IL241000B - 2-aminopyrimidin-6-one compounds and analogs showing anti-cancer and anti-proliferative activity - Google Patents
2-aminopyrimidin-6-one compounds and analogs showing anti-cancer and anti-proliferative activityInfo
- Publication number
- IL241000B IL241000B IL241000A IL24100015A IL241000B IL 241000 B IL241000 B IL 241000B IL 241000 A IL241000 A IL 241000A IL 24100015 A IL24100015 A IL 24100015A IL 241000 B IL241000 B IL 241000B
- Authority
- IL
- Israel
- Prior art keywords
- aminopyrimidin
- cancer
- ones
- proliferative activities
- analogs exhibiting
- Prior art date
Links
- XQCZBXHVTFVIFE-UHFFFAOYSA-N 2-amino-4-hydroxypyrimidine Chemical class NC1=NC=CC(O)=N1 XQCZBXHVTFVIFE-UHFFFAOYSA-N 0.000 title 1
- 230000001093 anti-cancer Effects 0.000 title 1
- 230000001028 anti-proliverative effect Effects 0.000 title 1
- 230000001747 exhibiting effect Effects 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Dermatology (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361792812P | 2013-03-15 | 2013-03-15 | |
| PCT/US2014/029661 WO2014145025A2 (en) | 2013-03-15 | 2014-03-14 | 2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL241000A0 IL241000A0 (en) | 2015-11-30 |
| IL241000B true IL241000B (en) | 2018-07-31 |
Family
ID=51529950
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL241000A IL241000B (en) | 2013-03-15 | 2015-09-01 | 2-aminopyrimidin-6-one compounds and analogs showing anti-cancer and anti-proliferative activity |
| IL260502A IL260502B (en) | 2013-03-15 | 2018-07-09 | 2-aminopyrimidine-6-one compounds and analogs showing anti-cancer and anti-proliferative activity |
| IL275422A IL275422B (en) | 2013-03-15 | 2020-06-16 | 2-aminopyrimidine-6-one compounds and analogs showing anti-cancer and anti-proliferative activity |
| IL289629A IL289629B2 (en) | 2013-03-15 | 2022-01-04 | 2-aminopyrimidine-6-one compounds and analogs exhibiting anti-cancer and anti-proliferative activity |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL260502A IL260502B (en) | 2013-03-15 | 2018-07-09 | 2-aminopyrimidine-6-one compounds and analogs showing anti-cancer and anti-proliferative activity |
| IL275422A IL275422B (en) | 2013-03-15 | 2020-06-16 | 2-aminopyrimidine-6-one compounds and analogs showing anti-cancer and anti-proliferative activity |
| IL289629A IL289629B2 (en) | 2013-03-15 | 2022-01-04 | 2-aminopyrimidine-6-one compounds and analogs exhibiting anti-cancer and anti-proliferative activity |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9181223B2 (enExample) |
| EP (1) | EP2968286B1 (enExample) |
| JP (6) | JP6165314B2 (enExample) |
| KR (4) | KR102628583B1 (enExample) |
| CN (2) | CN107311981B (enExample) |
| AU (5) | AU2014233411B2 (enExample) |
| BR (1) | BR112015022288B1 (enExample) |
| CA (1) | CA2903285C (enExample) |
| DK (1) | DK2968286T3 (enExample) |
| ES (1) | ES2651165T3 (enExample) |
| IL (4) | IL241000B (enExample) |
| MX (1) | MX365574B (enExample) |
| PH (1) | PH12015502114B1 (enExample) |
| PT (1) | PT2968286T (enExample) |
| RU (1) | RU2015143717A (enExample) |
| SG (1) | SG11201507660TA (enExample) |
| WO (1) | WO2014145025A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| MX365574B (es) * | 2013-03-15 | 2019-06-06 | Deciphera Pharmaceuticals Llc | 2-aminopirimidin-6-onas y analogos que exhiben actividades anticancerosas y antiproliferativas. |
| AR109179A1 (es) * | 2016-08-19 | 2018-11-07 | Pfizer | Inhibidores de diacilglicerol aciltransferasa 2 |
| WO2018214866A1 (zh) * | 2017-05-24 | 2018-11-29 | 上海和誉生物医药科技有限公司 | 一种氮杂芳基衍生物、其制备方法和在药学上的应用 |
| CN110461841B (zh) * | 2017-06-19 | 2020-09-15 | 上海和誉生物医药科技有限公司 | 一种具有csf1r抑制活性的氮杂芳基衍生物、其制备方法和应用 |
| JP2021512105A (ja) | 2018-01-31 | 2021-05-13 | デシフェラ・ファーマシューティカルズ，エルエルシー | 消化管間質腫瘍の治療のための併用療法 |
| CN118903436A (zh) | 2018-01-31 | 2024-11-08 | 德西费拉制药有限责任公司 | 治疗肥大细胞增多症的组合疗法 |
| CN110845476B (zh) * | 2018-08-21 | 2022-11-18 | 上海和誉生物医药科技有限公司 | 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用 |
| CA3124112A1 (en) | 2018-12-28 | 2020-07-02 | Deciphera Pharmaceuticals, Llc | Csf1r inhibitors for use in treating cancer |
| US11530206B2 (en) | 2019-05-10 | 2022-12-20 | Deciphera Pharmaceuticals, Llc | Phenylaminopyrimidine amide autophagy inhibitors and methods of use thereof |
| PT3966206T (pt) | 2019-05-10 | 2023-11-10 | Deciphera Pharmaceuticals Llc | Inibidores de autofagia de heteroarilaminopirimidina amida e métodos de utilização dos mesmos |
| JP7626722B2 (ja) | 2019-06-17 | 2025-02-04 | デシフェラ・ファーマシューティカルズ，エルエルシー | アミノピリミジンアミドオートファジー阻害剤およびその使用方法 |
| NZ784949A (en) | 2019-08-12 | 2025-09-26 | Deciphera Pharmaceuticals Llc | Ripretinib for treating gastrointestinal stromal tumors |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| SMT202400484T1 (it) | 2019-12-30 | 2025-01-14 | Deciphera Pharmaceuticals Llc | Composizioni di 1-(4-bromo-5-(1-etil-7-(metilammino)-2-osso-1,2-diidro-1,6-naftiridin-3-il)-2-fluorofenil)-3-fenilurea |
| FI4084778T3 (fi) | 2019-12-30 | 2023-12-18 | Deciphera Pharmaceuticals Llc | Amorfisia kinaasi-inhibiittoriformulaatioita ja menetelmiä niiden käyttämiseksi |
| JP2023549540A (ja) | 2020-11-18 | 2023-11-27 | デシフェラ・ファーマシューティカルズ，エルエルシー | Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法 |
| CN115385896B (zh) * | 2021-05-24 | 2024-11-15 | 上海和誉生物医药科技有限公司 | 一种csf-1r抑制剂中间体或其酸式盐的制备方法 |
| CN113880812A (zh) * | 2021-11-17 | 2022-01-04 | 上海皓元生物医药科技有限公司 | 一种csf-ir抑制剂的制备方法 |
| TW202337455A (zh) | 2021-12-09 | 2023-10-01 | 美商迪賽孚爾製藥有限公司 | Ｒａｆ激酶抑制劑及其使用方法 |
| WO2023125812A1 (zh) * | 2021-12-31 | 2023-07-06 | 上海海雁医药科技有限公司 | 取代的嘧啶酮衍生物、其药物组合物及医药上的用途 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
| US20250206720A1 (en) * | 2023-12-08 | 2025-06-26 | Deciphera Pharmaceuticals, Llc | Solid forms of an ulk inhibitor |
| WO2025122952A1 (en) | 2023-12-08 | 2025-06-12 | Deciphera Pharmaceuticals, Llc | Formulations of vimseltinib |
| WO2025231106A1 (en) * | 2024-05-01 | 2025-11-06 | Deciphera Pharmaceuticals, Llc | Csf-1r inhibitors and methods of use thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080255155A1 (en) * | 2006-10-18 | 2008-10-16 | Stephane Raeppel | Kinase inhibitors and uses thereof |
| US7687522B2 (en) * | 2006-12-20 | 2010-03-30 | Amgen Inc. | Substituted pyridines and pyrimidines and their use in treatment of cancer |
| CN102256493A (zh) * | 2008-10-29 | 2011-11-23 | 迪赛孚尔制药有限公司 | 表现出抗癌活性和抗增殖活性的环丙烷酰胺及其类似物 |
| WO2014145015A2 (en) * | 2013-03-15 | 2014-09-18 | Deciphera Pharmaceuticals, Llc | Imidazolidinones and analogs exhibiting anti-cancer and anti-proliferative activities |
| MX365574B (es) * | 2013-03-15 | 2019-06-06 | Deciphera Pharmaceuticals Llc | 2-aminopirimidin-6-onas y analogos que exhiben actividades anticancerosas y antiproliferativas. |
| US9193719B2 (en) * | 2013-03-15 | 2015-11-24 | Deciphera Pharmaceuticals, Llc | 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities |
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2014
- 2014-03-14 MX MX2015012736A patent/MX365574B/es active IP Right Grant
- 2014-03-14 RU RU2015143717A patent/RU2015143717A/ru not_active Application Discontinuation
- 2014-03-14 CA CA2903285A patent/CA2903285C/en active Active
- 2014-03-14 CN CN201710265111.9A patent/CN107311981B/zh active Active
- 2014-03-14 JP JP2016503185A patent/JP6165314B2/ja active Active
- 2014-03-14 WO PCT/US2014/029661 patent/WO2014145025A2/en not_active Ceased
- 2014-03-14 BR BR112015022288-9A patent/BR112015022288B1/pt active IP Right Grant
- 2014-03-14 KR KR1020227016381A patent/KR102628583B1/ko active Active
- 2014-03-14 SG SG11201507660TA patent/SG11201507660TA/en unknown
- 2014-03-14 DK DK14764032.0T patent/DK2968286T3/en active
- 2014-03-14 US US14/214,171 patent/US9181223B2/en active Active
- 2014-03-14 PT PT147640320T patent/PT2968286T/pt unknown
- 2014-03-14 KR KR1020217026183A patent/KR102399891B1/ko active Active
- 2014-03-14 ES ES14764032.0T patent/ES2651165T3/es active Active
- 2014-03-14 CN CN201480021743.5A patent/CN105120864B/zh active Active
- 2014-03-14 EP EP14764032.0A patent/EP2968286B1/en active Active
- 2014-03-14 AU AU2014233411A patent/AU2014233411B2/en active Active
- 2014-03-14 KR KR1020157029134A patent/KR102293086B1/ko active Active
- 2014-03-14 KR KR1020247001621A patent/KR20240013846A/ko not_active Ceased
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2015
- 2015-09-01 IL IL241000A patent/IL241000B/en active IP Right Grant
- 2015-09-14 PH PH12015502114A patent/PH12015502114B1/en unknown
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2017
- 2017-06-20 JP JP2017120849A patent/JP2017193567A/ja active Pending
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2018
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- 2018-11-28 AU AU2018271293A patent/AU2018271293B2/en active Active
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2019
- 2019-02-25 JP JP2019032014A patent/JP6936823B2/ja active Active
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2020
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2021
- 2021-08-27 JP JP2021138625A patent/JP7169412B2/ja active Active
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2022
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2024
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