|
US6342390B1
(en)
|
1994-11-23 |
2002-01-29 |
The United States Of America As Represented By The Secretary Of Health And Human Services |
Lipid vesicles containing adeno-associated virus rep protein for transgene integration and gene therapy
|
|
US6093570A
(en)
|
1995-06-07 |
2000-07-25 |
The University Of North Carolina At Chapel Hill |
Helper virus-free AAV production
|
|
WO1997006272A2
(en)
*
|
1995-08-03 |
1997-02-20 |
Avigen, Inc. |
High efficiency helper system for aav vector production
|
|
US6001650A
(en)
*
|
1995-08-03 |
1999-12-14 |
Avigen, Inc. |
High-efficiency wild-type-free AAV helper functions
|
|
US6632670B1
(en)
*
|
1995-09-08 |
2003-10-14 |
Genzyme Corporation |
AAV vectors for gene therapy
|
|
WO1998011244A2
(en)
|
1996-09-11 |
1998-03-19 |
The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Aav4 vector and uses thereof
|
|
US6548286B1
(en)
*
|
1997-04-14 |
2003-04-15 |
Cell Genesys, Inc. |
Methods for increasing the efficiency of recombinant AAV product
|
|
US6989264B2
(en)
|
1997-09-05 |
2006-01-24 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
US6566118B1
(en)
|
1997-09-05 |
2003-05-20 |
Targeted Genetics Corporation |
Methods for generating high titer helper-free preparations of released recombinant AAV vectors
|
|
IT1297074B1
(it)
|
1997-11-21 |
1999-08-03 |
Angeletti P Ist Richerche Bio |
Forme ormone-dipendenti delle proteine rep del virus adeno-associato (aav-2), sequenze di dna codificanti per esse, vettori che le
|
|
US6984517B1
(en)
|
1998-05-28 |
2006-01-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
AAV5 vector and uses thereof
|
|
WO1999061601A2
(en)
|
1998-05-28 |
1999-12-02 |
The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Aav5 vector and uses thereof
|
|
US6759237B1
(en)
|
1998-11-05 |
2004-07-06 |
The Trustees Of The University Of Pennsylvania |
Adeno-associated virus serotype 1 nucleic acid sequences, vectors and host cells containing same
|
|
US6759050B1
(en)
|
1998-12-03 |
2004-07-06 |
Avigen, Inc. |
Excipients for use in adeno-associated virus pharmaceutical formulations, and pharmaceutical formulations made therewith
|
|
DE19905501B4
(de)
|
1999-02-10 |
2005-05-19 |
MediGene AG, Gesellschaft für molekularbiologische Kardiologie und Onkologie |
Verfahren zur Herstellung eines rekombinanten Adeno-assoziierten Virus, geeignete Mittel hierzu sowie Verwendung zur Herstellung eines Arzneimittels
|
|
JP4693244B2
(ja)
*
|
1999-03-18 |
2011-06-01 |
ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア |
組換えアデノ随伴ウイルスのヘルパー無しの生産のための組成物および方法
|
|
US6498244B1
(en)
|
1999-05-28 |
2002-12-24 |
Cell Genesys, Inc. |
Adeno-associated virus capsid immunologic determinants
|
|
US7115391B1
(en)
|
1999-10-01 |
2006-10-03 |
Genovo, Inc. |
Production of recombinant AAV using adenovirus comprising AAV rep/cap genes
|
|
US7208315B2
(en)
|
2000-01-05 |
2007-04-24 |
Fred Hutchinson Cancer Research Center |
Compositions and methods for efficient AAV vector production
|
|
DE10044384A1
(de)
*
|
2000-09-08 |
2002-04-18 |
Medigene Ag |
Wirtszellen zur Verpackung von rekombinantem Adeno-assoziiertem Virus (rAAV), Verfahren zu ihrer Herstellung und deren Verwendung
|
|
WO2002053703A2
(en)
|
2001-01-05 |
2002-07-11 |
Children's Hospital, Inc. |
Aav2 vectors and methods
|
|
US6841357B1
(en)
|
2001-03-30 |
2005-01-11 |
Stratagene California |
Method and kits for titering adeno-associated virus vectors
|
|
US6723551B2
(en)
|
2001-11-09 |
2004-04-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Production of adeno-associated virus in insect cells
|
|
WO2003042361A2
(en)
|
2001-11-09 |
2003-05-22 |
Government Of The United States Of America, Department Of Health And Human Services |
Production of adeno-associated virus in insect cells
|
|
MX359371B
(es)
*
|
2001-11-13 |
2018-09-25 |
Univ Pennsylvania |
Un metodo para detectar y/o identificar secuencias del virus adeno-asociado y aislamiento de secuencias novedosas identificadas de ese modo.
|
|
PT1453547T
(pt)
|
2001-12-17 |
2016-12-28 |
Univ Pennsylvania |
Sequências do vírus adeno-associado (aav) do serotipo 8, vetores contendo as mesmas, e utilizações destas
|
|
AU2002367943A1
(en)
*
|
2001-12-18 |
2003-12-22 |
University Of North Carolina At Chapel Hill |
Improved reagents and methods for producing parvoviruses
|
|
US7419817B2
(en)
|
2002-05-17 |
2008-09-02 |
The United States Of America As Represented By The Secretary Department Of Health And Human Services, Nih. |
Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography
|
|
US7122348B2
(en)
|
2002-12-11 |
2006-10-17 |
City Of Hope |
AAV2 Rep protein fusions
|
|
US9233131B2
(en)
|
2003-06-30 |
2016-01-12 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
US9441244B2
(en)
|
2003-06-30 |
2016-09-13 |
The Regents Of The University Of California |
Mutant adeno-associated virus virions and methods of use thereof
|
|
EP2345731B1
(en)
|
2003-09-30 |
2015-10-21 |
The Trustees of the University of Pennsylvania |
Adeno-associated virus (AAV) clades, sequences, vectors containing same, and uses thereof
|
|
US7625570B1
(en)
|
2005-03-10 |
2009-12-01 |
The Regents Of The University Of California |
Methods for purifying adeno-associated virus
|
|
EP2311966A3
(en)
|
2005-10-20 |
2012-09-05 |
Amsterdam Molecular Therapeutics (AMT) B.V. |
Improved AAV vectors produced in insect cells
|
|
CN103849629B
(zh)
*
|
2006-06-21 |
2017-06-09 |
尤尼克尔Ip股份有限公司 |
具有经修饰的用于在昆虫细胞中产生aav的aav‑rep78翻译起始密码子的载体
|
|
WO2008024998A2
(en)
|
2006-08-24 |
2008-02-28 |
Virovek, Inc. |
Expression in insect cells of genes with overlapping open reading frames, methods and compositions therefor
|
|
KR20180000341A
(ko)
|
2009-06-16 |
2018-01-02 |
젠자임 코포레이션 |
재조합 aav 벡터에 대한 개선된 정제 방법
|
|
US8663624B2
(en)
|
2010-10-06 |
2014-03-04 |
The Regents Of The University Of California |
Adeno-associated virus virions with variant capsid and methods of use thereof
|
|
TR201908020T4
(tr)
|
2011-02-17 |
2019-06-21 |
Univ Pennsylvania |
Doku özgüllüğünü değiştirmek ve aav9-aracılı gen transferini geliştirmek için bileşimler ve yöntemler.
|
|
EP2500434A1
(en)
|
2011-03-12 |
2012-09-19 |
Association Institut de Myologie |
Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery
|
|
US20140155469A1
(en)
|
2011-04-19 |
2014-06-05 |
The Research Foundation Of State University Of New York |
Adeno-associated-virus rep sequences, vectors and viruses
|
|
CN105755044A
(zh)
|
2011-04-22 |
2016-07-13 |
加利福尼亚大学董事会 |
具有变异衣壳的腺相关病毒病毒体及其使用方法
|
|
US20140155471A1
(en)
*
|
2011-07-12 |
2014-06-05 |
University Of Rochester |
Treating neurological disease or injury with a dynamin-related protein 1 (drp1) encoding nucleic acid
|
|
CA2853482C
(en)
|
2011-10-28 |
2020-05-19 |
Joshua Grieger |
Cell line for production of adeno-associated virus
|
|
AU2013266968B2
(en)
|
2012-05-25 |
2017-06-29 |
Emmanuelle CHARPENTIER |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
EP2900686B1
(en)
*
|
2012-09-28 |
2020-06-10 |
The University of North Carolina At Chapel Hill |
Aav vectors targeted to oligodendrocytes
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
CN105765066B
(zh)
|
2013-11-29 |
2018-12-14 |
宝生物工程株式会社 |
用于定量腺伴随病毒的方法
|
|
CA2942289C
(en)
*
|
2014-03-10 |
2024-05-21 |
Uniqure Ip B.V. |
Further improved aav vectors produced in insect cells
|
|
EA201791630A1
(ru)
*
|
2015-01-20 |
2018-04-30 |
Джензим Корпорейшн |
Аналитическое ультрацентрифугирование для определения характеристик рекомбинантных вирусных частиц
|
|
WO2017112948A1
(en)
|
2015-12-24 |
2017-06-29 |
University Of Florida Research Foundation, Inc. |
Improved aav production using suspension adapted cells
|
|
CN108884446A
(zh)
*
|
2016-01-29 |
2018-11-23 |
西里昂生物技术有限责任公司 |
基于aav的条件表达系统
|
|
US10294452B2
(en)
|
2016-11-22 |
2019-05-21 |
Dao-Yao He |
Lysis, extraction and purification of adeno-associated virus and adenovirus from host cells
|
|
CA3112883A1
(en)
*
|
2018-10-25 |
2020-04-30 |
Baxalta Incorporated |
Aav triple-plasmid system
|
|
US10557149B1
(en)
*
|
2019-07-15 |
2020-02-11 |
Vigene Biosciences, Inc. |
Recombinantly-modified adeno-associated virus helper vectors and their use to improve the packaging efficiency of recombinantly-modified adeno-associated virus
|