JP2023502605A5 - - Google Patents

Info

Publication number
JP2023502605A5
JP2023502605A5 JP2022527685A JP2022527685A JP2023502605A5 JP 2023502605 A5 JP2023502605 A5 JP 2023502605A5 JP 2022527685 A JP2022527685 A JP 2022527685A JP 2022527685 A JP2022527685 A JP 2022527685A JP 2023502605 A5 JP2023502605 A5 JP 2023502605A5
Authority
JP
Japan
Prior art keywords
alkyl
compound
alkoxy
substituted
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2022527685A
Other languages
English (en)
Japanese (ja)
Other versions
JP7605504B2 (ja
JP2023502605A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/060459 external-priority patent/WO2021097243A1/en
Publication of JP2023502605A publication Critical patent/JP2023502605A/ja
Publication of JP2023502605A5 publication Critical patent/JP2023502605A5/ja
Application granted granted Critical
Publication of JP7605504B2 publication Critical patent/JP7605504B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2022527685A 2019-11-13 2020-11-13 タウタンパク質凝集物を分解する化合物及びその使用 Active JP7605504B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962935017P 2019-11-13 2019-11-13
US62/935,017 2019-11-13
PCT/US2020/060459 WO2021097243A1 (en) 2019-11-13 2020-11-13 Compounds for degrading tau protein aggregates and uses thereof

Publications (3)

Publication Number Publication Date
JP2023502605A JP2023502605A (ja) 2023-01-25
JP2023502605A5 true JP2023502605A5 (https=) 2023-11-15
JP7605504B2 JP7605504B2 (ja) 2024-12-24

Family

ID=75912369

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022527685A Active JP7605504B2 (ja) 2019-11-13 2020-11-13 タウタンパク質凝集物を分解する化合物及びその使用

Country Status (8)

Country Link
US (5) US20220354835A1 (https=)
EP (1) EP4058065A4 (https=)
JP (1) JP7605504B2 (https=)
KR (1) KR20220100921A (https=)
CN (1) CN114728071B (https=)
CA (1) CA3161455A1 (https=)
TW (1) TWI759962B (https=)
WO (1) WO2021097243A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4121046A4 (en) * 2020-03-18 2024-04-24 Dana-Farber Cancer Institute, Inc. Targeted degraders of aberrant tau based on the pet tracer pbb3
IL301690A (en) * 2020-10-16 2023-05-01 Dana Farber Cancer Inst Inc Piperidinyl small molecule degraders of helios and methods of use
WO2025117551A1 (en) * 2023-11-27 2025-06-05 Amydis, Inc. Amino acid derivatives for detecting neurological disorders
WO2025129172A1 (en) * 2023-12-14 2025-06-19 The Board Of Trustees Of The Leland Stanford Junior University Crbn molecular glue degraders and uses thereof

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3833863A (en) 1971-12-27 1974-09-03 Eastman Kodak Co Styryl and arylbutadienyl dye lasers
JPS5553333A (en) 1978-10-16 1980-04-18 Hitachi Ltd Composite type electrophotographic plate
JPS61275836A (ja) 1985-05-31 1986-12-05 Fuji Photo Film Co Ltd ハロゲン化銀写真乳剤
GB8921116D0 (en) 1989-09-18 1989-11-01 Du Pont Improvements in or relating to radiation sensitive compositions
US5264329A (en) 1989-09-18 1993-11-23 Dupont (U.K.) Limited Radiation sensitive compositions
RU2324686C2 (ru) 2000-08-24 2008-05-20 Юнивесити Оф Питсбэг ПРОИЗВОДНЫЕ ТИОФЛАВИНА, СВЯЗЫВАЮЩИЕ АМИЛОИД, СПОСОБ ОБНАРУЖЕНИЯ in vivo ОТЛОЖЕНИЙ АМИЛОИДА И СПОСОБ РАСПОЗНАВАНИЯ БОЛЕЗНИ АЛЬЦГЕЙМЕРА
WO2003048137A1 (en) * 2001-11-30 2003-06-12 Merck & Co., Inc. Metabotropic glutamate receptor-5 modulators
MXPA05012459A (es) 2003-05-19 2006-02-22 Irm Llc Compuestos y composiciones inmunosupresoras.
WO2005016384A1 (ja) 2003-08-13 2005-02-24 Bf Research Institute, Inc. アミロイド蓄積性疾患のプローブ、アミロイド染色剤、アミロイド蓄積性疾患の治療および予防薬、ならびに神経原線維変化の診断プローブおよび染色剤
CA2500358A1 (en) 2003-08-13 2005-02-24 Bf Research Institute, Inc. Probes for diseases in which amyloid accumulates, agents for staining amyloid, drugs for treatment and prophylaxis of diseases with accumulated amyloid, and probes for diagnosis of neurofibrillary tangles and agents for staining neurofibrillary tangles
JP2007106755A (ja) 2005-09-13 2007-04-26 Japan Health Science Foundation アミロイドイメージング用プローブ
WO2007034282A2 (en) 2005-09-19 2007-03-29 Pfizer Products Inc. Diaryl-imidazole compounds condensed with a heterocycle as c3a receptor antagonists
CN101351458A (zh) 2005-12-01 2009-01-21 匹兹堡大学 作为促淀粉样变蛋白成像剂的同位素标记的苯并噻唑化合物
TW201018678A (en) 2006-01-27 2010-05-16 Astrazeneca Ab Novel heteroaryl substituted benzothiazoles
FR2906250B1 (fr) 2006-09-22 2008-10-31 Sanofi Aventis Sa Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique
WO2008078424A1 (ja) 2006-12-25 2008-07-03 Tohoku University ベンゾキサゾール誘導体
EP2247558B2 (en) 2008-02-14 2024-07-03 Eli Lilly and Company Novel imaging agents for detecting neurological dysfunction
JP5603855B2 (ja) 2008-04-04 2014-10-08 アビッド レディオファーマシューティカルズ、インク. 神経変成疾患の放射性薬剤による画像化
JP2011529086A (ja) * 2008-07-24 2011-12-01 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド Ad病変を同定するために有用な造影剤
US8193363B2 (en) 2008-08-29 2012-06-05 Astrazeneca Ab Compounds suitable as precursors to compounds that are useful for imaging amyloid deposits
CA2737028C (en) 2008-09-23 2017-06-27 Wista Laboratories Ltd. Ligands for aggregated tau molecules
JP5591720B2 (ja) 2009-01-29 2014-09-17 株式会社林原 抗神経変性疾患剤
JPWO2010087315A1 (ja) 2009-01-29 2012-08-02 株式会社林原生物化学研究所 抗アルツハイマー病剤
US8691187B2 (en) 2009-03-23 2014-04-08 Eli Lilly And Company Imaging agents for detecting neurological disorders
JP2012521988A (ja) 2009-03-23 2012-09-20 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッド 神経学的障害を検知するためのイメージング剤
JP2010275836A (ja) 2009-06-01 2010-12-09 Miwa Lock Co Ltd 電気錠システムの雷サージ対策アダプタ
UA108363C2 (uk) 2009-10-08 2015-04-27 Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
US20120263646A1 (en) 2009-10-15 2012-10-18 Guerbet Imaging agents and their use for the diagnostic in vivo of neurodegenerative diseases, notably alzheimer's disease and derivative diseases
KR101116234B1 (ko) 2009-10-29 2014-03-06 (주)퓨쳐켐 (3-플루오로-2-히드록시)프로필 작용기가 도입된 아릴 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는 퇴행성 뇌질환의 진단 또는 치료용 약학적 조성물
US9133343B2 (en) 2009-11-30 2015-09-15 Enzo Biochem, Inc. Dyes and compositions, and processes for using same in analysis of protein aggregation and other applications
JP6106157B2 (ja) 2011-04-26 2017-03-29 レトロトップ、 インコーポレイテッドRetrotope, Inc. 神経変性障害および筋疾患に関与するpufa
EP2724161A1 (en) 2011-06-22 2014-04-30 F.Hoffmann-La Roche Ag A method for the identification of beta-sheet aggregated protein ligands
DK2767532T3 (en) 2012-12-21 2016-09-12 Nat Inst For Quantum And Radiological Science And Tech New connection for reproduction of tau protein heavy in the brain.
US9447054B2 (en) 2014-01-15 2016-09-20 Korea Institute Of Radiological & Medical Sciences Anticancer supplement agent including benzo[D]oxazol derivative as effective ingredient
WO2015188368A1 (en) 2014-06-13 2015-12-17 Merck Sharp & Dohme Corp. Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles
WO2016105518A1 (en) 2014-12-23 2016-06-30 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
US9694084B2 (en) 2014-12-23 2017-07-04 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
US10308871B2 (en) 2015-02-19 2019-06-04 Jnc Corporation Liquid crystal compound having benzothiophene, liquid crystal composition and liquid crystal display device
EP3270917A4 (en) 2015-03-18 2018-08-08 Arvinas, Inc. Compounds and methods for the enhanced degradation of targeted proteins
WO2017007612A1 (en) 2015-07-07 2017-01-12 Dana-Farber Cancer Institute, Inc. Methods to induce targeted protein degradation through bifunctional molecules
WO2017024318A1 (en) * 2015-08-06 2017-02-09 Dana-Farber Cancer Institute, Inc. Targeted protein degradation to attenuate adoptive t-cell therapy associated adverse inflammatory responses
US10772962B2 (en) 2015-08-19 2020-09-15 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of bromodomain-containing proteins
TW201722958A (zh) * 2015-09-15 2017-07-01 葛蘭素史克智慧財產(第二)有限公司 化學化合物
TW201722957A (zh) * 2015-09-15 2017-07-01 葛蘭素史克智慧財產(第二)有限公司 化學化合物
US10300155B2 (en) 2015-12-31 2019-05-28 Washington University Alpha-synuclein ligands
US10059878B2 (en) 2016-02-17 2018-08-28 Jnc Corporation Liquid crystal composition and liquid crystal display device
JP6696312B2 (ja) 2016-06-15 2020-05-20 Jnc株式会社 液晶組成物および液晶表示素子
PH12018502613B1 (en) 2016-07-12 2023-02-01 H Lundbeck As Antibodies specific for hyperphosphorylated tau and methods of use thereof
CA3030754C (en) 2016-07-20 2022-04-26 Anahit Ghochikyan Humanized anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies
MX2019005007A (es) 2016-11-01 2019-07-18 Arvinas Inc Protac dirigidos a la proteína tau y métodos asociados de uso.
KR20250117470A (ko) * 2016-12-23 2025-08-04 아비나스 오퍼레이션스, 인코포레이티드 급속 진행성 섬유육종 폴리펩티드의 표적화 분해를 위한 화합물 및 방법
JP2020505327A (ja) * 2016-12-23 2020-02-20 アルビナス・オペレーションズ・インコーポレイテッドArvinas Operations, Inc. Egfrタンパク質分解標的化キメラ分子およびその関連する使用方法
ES2965049T3 (es) * 2017-07-12 2024-04-10 Dana Farber Cancer Inst Inc Compuestos para la degradación de la proteína tau
US11919902B2 (en) * 2017-12-22 2024-03-05 Hibercell, Inc. Aryl-bipyridine amine derivatives as phosphatidylinositol phosphate kinase inhibitors
TW201946624A (zh) 2018-05-09 2019-12-16 新旭生技股份有限公司 雜芳基化合物及其用途
AU2019294835B2 (en) 2018-06-29 2025-04-17 Dana-Farber Cancer Institute, Inc. Ligands to cereblon (CRBN)
JP7297053B2 (ja) 2018-08-20 2023-06-23 アルビナス・オペレーションズ・インコーポレイテッド 神経変性疾患を治療するためのe3ユビキチンリガーゼ結合活性を有するキメラ(protac)化合物を標的とし、アルファ-シヌクレインタンパク質を標的とするタンパク質分解
EP3999182A1 (en) 2019-07-17 2022-05-25 Arvinas Operations, Inc. Tau-protein targeting compounds and associated methods of use

Similar Documents

Publication Publication Date Title
JP2023502605A5 (https=)
SU1428199A3 (ru) Способ получени производных 2,2-иминобисэтанола или их кислотно-аддитивных солей,или их стереохимически изомерных форм (его варианты)
ES2655899T3 (es) Compuestos de pirazolo[1,5-a]pirimidina sustituidos como inhibidores de la Trk cinasa
CA1327600C (en) Process for the preparation of 5-acylamino-2,4,6- triiodo-or tribromo-benzoic acid derivatives and corresponding novel 5-acylamino-2,4,6-triiodo or tribromo-benzoic acid derivatives obtained by said process
IE47812B1 (en) Alkylenediamine derivatives
FI95463C (fi) Menetelmä anti-tuumoriaineina käyttökelpoisten akryloyylisubstituoitujen pyrrolijohdannaisten valmistamiseksi
JP2021530442A5 (https=)
SK281705B6 (sk) 7-(substituované)-9-[(substituovaný glycyl)amido]-6-demetyl-6-deoxytetracyklíny, spôsob ich výroby, farmaceutické a veterinárne prípravky na ich báze a medziprodukty ich výroby
NO20072833L (no) Bi- og tricykliske substituterte fenylmetanoner som glycinetransportor I-(Glyt-1)-inhibitorer for behandling av Alzheimers sykdom
RU2004106617A (ru) Противоопухолевые аналоги
DK144942B (da) Analogifremgangsmaade til fremstilling af alkanophenon-o-(2-aminoethyl)-oximetherforbindelser eller deres salte
RU2004112780A (ru) Производные и промежуточные соединения n-адамантилметила в качестве фармацевтических композиций и способы их получения
CA2324418A1 (en) Novel opiate compounds, methods of making and methods of use
RU2012108173A (ru) Терапевтические арил-амидо-арильные соединения и их применение
RU2006113700A (ru) Аминозамещенный этиламито-агонисты бэта2-адренергических рецепторов
RU2010147938A (ru) Способ получения промежуточных соединений нафталин-2-ид-пиразол-3-она, используемых в синтезе ингибиторов сигма рецептора
RU2004126700A (ru) Синтез эктеинасцидинов, встречающихся в природе, и родственных соединений
RU2002123576A (ru) Соединения, обладающие противоопухолевой активностью: способ их получения и фармацевтические композиции, содержащие их
AU731638B2 (en) Novel terephthalamide derivatives
AU658266B2 (en) 4-amino-2-ureidopyrimidine-5-carboxamides, a process for the preparation thereof, pharmaceuticals containing these compounds, and the use thereof
HUP0100102A2 (hu) Fenil-amino-alkilkarbonsav-származékok és fenil-amino-alkilkarbonsav-származékokat tartalmazó gyógyszerészeti készítmények
JP2024517340A5 (https=)
HK196796A (en) Use of aromatic diamines for the treatment of angina pectoris, and diamines therefor
RU2008143546A (ru) Тиазолилдигидрохиназолины
SK144294A3 (en) Diamine salts of clavulanic acid, method of their preparing, pharmaceutical preparations on their base and using of these salts