CN105120864B - 表现出抗癌活性和抗增殖活性的2‑氨基嘧啶‑6‑酮及类似物 - Google Patents

表现出抗癌活性和抗增殖活性的2‑氨基嘧啶‑6‑酮及类似物 Download PDF

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CN105120864B
CN105120864B CN201480021743.5A CN201480021743A CN105120864B CN 105120864 B CN105120864 B CN 105120864B CN 201480021743 A CN201480021743 A CN 201480021743A CN 105120864 B CN105120864 B CN 105120864B
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methyl
pyridin
alkyl
oxy
pyrazol
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CN105120864A (zh
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M·D·考夫曼
D·L·弗林
Y·M·阿恩
L·沃杰蒂
T·M·考德威尔
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Deciphera Pharmaceuticals LLC
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CN201480021743.5A 2013-03-15 2014-03-14 表现出抗癌活性和抗增殖活性的2‑氨基嘧啶‑6‑酮及类似物 Active CN105120864B (zh)

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US201361792812P 2013-03-15 2013-03-15
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PCT/US2014/029661 WO2014145025A2 (en) 2013-03-15 2014-03-14 2-aminopyrimidin-6-ones and analogs exhibiting anti-cancer and anti-proliferative activities

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EP3746060A1 (en) 2018-01-31 2020-12-09 Deciphera Pharmaceuticals, LLC Combination therapy for the treatment of mastocytosis
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CN118878519A (zh) 2019-05-10 2024-11-01 德西费拉制药有限责任公司 苯基氨基嘧啶酰胺自噬抑制剂及其使用方法
IL287795B2 (en) 2019-05-10 2025-05-01 Deciphera Pharmaceuticals Llc Heteroarylaminopyrimidine amides as autophagy inhibitors and methods of using them
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KR20220045189A (ko) 2019-08-12 2022-04-12 데시페라 파마슈티칼스, 엘엘씨. 위장관 기질 종양을 치료하는 방법
WO2021030405A1 (en) 2019-08-12 2021-02-18 Deciphera Pharmaceuticals, Llc Ripretinib for treating gastrointestinal stromal tumors
SMT202300467T1 (it) 2019-12-30 2024-01-10 Deciphera Pharmaceuticals Llc Formulazioni di inibitori di chinasi amorfi e loro procedimenti d’uso
CN118948773A (zh) 2019-12-30 2024-11-15 德西费拉制药有限责任公司 1-(4溴-5-(1乙基-7-(甲氨基)-2侧氧基-1,2-二氢-1,6-萘啶-3基)-2氟苯基)-3-苯基脲的组合物
EP4247795A1 (en) 2020-11-18 2023-09-27 Deciphera Pharmaceuticals, LLC Gcn2 and perk kinase inhibitors and methods of use thereof
CN115385896B (zh) * 2021-05-24 2024-11-15 上海和誉生物医药科技有限公司 一种csf-1r抑制剂中间体或其酸式盐的制备方法
CN113880812A (zh) * 2021-11-17 2022-01-04 上海皓元生物医药科技有限公司 一种csf-ir抑制剂的制备方法
MX2024007042A (es) 2021-12-09 2024-09-04 Deciphera Pharmaceuticals Llc Inhibidores de raf quinasa y metodos de uso de los mismos.
WO2023125812A1 (zh) * 2021-12-31 2023-07-06 上海海雁医药科技有限公司 取代的嘧啶酮衍生物、其药物组合物及医药上的用途
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KR20210107143A (ko) 2021-08-31
SG11201507660TA (en) 2015-10-29
IL275422B (en) 2022-02-01
EP2968286A2 (en) 2016-01-20
CN107311981A (zh) 2017-11-03
AU2024202088A1 (en) 2024-05-02
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