JP2021530442A5 - - Google Patents
Info
- Publication number
- JP2021530442A5 JP2021530442A5 JP2020570791A JP2020570791A JP2021530442A5 JP 2021530442 A5 JP2021530442 A5 JP 2021530442A5 JP 2020570791 A JP2020570791 A JP 2020570791A JP 2020570791 A JP2020570791 A JP 2020570791A JP 2021530442 A5 JP2021530442 A5 JP 2021530442A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- heterocyclyl
- cycloalkyl
- heteroaryl
- Prior art date
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862691208P | 2018-06-28 | 2018-06-28 | |
| US62/691,208 | 2018-06-28 | ||
| PCT/US2019/039860 WO2020006432A1 (en) | 2018-06-28 | 2019-06-28 | Fused tricyclic heterocycle compounds and therapeutic uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2021530442A JP2021530442A (ja) | 2021-11-11 |
| JP2021530442A5 true JP2021530442A5 (https=) | 2022-06-22 |
| JPWO2020006432A5 JPWO2020006432A5 (https=) | 2022-06-22 |
Family
ID=68987618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020570791A Pending JP2021530442A (ja) | 2018-06-28 | 2019-06-28 | 縮合三環系複素環化合物およびその治療上の使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11535633B2 (https=) |
| EP (1) | EP3813827A4 (https=) |
| JP (1) | JP2021530442A (https=) |
| KR (1) | KR20210025016A (https=) |
| CN (1) | CN112351778B (https=) |
| TW (1) | TW202019408A (https=) |
| WO (1) | WO2020006432A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2929415T3 (es) | 2018-05-25 | 2022-11-29 | Incyte Corp | Compuestos heterocíclicos tricíclicos como activadores de STING |
| US11008344B2 (en) | 2018-07-31 | 2021-05-18 | Incyte Corporation | Tricyclic heteroaryl compounds as STING activators |
| US10875872B2 (en) | 2018-07-31 | 2020-12-29 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| JP7584802B2 (ja) * | 2018-08-24 | 2024-11-18 | アドライ・ノーティ・バイオファーマ・カンパニー・リミテッド | 高活性ｓｔｉｎｇタンパク質アゴニスト |
| CN111655682B (zh) * | 2018-08-29 | 2024-05-31 | 杭州阿诺生物医药科技有限公司 | 一种高活性sting蛋白激动剂化合物 |
| US11596692B1 (en) | 2018-11-21 | 2023-03-07 | Incyte Corporation | PD-L1/STING conjugates and methods of use |
| WO2020124059A1 (en) * | 2018-12-14 | 2020-06-18 | Eternity Bioscience Inc. | Tricyclic compounds as sting agonists, and preparation methods and medicinal uses thereof |
| US12129267B2 (en) | 2019-01-07 | 2024-10-29 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| CA3149482A1 (en) | 2019-08-02 | 2021-02-11 | Mersana Therapeutics, Inc. | Bis-[n-((5-carbamoyl)-1h-benzo[d]imidazol-2-yl)-pyrazol-5-carboxamide] derivatives and related compounds as sting (stimulator of interferon genes) agonists for the treatment of cancer |
| WO2021202984A1 (en) | 2020-04-02 | 2021-10-07 | Mersana Therapeutics, Inc. | Antibody drug conjugates comprising sting agonists |
| WO2021206158A1 (ja) | 2020-04-10 | 2021-10-14 | 小野薬品工業株式会社 | がん治療方法 |
| CN115554303B (zh) * | 2021-09-18 | 2024-07-09 | 上海科技大学 | 一种三环类化合物、其制备方法及其应用 |
| CN119110800A (zh) * | 2022-02-21 | 2024-12-10 | 健道生物医药有限公司 | 干扰素基因刺激因子（sting）调节剂及其组合物和方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2731708B1 (fr) * | 1995-03-13 | 1997-04-30 | Synthelabo | Derives de piperidine, leur procede de preparation et leur application en therapeutique |
| FR2747678B1 (fr) * | 1996-04-22 | 1998-05-22 | Synthelabo | Composes derives d'imidazobenzoxazine, leurs procedes de preparation et leurs utilisations en therapeutique |
| CA2332239A1 (en) * | 1998-05-15 | 1999-11-25 | Guilford Pharmaceuticals Inc. | Fused tricyclic compounds which inhibit parp activity |
| ECSP003637A (es) * | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
| CA2324090A1 (en) | 1999-10-25 | 2001-04-25 | Leviton Manufacturing Co., Inc. | Electrical wiring device with multiple types of wire terminations |
| KR20080035576A (ko) * | 2005-08-05 | 2008-04-23 | 아스트라제네카 아베 | 트리사이클릭 벤즈이미다졸 및 대사체 글루타메이트 수용체조절제로서 이들의 용도 |
| EP2324044A4 (en) | 2008-08-04 | 2012-04-25 | Univ Miami | STING (STIMULATOR OF INTERFERON GENES) AS A REGULATOR OF BORROWING IMMUNE REACTIONS |
| CA2825028A1 (en) * | 2011-02-09 | 2012-08-16 | F. Hoffman-La Roche Ag | Heterocyclic compounds as pi3 kinase inhibitors |
| JP2015516989A (ja) | 2012-04-30 | 2015-06-18 | バーバー, グレン, エヌ.BARBER, Glen, N. | 免疫反応の変調 |
| US9527864B2 (en) * | 2014-09-15 | 2016-12-27 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| HRP20220936T1 (hr) | 2016-04-07 | 2022-10-28 | Glaxosmithkline Intellectual Property Development Limited | Heterociklički amidi korisni kao modulatori proteina |
| JP2019510802A (ja) * | 2016-04-07 | 2019-04-18 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | タンパク質調節物質として有用な複素環アミド |
-
2019
- 2019-06-28 JP JP2020570791A patent/JP2021530442A/ja active Pending
- 2019-06-28 TW TW108123007A patent/TW202019408A/zh unknown
- 2019-06-28 EP EP19825637.2A patent/EP3813827A4/en not_active Withdrawn
- 2019-06-28 CN CN201980043105.6A patent/CN112351778B/zh active Active
- 2019-06-28 US US17/255,712 patent/US11535633B2/en active Active
- 2019-06-28 KR KR1020207037227A patent/KR20210025016A/ko not_active Ceased
- 2019-06-28 WO PCT/US2019/039860 patent/WO2020006432A1/en not_active Ceased
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