JP2022549380A5 - - Google Patents
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- Publication number
- JP2022549380A5 JP2022549380A5 JP2022520059A JP2022520059A JP2022549380A5 JP 2022549380 A5 JP2022549380 A5 JP 2022549380A5 JP 2022520059 A JP2022520059 A JP 2022520059A JP 2022520059 A JP2022520059 A JP 2022520059A JP 2022549380 A5 JP2022549380 A5 JP 2022549380A5
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025035714A JP2025110904A (ja) | 2019-09-30 | 2025-03-06 | 遺伝性難聴の処置のためのアデノ随伴ウイルス（ａａｖ）システム |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962907834P | 2019-09-30 | 2019-09-30 | |
| US62/907,834 | 2019-09-30 | ||
| PCT/US2020/053561 WO2021067448A1 (en) | 2019-09-30 | 2020-09-30 | Adeno-associated virus (aav) systems for treatment of genetic hearing loss |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025035714A Division JP2025110904A (ja) | 2019-09-30 | 2025-03-06 | 遺伝性難聴の処置のためのアデノ随伴ウイルス（ａａｖ）システム |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022549380A JP2022549380A (ja) | 2022-11-24 |
| JP2022549380A5 true JP2022549380A5 (https=) | 2023-10-10 |
| JPWO2021067448A5 JPWO2021067448A5 (https=) | 2023-10-10 |
| JP7713130B2 JP7713130B2 (ja) | 2025-07-25 |
Family
ID=75161339
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022520059A Active JP7713130B2 (ja) | 2019-09-30 | 2020-09-30 | 遺伝性難聴の処置のためのアデノ随伴ウイルス（ａａｖ）システム |
| JP2025035714A Pending JP2025110904A (ja) | 2019-09-30 | 2025-03-06 | 遺伝性難聴の処置のためのアデノ随伴ウイルス（ａａｖ）システム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025035714A Pending JP2025110904A (ja) | 2019-09-30 | 2025-03-06 | 遺伝性難聴の処置のためのアデノ随伴ウイルス（ａａｖ）システム |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US12241077B2 (https=) |
| EP (1) | EP4037771A4 (https=) |
| JP (2) | JP7713130B2 (https=) |
| KR (1) | KR20220133854A (https=) |
| CN (1) | CN115103710A (https=) |
| AU (1) | AU2020357740A1 (https=) |
| CA (1) | CA3153133A1 (https=) |
| IL (1) | IL291789A (https=) |
| WO (1) | WO2021067448A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2019530737A (ja) | 2016-08-23 | 2019-10-24 | アコーオス インコーポレイテッド | ヒト対象において非加齢性聴力障害を治療するための組成物および方法 |
| US12054724B2 (en) | 2018-04-10 | 2024-08-06 | President And Fellows Of Harvard College | AAV vectors encoding clarin-1 or GJB2 and uses thereof |
| JP7807380B2 (ja) | 2020-02-21 | 2026-01-27 | アコーオス インコーポレイテッド | ヒト対象において非加齢関連聴力障害を処置するための組成物および方法 |
| EP4164695A4 (en) * | 2020-05-13 | 2024-06-05 | Akouos, Inc. | COMPOSITIONS AND METHODS FOR TREATING GJB2-ASSOCIATED HEARING LOSS |
| CN116234917A (zh) | 2020-07-27 | 2023-06-06 | 安杰瑞姆生物科学公司 | Dna分子组合物及其制备方法和使用方法 |
| US20230340038A1 (en) * | 2020-09-14 | 2023-10-26 | President And Fellows Of Harvard College | Recombinant adeno associated virus (raav) encoding gjb2 and uses thereof |
| US12129287B2 (en) | 2020-09-14 | 2024-10-29 | President And Fellows Of Harvard College | Recombinant adeno associated virus encoding clarin-1 and uses thereof |
| JP2023541443A (ja) * | 2020-09-14 | 2023-10-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ＧＪＢ２をコードする組換えアデノ随伴ウイルス（ｒＡＡＶ）およびその使用。 |
| AU2021376225A1 (en) * | 2020-11-06 | 2023-06-22 | Eli Lilly And Company | Variant adeno-associated virus (aav)capsid polypeptides and gene therapeutics thereof for treatment of hearing loss |
| EP4278002A2 (en) * | 2021-01-18 | 2023-11-22 | Life Technologies Corporation | Compositions, kits and methods for direct amplification from crude biological samples |
| US20240197920A1 (en) * | 2021-04-27 | 2024-06-20 | The Children's Hospital Of Philadelphia | Adeno-associated viral vectors for transduction of cochlea |
| US20250339560A1 (en) * | 2021-05-13 | 2025-11-06 | Akouos, Inc. | Gene therapy delivery compositions and methods for treating hearing loss |
| WO2023106256A1 (ja) * | 2021-12-06 | 2023-06-15 | 学校法人順天堂 | 改変型アデノ随伴ウイルスベクター |
| US20240252685A1 (en) * | 2022-05-09 | 2024-08-01 | Akouos, Inc. | Cell specific gene therapy delivery compositions and methods for treating hearing loss |
| EP4536862A1 (en) * | 2022-06-09 | 2025-04-16 | Wisconsin Alumni Research Foundation | Generation of next generation recombinant aav gene therapy vectors that adopt 3d conformation |
| US20260103728A1 (en) * | 2022-10-12 | 2026-04-16 | The Johns Hopkins University | Method of treating lbsl by enhancing dars2 expression |
| CN115717166B (zh) * | 2022-12-15 | 2026-04-14 | 东南大学 | 遗传性耳聋检测系统、标志物或探针、药物及应用 |
| EP4658759A2 (en) * | 2023-02-02 | 2025-12-10 | Agathos Biologics | Baby hamster kidney (bhk) cells transformed with the adenoviral e1 gene for production of recombinant adeno-associated virus |
| EP4713463A1 (en) * | 2023-05-18 | 2026-03-25 | Decibel Therapeutics, Inc. | Compositions and methods for treating gjb2-related hearing loss |
| CN116925239B (zh) * | 2023-07-17 | 2024-10-18 | 苏州星奥拓维生物技术有限公司 | 双载体系统表达Otof基因的组合物和方法 |
| CN119510774A (zh) * | 2024-11-26 | 2025-02-25 | 华中科技大学同济医学院附属协和医院 | Sptbn1作为靶点在治疗gjb2相关感音神经性听力损失中的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050281786A1 (en) * | 2004-06-18 | 2005-12-22 | David Poulsen | AAV mediated gene delivery to cochlear cells |
| WO2007132169A1 (en) * | 2006-05-11 | 2007-11-22 | Crusade Laboratories Limited | Mutant hsv, materials and methods for generation of mutant hsv |
| US8105575B2 (en) * | 2006-10-10 | 2012-01-31 | Viromed Co., Ltd. | Expression vectors with improved safety |
| CA2940648A1 (en) * | 2014-02-25 | 2015-09-03 | Coda Therapeutics, Inc. | Treatment of resistant lesions |
| GB201513176D0 (en) * | 2015-07-27 | 2015-09-09 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
| GB2547179A (en) | 2015-10-26 | 2017-08-16 | Quethera Ltd | Genetic construct |
| SG11201804814YA (en) * | 2015-12-11 | 2018-07-30 | Massachusetts Eye & Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| WO2017136764A1 (en) * | 2016-02-05 | 2017-08-10 | The General Hospital Corporation | Hybrid system for efficient gene delivery to cells of the inner ear |
| EP3452101A2 (en) * | 2016-05-04 | 2019-03-13 | CureVac AG | Rna encoding a therapeutic protein |
| AU2018224044B2 (en) * | 2017-02-21 | 2024-01-25 | The Uab Research Foundation | Modified AAV capsid proteins and uses thereof |
| CN109055499B (zh) | 2018-08-30 | 2021-01-19 | 杭州杰毅生物技术有限公司 | 基于CRISPR-Cas的等温核酸检测方法及试剂盒 |
| JP2023541443A (ja) * | 2020-09-14 | 2023-10-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ＧＪＢ２をコードする組換えアデノ随伴ウイルス（ｒＡＡＶ）およびその使用。 |
-
2020
- 2020-09-30 CA CA3153133A patent/CA3153133A1/en active Pending
- 2020-09-30 KR KR1020227014445A patent/KR20220133854A/ko active Pending
- 2020-09-30 WO PCT/US2020/053561 patent/WO2021067448A1/en not_active Ceased
- 2020-09-30 AU AU2020357740A patent/AU2020357740A1/en active Pending
- 2020-09-30 CN CN202080083106.6A patent/CN115103710A/zh active Pending
- 2020-09-30 EP EP20870938.6A patent/EP4037771A4/en active Pending
- 2020-09-30 US US17/038,482 patent/US12241077B2/en active Active
- 2020-09-30 IL IL291789A patent/IL291789A/en unknown
- 2020-09-30 JP JP2022520059A patent/JP7713130B2/ja active Active
-
2025
- 2025-01-17 US US19/029,896 patent/US20250236887A1/en active Pending
- 2025-03-06 JP JP2025035714A patent/JP2025110904A/ja active Pending