JP6165314B2 - 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 - Google Patents

抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 Download PDF

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JP6165314B2
JP6165314B2 JP2016503185A JP2016503185A JP6165314B2 JP 6165314 B2 JP6165314 B2 JP 6165314B2 JP 2016503185 A JP2016503185 A JP 2016503185A JP 2016503185 A JP2016503185 A JP 2016503185A JP 6165314 B2 JP6165314 B2 JP 6165314B2
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methyl
pyridin
alkyl
oxy
pyrazol
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JP2016521255A (ja
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ディー． カウフマン，マイケル
ディー． カウフマン，マイケル
エル． フリン，ダニエル
エル． フリン，ダニエル
ミ アーン，ユ
ミ アーン，ユ
ヴォゲティ，ラクシュミナラヤナ
マルコム コールドウェル，ティモシー
マルコム コールドウェル，ティモシー
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デシフェラ ファーマシューティカルズ，エルエルシー
デシフェラ ファーマシューティカルズ，エルエルシー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings

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  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
JP2016503185A 2013-03-15 2014-03-14 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体 Active JP6165314B2 (ja)

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US201361792812P 2013-03-15 2013-03-15
US61/792,812 2013-03-15
PCT/US2014/029661 WO2014145025A2 (en) 2013-03-15 2014-03-14 2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities

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JP2016503185A Active JP6165314B2 (ja) 2013-03-15 2014-03-14 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体
JP2017120849A Pending JP2017193567A (ja) 2013-03-15 2017-06-20 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体
JP2019032014A Active JP6936823B2 (ja) 2013-03-15 2019-02-25 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体
JP2021138625A Active JP7169412B2 (ja) 2013-03-15 2021-08-27 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体
JP2022173722A Active JP7536064B2 (ja) 2013-03-15 2022-10-28 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体
JP2024071962A Pending JP2024105360A (ja) 2013-03-15 2024-04-25 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体

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JP2019032014A Active JP6936823B2 (ja) 2013-03-15 2019-02-25 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体
JP2021138625A Active JP7169412B2 (ja) 2013-03-15 2021-08-27 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体
JP2022173722A Active JP7536064B2 (ja) 2013-03-15 2022-10-28 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体
JP2024071962A Pending JP2024105360A (ja) 2013-03-15 2024-04-25 抗癌活性及び抗増殖活性を呈する２－アミノピリミジン－６－オン及び類似体

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US (1) US9181223B2 (enExample)
EP (1) EP2968286B1 (enExample)
JP (6) JP6165314B2 (enExample)
KR (4) KR102628583B1 (enExample)
CN (2) CN107311981B (enExample)
AU (5) AU2014233411B2 (enExample)
BR (1) BR112015022288B1 (enExample)
CA (1) CA2903285C (enExample)
DK (1) DK2968286T3 (enExample)
ES (1) ES2651165T3 (enExample)
IL (4) IL241000B (enExample)
MX (1) MX365574B (enExample)
PH (1) PH12015502114B1 (enExample)
PT (1) PT2968286T (enExample)
RU (1) RU2015143717A (enExample)
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WO (1) WO2014145025A2 (enExample)

Cited By (1)

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JP2017193567A (ja) * 2013-03-15 2017-10-26 デシフェラ ファーマシューティカルズ，エルエルシー 抗癌活性及び抗増殖活性を呈する２−アミノピリミジン−６−オン及び類似体

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WO2018214866A1 (zh) * 2017-05-24 2018-11-29 上海和誉生物医药科技有限公司 一种氮杂芳基衍生物、其制备方法和在药学上的应用
CN110461841B (zh) * 2017-06-19 2020-09-15 上海和誉生物医药科技有限公司 一种具有csf1r抑制活性的氮杂芳基衍生物、其制备方法和应用
JP2021512105A (ja) 2018-01-31 2021-05-13 デシフェラ・ファーマシューティカルズ，エルエルシー 消化管間質腫瘍の治療のための併用療法
CN118903436A (zh) 2018-01-31 2024-11-08 德西费拉制药有限责任公司 治疗肥大细胞增多症的组合疗法
CN110845476B (zh) * 2018-08-21 2022-11-18 上海和誉生物医药科技有限公司 一种高选择性csf1r抑制剂、其制备方法和在药学上的应用
CA3124112A1 (en) 2018-12-28 2020-07-02 Deciphera Pharmaceuticals, Llc Csf1r inhibitors for use in treating cancer
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PT3966206T (pt) 2019-05-10 2023-11-10 Deciphera Pharmaceuticals Llc Inibidores de autofagia de heteroarilaminopirimidina amida e métodos de utilização dos mesmos
JP7626722B2 (ja) 2019-06-17 2025-02-04 デシフェラ・ファーマシューティカルズ，エルエルシー アミノピリミジンアミドオートファジー阻害剤およびその使用方法
NZ784949A (en) 2019-08-12 2025-09-26 Deciphera Pharmaceuticals Llc Ripretinib for treating gastrointestinal stromal tumors
TWI878335B (zh) 2019-08-12 2025-04-01 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
SMT202400484T1 (it) 2019-12-30 2025-01-14 Deciphera Pharmaceuticals Llc Composizioni di 1-(4-bromo-5-(1-etil-7-(metilammino)-2-osso-1,2-diidro-1,6-naftiridin-3-il)-2-fluorofenil)-3-fenilurea
FI4084778T3 (fi) 2019-12-30 2023-12-18 Deciphera Pharmaceuticals Llc Amorfisia kinaasi-inhibiittoriformulaatioita ja menetelmiä niiden käyttämiseksi
JP2023549540A (ja) 2020-11-18 2023-11-27 デシフェラ・ファーマシューティカルズ，エルエルシー Ｇｃｎ２およびｐｅｒｋキナーゼ阻害剤およびその使用方法
CN115385896B (zh) * 2021-05-24 2024-11-15 上海和誉生物医药科技有限公司 一种csf-1r抑制剂中间体或其酸式盐的制备方法
CN113880812A (zh) * 2021-11-17 2022-01-04 上海皓元生物医药科技有限公司 一种csf-ir抑制剂的制备方法
TW202337455A (zh) 2021-12-09 2023-10-01 美商迪賽孚爾製藥有限公司 Ｒａｆ激酶抑制劑及其使用方法
WO2023125812A1 (zh) * 2021-12-31 2023-07-06 上海海雁医药科技有限公司 取代的嘧啶酮衍生物、其药物组合物及医药上的用途
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