JP2022549380A5 - - Google Patents
Info
- Publication number
- JP2022549380A5 JP2022549380A5 JP2022520059A JP2022520059A JP2022549380A5 JP 2022549380 A5 JP2022549380 A5 JP 2022549380A5 JP 2022520059 A JP2022520059 A JP 2022520059A JP 2022520059 A JP2022520059 A JP 2022520059A JP 2022549380 A5 JP2022549380 A5 JP 2022549380A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- gjb2
- promoter
- sequence
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025035714A JP2025110904A (ja) | 2019-09-30 | 2025-03-06 | 遺伝性難聴の処置のためのアデノ随伴ウイルス（ａａｖ）システム |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962907834P | 2019-09-30 | 2019-09-30 | |
| US62/907,834 | 2019-09-30 | ||
| PCT/US2020/053561 WO2021067448A1 (en) | 2019-09-30 | 2020-09-30 | Adeno-associated virus (aav) systems for treatment of genetic hearing loss |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025035714A Division JP2025110904A (ja) | 2019-09-30 | 2025-03-06 | 遺伝性難聴の処置のためのアデノ随伴ウイルス（ａａｖ）システム |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022549380A JP2022549380A (ja) | 2022-11-24 |
| JP2022549380A5 true JP2022549380A5 (https=) | 2023-10-10 |
| JP7713130B2 JP7713130B2 (ja) | 2025-07-25 |
Family
ID=75161339
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022520059A Active JP7713130B2 (ja) | 2019-09-30 | 2020-09-30 | 遺伝性難聴の処置のためのアデノ随伴ウイルス（ａａｖ）システム |
| JP2025035714A Pending JP2025110904A (ja) | 2019-09-30 | 2025-03-06 | 遺伝性難聴の処置のためのアデノ随伴ウイルス（ａａｖ）システム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025035714A Pending JP2025110904A (ja) | 2019-09-30 | 2025-03-06 | 遺伝性難聴の処置のためのアデノ随伴ウイルス（ａａｖ）システム |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12241077B2 (https=) |
| EP (1) | EP4037771A4 (https=) |
| JP (2) | JP7713130B2 (https=) |
| KR (1) | KR20220133854A (https=) |
| CN (1) | CN115103710A (https=) |
| AU (1) | AU2020357740A1 (https=) |
| CA (1) | CA3153133A1 (https=) |
| IL (1) | IL291789A (https=) |
| WO (1) | WO2021067448A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3510161A4 (en) | 2016-08-23 | 2020-04-22 | Akouos, Inc. | COMPOSITIONS AND METHODS FOR TREATING PERSONAL HEARING LOSS IN A PERSON |
| WO2019200016A1 (en) | 2018-04-10 | 2019-10-17 | President And Fellows Of Harvard College | Aav vectors encoding clarin-1 or gjb2 and uses thereof |
| KR20220157944A (ko) | 2020-02-21 | 2022-11-29 | 아카우오스, 인크. | 인간 대상체에서 비-연령-연관 청각 장애를 치료하기 위한 조성물 및 방법 |
| WO2021231808A2 (en) * | 2020-05-13 | 2021-11-18 | Akouos, Inc. | Compositions and methods for treating gjb2-associated hearing loss |
| JP2023535632A (ja) | 2020-07-27 | 2023-08-18 | アンジャリウム バイオサイエンシズ エージー | Ｄｎａ分子の組成物、その作製方法、及びその使用方法 |
| TW202227476A (zh) * | 2020-09-14 | 2022-07-16 | 哈佛大學校長及研究員協會 | 編碼GJB2之重組腺相關病毒(rAAV)及其用途 |
| US20230340038A1 (en) * | 2020-09-14 | 2023-10-26 | President And Fellows Of Harvard College | Recombinant adeno associated virus (raav) encoding gjb2 and uses thereof |
| US12129287B2 (en) | 2020-09-14 | 2024-10-29 | President And Fellows Of Harvard College | Recombinant adeno associated virus encoding clarin-1 and uses thereof |
| AU2021376225A1 (en) * | 2020-11-06 | 2023-06-22 | Eli Lilly And Company | Variant adeno-associated virus (aav)capsid polypeptides and gene therapeutics thereof for treatment of hearing loss |
| WO2022155588A2 (en) * | 2021-01-18 | 2022-07-21 | Life Technologies Corporation | Compositions, kits and methods for direct amplification from crude biological samples |
| EP4330413A4 (en) * | 2021-04-27 | 2026-01-28 | Childrens Hospital Philadelphia | Adeno-associated viral vectors for cochlear transduction |
| MX2023013394A (es) * | 2021-05-13 | 2023-12-14 | Akouos Inc | Composiciones de suministro de terapia genica y metodos para tratar perdida auditiva. |
| CN118043468A (zh) * | 2021-06-11 | 2024-05-14 | 分贝治疗公司 | 用于内耳中的细胞类型特异性基因表达的组合物和方法 |
| WO2023106256A1 (ja) * | 2021-12-06 | 2023-06-15 | 学校法人順天堂 | 改変型アデノ随伴ウイルスベクター |
| US20240252685A1 (en) * | 2022-05-09 | 2024-08-01 | Akouos, Inc. | Cell specific gene therapy delivery compositions and methods for treating hearing loss |
| EP4536862A1 (en) * | 2022-06-09 | 2025-04-16 | Wisconsin Alumni Research Foundation | Generation of next generation recombinant aav gene therapy vectors that adopt 3d conformation |
| WO2024081687A2 (en) * | 2022-10-12 | 2024-04-18 | The Johns Hopkins University | Method of treating lbsl by enhancing dars2 expression |
| CN115717166B (zh) * | 2022-12-15 | 2026-04-14 | 东南大学 | 遗传性耳聋检测系统、标志物或探针、药物及应用 |
| US20240263143A1 (en) * | 2023-02-02 | 2024-08-08 | Agathos Biologics | Baby Hamster Kidney (BHK) Cells Transformed with the Adenoviral E1 Gene for Production of Recombinant Adeno-Associated Virus |
| EP4713463A1 (en) * | 2023-05-18 | 2026-03-25 | Decibel Therapeutics, Inc. | Compositions and methods for treating gjb2-related hearing loss |
| CN116925239B (zh) * | 2023-07-17 | 2024-10-18 | 苏州星奥拓维生物技术有限公司 | 双载体系统表达Otof基因的组合物和方法 |
| CN119510774A (zh) * | 2024-11-26 | 2025-02-25 | 华中科技大学同济医学院附属协和医院 | Sptbn1作为靶点在治疗gjb2相关感音神经性听力损失中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1755400A2 (en) * | 2004-06-18 | 2007-02-28 | The University Of Montana | Aav mediated gene delivery to cochlear cells |
| US9085777B2 (en) * | 2006-05-11 | 2015-07-21 | Virttu Biologics Limited | Mutant HSV, materials and methods for generation of mutant HSV |
| JP2010505442A (ja) * | 2006-10-10 | 2010-02-25 | ビロメッド カンパニー， リミテッド | 安全性の改善された発現ベクター |
| WO2015130840A2 (en) * | 2014-02-25 | 2015-09-03 | Coda Therapeutics, Inc. | Treatment of resistant lesions |
| GB201513176D0 (en) * | 2015-07-27 | 2015-09-09 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
| GB2547179A (en) | 2015-10-26 | 2017-08-16 | Quethera Ltd | Genetic construct |
| SG10201913266UA (en) * | 2015-12-11 | 2020-02-27 | Massachusetts Eye & Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| WO2017136764A1 (en) * | 2016-02-05 | 2017-08-10 | The General Hospital Corporation | Hybrid system for efficient gene delivery to cells of the inner ear |
| WO2017191274A2 (en) * | 2016-05-04 | 2017-11-09 | Curevac Ag | Rna encoding a therapeutic protein |
| EP3585883A4 (en) * | 2017-02-21 | 2021-04-14 | University of Florida Research Foundation, Incorporated | MODIFIED AAV CAPSID PROTEINS AND USES THEREOF |
| CN109055499B (zh) * | 2018-08-30 | 2021-01-19 | 杭州杰毅生物技术有限公司 | 基于CRISPR-Cas的等温核酸检测方法及试剂盒 |
| TW202227476A (zh) * | 2020-09-14 | 2022-07-16 | 哈佛大學校長及研究員協會 | 編碼GJB2之重組腺相關病毒(rAAV)及其用途 |
-
2020
- 2020-09-30 WO PCT/US2020/053561 patent/WO2021067448A1/en not_active Ceased
- 2020-09-30 AU AU2020357740A patent/AU2020357740A1/en active Pending
- 2020-09-30 EP EP20870938.6A patent/EP4037771A4/en active Pending
- 2020-09-30 US US17/038,482 patent/US12241077B2/en active Active
- 2020-09-30 CA CA3153133A patent/CA3153133A1/en active Pending
- 2020-09-30 JP JP2022520059A patent/JP7713130B2/ja active Active
- 2020-09-30 IL IL291789A patent/IL291789A/en unknown
- 2020-09-30 KR KR1020227014445A patent/KR20220133854A/ko active Pending
- 2020-09-30 CN CN202080083106.6A patent/CN115103710A/zh active Pending
-
2025
- 2025-01-17 US US19/029,896 patent/US20250236887A1/en active Pending
- 2025-03-06 JP JP2025035714A patent/JP2025110904A/ja active Pending
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