JP2023153895A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2023153895A5 JP2023153895A5 JP2023122354A JP2023122354A JP2023153895A5 JP 2023153895 A5 JP2023153895 A5 JP 2023153895A5 JP 2023122354 A JP2023122354 A JP 2023122354A JP 2023122354 A JP2023122354 A JP 2023122354A JP 2023153895 A5 JP2023153895 A5 JP 2023153895A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- reagent
- capillary
- activatable antibody
- biological sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762534931P | 2017-07-20 | 2017-07-20 | |
| US62/534,931 | 2017-07-20 | ||
| JP2020502238A JP2020530554A (ja) | 2017-07-20 | 2018-07-20 | 活性化抗体の特性を定性的および/または定量的に分析する方法およびその使用 |
| PCT/US2018/043190 WO2019018828A1 (en) | 2017-07-20 | 2018-07-20 | METHODS OF QUALITATIVE AND / OR QUANTITATIVE ANALYSIS OF ACTIVATABLE ANTIBODY PROPERTIES AND USES THEREOF |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502238A Division JP2020530554A (ja) | 2017-07-20 | 2018-07-20 | 活性化抗体の特性を定性的および/または定量的に分析する方法およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023153895A JP2023153895A (ja) | 2023-10-18 |
| JP2023153895A5 true JP2023153895A5 (https=) | 2024-06-21 |
| JP7779882B2 JP7779882B2 (ja) | 2025-12-03 |
Family
ID=63165472
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502238A Pending JP2020530554A (ja) | 2017-07-20 | 2018-07-20 | 活性化抗体の特性を定性的および/または定量的に分析する方法およびその使用 |
| JP2023122354A Active JP7779882B2 (ja) | 2017-07-20 | 2023-07-27 | 活性化抗体の特性を定性的および/または定量的に分析する方法およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020502238A Pending JP2020530554A (ja) | 2017-07-20 | 2018-07-20 | 活性化抗体の特性を定性的および/または定量的に分析する方法およびその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US12498367B2 (https=) |
| EP (1) | EP3655779A1 (https=) |
| JP (2) | JP2020530554A (https=) |
| KR (1) | KR20200031113A (https=) |
| CN (1) | CN110998329B (https=) |
| AU (1) | AU2018304711B2 (https=) |
| WO (1) | WO2019018828A1 (https=) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2904969C (en) | 2013-03-13 | 2025-06-17 | Imaginab, Inc. | DIFFERENTIATION CLUSTER ANTIGEN-BINDING GENETIC CONSTRUCTIONS 8 |
| JP2020530554A (ja) | 2017-07-20 | 2020-10-22 | シートムエックス セラピューティクス,インコーポレイテッド | 活性化抗体の特性を定性的および/または定量的に分析する方法およびその使用 |
| CA3100005A1 (en) | 2018-05-14 | 2019-11-21 | Werewolf Therapeutics, Inc. | Activatable cytokine polypeptides and methods of use thereof |
| AU2019271148B9 (en) | 2018-05-14 | 2025-05-29 | Werewolf Therapeutics, Inc. | Activatable interleukin-2 polypeptides and methods of use thereof |
| KR20220023988A (ko) | 2019-05-14 | 2022-03-03 | 웨어울프 세라퓨틱스, 인크. | 분리 모이어티 및 이의 사용 방법 |
| CN110702669A (zh) * | 2019-09-19 | 2020-01-17 | 湖北科益药业股份有限公司 | 一种快速阿昔洛韦凝胶含量测定的方法 |
| BR112022009110A2 (pt) | 2019-11-14 | 2022-07-26 | Werewolf Therapeutics Inc | Polipeptídeos de citocina ativáveis e métodos de uso destes |
| US20230211024A1 (en) * | 2019-12-05 | 2023-07-06 | Imaginab, Inc. | Methods of imaging using multiple imaging agents |
| JP2023512446A (ja) * | 2020-01-13 | 2023-03-27 | アプティーボ リサーチ アンド デベロップメント エルエルシー | 治療的タンパク質の薬物送達システム構成要素への吸着を防ぐ方法および組成物 |
| BR112022019841A2 (pt) * | 2020-04-09 | 2022-12-06 | Cytomx Therapeutics Inc | Composições contendo anticorpos ativáveis |
| JP7495578B2 (ja) * | 2020-11-30 | 2024-06-04 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | キャピラリーベースのイムノアッセイシステムを使用する複合糖質の分析方法 |
| US20240384323A1 (en) | 2021-08-30 | 2024-11-21 | Cytomx Therapeutics, Inc. | Method for determining protease activity in a biological sample |
| WO2023183888A1 (en) | 2022-03-23 | 2023-09-28 | Cytomx Therapeutics, Inc. | Activatable antigen-binding protein constructs and uses of the same |
| US20250333487A1 (en) | 2022-03-25 | 2025-10-30 | Cytomx Therapeutics, Inc. | Activatable dual-anchored masked molecules and methods of use thereof |
| JP2025511187A (ja) | 2022-04-01 | 2025-04-15 | サイトムエックス セラピューティクス,インク. | Cd3結合タンパク質及びその使用方法 |
| WO2023192973A1 (en) | 2022-04-01 | 2023-10-05 | Cytomx Therapeutics, Inc. | Activatable multispecific molecules and methods of use thereof |
| AR130079A1 (es) | 2022-08-01 | 2024-10-30 | Cytomx Therapeutics Inc | Restos escindibles por proteasas, y métodos de uso de los mismos |
| US20260042849A1 (en) | 2022-08-01 | 2026-02-12 | Cytomx Therapeutics, Inc. | Protease-cleavable moieties and methods of use thereof |
| TW202424183A (zh) | 2022-08-01 | 2024-06-16 | 美商Cytomx生物製藥公司 | 蛋白酶可切割受質及其使用方法 |
| JP2025525868A (ja) | 2022-08-01 | 2025-08-07 | サイトムエックス セラピューティクス,インク. | プロテアーゼ切断性部分及びその使用方法 |
| JP2025525879A (ja) | 2022-08-01 | 2025-08-07 | サイトムエックス セラピューティクス,インク. | プロテアーゼ切断性基質及びその使用方法 |
| EP4695281A1 (en) | 2023-04-12 | 2026-02-18 | CytomX Therapeutics, Inc. | Masking polypeptides, activatable cytokine constructs, and related compositions and methods |
| WO2024216146A1 (en) | 2023-04-12 | 2024-10-17 | Cytomx Therapeutics, Inc. | Masking polypeptides, activatable cytokine constructs, and related compositions and methods |
| WO2024216170A2 (en) | 2023-04-12 | 2024-10-17 | Cytomx Therapeutics, Inc. | Activatable cytokine constructs and related compositions and methods |
| WO2026020161A1 (en) | 2024-07-19 | 2026-01-22 | Cytomx Therapeutics, Inc. | Activatable il-12 constructs and related compositions and methods |
| WO2026024841A1 (en) | 2024-07-24 | 2026-01-29 | Astellas Us Llc | Bispecific antibodies that bind cd3 and muc1 and methods of use thereof |
| WO2026035650A2 (en) | 2024-08-05 | 2026-02-12 | Cytomx Therapeutics, Inc. | Cleavable polypeptides and methods of use thereof |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| DE3788058T2 (de) | 1986-08-28 | 1994-04-21 | Teijin Ltd | Zelltoxischer antikörperkomplex und verfahren zu seiner herstellung. |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5151510A (en) | 1990-04-20 | 1992-09-29 | Applied Biosystems, Inc. | Method of synethesizing sulfurized oligonucleotide analogs |
| US5290920A (en) * | 1992-04-16 | 1994-03-01 | Allelix Biopharmaceuticals Inc. | Method of purifying human epidermal growth factor |
| MD1367C2 (ro) | 1992-11-13 | 2000-11-30 | Idec Pharmaceuticals Corporation | Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom. |
| US5338834A (en) * | 1993-01-26 | 1994-08-16 | Allelix Biopharmaceuticals Inc. | Ultrapure human interleukin-6 |
| WO2001091798A2 (en) | 2000-06-01 | 2001-12-06 | Universite Catholique De Louvain | Tumor activated prodrug compounds |
| ATE513563T1 (de) | 2000-10-09 | 2011-07-15 | Isis Innovation | Therapeutische und toleranz-induzierende antikörper |
| US7465790B2 (en) | 2000-10-09 | 2008-12-16 | Isis Innovation, Inc. | Therapeutic antibodies |
| DE60222427T2 (de) | 2001-07-16 | 2008-06-12 | Protein Forest, Inc., Waltham | Puffer-arrays zum nachweis von biomolekülen anhand ihres isoelektrischen punktes |
| US20040109855A1 (en) | 2002-07-23 | 2004-06-10 | Herman Waldmann | Therapeutic antibodies with reduced side effect |
| US8809504B2 (en) | 2002-09-03 | 2014-08-19 | Vit Lauermann | Inhibitor which is deactivatable by a reagent produced by a target cell |
| US20050000811A1 (en) * | 2003-05-06 | 2005-01-06 | Janos Luka | Electrophoretically enhanced methods |
| US20040259269A1 (en) | 2003-06-20 | 2004-12-23 | Groton Biosystems | Method for detection of molecular species in a crude sample using capillary electrophoresis |
| WO2006014680A1 (en) | 2004-07-19 | 2006-02-09 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| US7846676B2 (en) | 2004-07-19 | 2010-12-07 | Cell Biosciences, Inc. | Methods and devices for analyte detection |
| US8021611B2 (en) | 2005-04-09 | 2011-09-20 | ProteinSimple | Automated micro-volume assay system |
| EP2535346B1 (en) | 2005-08-31 | 2017-08-02 | The Regents of The University of California | Cellular libraries of peptide sequences (CLiPS) and methods of using the same |
| JP2009529522A (ja) | 2006-03-10 | 2009-08-20 | ディアト | 酵素で切断可能なリンカーを介して抗体に複合された抗癌剤 |
| US20080017512A1 (en) | 2006-07-24 | 2008-01-24 | Bordunov Andrei V | Coatings for capillaries capable of capturing analytes |
| US8702976B2 (en) * | 2007-04-18 | 2014-04-22 | Ondavia, Inc. | Hand-held microfluidic testing device |
| US20090023156A1 (en) | 2007-07-20 | 2009-01-22 | Voss Karl O | Methods and reagents for quantifying analytes |
| JP2009031001A (ja) | 2007-07-24 | 2009-02-12 | Dainichiseika Color & Chem Mfg Co Ltd | IgA抗体測定方法 |
| CA2697032C (en) | 2007-08-22 | 2021-09-14 | The Regents Of The University Of California | Activatable binding polypeptides and methods of identification and use thereof |
| ATE537272T1 (de) * | 2008-04-08 | 2011-12-15 | Hoffmann La Roche | Detektion von pcr-produkten in der gelelektrophorese |
| US8703438B2 (en) * | 2008-11-18 | 2014-04-22 | The Regents Of The University Of California | Ligand binding stabilization method for drug target identification |
| US20100189651A1 (en) | 2009-01-12 | 2010-07-29 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| US20110011740A1 (en) | 2009-04-17 | 2011-01-20 | Roach David J | Capillary immunoassay systems and methods |
| CA2853917A1 (en) * | 2011-12-19 | 2013-06-27 | F. Hoffmann-La Roche Ag | Method for the detection of free binding partner of a multispecific binder |
| CN104540518A (zh) | 2012-04-27 | 2015-04-22 | 西托姆克斯治疗公司 | 结合表皮生长因子受体的可活化的抗体其使用方法 |
| WO2013192546A1 (en) | 2012-06-22 | 2013-12-27 | Cytomx Therapeutics, Inc. | Activatable antibodies having non-binding steric moieties and mehtods of using the same |
| US9304123B2 (en) | 2012-08-08 | 2016-04-05 | Nutech Ventures | Biomarkers used to detect and monitor neurological autoimmune diseases |
| US9309510B2 (en) | 2012-08-10 | 2016-04-12 | Cytomx Therapeutics, Inc. | Protease-resistant systems for polypeptide display and methods of making and using thereof |
| US9487590B2 (en) | 2012-09-25 | 2016-11-08 | Cytomx Therapeutics, Inc. | Activatable antibodies that bind interleukin-6 receptor and methods of use thereof |
| CN105722859B (zh) * | 2013-07-25 | 2021-05-07 | 西托姆克斯治疗公司 | 多特异性抗体、多特异性可活化抗体及其使用方法 |
| US9766206B2 (en) | 2013-09-27 | 2017-09-19 | ProteinSimple | Apparatus, systems, and methods for capillary electrophoresis |
| US20150093757A1 (en) * | 2013-09-27 | 2015-04-02 | Protein Simple | Methods. apparatus and systems for detection of total protein using capillary electrophoresis |
| IL270562B (en) * | 2014-01-31 | 2022-08-01 | Cytomx Therapeutics Inc | Polypeptide substrates that activate matriptase and u-plasminogen and other cleavable groups, preparations containing them and their uses |
| JP7020909B2 (ja) | 2014-07-25 | 2022-02-16 | シトムクス セラピューティクス,インコーポレイティド | 抗-cd3抗体、活性化可能抗-cd3抗体、多重特異的抗-cd3抗体、多重特異的活性化可能抗-cd3抗体、及びそれらの使用方法 |
| GB201416849D0 (en) | 2014-09-24 | 2014-11-05 | Genovis Ab | Method |
| MA41374A (fr) * | 2015-01-20 | 2017-11-28 | Cytomx Therapeutics Inc | Substrats clivables par métalloprotéase matricielle et clivables par sérine protéase et procédés d'utilisation de ceux-ci |
| MA41613A (fr) | 2015-02-23 | 2018-01-02 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-dll3 et procédés d'utilisation desdits récepteurs |
| JP7237449B2 (ja) | 2015-02-27 | 2023-03-13 | アイセル・ジーン・セラピューティクス・エルエルシー | 血液系腫瘍を標的としたキメラ抗体受容体(CARs)の構成およびその使用方法 |
| CN108112254B (zh) | 2015-03-13 | 2022-01-28 | 西托姆克斯治疗公司 | 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法 |
| CN113155936B (zh) | 2015-05-20 | 2024-02-20 | 普诺森公司 | 用于分析物的电泳分离和分析的系统和方法 |
| EP4465050A3 (en) | 2015-06-05 | 2025-06-11 | Genentech, Inc. | Anti-tau antibodies and methods of use |
| CN114591433A (zh) * | 2015-07-13 | 2022-06-07 | 西托姆克斯治疗公司 | 抗pd-1抗体、可活化抗pd-1抗体及其使用方法 |
| AU2016334051B2 (en) | 2015-10-06 | 2023-10-26 | Alector Llc | Anti-TREM2 antibodies and methods of use thereof |
| EP3403082A4 (en) | 2016-01-13 | 2019-08-28 | ProteinSimple | SYSTEMS AND METHODS FOR CAPILLARY ELECTROPHORESIS, ANALYSIS OF THE ISOELECTRIC POINT AND MOLECULAR WEIGHT |
| WO2018102411A1 (en) | 2016-11-29 | 2018-06-07 | ProteinSimple | Methods and apparatus for simultaneously detecting a large range of protein concentrations |
| JP2020530554A (ja) | 2017-07-20 | 2020-10-22 | シートムエックス セラピューティクス,インコーポレイテッド | 活性化抗体の特性を定性的および/または定量的に分析する方法およびその使用 |
-
2018
- 2018-07-20 JP JP2020502238A patent/JP2020530554A/ja active Pending
- 2018-07-20 US US16/632,265 patent/US12498367B2/en active Active
- 2018-07-20 AU AU2018304711A patent/AU2018304711B2/en not_active Expired - Fee Related
- 2018-07-20 EP EP18752918.5A patent/EP3655779A1/en active Pending
- 2018-07-20 KR KR1020207002684A patent/KR20200031113A/ko not_active Ceased
- 2018-07-20 CN CN201880050708.4A patent/CN110998329B/zh active Active
- 2018-07-20 WO PCT/US2018/043190 patent/WO2019018828A1/en not_active Ceased
-
2023
- 2023-07-27 JP JP2023122354A patent/JP7779882B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023153895A5 (https=) | ||
| JP6441407B2 (ja) | 非特異的結合を減少させるためのイムノアッセイ方法及び試薬 | |
| US6838250B2 (en) | Immunoassay for C-reactive protein | |
| JP6242893B2 (ja) | クエチアピンに対する抗体及びその使用 | |
| RU2014104113A (ru) | Elisa для vegf | |
| JP5425063B2 (ja) | IgA腎症の検査方法及び検出キット | |
| JP2010210644A (ja) | 診断目的のための生物学的液体における中間領域プロアドレノメデュリン部分領域の測定およびこのような測定を行うためのイムノアッセイ | |
| RU2013129203A (ru) | Моноклональное антитело, распознающее белок l2 папилломавируса человека (впч), и способ определения титра впч-нейтрализующего антитела, использующий такое антитело | |
| JP2017505436A5 (https=) | ||
| CN106053812A (zh) | 一种用于肝癌早期筛查和诊断的多种自身抗体联合检测elisa试剂盒 | |
| JP2019504013A5 (https=) | ||
| To et al. | False-positive SARS-CoV-2 serology in 3 children with Kawasaki disease | |
| US10766948B2 (en) | Monoclonal antibodies specific for the pIII antigen of human Adenovirus (ADV), produced and secreted by cell hybridomas, useful for detection and diagnosis of ADV infection | |
| US12145980B2 (en) | Monoclonal antibodies specific for the PB2 antigen of the human influenza A virus (flu), nucleotide sequences, method and diagnostic kit for flu infection | |
| JP7044721B2 (ja) | Hcvコア抗原の迅速な検出のための前処理法 | |
| GB2547603A (en) | Specific monoclonal antibodies of the antigen M of the human metapneumovirus (HMPV) and use thereof in a diagnostic method | |
| US20240118278A1 (en) | Hbv diagnostic, prognostic, and therapeutic methods and products | |
| WO2006109793A1 (ja) | 心疾患診断用バイオマーカー及びその利用 | |
| WO2017204295A1 (ja) | 消化器癌の判定方法 | |
| Krajewski et al. | Nonstripping “Rainbow” and multiple antigen detection (MAD) western blotting | |
| JPWO2021007338A5 (https=) | ||
| CN110234995A (zh) | 使用至少两种聚乙二醇化的分析物特异性结合试剂的免疫测定 | |
| JPWO2021170838A5 (https=) | ||
| US12510542B1 (en) | Capture antibody and detection antibody binding MMP9 protein | |
| JPH04135484A (ja) | 8―ハイドロキシ―2’―デオキシグアノシンのモノクローナル抗体及びその製造法並びにモノクローナル抗体を生産するハイブリッド細胞 |