 2009-06-12 | 2012-11-28 | 住友橡胶工业株式会社 | 车辆 |
| CN102918034B (zh) | 2010-03-30 | 2015-06-03 | 维颂公司 | 多取代芳族化合物作为凝血酶的抑制剂 |
| JP2014509297A (ja) * | 2010-10-05 | 2014-04-17 | アンジオン バイオメディカ コーポレイション | 肝細胞増殖因子(散乱因子)活性の小分子モジュレーターの使用方法 |
| LT2968297T (lt) | 2013-03-15 | 2019-01-10 | Verseon Corporation | Multipakeistieji aromatiniai junginiai kaip serino proteazės inhibitoriai |
| ES2791749T3 (es) | 2013-03-15 | 2020-11-05 | Verseon Corp | Halogenopirazoles como inhibidores de la trombina |
| CN106687445A (zh) | 2014-09-17 | 2017-05-17 | 维颂公司 | 作为丝氨酸蛋白酶抑制剂的吡唑基取代的吡啶酮化合物 |
| RU2017131562A (ru) | 2015-02-27 | 2019-03-27 | Версеон Корпорейшн | Замещенные пиразольные соединения как ингибиторы сериновых протеаз |
| WO2018112816A1 (zh) * | 2016-12-22 | 2018-06-28 | 高雄医学大学 | (2r,4r)-1,2,4-三羟基十七碳-16-炔在制备预防或治疗肝损伤医药组合物中的应用 |
| EP3927702A4 (en) * | 2019-04-11 | 2022-05-11 | Angion Biomedica Corp. | SOLID FORMS OF (E)-3-[2-(2-THIENYL)VINYL]-1H-PYRAZOLE |
| US20230000828A1 (en) * | 2019-10-31 | 2023-01-05 | Angion Biomedica Corp. | Improving renal function after kidney transplantation |
| CN119504599B (zh) * | 2024-11-18 | 2025-09-26 | 安徽医科大学 | 一种用于治疗肾脏纤维化的吡唑类化合物及其应用 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE138770C (enExample) | ||||
| JPS48713Y1 (enExample) | 1967-12-19 | 1973-01-09 | ||
| DD138770A1 (de) | 1978-09-20 | 1979-11-21 | Juergen Liebscher | Verfahren zur herstellung von 5-styryl-pyrazolen und ihren vinylogen |
| US4806535A (en) * | 1987-07-22 | 1989-02-21 | Rorer Pharmaceutical Corporation | Imidazolylphenyl and 1,2,4-triazolylphenyl benzopyridazinone and pyridopyridazinone compounds and their use for increasing cardiatonic contractility |
| JPH02193994A (ja) | 1989-01-23 | 1990-07-31 | Kyowa Hakko Kogyo Co Ltd | ピリダジノン誘導体 |
| US6566098B1 (en) * | 1990-09-14 | 2003-05-20 | The United States Of America As Represented By The Department Of Health And Human Services | DNA encoding truncated hepatocyte growth factor variants |
| JP3680114B2 (ja) * | 1993-09-17 | 2005-08-10 | 敏一 中村 | 脳神経障害治療剤 |
| US5837676A (en) * | 1993-10-18 | 1998-11-17 | Long Island Jewish Medical Center | Use of scatter factor to enhance angiogenesis |
| US6498144B1 (en) * | 1993-10-18 | 2002-12-24 | North Shore - Long Island Jewish Research Institute | Use of scatter factor to enhance angiogenesis |
| JP3818322B2 (ja) * | 1994-04-28 | 2006-09-06 | 敏一 中村 | コラーゲン分解促進剤 |
| CA2230819C (en) * | 1995-08-29 | 2009-04-14 | Sumitomo Pharmaceuticals Co., Ltd. | Medicament comprising hgf gene |
| US5830879A (en) * | 1995-10-02 | 1998-11-03 | St. Elizabeth's Medical Center Of Boston, Inc. | Treatment of vascular injury using vascular endothelial growth factor |
| JPH11288112A (ja) | 1998-04-06 | 1999-10-19 | Mitsubishi Paper Mills Ltd | 電子写真感光体 |
| KR20010101675A (ko) * | 1999-01-26 | 2001-11-14 | 우에노 도시오 | 2h-프탈라진-1-온 유도체 및 그 유도체를 유효 성분으로하는 약제 |
| PE20010306A1 (es) | 1999-07-02 | 2001-03-29 | Agouron Pharma | Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa |
| US6437006B1 (en) * | 1999-09-27 | 2002-08-20 | American Cyanamid Company | Pharmaceutical carrier formulation |
| WO2001034650A1 (en) | 1999-11-09 | 2001-05-17 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Heatlh And Human Services | Hgf-sf monoclonal antibody combinations |
| EP2213743A1 (en) * | 2000-04-12 | 2010-08-04 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| AU2001277854B2 (en) * | 2000-06-29 | 2007-03-01 | North Shore-Long Island Jewish Health System | Modulators of cellular proliferation and angiogenesis, methods for use and identification thereof |
| DE10047486A1 (de) * | 2000-09-26 | 2002-04-11 | Bayer Ag | Phenoxyphenyl Alkansulfonate |
| US7151102B2 (en) * | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
| US6610726B2 (en) * | 2001-06-29 | 2003-08-26 | North Shore-Long Island Jewish Research Institute | Compositions and agents for modulating cellular proliferation and angiogenesis |
| US6589997B2 (en) * | 2001-06-29 | 2003-07-08 | North Shore-Long Island Jewish Health System | Small-molecule modulators of hepatocyte growth factor/scatter factor activities |
| US20030073692A1 (en) * | 2001-08-07 | 2003-04-17 | Pharmacia & Upjohn S.P.A. | Amino-phthalazinone derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions containing them |
| CN101172104B (zh) * | 2002-02-22 | 2013-04-03 | 默沙东公司 | 抗肿瘤剂,特别是替莫唑胺的药物制剂,其制备方法和用途 |
| AU2002313690A1 (en) | 2002-07-19 | 2004-02-09 | Targacept, Inc. | Five-membered heteroaromatic olefinic azacyclic compounds, pharmaceutical compositions containing them and their use as inhibitors of ncotinic cholinergic receptors |
| US7192976B2 (en) | 2002-12-21 | 2007-03-20 | Angion Biomedica Corporation | Small molecule modulators of hepatocyte growth factor (scatter factor) activity |
| FR2868519B1 (fr) * | 2004-03-30 | 2006-06-16 | Christian Muller | Generateur thermique a materiau magneto-calorique et procede de generation de thermies |
| GB0419072D0 (en) * | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
| AU2005289560A1 (en) * | 2004-09-28 | 2006-04-06 | Angion Biomedica Corp. | Small molecule modulators of cytokine activity |
| US20110230407A1 (en) * | 2005-03-14 | 2011-09-22 | Alexander Yuzhakov | Hepatocyte growth factor pathway activators in demyelinating diseases and central nervous system trauma |
| US7879898B1 (en) | 2006-02-14 | 2011-02-01 | Angion Biomedica Corp. | Hepatocyte growth factor pathway activators in chronic obstructive pulmonary disease |
| US8299256B2 (en) * | 2007-03-08 | 2012-10-30 | Janssen Pharmaceutica Nv | Quinolinone derivatives as PARP and TANK inhibitors |
| US8193177B2 (en) * | 2007-11-13 | 2012-06-05 | Angion Biomedica Corp. | Hepatocyte growth factor pathway activators in fibrotic connective tissue diseases |
| CN102149379A (zh) | 2008-07-10 | 2011-08-10 | 安吉翁生物医药有限公司 | 调节肝细胞生长因子(分散因子)活性的方法和肝细胞生长因子(分散因子)活性的小分子调节剂组合物 |
| US20110098304A1 (en) * | 2008-10-22 | 2011-04-28 | Bijoy Panicker | Small molecule inhibitors of PARP activity |
| WO2011019400A2 (en) | 2009-08-12 | 2011-02-17 | Angion Biomedica Corp. | Enhancement of cellular transplantation using small molecule modulators hepatocyte growth factor (scatter factor) activity |
| JP2014509297A (ja) | 2010-10-05 | 2014-04-17 | アンジオン バイオメディカ コーポレイション | 肝細胞増殖因子(散乱因子)活性の小分子モジュレーターの使用方法 |
-
2009
- 2009-07-09 CN CN2009801353421A patent/CN102149379A/zh active Pending
- 2009-07-09 EP EP09794828A patent/EP2313093A4/en not_active Withdrawn
- 2009-07-09 WO PCT/US2009/004014 patent/WO2010005580A2/en not_active Ceased
- 2009-07-09 US US13/003,514 patent/US8772326B2/en active Active
- 2009-07-09 CA CA2767331A patent/CA2767331A1/en not_active Abandoned
- 2009-07-09 JP JP2011517424A patent/JP5775452B2/ja not_active Expired - Fee Related
-
2011
- 2011-01-10 IL IL210544A patent/IL210544A/en not_active IP Right Cessation
-
2014
- 2014-05-25 US US14/287,039 patent/US20140256727A1/en not_active Abandoned
-
2015
- 2015-01-26 JP JP2015012415A patent/JP2015108002A/ja active Pending
-
2017
- 2017-02-23 US US15/440,398 patent/US20180009793A1/en not_active Abandoned
-
2019
- 2019-01-04 US US16/239,836 patent/US10899750B2/en not_active Expired - Fee Related
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