JP2024105360A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2024105360A5 JP2024105360A5 JP2024071962A JP2024071962A JP2024105360A5 JP 2024105360 A5 JP2024105360 A5 JP 2024105360A5 JP 2024071962 A JP2024071962 A JP 2024071962A JP 2024071962 A JP2024071962 A JP 2024071962A JP 2024105360 A5 JP2024105360 A5 JP 2024105360A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- formula
- compound
- nhc
- optionally substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361792812P | 2013-03-15 | 2013-03-15 | |
| US61/792,812 | 2013-03-15 | ||
| JP2019032014A JP6936823B2 (ja) | 2013-03-15 | 2019-02-25 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2021138625A JP7169412B2 (ja) | 2013-03-15 | 2021-08-27 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
| JP2022173722A JP7536064B2 (ja) | 2013-03-15 | 2022-10-28 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022173722A Division JP7536064B2 (ja) | 2013-03-15 | 2022-10-28 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024105360A JP2024105360A (ja) | 2024-08-06 |
| JP2024105360A5 true JP2024105360A5 (enExample) | 2025-01-21 |
Family
ID=51529950
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503185A Active JP6165314B2 (ja) | 2013-03-15 | 2014-03-14 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2017120849A Pending JP2017193567A (ja) | 2013-03-15 | 2017-06-20 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2019032014A Active JP6936823B2 (ja) | 2013-03-15 | 2019-02-25 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2021138625A Active JP7169412B2 (ja) | 2013-03-15 | 2021-08-27 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
| JP2022173722A Active JP7536064B2 (ja) | 2013-03-15 | 2022-10-28 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
| JP2024071962A Pending JP2024105360A (ja) | 2013-03-15 | 2024-04-25 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016503185A Active JP6165314B2 (ja) | 2013-03-15 | 2014-03-14 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2017120849A Pending JP2017193567A (ja) | 2013-03-15 | 2017-06-20 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2019032014A Active JP6936823B2 (ja) | 2013-03-15 | 2019-02-25 | 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 |
| JP2021138625A Active JP7169412B2 (ja) | 2013-03-15 | 2021-08-27 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
| JP2022173722A Active JP7536064B2 (ja) | 2013-03-15 | 2022-10-28 | 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9181223B2 (enExample) |
| EP (1) | EP2968286B1 (enExample) |
| JP (6) | JP6165314B2 (enExample) |
| KR (4) | KR102293086B1 (enExample) |
| CN (2) | CN105120864B (enExample) |
| AU (5) | AU2014233411B2 (enExample) |
| BR (1) | BR112015022288B1 (enExample) |
| CA (1) | CA2903285C (enExample) |
| DK (1) | DK2968286T3 (enExample) |
| ES (1) | ES2651165T3 (enExample) |
| IL (4) | IL241000B (enExample) |
| MX (1) | MX365574B (enExample) |
| PH (1) | PH12015502114B1 (enExample) |
| PT (1) | PT2968286T (enExample) |
| RU (1) | RU2015143717A (enExample) |
| SG (1) | SG11201507660TA (enExample) |
| WO (1) | WO2014145025A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| ES2651165T3 (es) * | 2013-03-15 | 2018-01-24 | Deciphera Pharmaceuticals, Llc | 2-aminopirimidin-6-onas y análogos que presentan actividades anti-cáncer y antiproliferativa |
| AR109179A1 (es) | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
| ES2968804T3 (es) * | 2017-05-24 | 2024-05-14 | Abbisko Therapeutics Co Ltd | Derivado de azaarilo, método de preparación del mismo y uso farmacéutico del mismo |
| WO2018233527A1 (zh) * | 2017-06-19 | 2018-12-27 | 上海和誉生物医药科技有限公司 | 一种具有csf1r抑制活性的氮杂芳基衍生物、其制备方法和应用 |
| SG11202007198WA (en) | 2018-01-31 | 2020-08-28 | Deciphera Pharmaceuticals Llc | Combination therapy for the treatment of gastrointestinal stromal tumors |
| EA202091763A1 (ru) | 2018-01-31 | 2020-12-14 | ДЕСИФЕРА ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи | Комбинированная терапия для лечения мастоцитоза |
| CN110845476B (zh) * | 2018-08-21 | 2022-11-18 | 上海和誉生物医药科技有限公司 | 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用 |
| RS67303B1 (sr) * | 2018-12-28 | 2025-11-28 | Deciphera Pharmaceuticals Llc | Inhibitori csf1r za upotrebu u lečenju tenosinovijalnih tumora džinovskih ćelija |
| EP3938363A1 (en) | 2019-03-11 | 2022-01-19 | Teva Pharmaceuticals International GmbH | Solid state forms of ripretinib |
| RS65019B1 (sr) | 2019-05-10 | 2024-01-31 | Deciphera Pharmaceuticals Llc | Fenilaminopirimidin amidni inhibitori autofagije i postupci njihove primene |
| AU2020274011B2 (en) | 2019-05-10 | 2024-02-15 | Deciphera Pharmaceuticals, Llc | Heteroarylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
| CN119241444A (zh) | 2019-06-17 | 2025-01-03 | 德西费拉制药有限责任公司 | 氨基嘧啶酰胺自噬抑制剂及其使用方法 |
| JP7818502B2 (ja) | 2019-08-12 | 2026-02-20 | デシフェラ・ファーマシューティカルズ，エルエルシー | 胃腸間質腫瘍を治療するためのリプレチニブ |
| WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| SI4084778T1 (sl) | 2019-12-30 | 2024-01-31 | Deciphera Pharmaceuticals, Llc | Formulacije inhibitorja amorfne kinaze in načini njihove uporabe |
| AU2020417282B2 (en) | 2019-12-30 | 2023-08-31 | Deciphera Pharmaceuticals, Llc | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
| JP2023549540A (ja) | 2020-11-18 | 2023-11-27 | デシフェラ・ファーマシューティカルズ，エルエルシー | Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法 |
| CN115385896B (zh) * | 2021-05-24 | 2024-11-15 | 上海和誉生物医药科技有限公司 | 一种csf-1r抑制剂中间体或其酸式盐的制备方法 |
| CN113880812A (zh) * | 2021-11-17 | 2022-01-04 | 上海皓元生物医药科技有限公司 | 一种csf-ir抑制剂的制备方法 |
| JP2024544632A (ja) | 2021-12-03 | 2024-12-03 | デシフェラ・ファーマシューティカルズ，エルエルシー | Ｇｃｎ２及びｐｅｒｋキナーゼ阻害剤としての複素環式化合物 |
| CA3240263A1 (en) | 2021-12-09 | 2023-06-15 | Daniel L. Flynn | Raf kinase inhibitors and methods of use thereof |
| WO2023125812A1 (zh) * | 2021-12-31 | 2023-07-06 | 上海海雁医药科技有限公司 | 取代的嘧啶酮衍生物、其药物组合物及医药上的用途 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| TW202542127A (zh) | 2023-12-08 | 2025-11-01 | 美商迪賽孚爾製藥有限公司 | 激酶抑制劑之固態形式 |
| US20250205161A1 (en) | 2023-12-08 | 2025-06-26 | Deciphera Pharmaceuticals, Llc | Formulations of vimseltinib |
| WO2025231106A1 (en) | 2024-05-01 | 2025-11-06 | Deciphera Pharmaceuticals, Llc | Csf-1r inhibitors and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008046216A1 (en) * | 2006-10-18 | 2008-04-24 | Methylgene, Inc. | Kinase inhibitors and uses thereof |
| EP2125781A2 (en) * | 2006-12-20 | 2009-12-02 | Amgen Inc. | Substituted heterocycles and methods of use |
| EP2365752B1 (en) * | 2008-10-29 | 2014-09-24 | Deciphera Pharmaceuticals, Llc | Cyclopropane amides and analogs exhibiting anti-cancer and anti-proliferative activities |
| ES2651165T3 (es) * | 2013-03-15 | 2018-01-24 | Deciphera Pharmaceuticals, Llc | 2-aminopirimidin-6-onas y análogos que presentan actividades anti-cáncer y antiproliferativa |
| US9133183B2 (en) | 2013-03-15 | 2015-09-15 | Deciphera Pharmaceuticals, Llc | Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities |
| US9193719B2 (en) * | 2013-03-15 | 2015-11-24 | Deciphera Pharmaceuticals, Llc | 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
-
2014
- 2014-03-14 ES ES14764032.0T patent/ES2651165T3/es active Active
- 2014-03-14 SG SG11201507660TA patent/SG11201507660TA/en unknown
- 2014-03-14 WO PCT/US2014/029661 patent/WO2014145025A2/en not_active Ceased
- 2014-03-14 MX MX2015012736A patent/MX365574B/es active IP Right Grant
- 2014-03-14 RU RU2015143717A patent/RU2015143717A/ru not_active Application Discontinuation
- 2014-03-14 DK DK14764032.0T patent/DK2968286T3/en active
- 2014-03-14 CA CA2903285A patent/CA2903285C/en active Active
- 2014-03-14 JP JP2016503185A patent/JP6165314B2/ja active Active
- 2014-03-14 EP EP14764032.0A patent/EP2968286B1/en active Active
- 2014-03-14 KR KR1020157029134A patent/KR102293086B1/ko active Active
- 2014-03-14 KR KR1020247001621A patent/KR20240013846A/ko not_active Ceased
- 2014-03-14 CN CN201480021743.5A patent/CN105120864B/zh active Active
- 2014-03-14 AU AU2014233411A patent/AU2014233411B2/en active Active
- 2014-03-14 KR KR1020227016381A patent/KR102628583B1/ko active Active
- 2014-03-14 US US14/214,171 patent/US9181223B2/en active Active
- 2014-03-14 KR KR1020217026183A patent/KR102399891B1/ko active Active
- 2014-03-14 CN CN201710265111.9A patent/CN107311981B/zh active Active
- 2014-03-14 PT PT147640320T patent/PT2968286T/pt unknown
- 2014-03-14 BR BR112015022288-9A patent/BR112015022288B1/pt active IP Right Grant
-
2015
- 2015-09-01 IL IL241000A patent/IL241000B/en active IP Right Grant
- 2015-09-14 PH PH12015502114A patent/PH12015502114B1/en unknown
-
2017
- 2017-06-20 JP JP2017120849A patent/JP2017193567A/ja active Pending
-
2018
- 2018-07-09 IL IL260502A patent/IL260502B/en active IP Right Grant
- 2018-11-28 AU AU2018271293A patent/AU2018271293B2/en active Active
-
2019
- 2019-02-25 JP JP2019032014A patent/JP6936823B2/ja active Active
-
2020
- 2020-06-16 IL IL275422A patent/IL275422B/en unknown
- 2020-07-15 AU AU2020205294A patent/AU2020205294B2/en active Active
-
2021
- 2021-08-27 JP JP2021138625A patent/JP7169412B2/ja active Active
-
2022
- 2022-01-04 IL IL289629A patent/IL289629B2/en unknown
- 2022-06-15 AU AU2022204166A patent/AU2022204166C1/en active Active
- 2022-10-28 JP JP2022173722A patent/JP7536064B2/ja active Active
-
2024
- 2024-04-02 AU AU2024202088A patent/AU2024202088A1/en active Pending
- 2024-04-25 JP JP2024071962A patent/JP2024105360A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2024105360A5 (enExample) | ||
| JP2023010738A5 (enExample) | ||
| IL289629B2 (en) | 2-aminopyrimidine-6-one compounds and analogs exhibiting anti-cancer and anti-proliferative activity | |
| CA2407208A1 (en) | Process for producing optically active sulfoxide derivative | |
| JP2001516757A5 (enExample) | ||
| CA2587528A1 (en) | Method for preparing n-phenylpyrazole-1-carboxamides | |
| CA2454306A1 (en) | Substituted dihydro 3-halo-1h-pyrazole-5-carboxylates their preparation and use | |
| RU2005127626A (ru) | Способ получения производных топирамата-антиконвульсантов | |
| RU2009105669A (ru) | Способ получения 3-замещенных 2-амино-5-галогенбензамидов | |
| RU2000125568A (ru) | Производные циклоалкенов, их получение и применение | |
| EP1826196A3 (en) | Vinyl ether compounds | |
| WO2004109400A3 (en) | Novel photosensitive resin compositions | |
| CA2549431A1 (en) | Optically active quaternary ammonium salt having axial asymmetry and process for producing .alpha.-amino acid and derivative thereof with the same | |
| KR930012748A (ko) | 5-(치환 메틸)-2,3-피리딘디카르복시산의 제조에 유용한 5,6-이치환-3-피리딜메틸 암모늄 할라이드 화합물, 및 이들의 제조방법 | |
| RU2001120697A (ru) | Способ синтеза нитроксиметилфениловых эфиров производных аспирина | |
| RU2005135439A (ru) | Производные индена в качестве фармацевтических средств | |
| KR840005719A (ko) | 트리아졸 유도체의 제조방법 | |
| CA2598224A1 (en) | Process for the preparation of optically active derivatives of 2-(2-pyridylmethylsulfinyl)-benzimidazole via inclusion complex with 1,1'-binaphthalene-2, 2'diol | |
| GB1062713A (en) | 4'-hydroxy-4'-piperidyl-ketones | |
| DE60313156D1 (de) | Amonafidsalze | |
| JP2008519099A5 (enExample) | ||
| JP2006528709A5 (enExample) | ||
| KR920004397A (ko) | 1-옥사-3,8-디아자-4-옥소스피로[4,5]데칸 화합물의 제조방법. | |
| CA2671816A1 (en) | Salts of imidazole-5-carboxylic acid derivatives, a method for preparing same and pharmaceutical compositions comprising same | |
| RU2012121591A (ru) | Способ получения органических соединений |