JP2023010738A5 - - Google Patents
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- JP2023010738A5 JP2023010738A5 JP2022173722A JP2022173722A JP2023010738A5 JP 2023010738 A5 JP2023010738 A5 JP 2023010738A5 JP 2022173722 A JP2022173722 A JP 2022173722A JP 2022173722 A JP2022173722 A JP 2022173722A JP 2023010738 A5 JP2023010738 A5 JP 2023010738A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- formula
- nhc
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 55
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 27
- 238000000034 method Methods 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 13
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 11
- 125000002947 alkylene group Chemical group 0.000 claims 8
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 6
- 239000003054 catalyst Substances 0.000 claims 6
- 125000004093 cyano group Chemical group *C#N 0.000 claims 6
- 229910052763 palladium Inorganic materials 0.000 claims 6
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims 6
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- CYPYTURSJDMMMP-WVCUSYJESA-N (1e,4e)-1,5-diphenylpenta-1,4-dien-3-one;palladium Chemical compound [Pd].[Pd].C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 CYPYTURSJDMMMP-WVCUSYJESA-N 0.000 claims 3
- 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 claims 3
- 125000005620 boronic acid group Chemical class 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 claims 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 2
- 125000005330 8 membered heterocyclic group Chemical group 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims 2
- 235000019270 ammonium chloride Nutrition 0.000 claims 2
- -1 branched C3-C8 alkyl Chemical group 0.000 claims 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 239000011630 iodine Substances 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 239000003586 protic polar solvent Substances 0.000 claims 2
- 229910052725 zinc Inorganic materials 0.000 claims 2
- 239000011592 zinc chloride Substances 0.000 claims 2
- 235000005074 zinc chloride Nutrition 0.000 claims 2
- ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical class OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 claims 1
- FJBFPHVGVWTDIP-UHFFFAOYSA-N dibromomethane Chemical compound BrCBr FJBFPHVGVWTDIP-UHFFFAOYSA-N 0.000 claims 1
- NZZFYRREKKOMAT-UHFFFAOYSA-N diiodomethane Chemical compound ICI NZZFYRREKKOMAT-UHFFFAOYSA-N 0.000 claims 1
- IOGXOCVLYRDXLW-UHFFFAOYSA-N tert-butyl nitrite Chemical compound CC(C)(C)ON=O IOGXOCVLYRDXLW-UHFFFAOYSA-N 0.000 claims 1
- 239000012414 tert-butyl nitrite Substances 0.000 claims 1
- JRMUNVKIHCOMHV-UHFFFAOYSA-M tetrabutylammonium bromide Chemical compound [Br-].CCCC[N+](CCCC)(CCCC)CCCC JRMUNVKIHCOMHV-UHFFFAOYSA-M 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024071962A JP2024105360A (ja) | 2013-03-15 | 2024-04-25 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361792812P | 2013-03-15 | 2013-03-15 | |
| US61/792,812 | 2013-03-15 | ||
| JP2019032014A JP6936823B2 (ja) | 2013-03-15 | 2019-02-25 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2021138625A JP7169412B2 (ja) | 2013-03-15 | 2021-08-27 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021138625A Division JP7169412B2 (ja) | 2013-03-15 | 2021-08-27 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024071962A Division JP2024105360A (ja) | 2013-03-15 | 2024-04-25 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023010738A JP2023010738A (ja) | 2023-01-20 |
| JP2023010738A5 true JP2023010738A5 (enExample) | 2023-08-07 |
| JP7536064B2 JP7536064B2 (ja) | 2024-08-19 |
Family
ID=51529950
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503185A Active JP6165314B2 (ja) | 2013-03-15 | 2014-03-14 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2017120849A Pending JP2017193567A (ja) | 2013-03-15 | 2017-06-20 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2019032014A Active JP6936823B2 (ja) | 2013-03-15 | 2019-02-25 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2021138625A Active JP7169412B2 (ja) | 2013-03-15 | 2021-08-27 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
| JP2022173722A Active JP7536064B2 (ja) | 2013-03-15 | 2022-10-28 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
| JP2024071962A Pending JP2024105360A (ja) | 2013-03-15 | 2024-04-25 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Family Applications Before (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503185A Active JP6165314B2 (ja) | 2013-03-15 | 2014-03-14 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2017120849A Pending JP2017193567A (ja) | 2013-03-15 | 2017-06-20 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2019032014A Active JP6936823B2 (ja) | 2013-03-15 | 2019-02-25 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2021138625A Active JP7169412B2 (ja) | 2013-03-15 | 2021-08-27 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024071962A Pending JP2024105360A (ja) | 2013-03-15 | 2024-04-25 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9181223B2 (enExample) |
| EP (1) | EP2968286B1 (enExample) |
| JP (6) | JP6165314B2 (enExample) |
| KR (4) | KR102293086B1 (enExample) |
| CN (2) | CN105120864B (enExample) |
| AU (5) | AU2014233411B2 (enExample) |
| BR (1) | BR112015022288B1 (enExample) |
| CA (1) | CA2903285C (enExample) |
| DK (1) | DK2968286T3 (enExample) |
| ES (1) | ES2651165T3 (enExample) |
| IL (4) | IL241000B (enExample) |
| MX (1) | MX365574B (enExample) |
| PH (1) | PH12015502114B1 (enExample) |
| PT (1) | PT2968286T (enExample) |
| RU (1) | RU2015143717A (enExample) |
| SG (1) | SG11201507660TA (enExample) |
| WO (1) | WO2014145025A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| ES2651165T3 (es) * | 2013-03-15 | 2018-01-24 | Deciphera Pharmaceuticals, Llc | 2-aminopirimidin-6-onas y análogos que presentan actividades anti-cáncer y antiproliferativa |
| AR109179A1 (es) | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
| ES2968804T3 (es) * | 2017-05-24 | 2024-05-14 | Abbisko Therapeutics Co Ltd | Derivado de azaarilo, método de preparación del mismo y uso farmacéutico del mismo |
| WO2018233527A1 (zh) * | 2017-06-19 | 2018-12-27 | 上海和誉生物医药科技有限公司 | 一种具有csf1r抑制活性的氮杂芳基衍生物、其制备方法和应用 |
| SG11202007198WA (en) | 2018-01-31 | 2020-08-28 | Deciphera Pharmaceuticals Llc | Combination therapy for the treatment of gastrointestinal stromal tumors |
| EA202091763A1 (ru) | 2018-01-31 | 2020-12-14 | ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Комбинированная терапия для лечения мастоцитоза |
| CN110845476B (zh) * | 2018-08-21 | 2022-11-18 | 上海和誉生物医药科技有限公司 | 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用 |
| RS67303B1 (sr) * | 2018-12-28 | 2025-11-28 | Deciphera Pharmaceuticals Llc | Inhibitori csf1r za upotrebu u lečenju tenosinovijalnih tumora džinovskih ćelija |
| EP3938363A1 (en) | 2019-03-11 | 2022-01-19 | Teva Pharmaceuticals International GmbH | Solid state forms of ripretinib |
| RS65019B1 (sr) | 2019-05-10 | 2024-01-31 | Deciphera Pharmaceuticals Llc | Fenilaminopirimidin amidni inhibitori autofagije i postupci njihove primene |
| AU2020274011B2 (en) | 2019-05-10 | 2024-02-15 | Deciphera Pharmaceuticals, Llc | Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
| CN119241444A (zh) | 2019-06-17 | 2025-01-03 | 德西费拉制药有限责任公司 | 氨基嘧啶酰胺自噬抑制剂及其使用方法 |
| JP7818502B2 (ja) | 2019-08-12 | 2026-02-20 | デシフェラ・ファーマシューティカルズ，エルエルシー | 胃腸間質腫瘍を治療するためのリプレチニブ |
| WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| SI4084778T1 (sl) | 2019-12-30 | 2024-01-31 | Deciphera Pharmaceuticals, Llc | Formulacije inhibitorja amorfne kinaze in načini njihove uporabe |
| AU2020417282B2 (en) | 2019-12-30 | 2023-08-31 | Deciphera Pharmaceuticals, Llc | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
| JP2023549540A (ja) | 2020-11-18 | 2023-11-27 | デシフェラ・ファーマシューティカルズ，エルエルシー | Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法 |
| CN115385896B (zh) * | 2021-05-24 | 2024-11-15 | 上海和誉生物医药科技有限公司 | 一种csf-1r抑制剂中间体或其酸式盐的制备方法 |
| CN113880812A (zh) * | 2021-11-17 | 2022-01-04 | 上海皓元生物医药科技有限公司 | 一种csf-ir抑制剂的制备方法 |
| JP2024544632A (ja) | 2021-12-03 | 2024-12-03 | デシフェラ・ファーマシューティカルズ，エルエルシー | Ｇｃｎ２及びｐｅｒｋキナーゼ阻害剤としての複素環式化合物 |
| CA3240263A1 (en) | 2021-12-09 | 2023-06-15 | Daniel L. Flynn | Raf kinase inhibitors and methods of use thereof |
| WO2023125812A1 (zh) * | 2021-12-31 | 2023-07-06 | 上海海雁医药科技有限公司 | 取代的嘧啶酮衍生物、其药物组合物及医药上的用途 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| TW202542127A (zh) | 2023-12-08 | 2025-11-01 | 美商迪賽孚爾製藥有限公司 | 激酶抑制劑之固態形式 |
| US20250205161A1 (en) | 2023-12-08 | 2025-06-26 | Deciphera Pharmaceuticals, Llc | Formulations of vimseltinib |
| WO2025231106A1 (en) | 2024-05-01 | 2025-11-06 | Deciphera Pharmaceuticals, Llc | Csf-1r inhibitors and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008046216A1 (en) * | 2006-10-18 | 2008-04-24 | Methylgene, Inc. | Kinase inhibitors and uses thereof |
| EP2125781A2 (en) * | 2006-12-20 | 2009-12-02 | Amgen Inc. | Substituted heterocycles and methods of use |
| EP2365752B1 (en) * | 2008-10-29 | 2014-09-24 | Deciphera Pharmaceuticals, Llc | Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| ES2651165T3 (es) * | 2013-03-15 | 2018-01-24 | Deciphera Pharmaceuticals, Llc | 2-aminopirimidin-6-onas y análogos que presentan actividades anti-cáncer y antiproliferativa |
| US9133183B2 (en) | 2013-03-15 | 2015-09-15 | Deciphera Pharmaceuticals, Llc | Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities |
| US9193719B2 (en) * | 2013-03-15 | 2015-11-24 | Deciphera Pharmaceuticals, Llc | 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
-
2014
- 2014-03-14 ES ES14764032.0T patent/ES2651165T3/es active Active
- 2014-03-14 SG SG11201507660TA patent/SG11201507660TA/en unknown
- 2014-03-14 WO PCT/US2014/029661 patent/WO2014145025A2/en not_active Ceased
- 2014-03-14 MX MX2015012736A patent/MX365574B/es active IP Right Grant
- 2014-03-14 RU RU2015143717A patent/RU2015143717A/ru not_active Application Discontinuation
- 2014-03-14 DK DK14764032.0T patent/DK2968286T3/en active
- 2014-03-14 CA CA2903285A patent/CA2903285C/en active Active
- 2014-03-14 JP JP2016503185A patent/JP6165314B2/ja active Active
- 2014-03-14 EP EP14764032.0A patent/EP2968286B1/en active Active
- 2014-03-14 KR KR1020157029134A patent/KR102293086B1/ko active Active
- 2014-03-14 KR KR1020247001621A patent/KR20240013846A/ko not_active Ceased
- 2014-03-14 CN CN201480021743.5A patent/CN105120864B/zh active Active
- 2014-03-14 AU AU2014233411A patent/AU2014233411B2/en active Active
- 2014-03-14 KR KR1020227016381A patent/KR102628583B1/ko active Active
- 2014-03-14 US US14/214,171 patent/US9181223B2/en active Active
- 2014-03-14 KR KR1020217026183A patent/KR102399891B1/ko active Active
- 2014-03-14 CN CN201710265111.9A patent/CN107311981B/zh active Active
- 2014-03-14 PT PT147640320T patent/PT2968286T/pt unknown
- 2014-03-14 BR BR112015022288-9A patent/BR112015022288B1/pt active IP Right Grant
-
2015
- 2015-09-01 IL IL241000A patent/IL241000B/en active IP Right Grant
- 2015-09-14 PH PH12015502114A patent/PH12015502114B1/en unknown
-
2017
- 2017-06-20 JP JP2017120849A patent/JP2017193567A/ja active Pending
-
2018
- 2018-07-09 IL IL260502A patent/IL260502B/en active IP Right Grant
- 2018-11-28 AU AU2018271293A patent/AU2018271293B2/en active Active
-
2019
- 2019-02-25 JP JP2019032014A patent/JP6936823B2/ja active Active
-
2020
- 2020-06-16 IL IL275422A patent/IL275422B/en unknown
- 2020-07-15 AU AU2020205294A patent/AU2020205294B2/en active Active
-
2021
- 2021-08-27 JP JP2021138625A patent/JP7169412B2/ja active Active
-
2022
- 2022-01-04 IL IL289629A patent/IL289629B2/en unknown
- 2022-06-15 AU AU2022204166A patent/AU2022204166C1/en active Active
- 2022-10-28 JP JP2022173722A patent/JP7536064B2/ja active Active
-
2024
- 2024-04-02 AU AU2024202088A patent/AU2024202088A1/en active Pending
- 2024-04-25 JP JP2024071962A patent/JP2024105360A/ja active Pending
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