JP2006500917A5 - - Google Patents

Download PDF

Info

Publication number
JP2006500917A5
JP2006500917A5 JP2004510837A JP2004510837A JP2006500917A5 JP 2006500917 A5 JP2006500917 A5 JP 2006500917A5 JP 2004510837 A JP2004510837 A JP 2004510837A JP 2004510837 A JP2004510837 A JP 2004510837A JP 2006500917 A5 JP2006500917 A5 JP 2006500917A5
Authority
JP
Japan
Prior art keywords
transporter
peptide
effector
unit according
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2004510837A
Other languages
English (en)
Japanese (ja)
Other versions
JP2006500917A (ja
JP4514607B2 (ja
Filing date
Publication date
Priority claimed from US10/165,015 external-priority patent/US7033597B2/en
Application filed filed Critical
Publication of JP2006500917A publication Critical patent/JP2006500917A/ja
Publication of JP2006500917A5 publication Critical patent/JP2006500917A5/ja
Application granted granted Critical
Publication of JP4514607B2 publication Critical patent/JP4514607B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2004510837A 2002-06-07 2003-06-06 生物学的エフェクターの細胞内送達 Expired - Fee Related JP4514607B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/165,015 US7033597B2 (en) 2000-10-13 2002-06-07 Intracellular delivery of biological effectors
PCT/IB2003/003097 WO2003103718A2 (en) 2002-06-07 2003-06-06 Intracellular delivery of biological effectors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009252478A Division JP2010024250A (ja) 2002-06-07 2009-11-02 生物学的エフェクターの細胞内送達

Publications (3)

Publication Number Publication Date
JP2006500917A JP2006500917A (ja) 2006-01-12
JP2006500917A5 true JP2006500917A5 (enExample) 2006-07-13
JP4514607B2 JP4514607B2 (ja) 2010-07-28

Family

ID=29732051

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2004510837A Expired - Fee Related JP4514607B2 (ja) 2002-06-07 2003-06-06 生物学的エフェクターの細胞内送達
JP2009252478A Withdrawn JP2010024250A (ja) 2002-06-07 2009-11-02 生物学的エフェクターの細胞内送達

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009252478A Withdrawn JP2010024250A (ja) 2002-06-07 2009-11-02 生物学的エフェクターの細胞内送達

Country Status (6)

Country Link
US (2) US7033597B2 (enExample)
EP (1) EP1511763A2 (enExample)
JP (2) JP4514607B2 (enExample)
AU (1) AU2003274822B2 (enExample)
CA (1) CA2488716A1 (enExample)
WO (1) WO2003103718A2 (enExample)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040082509A1 (en) 1999-10-12 2004-04-29 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US8183339B1 (en) 1999-10-12 2012-05-22 Xigen S.A. Cell-permeable peptide inhibitors of the JNK signal transduction pathway
AU2001268228A1 (en) 2000-06-08 2001-12-17 La Jolla Pharmaceutical Company Multivalent platform molecules comprising high molecular weight polyethylene oxide
US20040248158A1 (en) * 2003-01-28 2004-12-09 Loughran Thomas P Differentially expressed genes in large granular lymphocyte leukemia
US7342095B2 (en) 2003-02-20 2008-03-11 University Of South Florida Peptidomimetic inhibitors of STAT activity and uses thereof
US7189694B2 (en) * 2003-04-18 2007-03-13 University Of Florida Research Foundation, Inc. Inhibitors of autophosphorylation protein kinases
US7566798B2 (en) 2003-08-13 2009-07-28 University Of South Florida Platinum complexes and methods of use
US8227434B1 (en) 2003-11-04 2012-07-24 H. Lee Moffitt Cancer Center & Research Institute, Inc. Materials and methods for treating oncological disorders
US20050288365A1 (en) * 2004-01-06 2005-12-29 Heidi Kay Platinum complexes and methods for inhibiting tumor cell proliferation
US8669376B2 (en) 2004-02-17 2014-03-11 University Of South Florida Cytotoxin compounds and methods of isolation
AU2005214979B2 (en) * 2004-02-17 2009-09-10 The Uab Research Foundation Cytotoxin compound and method of isolation
US8080517B2 (en) 2005-09-12 2011-12-20 Xigen Sa Cell-permeable peptide inhibitors of the JNK signal transduction pathway
WO2007031098A1 (en) 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
WO2007047623A2 (en) * 2005-10-14 2007-04-26 University Of South Florida Methods of inhibiting cell growth and methods of enhancing radiation responses
DE102006040647A1 (de) * 2006-08-30 2008-03-13 Robert Bosch Gmbh Handwerkzeugmaschine
WO2008079945A2 (en) * 2006-12-20 2008-07-03 University Of South Florida Rock inhibitors and uses thereof
EP3327142A1 (en) * 2007-07-13 2018-05-30 University of Pittsburgh- Of the Commonwealth System of Higher Education Virus derived antimicrobial peptides
WO2009143864A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
US8673910B2 (en) * 2008-06-30 2014-03-18 H. Lee Moffitt Cancer Center And Research Institute Proteasome inhibitors for selectively inducing apoptosis in cancer cells
US9174969B2 (en) * 2008-07-21 2015-11-03 University Of South Florida Indoline scaffold SHP-2 inhibitors and cancer treatment method
US9132168B2 (en) 2008-08-05 2015-09-15 University Of South Florida Methods of treating cognitive impairment
KR20110068993A (ko) * 2008-08-05 2011-06-22 유니버시티 오브 사우스 플로리다 인지장애의 치료방법
WO2010072228A1 (en) * 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
US8715685B2 (en) * 2009-07-14 2014-05-06 Lucia Irene Gonzalez Stereoisomer peptides and their polymer conjugates for HIV disease
US9221808B2 (en) 2010-04-16 2015-12-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinase (ROCK) and methods of use
WO2011160653A1 (en) 2010-06-21 2011-12-29 Xigen S.A. Novel jnk inhibitor molecules
AU2010362444B2 (en) 2010-10-14 2015-08-06 Xigen Inflammation Ltd. Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases
US9616064B2 (en) 2011-03-30 2017-04-11 H. Lee Moffitt Cancer Center And Research Institute, Inc. Rho kinase inhibitors and methods of use
WO2013091670A1 (en) 2011-12-21 2013-06-27 Xigen S.A. Novel jnk inhibitor molecules for treatment of various diseases
US9409868B2 (en) 2012-01-24 2016-08-09 H. Lee Moffin Cancer Center and Research Institute, Inc. Inhibitors of rho associated protein kinases (ROCK) and methods of use
JP6233812B2 (ja) 2012-03-07 2017-11-22 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 選択的ヒストンデアセチラーゼ6阻害剤
US10098967B2 (en) 2012-12-03 2018-10-16 Ohio State Innovation Foundation Self-assembly of therapeutic agent-peptide nanostructures
WO2014086835A1 (en) * 2012-12-05 2014-06-12 Ruprecht-Karls-Universität Heidelberg Conjugates of proteins and multivalent cell-penetrating peptides and their uses
WO2014140113A1 (en) * 2013-03-13 2014-09-18 Biocrine Ab Methods for treating and/or limiting development of diabetes
WO2015197097A1 (en) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases
WO2014206427A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
EA201501080A1 (ru) 2013-06-26 2016-07-29 Ксижен Инфлемейшн Лтд. Новое применение обладающих способностью проникать в клетку пептидных ингибиторов пути трансдукции сигнала jnk для лечения различных заболеваний
CN105592850B (zh) 2013-08-06 2019-11-15 H·李·莫菲特癌症中心研究所公司 Ack1/tnk2酪氨酸激酶的抑制剂
WO2015025323A1 (en) 2013-08-21 2015-02-26 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Treatment of mood and stress related disorders
US10626178B2 (en) 2013-08-21 2020-04-21 Raz Yirmiya Treatment of mood and stress related disorders
AU2015209143A1 (en) 2014-01-23 2016-08-04 H. Lee Moffitt Cancer Center And Research Institute, Inc. Icariin derivatives
WO2015112904A1 (en) 2014-01-24 2015-07-30 University Of Florida Research Foundation, Inc. Socs mimetics for the treatment of diseases
US10463684B2 (en) 2014-01-29 2019-11-05 Board Of Regents, The Uneversety Of Texas System Nucleobase analogue derivatives and their applications
WO2015153560A1 (en) 2014-03-31 2015-10-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. Stabilized peptoid-peptide hybrids and uses thereof
US9987258B2 (en) 2014-04-06 2018-06-05 H. Lee Moffitt Cancer Center And Research Institute, Inc. Histone deacetylase as a modulator of PDL1 expression and activity
ES2980788T3 (es) 2014-04-10 2024-10-03 H Lee Moffitt Cancer Ct & Res Expansión mejorada de linfocitos infiltrantes de tumores para terapia celular adoptiva
HRP20191254T1 (hr) 2014-05-21 2019-10-18 Entrada Therapeutics, Inc. Peptidi koji prodiru u stanice i postupci za njihovu proizvodnju i uporabu
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
EP3185880B1 (en) 2014-08-27 2020-02-12 Ohio State Innovation Foundation Improved peptidyl calcineurin inhibitors
WO2016154586A1 (en) 2015-03-26 2016-09-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Toll-like receptor 2 ligands and methods of making and using thereof
JP6959142B2 (ja) 2015-05-06 2021-11-02 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド Mc1rを標的とする放射線療法用作用物質およびコンパニオンイメージング作用物質
WO2016197067A1 (en) 2015-06-05 2016-12-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. Gm-csf/cd40l vaccine and checkpoint inhibitor combination therapy
CN108348779A (zh) 2015-08-02 2018-07-31 H·李·莫菲特癌症中心研究有限公司 Ack1/tnk2酪氨酸激酶的抑制剂
ES2989922T3 (es) 2015-09-17 2024-11-28 Ohio State Innovation Foundation Compuestos de carborano y métodos de uso de los mismos
US10738016B2 (en) 2015-10-13 2020-08-11 H. Lee Moffitt Cancer Center And Research Institute, Inc. BRD4-kinase inhibitors as cancer therapeutics
WO2017100650A1 (en) 2015-12-09 2017-06-15 Vanderbilt University Biosynthesis of everninomicin analogs in micromonospora carbonacea var aurantiaca
WO2017156527A1 (en) 2016-03-11 2017-09-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Aurora kinase and janus kinase inhibitors for prevention of graft versus host disease
US11395820B2 (en) 2016-03-16 2022-07-26 H. Lee Moffitt Cancer Center And Research Institute, Inc. Small molecules against cereblon to enhance effector t cell function
RU2018142711A (ru) 2016-05-04 2020-06-04 Х. Ли Моффитт Кэнсер Сентер Энд Рисёч Инститьют, Инк. Средство для целенаправленного воздействия на дельта-опиоидный рецептор для молекулярной визуализации и иммунотерапии рака
CN110114075B (zh) 2016-11-09 2024-01-12 俄亥俄州国家创新基金会 含有二硫化物的细胞穿透肽及其制备和使用方法
WO2018098282A2 (en) 2016-11-22 2018-05-31 Ohio State Innovation Foundation Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof
TW202500573A (zh) 2016-11-22 2025-01-01 俄亥俄州立創新基金會 細胞穿透肽序列
WO2018098226A1 (en) 2016-11-22 2018-05-31 Ohio State Innovation Foundation Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha
US11583525B2 (en) 2017-06-06 2023-02-21 H. Lee Moffitt Cancer Center And Research Institute, Inc. Geranylgeranyltransferase I inhibitor for treatment of a PTEN defective cancer
WO2019070962A1 (en) 2017-10-04 2019-04-11 Ohio State Innovation Foundation BICYCLIC PEPTIDE INHIBITORS
CN117567639A (zh) 2017-10-27 2024-02-20 俄亥俄州国家创新基金会 用于细胞内递送装订肽的多肽缀合物
US11793884B2 (en) 2018-01-29 2023-10-24 Ohio State Innovation Foundation Cyclic peptidyl inhibitors of CAL-PDZ binding domain
WO2019148194A2 (en) 2018-01-29 2019-08-01 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-nfat interaction
WO2019165183A1 (en) 2018-02-22 2019-08-29 Entrada Therapeutics, Inc. Compositions and methods for treating mitochondrial neurogastrointestinal encephalopathy
WO2019213662A1 (en) 2018-05-04 2019-11-07 Ohio State Innovation Foundation Non-peptidic cell-penetrating motifs
EP3790890A4 (en) 2018-05-09 2022-03-02 Ohio State Innovation Foundation CYCLIC PEPTIDES OF CELL PENETRATION WITH ONE OR MORE HYDROPHOBIC RESIDUES
US11730726B2 (en) 2018-07-11 2023-08-22 H. Lee Moffitt Cancer Center And Research Institute, Inc. Dimeric immuno-modulatory compounds against cereblon-based mechanisms
US10898460B1 (en) 2018-07-20 2021-01-26 University Of South Florida Leishmania inhibitors
WO2020028814A1 (en) 2018-08-03 2020-02-06 H. Lee Moffitt Cancer Center And Research Institute, Inc. Allosteric inhibitor of wee1 kinase
WO2020037116A1 (en) 2018-08-17 2020-02-20 H. Lee Moffitt Cancer Center And Research Institute, Inc. Small molecule pyrin-domain targeted nlrp3 inflammasome inhibitors
US12162856B2 (en) 2018-10-18 2024-12-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. β-catenin and B-cell lymphoma 9 (BCL9) inhibitors
US12269899B2 (en) 2018-12-07 2025-04-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. Peptidomimetic inhibitors of β-catenin/Tcf protein-protein interaction
CN114616240A (zh) 2019-11-08 2022-06-10 高等教育联邦系统-匹兹堡大学 包含抗微生物肽的组合物
KR102811112B1 (ko) 2020-01-20 2025-05-21 삼성전자주식회사 매립형 공기청정장치
WO2021150954A1 (en) 2020-01-24 2021-07-29 Ohio State Innovation Foundation Bacterial topoisomerase inhibitors derived from isomannide
WO2021236852A1 (en) 2020-05-20 2021-11-25 Sana Biotechnology, Inc. Methods and compositions for treatment of viral infections
MX2023011612A (es) 2021-03-31 2023-12-15 Entrada Therapeutics Inc Peptidos de penetracion celular ciclicos.
US12371463B2 (en) 2021-04-20 2025-07-29 University of Pittsburgh—of the Commonwealth System of Higher Education Methods and compositions for treatment of antibiotic-resistant bacterial infections
EP4337263A1 (en) 2021-05-10 2024-03-20 Entrada Therapeutics, Inc. Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
CA3217463A1 (en) 2021-05-10 2022-11-17 Ziqing QIAN Compositions and methods for modulating mrna splicing
CA3218805A1 (en) 2021-05-10 2022-11-17 Ziqing QIAN Compositions and methods for intracellular therapeutics
EP4359006A1 (en) 2021-06-23 2024-05-01 Entrada Therapeutics, Inc. Antisense compounds and methods for targeting cug repeats
AU2022339769A1 (en) 2021-09-01 2024-03-28 Entrada Therapeutics, Inc. Compounds and methods for skipping exon 44 in duchenne muscular dystrophy
WO2023219933A1 (en) 2022-05-09 2023-11-16 Entrada Therapeutics, Inc. Compositions and methods for delivery of nucleic acid therapeutics
IL318248A (en) 2022-07-15 2025-03-01 Entrada Therapeutics Inc Hybrid oligonucleotides
WO2024073042A1 (en) 2022-09-30 2024-04-04 Entrada Therapeutics, Inc. Ocular delivery of therapeutic agents
WO2024115720A1 (en) * 2022-12-01 2024-06-06 Hairvel Oü Novel peptide conjugates
WO2025038901A1 (en) 2023-08-17 2025-02-20 Entrada Therapeutics, Inc. Cyclic peptides for delivering therapeutics
WO2025038902A2 (en) 2023-08-17 2025-02-20 Entrada Therapeutics, Inc. Intracellular targeting of oligonucleotides
WO2025072246A1 (en) 2023-09-26 2025-04-03 Entrada Therapeutics, Inc. Compounds and methods for skipping exon 50 in duchenne muscular dystrophy

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2131620A1 (en) * 1992-03-20 1993-09-30 Louis C. Smith A dna transporter system and method of use
JP4074658B2 (ja) * 1992-04-03 2008-04-09 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 自己構築ポリヌクレオチド送達システム
CA2094658A1 (en) 1992-04-23 1993-10-24 Martin Sumner-Smith Intracellular delivery of biochemical agents
EP0693939A1 (de) 1993-04-14 1996-01-31 Roche Diagnostics GmbH Nukleinsäure-transferpeptide und deren verwendung zur einschleusung von nukleinsäuren in eukaryontische zellen
US6361938B1 (en) 1996-11-08 2002-03-26 Elan Corporation, Plc Peptides which enhance transport across tissues and methods of identifying and using the same
WO1998051325A2 (en) 1997-05-15 1998-11-19 Cytogen Corporation Random peptides that bind to gastro-intestinal tract (git) transport receptors and related methods
CA2291074C (en) * 1997-05-21 2008-04-01 The Board Of Trustees Of The Leland Stanford Junior University Composition and method for enhancing transport across biological membranes
FR2766826B1 (fr) 1997-08-04 2001-05-18 Pasteur Institut Vecteurs derives d'anticorps pour le transfert de substances dans les cellules
FR2767323B1 (fr) * 1997-08-12 2001-01-05 Synt Em Peptides lineaires derives de peptides antibiotiques, leur preparation et leur utilisation pour vectoriser des substances actives
ES2170042T3 (es) 1998-08-28 2004-10-01 Gryphon Therapeutics, Inc. Procedimiento para la preparacion de cadenas de poliamida de longitud precisa y sus conjugados con proteinas.
WO2000075164A1 (en) * 1999-06-07 2000-12-14 Mirus Corporation COMPOSITIONS AND METHODS FOR DRUG DELIVERY USING pH SENSITIVE MOLECULES
US20030104622A1 (en) * 1999-09-01 2003-06-05 Robbins Paul D. Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses
FR2805821B1 (fr) 2000-03-01 2004-01-16 Diatos Sequences d'acides amines facilitant la penetration d'une substance d'interet a l'interieur des cellules et/ou des noyaux cellulaires
US6960648B2 (en) 2000-10-13 2005-11-01 Universite De Lausanne Intracellular delivery of biological effectors

Similar Documents

Publication Publication Date Title
JP2006500917A5 (enExample)
US20250059532A1 (en) Modified Guide RNAs
US20220372483A1 (en) Modified Guide RNAs for Gene Editing
US20210087568A1 (en) Modified Guide RNAs for Gene Editing
JP6954843B2 (ja) ペプチドオリゴヌクレオチドコンジュゲート
US6150168A (en) Nucleic acid transporter systems and methods of use
ES2200051T3 (es) Metodos y composiciones para la lipidizacion de moleculas hidrofilas.
US7109165B2 (en) Conjugates and compositions for cellular delivery
US20110105413A1 (en) Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides
SK282173B6 (sk) Lipopolyamíny ako transfekčné činidlá, spôsob ich prípravy a farmaceutické kompozície s ich obsahom
CN102231951A (zh) 用于核酸传递系统的可释放的偶联物
JP2005506340A5 (enExample)
JP2024539512A (ja) Mrnaワクチン組成物
CA3236675A1 (en) Lipid formulations containing nucleic acids and methods of treatment for cystic fibrosis
McCollum et al. Safety and biodistribution of nanoligomers targeting the SARS-CoV-2 genome for the treatment of COVID-19
Mousazadeh et al. Gene delivery to brain cells with apoprotein E derived peptide conjugated to polylysine (apoEdp-PLL)
AU1866400A (en) Synergic fungicide composition comprising a compound analogue of strobilurin
US9492470B2 (en) Use of HMGA-targeted phosphorothioate DNA aptamers to suppress carcinogenic activity and increase sensitivity to chemotherapy agents in human cancer cells
TW202002990A (zh) 用於反義遞送之嵌合肽
TW202221126A (zh) 用於鑑別及特徵化指環病毒之方法及其用途
Driessen et al. Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells and rat proliferating endothelial cells
CN118063584A (zh) 促肿瘤焦亡蛋白、靶向her2免疫促肿瘤焦亡蛋白及其编码基因与应用
WO2023120658A1 (ja) 酵素、複合体、組換えベクター、遺伝性疾患治療薬及びポリヌクレオチド
IT201800007017A1 (it) Aptameri per l'uso nella terapia, prevenzione, diagnosi e rilevamento del papillomavirus
JPH0799976A (ja) 修飾オリゴヌクレオチド