|
EP1251170A3
(en)
|
1992-07-17 |
2002-10-30 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for treatment of NF-kappaB dependent animal diseases
|
|
US6054299A
(en)
|
1994-04-29 |
2000-04-25 |
Conrad; Charles A. |
Stem-loop cloning vector and method
|
|
WO2000022114A1
(en)
|
1998-10-09 |
2000-04-20 |
Ingene, Inc. |
PRODUCTION OF ssDNA $i(IN VIVO)
|
|
US20030073640A1
(en)
|
1997-07-23 |
2003-04-17 |
Ribozyme Pharmaceuticals, Inc. |
Novel compositions for the delivery of negatively charged molecules
|
|
BR9914772A
(pt)
|
1998-10-09 |
2001-12-11 |
Ingene Inc |
Conjunto de elementos genéticos, vetor, célulahospedeira, conjunto para a produção de umasequência de ácido nucléico, método para aprodução in vivo ou in vitro de uma sequência deácido nucléico, transcrição de cdna, molécula deácido nucléico inibidor, transcrição de mrna,molécula heteroduplex e composiçãofarmacêutica
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US7013219B2
(en)
|
1999-01-12 |
2006-03-14 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
AU2001290241A1
(en)
*
|
2000-09-20 |
2002-04-02 |
Kyowa Hakko Kogyo Co. Ltd. |
Tumor cell proliferation inhibitors
|
|
US7708915B2
(en)
|
2004-05-06 |
2010-05-04 |
Castor Trevor P |
Polymer microspheres/nanospheres and encapsulating therapeutic proteins therein
|
|
WO2003016559A2
(en)
*
|
2001-08-17 |
2003-02-27 |
Novo Nordisk A/S |
Method for treating diabetes based on the modulation of nh4alpha gene expression
|
|
WO2003016496A2
(en)
*
|
2001-08-20 |
2003-02-27 |
The Scripps Research Institute |
Zinc finger binding domains for cnn
|
|
WO2003092665A2
(en)
|
2002-05-02 |
2003-11-13 |
Massachusetts Eye And Ear Infirmary |
Ocular drug delivery systems and use thereof
|
|
US8084599B2
(en)
|
2004-03-15 |
2011-12-27 |
City Of Hope |
Methods and compositions for the specific inhibition of gene expression by double-stranded RNA
|
|
WO2006097793A2
(en)
|
2004-04-15 |
2006-09-21 |
Chiasma, Ltd. |
Compositions capable of facilitating penetration across a biological barrier
|
|
US20060134189A1
(en)
|
2004-11-17 |
2006-06-22 |
Protiva Biotherapeutics, Inc |
siRNA silencing of apolipoprotein B
|
|
US8192718B1
(en)
|
2005-01-04 |
2012-06-05 |
Gp Medical, Inc. |
Pharmaceutical composition of nanoparticles
|
|
WO2007086883A2
(en)
|
2005-02-14 |
2007-08-02 |
Sirna Therapeutics, Inc. |
Cationic lipids and formulated molecular compositions containing them
|
|
US7404969B2
(en)
|
2005-02-14 |
2008-07-29 |
Sirna Therapeutics, Inc. |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
|
|
ATE541928T1
(de)
|
2005-03-31 |
2012-02-15 |
Calando Pharmaceuticals Inc |
Inhibitoren der untereinheit 2 der ribonukleotidreduktase und ihre verwendungen
|
|
WO2007117706A2
(en)
|
2006-04-07 |
2007-10-18 |
Merrion Research Iii Limited |
Solid oral dosage form containing an enhancer
|
|
WO2008006028A2
(en)
*
|
2006-07-05 |
2008-01-10 |
The Scripps Research Institute |
Chimeric zinc finger recombinases optimized for catalysis by directed evolution
|
|
WO2008042973A2
(en)
|
2006-10-03 |
2008-04-10 |
Alnylam Pharmaceuticals, Inc. |
Lipid containing formulations
|
|
WO2008050654A1
(en)
|
2006-10-25 |
2008-05-02 |
Panasonic Corporation |
Refrigeration cycle device and fluid machine used for the same
|
|
JP2010519203A
(ja)
|
2007-02-16 |
2010-06-03 |
メルク・シャープ・エンド・ドーム・コーポレイション |
生物活性分子の活性を強化するための組成物及び方法
|
|
US8399218B2
(en)
*
|
2007-09-27 |
2013-03-19 |
Dow Agrosciences, Llc |
Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
|
|
SI2644192T1
(sl)
|
2007-09-28 |
2017-08-31 |
Pfizer Inc. |
Ciljanje rakavih celic z uporabo nanodelcev
|
|
CA2917512C
(en)
|
2007-10-12 |
2025-08-05 |
President And Fellows Of Harvard College |
VACCINE NANOTECHNOLOGY
|
|
JP5749494B2
(ja)
|
2008-01-02 |
2015-07-15 |
テクミラ ファーマシューティカルズ コーポレイション |
核酸の送達のための改善された組成物および方法
|
|
WO2010005726A2
(en)
|
2008-06-16 |
2010-01-14 |
Bind Biosciences Inc. |
Therapeutic polymeric nanoparticles with mtor inhibitors and methods of making and using same
|
|
EA020954B1
(ru)
|
2008-06-16 |
2015-03-31 |
Бинд Терапьютикс, Инк. |
Загруженные лекарственным средством полимерные наночастицы, фармацевтическая композиция и способ лечения рака
|
|
EP2309991B1
(en)
|
2008-06-16 |
2019-03-06 |
Pfizer Inc |
Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same
|
|
HUE035770T2
(en)
|
2008-06-16 |
2018-05-28 |
Pfizer |
Process for the preparation of diblock copolymers functionalized with targeting material for use in the preparation of therapeutic nanoparticles
|
|
EP2326331A4
(en)
|
2008-08-18 |
2013-05-15 |
Merck Sharp & Dohme |
NEW LIPID NANOPARTICLES AND NEW COMPONENTS FOR THE RELEASE OF NUCLEIC ACIDS
|
|
WO2010030763A2
(en)
|
2008-09-10 |
2010-03-18 |
Bind Biosciences, Inc. |
High throughput fabrication of nanoparticles
|
|
JP5777519B2
(ja)
|
2008-10-09 |
2015-09-09 |
テクミラ ファーマシューティカルズ コーポレイション |
改良されたアミノ脂質および核酸の送達方法
|
|
WO2010068866A2
(en)
|
2008-12-12 |
2010-06-17 |
Bind Biosciences |
Therapeutic particles suitable for parenteral administration and methods of making and using same
|
|
EP2379064B1
(en)
|
2008-12-15 |
2020-02-26 |
Pfizer Inc. |
Long circulating nanoparticles for sustained release of therapeutic agents
|
|
EP2379083B1
(en)
|
2008-12-18 |
2017-08-16 |
Dicerna Pharmaceuticals, Inc. |
Extended dicer substrate agents and methods for the specific inhibition of gene expression
|
|
WO2010080724A1
(en)
|
2009-01-12 |
2010-07-15 |
Merck Sharp & Dohme Corp. |
Novel lipid nanoparticles and novel components for delivery of nucleic acids
|
|
WO2010093788A2
(en)
|
2009-02-11 |
2010-08-19 |
Dicerna Pharmaceuticals, Inc. |
Multiplex dicer substrate rna interference molecules having joining sequences
|
|
WO2010113037A1
(en)
|
2009-04-03 |
2010-10-07 |
Centre National De La Recherche Scientifique |
Gene transfer vectors comprising genetic insulator elements and methods to identify genetic insulator elements
|
|
SG176553A1
(en)
|
2009-05-05 |
2012-01-30 |
Muthiah Manoharan |
Lipid compositions
|
|
TR201811076T4
(tr)
|
2009-06-10 |
2018-08-27 |
Arbutus Biopharma Corp |
Geliştirilmiş lipit formulasyonu.
|
|
US9051567B2
(en)
|
2009-06-15 |
2015-06-09 |
Tekmira Pharmaceuticals Corporation |
Methods for increasing efficacy of lipid formulated siRNA
|
|
US8283333B2
(en)
|
2009-07-01 |
2012-10-09 |
Protiva Biotherapeutics, Inc. |
Lipid formulations for nucleic acid delivery
|
|
US8569256B2
(en)
|
2009-07-01 |
2013-10-29 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods for the delivery of therapeutic agents
|
|
WO2011022460A1
(en)
|
2009-08-20 |
2011-02-24 |
Merck Sharp & Dohme Corp. |
Novel cationic lipids with various head groups for oligonucleotide delivery
|
|
WO2011043913A2
(en)
|
2009-10-08 |
2011-04-14 |
Merck Sharp & Dohme Corp. |
Novel cationic lipids with short lipid chains for oligonucleotide delivery
|
|
PL3338765T3
(pl)
|
2009-12-01 |
2019-06-28 |
Translate Bio, Inc. |
Pochodna steroidowa dla dostarczania mrna w ludzkich chorobach genetycznych
|
|
WO2011071860A2
(en)
|
2009-12-07 |
2011-06-16 |
Alnylam Pharmaceuticals, Inc. |
Compositions for nucleic acid delivery
|
|
NO2510096T3
(enExample)
|
2009-12-10 |
2015-03-21 |
|
|
|
TR201906255T4
(tr)
|
2009-12-11 |
2019-05-21 |
Pfizer |
Terapötik partiküllerin liyofilize edilmesine yönelik stabil formülasyonlar.
|
|
ES2780156T3
(es)
|
2009-12-15 |
2020-08-24 |
Pfizer |
Composiciones terapéuticas de nanopartículas poliméricas con alta temperatura de transición vítrea o copolímeros de alto peso molecular
|
|
DE102009058769A1
(de)
|
2009-12-16 |
2011-06-22 |
MagForce Nanotechnologies AG, 10589 |
Temperaturabhängige Aktivierung von katalytischen Nukleinsäuren zur kontrollierten Wirkstofffreisetzung
|
|
EP3494963A1
(en)
|
2009-12-18 |
2019-06-12 |
The University of British Columbia |
Methods and compositions for delivery of nucleic acids
|
|
AU2010334911A1
(en)
|
2009-12-23 |
2012-07-12 |
Novartis Ag |
Lipids, lipid compositions, and methods of using them
|
|
EP2525781A1
(en)
|
2010-01-22 |
2012-11-28 |
Schering Corporation |
Novel cationic lipids for oligonucleotide delivery
|
|
US9149432B2
(en)
|
2010-03-19 |
2015-10-06 |
Massachusetts Institute Of Technology |
Lipid vesicle compositions and methods of use
|
|
WO2011127255A1
(en)
|
2010-04-08 |
2011-10-13 |
Merck Sharp & Dohme Corp. |
Preparation of lipid nanoparticles
|
|
WO2011127456A2
(en)
|
2010-04-09 |
2011-10-13 |
Pacira Pharmaceuticals, Inc. |
Method for formulating large diameter synthetic membrane vesicles
|
|
US20110262491A1
(en)
|
2010-04-12 |
2011-10-27 |
Selecta Biosciences, Inc. |
Emulsions and methods of making nanocarriers
|
|
WO2011143230A1
(en)
|
2010-05-10 |
2011-11-17 |
Alnylam Pharmaceuticals |
Methods and compositions for delivery of active agents
|
|
US20130123338A1
(en)
|
2010-05-12 |
2013-05-16 |
Protiva Biotherapeutics, Inc. |
Novel cationic lipids and methods of use thereof
|
|
US8802863B2
(en)
|
2010-05-24 |
2014-08-12 |
Sirna Therapeutics, Inc. |
Amino alcohol cationic lipids for oligonucleotide delivery
|
|
US8748667B2
(en)
|
2010-06-04 |
2014-06-10 |
Sirna Therapeutics, Inc. |
Low molecular weight cationic lipids for oligonucleotide delivery
|
|
WO2012000104A1
(en)
|
2010-06-30 |
2012-01-05 |
Protiva Biotherapeutics, Inc. |
Non-liposomal systems for nucleic acid delivery
|
|
AU2011276234B2
(en)
|
2010-07-06 |
2016-02-25 |
Glaxosmithkline Biologicals S.A. |
Liposomes with lipids having an advantageous pKa- value for RNA delivery
|
|
DE102010032758B4
(de)
|
2010-07-29 |
2012-02-23 |
Fujitsu Technology Solutions Intellectual Property Gmbh |
Computersystem, Verfahren zum Programmieren einer Echtzeituhr und Computerprogrammprodukt
|
|
CA2807552A1
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
WO2012031043A1
(en)
|
2010-08-31 |
2012-03-08 |
Novartis Ag |
Pegylated liposomes for delivery of immunogen-encoding rna
|
|
BR112013004879A2
(pt)
|
2010-08-31 |
2018-04-24 |
Novartis Ag |
lipossomas pequenos para entrega de rna que codifica imunogénio
|
|
TR201908635T4
(tr)
|
2010-08-31 |
2019-07-22 |
Glaxosmithkline Biologicals Sa |
Protein kodlayıcı rna?nın lipozomal verilmesine uygun lipitler.
|
|
US8466122B2
(en)
|
2010-09-17 |
2013-06-18 |
Protiva Biotherapeutics, Inc. |
Trialkyl cationic lipids and methods of use thereof
|
|
MX349088B
(es)
|
2010-09-20 |
2017-07-10 |
Merck Sharp & Dohme |
Lípidos catiónicos novedosos de bajo peso molecular para la entrega de oligonucleótidos.
|
|
KR20130114115A
(ko)
|
2010-09-30 |
2013-10-16 |
머크 샤프 앤드 돔 코포레이션 |
올리고뉴클레오티드 전달을 위한 저분자량 양이온성 지질
|
|
CN103153347A
(zh)
|
2010-10-21 |
2013-06-12 |
默沙东公司 |
用于寡核苷酸递送的新型低分子量阳离子脂质
|
|
EP2629760A4
(en)
|
2010-10-22 |
2014-04-02 |
Bind Therapeutics Inc |
THERAPEUTIC NANOPARTICLES CONTAINING COPOLYMERS OF HIGH MOLECULAR WEIGHT
|
|
WO2012061259A2
(en)
|
2010-11-05 |
2012-05-10 |
Merck Sharp & Dohme Corp. |
Novel low molecular weight cyclic amine containing cationic lipids for oligonucleotide delivery
|
|
PH12013500907A1
(en)
|
2010-11-05 |
2013-07-08 |
Firmenich Incorporated |
Compounds useful as modulators of trpm8
|
|
EP2694040A4
(en)
|
2011-03-25 |
2014-09-03 |
Selecta Biosciences Inc |
SYNTHETIC NANOTRACKERS WITH OSMOTICALLY MEDIATED RELEASE
|
|
US9611510B2
(en)
|
2011-04-06 |
2017-04-04 |
The University Of Chicago |
Composition and methods related to modification of 5-methylcytosine (5-mC)
|
|
KR20140041505A
(ko)
|
2011-04-29 |
2014-04-04 |
셀렉타 바이오사이언시즈, 인크. |
조절 b 세포 유도를 위한 관용원성 합성 나노운반체
|
|
DK3336082T3
(da)
|
2011-06-08 |
2020-04-27 |
Translate Bio Inc |
Spaltelige lipider
|
|
US9126966B2
(en)
|
2011-08-31 |
2015-09-08 |
Protiva Biotherapeutics, Inc. |
Cationic lipids and methods of use thereof
|
|
US20140328759A1
(en)
|
2011-10-25 |
2014-11-06 |
The University Of British Columbia |
Limit size lipid nanoparticles and related methods
|
|
KR20150000461A
(ko)
|
2011-10-27 |
2015-01-02 |
메사추세츠 인스티튜트 오브 테크놀로지 |
약물 캡슐화 마이크로스피어를 형성할 수 있는, ｎ-말단 상에 관능화된 아미노산 유도체
|
|
US8895264B2
(en)
*
|
2011-10-27 |
2014-11-25 |
Sangamo Biosciences, Inc. |
Methods and compositions for modification of the HPRT locus
|
|
AU2012328457A1
(en)
|
2011-10-28 |
2014-04-24 |
Presage Biosciences, Inc. |
Methods for drug delivery
|
|
ES3065854T3
(en)
|
2011-12-07 |
2026-05-08 |
Alnylam Pharmaceuticals Inc |
Biodegradable lipids for the delivery of active agents
|
|
WO2013086373A1
(en)
|
2011-12-07 |
2013-06-13 |
Alnylam Pharmaceuticals, Inc. |
Lipids for the delivery of active agents
|
|
JP6182457B2
(ja)
|
2011-12-12 |
2017-08-16 |
協和発酵キリン株式会社 |
カチオン性脂質を含有するドラックデリバリーシステムのための脂質ナノ粒子
|
|
WO2013090601A2
(en)
|
2011-12-16 |
2013-06-20 |
Massachusetts Institute Of Technology |
Compact nanoparticles for biological applications
|
|
WO2013105101A1
(en)
|
2012-01-13 |
2013-07-18 |
Department Of Biotechnology |
Solid lipid nanoparticles entrapping hydrophilic/ amphiphilic drug and a process for preparing the same
|
|
AU2013209452B2
(en)
|
2012-01-19 |
2015-11-05 |
The Johns Hopkins University |
Nanoparticle formulations with enhanced mucosal penetration
|
|
WO2013116126A1
(en)
|
2012-02-01 |
2013-08-08 |
Merck Sharp & Dohme Corp. |
Novel low molecular weight, biodegradable cationic lipids for oligonucleotide delivery
|
|
DK2817287T3
(da)
|
2012-02-24 |
2019-01-02 |
Arbutus Biopharma Corp |
Trialkyl kationisk lipid og metoder til anvendelse deraf
|
|
US10322089B2
(en)
|
2012-03-14 |
2019-06-18 |
The Board Of Trustees Of The Leland Stanford Junior University |
Nanoparticles, nanoparticle delivery methods, and systems of delivery
|
|
LT3401400T
(lt)
|
2012-05-25 |
2019-06-10 |
The Regents Of The University Of California |
Būdai ir kompozicijos, skirtos rnr molekulės nukreipiamai tikslinės dnr modifikacijai ir rnr molekulės nukreipiamam transkripcijos moduliavimui
|
|
US9415109B2
(en)
|
2012-07-06 |
2016-08-16 |
Alnylam Pharmaceuticals, Inc. |
Stable non-aggregating nucleic acid lipid particle formulations
|
|
EP2882706A1
(en)
|
2012-08-13 |
2015-06-17 |
Massachusetts Institute of Technology |
Amine-containing lipidoids and uses thereof
|
|
DK2890780T3
(da)
*
|
2012-08-29 |
2020-09-21 |
Sangamo Therapeutics Inc |
Fremgangsmåder og sammensætninger til behandling af en genetisk tilstand
|
|
PL4397760T3
(pl)
|
2012-10-23 |
2026-03-30 |
Toolgen Incorporated |
Kompozycja do rozszczepiania docelowego dna zawierająca prowadzące rna specyficzne dla docelowego dna i kwas nukleinowy kodujący białko cas lub białko cas oraz jej zastosowanie
|
|
US20140310830A1
(en)
|
2012-12-12 |
2014-10-16 |
Feng Zhang |
CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes
|
|
CN114634950A
(zh)
|
2012-12-12 |
2022-06-17 |
布罗德研究所有限公司 |
用于序列操纵的crispr-cas组分系统、方法以及组合物
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
EP2931898B1
(en)
|
2012-12-12 |
2016-03-09 |
The Broad Institute, Inc. |
Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains
|
|
ES2576126T3
(es)
|
2012-12-12 |
2016-07-05 |
The Broad Institute, Inc. |
Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias
|
|
JP2016504026A
(ja)
|
2012-12-12 |
2016-02-12 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
配列操作のための系、方法および最適化ガイド組成物のエンジニアリング
|
|
CA2896554C
(en)
|
2012-12-27 |
2019-11-05 |
Drexel University |
Novel antiviral agents against hbv infection
|
|
US10258698B2
(en)
|
2013-03-14 |
2019-04-16 |
Modernatx, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
|
US10378027B2
(en)
|
2013-03-15 |
2019-08-13 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
US9234213B2
(en)
|
2013-03-15 |
2016-01-12 |
System Biosciences, Llc |
Compositions and methods directed to CRISPR/Cas genomic engineering systems
|
|
WO2014172470A2
(en)
|
2013-04-16 |
2014-10-23 |
Whitehead Institute For Biomedical Research |
Methods of mutating, modifying or modulating nucleic acid in a cell or nonhuman mammal
|
|
MX2015017312A
(es)
|
2013-06-17 |
2017-04-10 |
Broad Inst Inc |
Suministro y uso de composiciones, vectores y sistemas crispr-cas para la modificación dirigida y terapia hepáticas.
|
|
WO2015033293A1
(en)
|
2013-09-04 |
2015-03-12 |
Csir |
Site-specific nuclease single-cell assay targeting gene regulatory elements to silence gene expression
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9925277B2
(en)
|
2013-09-13 |
2018-03-27 |
Modernatx, Inc. |
Polynucleotide compositions containing amino acids
|
|
WO2015154188A1
(en)
|
2014-04-09 |
2015-10-15 |
The University Of British Columbia |
Drill cover and chuck mechanism
|
|
US20170044540A1
(en)
|
2014-04-22 |
2017-02-16 |
Mina Therapeutics Limited |
Sarna compositions and methods of use
|
|
US20150376612A1
(en)
|
2014-06-10 |
2015-12-31 |
The General Hospital Corporation |
CCCTC-Binding Factor (CTCF) RNA Interactome
|
|
WO2015196128A2
(en)
|
2014-06-19 |
2015-12-23 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules and uses thereof
|
|
IL316479A
(en)
|
2014-06-25 |
2024-12-01 |
Acuitas Therapeutics Inc |
Novel lipids and lipid nanoparticle compositions for nucleic acid delivery
|
|
US9816074B2
(en)
|
2014-07-25 |
2017-11-14 |
Sangamo Therapeutics, Inc. |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
|
|
WO2016022363A2
(en)
|
2014-07-30 |
2016-02-11 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
GB201418965D0
(enExample)
|
2014-10-24 |
2014-12-10 |
Ospedale San Raffaele And Fond Telethon |
|
|
JP6788584B2
(ja)
|
2014-10-31 |
2020-11-25 |
マサチューセッツ インスティテュート オブ テクノロジー |
Ｃｒｉｓｐｒについての超並列コンビナトリアル遺伝学
|
|
WO2016073990A2
(en)
|
2014-11-07 |
2016-05-12 |
Editas Medicine, Inc. |
Methods for improving crispr/cas-mediated genome-editing
|
|
WO2016081798A1
(en)
|
2014-11-20 |
2016-05-26 |
Children's Medical Center Corporation |
Methods relating to the detection of recurrent and non-specific double strand breaks in the genome
|
|
EP3754027A1
(en)
|
2014-12-01 |
2020-12-23 |
The Broad Institute, Inc. |
Methods for altering or modulating spatial proximity between nucleic acids inside of a cell
|
|
AU2015370435A1
(en)
|
2014-12-24 |
2017-06-15 |
Dana-Farber Cancer Institute, Inc. |
Systems and methods for genome modification and regulation
|
|
CN107429263A
(zh)
|
2015-01-15 |
2017-12-01 |
斯坦福大学托管董事会 |
调控基因组编辑的方法
|
|
US10023922B2
(en)
|
2015-03-23 |
2018-07-17 |
Whitehead Institute For Biomedical Research |
Reporter of genomic methylation and uses thereof
|
|
KR102888521B1
(ko)
|
2015-04-06 |
2025-11-19 |
더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 |
Crispr/cas-매개 유전자 조절을 위한 화학적으로 변형된 가이드 rna
|
|
JP2018526321A
(ja)
|
2015-04-27 |
2018-09-13 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
適応免疫応答を誘導するためのヌクレオシド修飾ｒｎａ
|
|
EP3087974A1
(en)
|
2015-04-29 |
2016-11-02 |
Rodos BioTarget GmbH |
Targeted nanocarriers for targeted drug delivery of gene therapeutics
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
HUE067372T2
(hu)
|
2015-06-29 |
2024-10-28 |
Acuitas Therapeutics Inc |
Lipidek és nanoszemcsés lipid formulázások nukleinsavak beadására
|
|
US20170014449A1
(en)
|
2015-07-13 |
2017-01-19 |
Elwha LLC, a limited liability company of the State of Delaware |
Site-specific epigenetic editing
|
|
WO2017011710A2
(en)
|
2015-07-14 |
2017-01-19 |
Whitehead Institute For Biomedical Research |
Chromosome neighborhood structures and methods relating thereto
|
|
US11214800B2
(en)
|
2015-08-18 |
2022-01-04 |
The Broad Institute, Inc. |
Methods and compositions for altering function and structure of chromatin loops and/or domains
|
|
US20180245057A1
(en)
|
2015-09-01 |
2018-08-30 |
Dana-Farber Cancer Institute, Inc. |
Systems and methods for selection of grna targeting strands for cas9 localization
|
|
CA2998287A1
(en)
|
2015-09-24 |
2017-04-20 |
Crispr Therapeutics Ag |
Novel family of rna-programmable endonucleases and their uses in genome editing and other applications
|
|
US20170130247A1
(en)
|
2015-09-30 |
2017-05-11 |
Whitehead Institute For Biomedical Research |
Compositions and methods for altering gene expression
|
|
RS63986B1
(sr)
|
2015-10-28 |
2023-03-31 |
Acuitas Therapeutics Inc |
Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina
|
|
EP3390656B1
(en)
|
2015-12-14 |
2020-04-08 |
The General Hospital Corporation |
Methods of detecting insulator dysfunction and oncogene activation for screening, diagnosis and treatment of patients in need thereof
|
|
EP3397613A1
(en)
|
2015-12-30 |
2018-11-07 |
Acuitas Therapeutics Inc. |
Lipids and lipid nanoparticle formulations for delivery of nucleic acids
|
|
EP3416976A2
(en)
|
2016-02-16 |
2018-12-26 |
Yale University |
Compositions for enhancing targeted gene editing and methods of use thereof
|
|
GB201608000D0
(en)
|
2016-05-06 |
2016-06-22 |
Oxford Biodynamics Ltd |
Chromosome detection
|
|
AU2017286980B2
(en)
|
2016-06-30 |
2023-10-26 |
Arbutus Biopharma Corporation |
Compositions and methods for delivering messenger RNA
|
|
WO2018020012A1
(en)
|
2016-07-29 |
2018-02-01 |
Danmarks Tekniske Universitet |
Methods for decoupling cell growth from production of biochemicals and recombinant polypeptides
|
|
WO2018031762A1
(en)
|
2016-08-10 |
2018-02-15 |
Duke University |
Compositions, systems and methods for programming immune cell function through targeted gene regulation
|
|
CN109863246A
(zh)
|
2016-08-19 |
2019-06-07 |
怀特黑德生物医学研究所 |
编辑dna甲基化的方法
|
|
WO2018049075A1
(en)
|
2016-09-07 |
2018-03-15 |
Flagship Pioneering, Inc. |
Methods and compositions for modulating gene expression
|
|
EP4714454A2
(en)
|
2016-10-26 |
2026-03-25 |
Acuitas Therapeutics Inc. |
Lipid nanoparticle formulations
|
|
MX2019004913A
(es)
|
2016-10-26 |
2019-09-16 |
Curevac Ag |
Vacunas de nanoparticulas lipidicas que comprenden acido ribonucleico mensajero (arnm).
|
|
EP3532097A1
(en)
|
2016-10-27 |
2019-09-04 |
The Trustees Of The University Of Pennsylvania |
Nucleoside-modified rna for inducing an adaptive immune response
|
|
EP3551169A4
(en)
|
2016-12-09 |
2020-09-09 |
Sangamo Therapeutics, Inc. |
TARGET-SPECIFIC NUCLEASES ADMINISTRATION
|
|
WO2018111944A1
(en)
|
2016-12-12 |
2018-06-21 |
Whitehead Institute For Biomedical Research |
Regulation of transcription through ctcf loop anchors
|
|
FI3565891T3
(fi)
|
2017-01-09 |
2023-07-04 |
Whitehead Inst Biomedical Res |
Menetelmiä geeniekspression muuttamiseksi häiritsemällä säätelysilmukoita muodostavia transkriptiotekijämultimeerejä
|
|
WO2018191719A1
(en)
|
2017-04-13 |
2018-10-18 |
Acuitas Therapeutics, Inc. |
Lipid delivery of therapeutic agents to adipose tissue
|
|
WO2018191657A1
(en)
|
2017-04-13 |
2018-10-18 |
Acuitas Therapeutics, Inc. |
Lipids for delivery of active agents
|
|
ES2981244T3
(es)
|
2017-04-28 |
2024-10-07 |
Acuitas Therapeutics Inc |
Novedosas formulaciones de nanopartículas de lípidos de carbonilo y lípidos para la administración de ácidos nucleicos
|
|
US20210254056A1
(en)
|
2017-05-05 |
2021-08-19 |
Camp4 Therapeutics Corporation |
Identification and targeted modulation of gene signaling networks
|
|
RU2695605C2
(ru)
|
2017-06-30 |
2019-07-24 |
Общество С Ограниченной Ответственностью "Экзоатлет" |
Способ оценки степени реабилитации с использованием активного экзоскелета у пациентов с нарушениями опорно-двигательного аппарата
|
|
EP3668993A4
(en)
|
2017-08-14 |
2021-05-12 |
Camp4 Therapeutics Corporation |
HEPATIC DISEASE TREATMENT METHODS
|
|
US11639329B2
(en)
|
2017-08-16 |
2023-05-02 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
|
US11542225B2
(en)
|
2017-08-17 |
2023-01-03 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
|
WO2019036030A1
(en)
|
2017-08-17 |
2019-02-21 |
Acuitas Therapeutics, Inc. |
LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
|
|
EP4501322A3
(en)
|
2017-08-17 |
2025-04-16 |
Acuitas Therapeutics, Inc. |
Lipids for use in lipid nanoparticle formulations
|
|
CA3075205A1
(en)
*
|
2017-09-08 |
2019-03-14 |
Mina Therapeutics Limited |
Stabilized hnf4a sarna compositions and methods of use
|
|
WO2019071054A1
(en)
|
2017-10-04 |
2019-04-11 |
The Broad Institute, Inc. |
METHODS AND COMPOSITIONS FOR MODIFYING THE FUNCTION AND STRUCTURE OF BUCKLES AND / OR CHROMATIN DOMAINS
|
|
WO2019089828A1
(en)
|
2017-10-31 |
2019-05-09 |
Acuitas Therapeutics, Inc. |
Lamellar lipid nanoparticles
|
|
JP7401432B2
(ja)
|
2017-12-01 |
2023-12-19 |
エンコーデッド セラピューティクス， インコーポレイテッド |
操作されたｄｎａ結合タンパク質
|
|
CN108949794B
(zh)
*
|
2018-07-04 |
2021-06-01 |
东南大学 |
一种tale表达载体及其快速构建方法和应用
|
|
CN109055375B
(zh)
*
|
2018-07-26 |
2021-11-12 |
东南大学 |
一种crispr辅助反式增强子激活基因表达的方法及其应用
|
|
US12583816B2
(en)
|
2018-10-18 |
2026-03-24 |
Acuitas Therapeutics, Inc. |
Lipids for lipid nanoparticle delivery of active agents
|
|
CN113286882A
(zh)
|
2018-11-09 |
2021-08-20 |
阿布特斯生物制药公司 |
脂质纳米颗粒制剂
|
|
EA202191315A1
(ru)
|
2018-11-09 |
2021-09-08 |
Арбутус Биофарма Корпорэйшн |
Катионные липиды, содержащие кремний
|
|
WO2020097493A1
(en)
|
2018-11-09 |
2020-05-14 |
Arbutus Biopharma Corporation |
Negatively charged peg-lipid conjugates
|
|
CN113728101A
(zh)
|
2018-11-09 |
2021-11-30 |
阿布特斯生物制药公司 |
脂质纳米颗粒制剂
|
|
JP7523449B2
(ja)
|
2019-01-11 |
2024-07-26 |
アクイタス セラピューティクス インコーポレイテッド |
活性剤の脂質ナノ粒子送達のための脂質
|
|
CN109929865B
(zh)
*
|
2019-03-11 |
2022-03-08 |
东南大学 |
基于gal4-uas系统的crispr辅助反式增强子激活基因表达的方法及其应用
|
|
CN114787353A
(zh)
|
2019-09-23 |
2022-07-22 |
欧密格治疗有限公司 |
调节共济蛋白表达和治疗弗里德赖希共济失调的方法和组合物
|
|
CN114391040A
(zh)
|
2019-09-23 |
2022-04-22 |
欧米茄治疗公司 |
用于调节载脂蛋白b(apob)基因表达的组合物和方法
|
|
WO2021183720A1
(en)
|
2020-03-11 |
2021-09-16 |
Omega Therapeutics, Inc. |
Compositions and methods for modulating forkhead box p3 (foxp3) gene expression
|