HUP0100102A2 - Fenil-amino-alkilkarbonsav-származékok és fenil-amino-alkilkarbonsav-származékokat tartalmazó gyógyszerészeti készítmények - Google Patents

Fenil-amino-alkilkarbonsav-származékok és fenil-amino-alkilkarbonsav-származékokat tartalmazó gyógyszerészeti készítmények

Info

Publication number
HUP0100102A2
HUP0100102A2 HU0100102A HUP0100102A HUP0100102A2 HU P0100102 A2 HUP0100102 A2 HU P0100102A2 HU 0100102 A HU0100102 A HU 0100102A HU P0100102 A HUP0100102 A HU P0100102A HU P0100102 A2 HUP0100102 A2 HU P0100102A2
Authority
HU
Hungary
Prior art keywords
group
hydrogen
lower alkyl
acid derivatives
same
Prior art date
Application number
HU0100102A
Other languages
English (en)
Inventor
Masuo Akahane
Akihito Hirabayashi
Harunobu Mukaiyama
Hideyuki Muranaka
Masaaki Sato
Tetsuro Tamai
Nobuyuki Tanaka
Original Assignee
Kissei Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co., Ltd. filed Critical Kissei Pharmaceutical Co., Ltd.
Publication of HUP0100102A2 publication Critical patent/HUP0100102A2/hu
Publication of HUP0100102A3 publication Critical patent/HUP0100102A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

Abstract

A jelen találmány tárgyát az (I) általános képletű fenil-amino-alkilkarbonsav-származékok és azok gyógyszerészetileg elfogadható sóiképezik, ahol az R1 jelentése hidroxi-; kis szénatomszámú alkoxi-;aralkoxi-; amino-; aliciklikus aminocsoport; illetve mono- vagy di-(kis szénatomszámú alkil)-amino-csoport, amely szubsztituenskénthidroxi- vagy kis szénatomszámú alkoxicsoportot tartalmazhat; az R2jelentése hidrogénatom vagy kis szénatomszámú alkilcsoport; az R3jelentése hidrogén- vagy halogénatom; az R4 és az R5 mindegyikehidrogén- vagy halogénatomot, illetve kis szénatomszámú alkilcsoportotjelent, és ezen két szubsztituens vagy azonos vagy különböző; az Ajelentése kis szénatomszámú alkiléncsoport; az (R)-rel jelölt szénatom(R)-konfigurációjú, az (S)-sel jelölt szénatom pedig (S)-konfigurációjú. A vegyületek b3-adrenerg receptor stimuláló hatássalrendelkeznek, és alkalmasak a kóros elhízás, a hiperglikémia, a bélhipermotilitása által okozott betegségek, a gyakori vizelés, a vizeletvisszatartási képtelenség, a depresszió, az epekő és az epevezetékhipermotilitása által okozott betegségek megelőzésére vagy kezelésére. Ó
HU0100102A 1997-12-18 1998-12-11 Phenylaminoalkylcarboxylic acid derivatives and medicinal compositions containing the same HUP0100102A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP37008797 1997-12-18
PCT/JP1998/005605 WO1999031045A1 (fr) 1997-12-18 1998-12-11 Derives d'acide phenylaminoalkylcarboxylique et compositions medicamenteuses les contenant

Publications (2)

Publication Number Publication Date
HUP0100102A2 true HUP0100102A2 (hu) 2001-05-28
HUP0100102A3 HUP0100102A3 (en) 2002-11-28

Family

ID=18496040

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0100102A HUP0100102A3 (en) 1997-12-18 1998-12-11 Phenylaminoalkylcarboxylic acid derivatives and medicinal compositions containing the same

Country Status (23)

Country Link
US (1) US6353025B1 (hu)
EP (1) EP1043308B1 (hu)
JP (1) JP4156799B2 (hu)
KR (1) KR100545474B1 (hu)
AR (1) AR017858A1 (hu)
AT (1) ATE250570T1 (hu)
AU (1) AU754317B2 (hu)
CA (1) CA2315235C (hu)
CO (1) CO5070654A1 (hu)
CZ (1) CZ296433B6 (hu)
DE (1) DE69818516T2 (hu)
ES (1) ES2209226T3 (hu)
HU (1) HUP0100102A3 (hu)
IL (1) IL136612A (hu)
MY (1) MY120466A (hu)
NO (1) NO20003105L (hu)
NZ (1) NZ505103A (hu)
PE (1) PE20000131A1 (hu)
PL (1) PL341221A1 (hu)
SA (1) SA99191012B1 (hu)
TW (1) TW503229B (hu)
WO (1) WO1999031045A1 (hu)
ZA (1) ZA9811655B (hu)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69919860T2 (de) 1998-04-14 2005-08-25 Kissei Pharmaceutical Co., Ltd., Matsumoto 2-methylpropionsäure-derivate und sie enthaltende medizinische zubereitungen
EP1258253A1 (en) * 2000-01-28 2002-11-20 Asahi Kasei Kabushiki Kaisha Novel remedies with the use of beta3 agonist
US6653323B2 (en) 2001-11-13 2003-11-25 Theravance, Inc. Aryl aniline β2 adrenergic receptor agonists
TWI249515B (en) 2001-11-13 2006-02-21 Theravance Inc Aryl aniline beta2 adrenergic receptor agonists
ATE500827T1 (de) 2002-11-07 2011-03-15 Astellas Pharma Inc Mittel zur behandlung von blasenhyperaktivität mit einem essigsäureanilid-derivat als wirkstoff
EP1424079A1 (en) * 2002-11-27 2004-06-02 Boehringer Ingelheim International GmbH Combination of a beta-3-receptor agonist and of a reuptake inhibitor of serotonin and/or norepinephrine
WO2004106283A1 (ja) * 2003-05-28 2004-12-09 Kissei Pharmaceutical Co., Ltd. アミノアルコール誘導体、それを含有する医薬組成物およびそれらの用途
CN1993357B (zh) 2004-07-02 2011-10-19 伯拉考成像股份公司 用于磁共振成像(mri)的含有具有多羟基化取代基的螯合部分的高弛豫造影剂
US8109981B2 (en) 2005-01-25 2012-02-07 Valam Corporation Optical therapies and devices
TWI478712B (zh) 2008-09-30 2015-04-01 Astellas Pharma Inc 釋控性醫藥組成物
CA2740772A1 (en) 2008-10-09 2010-04-15 Asahi Kasei Pharma Corporation Indazole compounds
CN102171191A (zh) * 2008-10-09 2011-08-31 旭化成制药株式会社 吲唑衍生物
US20100222404A1 (en) * 2008-11-04 2010-09-02 Asahi Kasei Pharma Corporation Indazole derivative dihydrochloride
JP5849947B2 (ja) 2010-03-29 2016-02-03 アステラス製薬株式会社 放出制御医薬組成物

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4146638A (en) * 1976-02-17 1979-03-27 Boehringer Ingelheim Gmbh N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines
EP0068669A1 (en) 1981-06-20 1983-01-05 Beecham Group Plc Secondary phenylethanol amines, processes for their preparation and their pharmaceutical application
DE3368258D1 (en) 1982-07-16 1987-01-22 Beecham Group Plc 2-aminoethyl ether derivatives, processes for their preparation and pharmaceutical compositions containing them
ZA835126B (en) * 1982-07-16 1984-06-27 Beecham Group Plc Secondary amines
GB8528633D0 (en) 1985-11-21 1985-12-24 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
DE69818516T2 (de) 2004-07-08
US6353025B1 (en) 2002-03-05
EP1043308B1 (en) 2003-09-24
CZ296433B6 (cs) 2006-03-15
WO1999031045A1 (fr) 1999-06-24
NO20003105L (no) 2000-08-17
PE20000131A1 (es) 2000-03-15
EP1043308A4 (en) 2001-11-14
KR100545474B1 (ko) 2006-01-24
AU1506199A (en) 1999-07-05
SA99191012B1 (ar) 2006-07-03
AU754317B2 (en) 2002-11-14
DE69818516D1 (de) 2003-10-30
IL136612A (en) 2003-11-23
KR20010024747A (ko) 2001-03-26
MY120466A (en) 2005-10-31
AR017858A1 (es) 2001-10-24
NZ505103A (en) 2003-03-28
PL341221A1 (en) 2001-03-26
CO5070654A1 (es) 2001-08-28
HUP0100102A3 (en) 2002-11-28
IL136612A0 (en) 2001-06-14
TW503229B (en) 2002-09-21
ATE250570T1 (de) 2003-10-15
NO20003105D0 (no) 2000-06-16
ES2209226T3 (es) 2004-06-16
CA2315235C (en) 2009-07-28
CA2315235A1 (en) 1999-06-24
EP1043308A1 (en) 2000-10-11
CZ20002244A3 (cs) 2000-11-15
JP4156799B2 (ja) 2008-09-24
ZA9811655B (en) 1999-06-23

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