JP2006500917A5 - - Google Patents

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Publication number
JP2006500917A5
JP2006500917A5 JP2004510837A JP2004510837A JP2006500917A5 JP 2006500917 A5 JP2006500917 A5 JP 2006500917A5 JP 2004510837 A JP2004510837 A JP 2004510837A JP 2004510837 A JP2004510837 A JP 2004510837A JP 2006500917 A5 JP2006500917 A5 JP 2006500917A5
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JP
Japan
Prior art keywords
transporter
peptide
effector
unit according
group
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JP2004510837A
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English (en)
Japanese (ja)
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JP4514607B2 (ja
JP2006500917A (ja
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Priority claimed from US10/165,015 external-priority patent/US7033597B2/en
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Publication of JP2006500917A5 publication Critical patent/JP2006500917A5/ja
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Publication of JP4514607B2 publication Critical patent/JP4514607B2/ja
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Expired - Fee Related legal-status Critical Current

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JP2004510837A 2002-06-07 2003-06-06 生物学的エフェクターの細胞内送達 Expired - Fee Related JP4514607B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/165,015 US7033597B2 (en) 2000-10-13 2002-06-07 Intracellular delivery of biological effectors
PCT/IB2003/003097 WO2003103718A2 (en) 2002-06-07 2003-06-06 Intracellular delivery of biological effectors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009252478A Division JP2010024250A (ja) 2002-06-07 2009-11-02 生物学的エフェクターの細胞内送達

Publications (3)

Publication Number Publication Date
JP2006500917A JP2006500917A (ja) 2006-01-12
JP2006500917A5 true JP2006500917A5 (enExample) 2006-07-13
JP4514607B2 JP4514607B2 (ja) 2010-07-28

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Family Applications (2)

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JP2004510837A Expired - Fee Related JP4514607B2 (ja) 2002-06-07 2003-06-06 生物学的エフェクターの細胞内送達
JP2009252478A Withdrawn JP2010024250A (ja) 2002-06-07 2009-11-02 生物学的エフェクターの細胞内送達

Family Applications After (1)

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JP2009252478A Withdrawn JP2010024250A (ja) 2002-06-07 2009-11-02 生物学的エフェクターの細胞内送達

Country Status (6)

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US (2) US7033597B2 (enExample)
EP (1) EP1511763A2 (enExample)
JP (2) JP4514607B2 (enExample)
AU (1) AU2003274822B2 (enExample)
CA (1) CA2488716A1 (enExample)
WO (1) WO2003103718A2 (enExample)

Families Citing this family (96)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040082509A1 (en) 1999-10-12 2004-04-29 Christophe Bonny Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US8183339B1 (en) 1999-10-12 2012-05-22 Xigen S.A. Cell-permeable peptide inhibitors of the JNK signal transduction pathway
AU2001268228A1 (en) 2000-06-08 2001-12-17 La Jolla Pharmaceutical Company Multivalent platform molecules comprising high molecular weight polyethylene oxide
US20040248158A1 (en) * 2003-01-28 2004-12-09 Loughran Thomas P Differentially expressed genes in large granular lymphocyte leukemia
CA2516685A1 (en) 2003-02-20 2004-09-02 University Of South Florida Peptidomimetic inhibitors of stat3 activity and their medical uses
US7189694B2 (en) * 2003-04-18 2007-03-13 University Of Florida Research Foundation, Inc. Inhibitors of autophosphorylation protein kinases
WO2005023824A2 (en) * 2003-08-13 2005-03-17 University Of South Florida Methods for inhibiting tumor cell proliferation
US8227434B1 (en) 2003-11-04 2012-07-24 H. Lee Moffitt Cancer Center & Research Institute, Inc. Materials and methods for treating oncological disorders
US20050288365A1 (en) * 2004-01-06 2005-12-29 Heidi Kay Platinum complexes and methods for inhibiting tumor cell proliferation
US8669376B2 (en) 2004-02-17 2014-03-11 University Of South Florida Cytotoxin compounds and methods of isolation
EP1718631A4 (en) * 2004-02-17 2009-04-15 Univ South Florida CYTOTOXIN COMPOUND AND INSULATION METHOD
WO2007031098A1 (en) 2005-09-12 2007-03-22 Xigen S.A. Cell-permeable peptide inhibitors of the jnk signal transduction pathway
US8080517B2 (en) 2005-09-12 2011-12-20 Xigen Sa Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US20100247427A1 (en) * 2005-10-14 2010-09-30 University Of South Florida Methods of inhibiting cell growth and methods of enhancing radiation responses
DE102006040647A1 (de) * 2006-08-30 2008-03-13 Robert Bosch Gmbh Handwerkzeugmaschine
WO2008079945A2 (en) * 2006-12-20 2008-07-03 University Of South Florida Rock inhibitors and uses thereof
WO2009012143A2 (en) * 2007-07-13 2009-01-22 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Virus derived antimicrobial peptides
WO2009143864A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of chronic or non-chronic inflammatory digestive diseases
WO2009143865A1 (en) 2008-05-30 2009-12-03 Xigen S.A. Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
US8673910B2 (en) * 2008-06-30 2014-03-18 H. Lee Moffitt Cancer Center And Research Institute Proteasome inhibitors for selectively inducing apoptosis in cancer cells
WO2010011666A2 (en) * 2008-07-21 2010-01-28 University Of South Florida Indoline scaffold shp-2 inhibitors and cancer treatment method
BRPI0917417A2 (pt) 2008-08-05 2015-12-01 Univ South Florida mnétodos de tratar deficiência cognitiva
US9132168B2 (en) 2008-08-05 2015-09-15 University Of South Florida Methods of treating cognitive impairment
WO2010072228A1 (en) 2008-12-22 2010-07-01 Xigen S.A. Novel transporter constructs and transporter cargo conjugate molecules
CA2768149A1 (en) * 2009-07-14 2011-01-20 Lucia Irene Gonzalez Stereoisomer peptides and their polymer conjugates for hiv disease
US9221808B2 (en) 2010-04-16 2015-12-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinase (ROCK) and methods of use
WO2011160653A1 (en) 2010-06-21 2011-12-29 Xigen S.A. Novel jnk inhibitor molecules
JP5857056B2 (ja) 2010-10-14 2016-02-10 ザイジェン インフラメーション エルティーディー 慢性又は非慢性の炎症性眼疾患を治療するためのjnkシグナル伝達経路の細胞透過性ペプチド阻害剤の使用
WO2012135697A2 (en) 2011-03-30 2012-10-04 H. Lee Moffitt Cancer Center & Research Institute Inc. Novel rho kinase inhibitors and methods of use
WO2013091670A1 (en) 2011-12-21 2013-06-27 Xigen S.A. Novel jnk inhibitor molecules for treatment of various diseases
WO2013112722A1 (en) 2012-01-24 2013-08-01 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibitors of rho associated protein kinases (rock) and methods of use
JP6233812B2 (ja) 2012-03-07 2017-11-22 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド 選択的ヒストンデアセチラーゼ6阻害剤
US10098967B2 (en) 2012-12-03 2018-10-16 Ohio State Innovation Foundation Self-assembly of therapeutic agent-peptide nanostructures
WO2014086835A1 (en) * 2012-12-05 2014-06-12 Ruprecht-Karls-Universität Heidelberg Conjugates of proteins and multivalent cell-penetrating peptides and their uses
PL2970463T3 (pl) * 2013-03-13 2018-04-30 Biocrine Ab Sposoby leczenia i/lub ograniczania rozwoju cukrzycy
WO2015197097A1 (en) 2014-06-26 2015-12-30 Xigen Inflammation Ltd. New use for jnk inhibitor molecules for treatment of various diseases
WO2014206427A1 (en) 2013-06-26 2014-12-31 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases
AU2014301631A1 (en) 2013-06-26 2015-08-27 Xigen Inflammation Ltd. New use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of various diseases
EP3030241A4 (en) 2013-08-06 2019-06-19 H. Lee Moffitt Cancer Center And Research Institute, Inc. INHIBITORS OF ACK1 / TNK2.TYROSINE KINASE
US9950036B2 (en) 2013-08-21 2018-04-24 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Treatment of mood and stress related disorders
US10626178B2 (en) 2013-08-21 2020-04-21 Raz Yirmiya Treatment of mood and stress related disorders
MX2016009663A (es) 2014-01-23 2016-11-17 H Lee Moffitt Cancer Ct & Res Derivados de icariina.
EP3096775B1 (en) 2014-01-24 2023-01-11 University of Florida Research Foundation, Inc. Socs mimetics for the treatment of diseases
US10463684B2 (en) 2014-01-29 2019-11-05 Board Of Regents, The Uneversety Of Texas System Nucleobase analogue derivatives and their applications
WO2015153560A1 (en) 2014-03-31 2015-10-08 H. Lee Moffitt Cancer Center And Research Institute, Inc. Stabilized peptoid-peptide hybrids and uses thereof
WO2015157162A1 (en) 2014-04-06 2015-10-15 H. Lee Moffitt Cancer Center And Research Institute, Inc. Histone deacetylase as a modulator of pdl1 expression and activity
ES2980788T3 (es) 2014-04-10 2024-10-03 H Lee Moffitt Cancer Ct & Res Expansión mejorada de linfocitos infiltrantes de tumores para terapia celular adoptiva
DK3149025T3 (da) 2014-05-21 2019-07-22 Entrada Therapeutics Inc Cellepenetrerende peptider og fremgangsmåder til frembringelse og anvendelse deraf
US10815276B2 (en) 2014-05-21 2020-10-27 Entrada Therapeutics, Inc. Cell penetrating peptides and methods of making and using thereof
EP3185880B1 (en) 2014-08-27 2020-02-12 Ohio State Innovation Foundation Improved peptidyl calcineurin inhibitors
WO2016154586A1 (en) 2015-03-26 2016-09-29 H. Lee Moffitt Cancer Center And Research Institute, Inc. Toll-like receptor 2 ligands and methods of making and using thereof
JP6959142B2 (ja) 2015-05-06 2021-11-02 エイチ リー モフィット キャンサー センター アンド リサーチ インスティテュート インコーポレイテッド Mc1rを標的とする放射線療法用作用物質およびコンパニオンイメージング作用物質
CN106714836A (zh) 2015-06-05 2017-05-24 H·李·莫菲特癌症中心研究有限公司 Gm‑csf/cd40l疫苗和检查点抑制剂联合治疗
WO2017023899A1 (en) 2015-08-02 2017-02-09 H. Lee Moffitt Cancer Center & Research Institute Inhibitors of ack1/tnk2 tyrosine kinase
AU2016324495B2 (en) 2015-09-17 2020-12-03 Institute Of Molecular Genetics As Cr, V.V.I. Carborane compounds and methods of use thereof
US10738016B2 (en) 2015-10-13 2020-08-11 H. Lee Moffitt Cancer Center And Research Institute, Inc. BRD4-kinase inhibitors as cancer therapeutics
EP3387133B1 (en) 2015-12-09 2021-11-17 Vanderbilt University Biosynthesis of everninomicin analogs in micromonospora carbonacea var aurantiaca
US11203576B2 (en) 2016-03-11 2021-12-21 H. Lee Moffitt Cancer Center And Research Institute, Inc. Aurora kinase and Janus kinase inhibitors for prevention of graft versus host disease
MX2022008085A (es) 2016-03-16 2022-07-11 H Lee Moffitt Cancer Ct & Res Moleculas peque?as contra cereblon para mejorar la funcion efectora de los linfocitos t.
EP3452110A4 (en) 2016-05-04 2019-12-25 H. Lee Moffitt Cancer Center And Research Institute, Inc. AGENT FOR THE MOLECULAR IMAGING AND IMMUNOTHERAPY OF CANCER DISEASES TARGETING THE DELTA OPIOID RECEPTOR
EP3538125A4 (en) 2016-11-09 2020-10-07 Ohio State Innovation Foundation DISULPHIDE-BOUND CELL PENETRATION PEPTIDES, THEIR PREPARATION AND USE METHODS
US11352394B2 (en) 2016-11-22 2022-06-07 Ohio State Innovation Foundation Cyclic cell penetrating peptides comprising beta-hairpin motifs and methods of making and using thereof
WO2018098226A1 (en) 2016-11-22 2018-05-31 Ohio State Innovation Foundation Bicyclic peptidyl inhibitor of tumor necrosis factor-alpha
TWI853790B (zh) 2016-11-22 2024-09-01 俄亥俄州立創新基金會 細胞穿透肽序列
WO2018226791A1 (en) 2017-06-06 2018-12-13 H. Lee Moffitt Cancer Center And Research Institute, Inc. Geranylgeranyltransferase i inhibitor for treatment of a pten defective cancer
WO2019070962A1 (en) 2017-10-04 2019-04-11 Ohio State Innovation Foundation BICYCLIC PEPTIDE INHIBITORS
US11510991B2 (en) 2017-10-27 2022-11-29 Ohio State Innovation Foundation Polypeptide conjugates for intracellular delivery of stapled peptides
US11793884B2 (en) 2018-01-29 2023-10-24 Ohio State Innovation Foundation Cyclic peptidyl inhibitors of CAL-PDZ binding domain
WO2019148194A2 (en) 2018-01-29 2019-08-01 Ohio State Innovation Foundation Peptidyl inhibitors of calcineurin-nfat interaction
EP3755351A4 (en) 2018-02-22 2021-11-24 Entrada Therapeutics, Inc. COMPOSITIONS AND TREATMENT METHODS FOR MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY
US11814341B2 (en) 2018-05-04 2023-11-14 Ohio State Innovation Foundation Non-peptidic cell-penetrating motifs
US11987647B2 (en) 2018-05-09 2024-05-21 Ohio State Innovation Foundation Cyclic cell-penetrating peptides with one or more hydrophobic residues
SG11202012464WA (en) 2018-07-11 2021-01-28 H Lee Moffitt Cancer Center And Research Institute Inc Dimeric immuno-modulatory compounds against cereblon-based mechanisms
US10898460B1 (en) 2018-07-20 2021-01-26 University Of South Florida Leishmania inhibitors
WO2020028814A1 (en) 2018-08-03 2020-02-06 H. Lee Moffitt Cancer Center And Research Institute, Inc. Allosteric inhibitor of wee1 kinase
US12319685B2 (en) 2018-08-17 2025-06-03 H. Lee Moffitt Cancer Center And Research Institute, Inc. Small molecule pyrin-domain targeted NLRP3 inflammasome inhibitors
US12162856B2 (en) 2018-10-18 2024-12-10 H. Lee Moffitt Cancer Center And Research Institute, Inc. β-catenin and B-cell lymphoma 9 (BCL9) inhibitors
WO2020118179A1 (en) 2018-12-07 2020-06-11 H. Lee Moffitt Cancer Center And Research Institute, Inc. Peptidomimetic inhibitors of β-catenin/tcf protein–protein interaction
JP2023501385A (ja) 2019-11-08 2023-01-18 ユニバーシティ オブ ピッツバーグ - オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション 抗微生物ペプチドを含む組成物
KR102811112B1 (ko) 2020-01-20 2025-05-21 삼성전자주식회사 매립형 공기청정장치
EP4093216A4 (en) 2020-01-24 2024-01-10 Ohio State Innovation Foundation ISOMANNIDE-DERIVED BACTERIAL TOPOISOMERASE INHIBITORS
US20230190871A1 (en) 2020-05-20 2023-06-22 Sana Biotechnology, Inc. Methods and compositions for treatment of viral infections
US20250243244A1 (en) 2021-03-31 2025-07-31 Entrada Therapeutics, Inc. Cyclic cell penetrating peptides
US12371463B2 (en) 2021-04-20 2025-07-29 University of Pittsburgh—of the Commonwealth System of Higher Education Methods and compositions for treatment of antibiotic-resistant bacterial infections
JP2024518476A (ja) 2021-05-10 2024-05-01 エントラーダ セラピューティクス,インコーポレイティド mRNAスプライシングを調節するための組成物及び方法
MX2023013352A (es) 2021-05-10 2024-01-31 Entrada Therapeutics Inc Composiciones y métodos para terapéuticos intracelulares.
US20250051393A1 (en) 2021-05-10 2025-02-13 Entrada Therapeutics, Inc. Compositions and methods for modulating interferon regulatory factor-5 (irf-5) activity
KR20240038967A (ko) 2021-06-23 2024-03-26 엔트라다 테라퓨틱스, 인크. Cug 반복을 표적화하기 위한 안티센스 화합물 및 방법
CA3229661A1 (en) 2021-09-01 2023-03-09 Xiang Li Compounds and methods for skipping exon 44 in duchenne muscular dystrophy
WO2023219933A1 (en) 2022-05-09 2023-11-16 Entrada Therapeutics, Inc. Compositions and methods for delivery of nucleic acid therapeutics
WO2024015924A2 (en) 2022-07-15 2024-01-18 Entrada Therapeutics, Inc. Hybrid oligonucleotides
WO2024073042A1 (en) 2022-09-30 2024-04-04 Entrada Therapeutics, Inc. Ocular delivery of therapeutic agents
EP4626905A1 (en) * 2022-12-01 2025-10-08 Hairvel Oü Novel peptide conjugates
WO2025038902A2 (en) 2023-08-17 2025-02-20 Entrada Therapeutics, Inc. Intracellular targeting of oligonucleotides
WO2025038901A1 (en) 2023-08-17 2025-02-20 Entrada Therapeutics, Inc. Cyclic peptides for delivering therapeutics
WO2025072246A1 (en) 2023-09-26 2025-04-03 Entrada Therapeutics, Inc. Compounds and methods for skipping exon 50 in duchenne muscular dystrophy

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018759A1 (en) * 1992-03-20 1993-09-30 Baylor College Of Medicine A dna transporter system and method of use
WO1993019768A1 (en) * 1992-04-03 1993-10-14 The Regents Of The University Of California Self-assembling polynucleotide delivery system
CA2094658A1 (en) 1992-04-23 1993-10-24 Martin Sumner-Smith Intracellular delivery of biochemical agents
WO1994023751A1 (de) 1993-04-14 1994-10-27 Boehringer Mannheim Gmbh Nukleinsäure-transferpeptide und deren verwendung zur einschleusung von nukleinsäuren in eukaryontische zellen
US6361938B1 (en) 1996-11-08 2002-03-26 Elan Corporation, Plc Peptides which enhance transport across tissues and methods of identifying and using the same
JP4129298B2 (ja) 1997-05-15 2008-08-06 サイトジェン コーポレーション 胃腸管(git)輸送受容体に結合するランダムペプチド、及び関連した方法
EP0975370B9 (en) * 1997-05-21 2004-11-03 The Board Of Trustees Of The Leland Stanford Junior University Composition and method for enhancing transport across biological membranes
FR2766826B1 (fr) 1997-08-04 2001-05-18 Pasteur Institut Vecteurs derives d'anticorps pour le transfert de substances dans les cellules
FR2767323B1 (fr) 1997-08-12 2001-01-05 Synt Em Peptides lineaires derives de peptides antibiotiques, leur preparation et leur utilisation pour vectoriser des substances actives
ES2170042T3 (es) 1998-08-28 2004-10-01 Gryphon Therapeutics, Inc. Procedimiento para la preparacion de cadenas de poliamida de longitud precisa y sus conjugados con proteinas.
EP1102785B1 (en) * 1999-06-07 2013-02-13 Arrowhead Research Corporation COMPOSITIONS FOR DRUG DELIVERY USING pH SENSITIVE MOLECULES
US20030104622A1 (en) * 1999-09-01 2003-06-05 Robbins Paul D. Identification of peptides that facilitate uptake and cytoplasmic and/or nuclear transport of proteins, DNA and viruses
FR2805821B1 (fr) 2000-03-01 2004-01-16 Diatos Sequences d'acides amines facilitant la penetration d'une substance d'interet a l'interieur des cellules et/ou des noyaux cellulaires
AU2002220979A1 (en) 2000-10-13 2002-04-22 Xigen Sa Intracellular delivery of biological effectors by novel transporter peptide sequences

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